LOCUS       NM_001015028            4367 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ankyrin repeat and sterile alpha motif domain
            containing 6 (Anks6), mRNA.
ACCESSION   NM_001015028 XM_342833
VERSION     NM_001015028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4367)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   2  (bases 1 to 4367)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4367)
  AUTHORS   Delestre,L., Bakey,Z., Prado,C., Hoffmann,S., Bihoreau,M.T.,
            Lelongt,B. and Gauguier,D.
  TITLE     ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is
            Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice
  JOURNAL   PLoS One 10 (9), e0136781 (2015)
   PUBMED   26327442
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4367)
  AUTHORS   Ramachandran,H., Engel,C., Muller,B., Dengjel,J., Walz,G. and
            Yakulov,T.A.
  TITLE     Anks3 alters the sub-cellular localization of the Nek7 kinase
  JOURNAL   Biochem Biophys Res Commun 464 (3), 901-907 (2015)
   PUBMED   26188091
REFERENCE   5  (bases 1 to 4367)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 4367)
  AUTHORS   Stagner,E.E., Bouvrette,D.J., Cheng,J. and Bryda,E.C.
  TITLE     The polycystic kidney disease-related proteins Bicc1 and SamCystin
            interact
  JOURNAL   Biochem Biophys Res Commun 383 (1), 16-21 (2009)
   PUBMED   19324013
  REMARK    GeneRIF: Bicc1 and SamCystin interact at the protein level
            suggesting that they function in a common molecular pathway that
            when perturbed, is involved in cystogenesis.
REFERENCE   7  (bases 1 to 4367)
  AUTHORS   Kaisaki,P.J., Bergmann,C., Brown,J.H., Outeda,P., Lens,X.M.,
            Peters,D.J., Gretz,N., Gauguier,D. and Bihoreau,M.T.
  TITLE     Genomic organization and mutation screening of the human ortholog
            of Pkdr1 associated with polycystic kidney disease in the rat
  JOURNAL   Eur J Med Genet 51 (4), 325-331 (2008)
   PUBMED   18434273
  REMARK    GeneRIF: Susceptibility to renal cyst formation in the (cy/+) rat
            is caused by a missense mutation in Pkdr1 encoding the novel
            protein SamCystin.
REFERENCE   8  (bases 1 to 4367)
  AUTHORS   Brown,J.H., Bihoreau,M.T., Hoffmann,S., Kranzlin,B.,
            Tychinskaya,I., Obermuller,N., Podlich,D., Boehn,S.N.,
            Kaisaki,P.J., Megel,N., Danoy,P., Copley,R.R., Broxholme,J.,
            Witzgall,R., Lathrop,M., Gretz,N. and Gauguier,D.
  TITLE     Missense mutation in sterile alpha motif of novel protein SamCystin
            is associated with polycystic kidney disease in (cy/+) rat
  JOURNAL   J Am Soc Nephrol 16 (12), 3517-3526 (2005)
   PUBMED   16207829
REFERENCE   9  (bases 1 to 4367)
  AUTHORS   Bihoreau,M.T., Ceccherini,I., Browne,J., Kranzlin,B., Romeo,G.,
            Lathrop,G.M., James,M.R. and Gretz,N.
  TITLE     Location of the first genetic locus, PKDr1, controlling autosomal
            dominant polycystic kidney disease in Han:SPRD cy/+ rat
  JOURNAL   Hum Mol Genet 6 (4), 609-613 (1997)
   PUBMED   9097967
REFERENCE   10 (bases 1 to 4367)
  AUTHORS   Schafer,K., Gretz,N., Bader,M., Oberbaumer,I., Eckardt,K.U.,
            Kriz,W. and Bachmann,S.
  TITLE     Characterization of the Han:SPRD rat model for hereditary
            polycystic kidney disease
  JOURNAL   Kidney Int 46 (1), 134-152 (1994)
   PUBMED   7933831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY661303.1.
            
            On or before Dec 3, 2005 this sequence version replaced
            XM_342833.2, NM_001015028.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY661303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4367
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 6"
                     /db_xref="GeneID:362515"
                     /db_xref="RGD:3334"
     exon            1..483
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2809
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /note="samcystin; polycystic kidney disease protein 1;
                     sterile alpha motif domain-containing protein 6; SAM
                     domain-containing protein 6"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     6"
                     /protein_id="NP_001015028.2"
                     /db_xref="GeneID:362515"
                     /db_xref="RGD:3334"
                     /translation="MGEGALAPGLQLLLRACEQGDTDTARRLLEPGGEPVAGSEAGAE
                     PAGPEAARAVEAGTPVPVDCSDEAGNSALQLAAAGGHEPLVRFLLRRGASVNSRNHYG
                     WSALMQAARCGHASVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAT
                     VDHRNPSGESTASGGSRDELLGITALMAAVQHGHEAVVRLLMEWGADPNHTARTVGWS
                     PLMLAALLGKLSVVQQLVEKGANPDHLGVLEKTAFEVALDRKHRDLADYLDPLTTVRP
                     KTDEEKRRPDIFHALKMGNFQLVKEIADEDPNHVNLVNGDGATPLMLAAVTGQLPLVQ
                     LLVEKHADMNKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM
                     LLNDPDTELVRLLASVCMQVNKDRGGRPSHRPPLPHSKARQPWSIPMLPDDKGGLKSW
                     WSRMSNRFRKLKLMQTLPRGLAANQPLPFSDEPELALDSTMRAPPQDRTNHLGPPEAA
                     HAAKDSGPGNPRREKDDVLLTTMLRNGAPFPRLPSDKLKAVIPPFLPPSSFELWSSDR
                     SRTCPNGKADPMKTVLPPRASRAHPVGCVGTDGAAGRPVKFPSISRSPTSPASSGNFN
                     HSPHSSGGASGVGSMSRLGGELHNRSGGSVDSVLSQIAAQRKKAAGLCEQKPPCQQSS
                     PVGPATGSSPPELPASLLGSGSGSSNVTSSSKKLDPGKRPPSGTSATSKSTSPTLTPS
                     PSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQE
                     VDMEAFLTLTDGDLQELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFE
                     SSASNTRAPGNSPSMAGWVRPEETVSSRR"
     exon            484..986
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1031
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1236
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1343
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1495
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1694
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1744
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1948
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2102
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2293
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2477
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2545
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2662
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2759
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..4367
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacaagccc ggaggcgggt cctgcgcgcg cgtactcagc aggcgcggcc ccggaggcgc
       61 gcgcgcaccc agggggcggg cctgcggaag gcggcgggca cgcgcggact cggggtggga
      121 gcgggcggcg gcgcggagcg agcggcgggc gatgggcgag ggcgcgctgg ccccgggcct
      181 gcagctgctg ctccgcgcct gcgagcaggg tgacacggac acggcgcggc gcctgctgga
      241 gccaggaggg gagccggtcg cggggtccga ggcgggagcg gagccggcag ggcccgaggc
      301 ggcccgggca gtggaggccg ggacgccggt gccggtggac tgctcggatg aggcgggcaa
      361 ctcggcgctg cagctggcgg cggccggtgg tcacgagcca ctcgtgaggt tcctgctgcg
      421 ccgcggagcc tcggtcaaca gccgcaacca ctacggctgg agcgcgctca tgcaggcggc
      481 caggtgtggg catgcgagcg tggcacacct ccttttggat catggagctg atgtcaacgc
      541 tcagaatcgg ctgggtgcca gtgtgctcac tgtggcttcc cgagggggcc acctgggtgt
      601 ggtgaaactg ctgctcgagg caggcgccac tgtggaccat cgtaaccctt ctggagagtc
      661 aacagcatcg ggaggcagca gggacgaact gctgggcatc acagccctga tggctgccgt
      721 ccagcatggg catgaggccg tcgtacgcct gctgatggag tggggtgcgg accccaacca
      781 cacagcccgg actgtgggct ggagccctct gatgctggca gccctcctcg ggaagctcag
      841 tgtggtgcag cagctggtcg agaagggagc caaccccgac cacctcggcg tgctggagaa
      901 gacagccttc gaggttgccc ttgaccgaaa acacagggat ctagctgatt acctggaccc
      961 actgaccact gtcaggccga aaacagatga ggagaagagg cgacctgata ttttccacgc
     1021 cctgaagatg ggaaacttcc agctggtcaa ggagattgct gacgaagacc ccaaccacgt
     1081 gaacctggtc aacggggacg gggcgacccc actgatgctg gctgctgtca cgggacagtt
     1141 gcccctggta cagctgctgg tagagaagca tgcagacatg aacaagcagg acagcgtgca
     1201 tggctggacg gccctcatgc aggccaccta ccatggaaat aaagaaattg taaagtatct
     1261 gctaaatcaa ggggctgatg ttactcttcg agccaaaaac ggatacacgg ccttcgacct
     1321 ggtaatgctg ctgaatgatc ctgacactga acttgttcga ctgctagcgt ctgtgtgcat
     1381 gcaggtgaat aaggaccgag gtggtcggcc cagccaccgt ccacccctgc cccactcgaa
     1441 ggccaggcaa ccctggagca tccccatgct gcccgacgac aagggaggcc tgaagtcctg
     1501 gtggagccgg atgtccaaca ggttccgaaa actcaaactt atgcagacac tgccacgcgg
     1561 gctggctgcc aaccaacctt tgcctttctc tgacgagcct gagctggcac tggactccac
     1621 catgcgggca cccccccagg acaggactaa ccaccttggg ccacctgaag cagcccatgc
     1681 agccaaagac agtggccctg ggaacccgag aagggagaag gacgatgtgt tactgacgac
     1741 catgctgcgc aatggagccc ccttcccccg gctccccagt gacaagctga aggccgtcat
     1801 cccacccttc ctgcccccgt ccagcttcga actgtggagc tccgacaggt cccgcacgtg
     1861 tcccaatggg aaggcggacc ccatgaagac tgtgctgccc ccaagagcca gcagggccca
     1921 ccctgtgggc tgcgtgggca cagacggtgc tgctggcagg ccagtcaaat tccccagcat
     1981 ctccaggagc cccacgtccc ctgccagctc cgggaacttt aaccactcgc ctcattcttc
     2041 agggggtgcc agtggcgtgg gcagcatgag caggctgggg ggagagctgc ataaccgctc
     2101 aggtggcagc gtagacagtg tcctctccca gatcgctgct cagaggaaaa aagcggctgg
     2161 cctgtgtgag cagaagcccc cctgccagca gtccagtcct gtggggccag cgaccggctc
     2221 cagcccacct gagctgccag cctccctcct gggcagtggt agtggctctt ccaatgttac
     2281 ttccagcagc aagaaactgg accctggcaa acggcctccc tctggaactt ctgctacctc
     2341 taaaagcacc tctcccaccc tcacgccttc cccctctccc aaaggccaca ctgcggagtc
     2401 ctcagtgtct tcctcctcgt cccaccggca atctaagagc agtgggggct ctagcagtgg
     2461 caccatcacc gatgaggatg agctgactgg aatccttaag aagttatcac ttgagaaata
     2521 ccagcccatc ttcgaggagc aagaggtgga catggaagct ttcctcacac tcaccgacgg
     2581 tgacctgcag gagctgggga ttaagacgga tggttcccgg cagcagattc tggcggccat
     2641 ctctgagctg aatgcgggca aggggcgtga gaggcagatt ctacaggaaa ccattcacaa
     2701 cttccactct tcctttgaga gcagcgccag caacaccaga gcccctggca acagtccctc
     2761 catggccgga tgggtaaggc cagaagaaac agtgtcgagc aggaggtagc cacagcttgg
     2821 gcggctccgc tggcctcgga gccctgaggt ggtgaggact gagcagtgaa cccccgccct
     2881 tcctctgtgt ctgctcctgg gttatttctt ccctgggact cacagcaagt ggacagagag
     2941 aaggctggct agccagatcc tcagggctga tgcagtgggc agagcctgag aagccacctt
     3001 tgcagaggcc tgagaatatg caggccgtgc tggatgccgc acggctgcag gtacaaaccc
     3061 gaacctgcat gtgcaaggac gtgctgccct ccaggcctag gacccttcca gaaaagatgc
     3121 tatacccagt gaacccctgc agaaggtgtg gtgaagcacc cactgtgaac ccctgcagaa
     3181 ggtgtggtga agcacccgca gtgaacccct gcagaaggtg tggtgaagca cccgcagtga
     3241 acctctgcag aaggtgtggt gaagcaccca ctgtgaaccc ctgcagaagg tgtggtgaag
     3301 cacccactgt aactgctgtt gcttgtttta cgcagtcacc aacaggtcct cttcagcatg
     3361 tgaggaagct caatgctgtc cctaatgaag ctggtgcccg agtctgcaga ctgcccagga
     3421 gaggggcccg agaccctggg agtttcctgc ttattcacgt gaggcctcca gagaacaggc
     3481 caggctcccc cctgctcttg agacgctaca agcctggtca cagccatggt tgtagtacag
     3541 ctgtgcacaa atggacagtg aggggagggt gcaggaggga gctgttgatg aagagccacg
     3601 ttggaagagc gcgccaagcc tgcccacttc acttgtcttc agctccttcc accccactgg
     3661 gcttccttcc tgtggccaaa accatgcttg ctgctggcca aagccctgcc gctgagtgga
     3721 gccgactcag ctcagagcaa cctcctgtgt cccgtgtgag ccttccctct aagaccagca
     3781 gacagggtca tcttcatcag gataccccag tggcaggact agaatgacct tgtcccagct
     3841 cacactggag taccctgaat ggtcagaagc cacggcgcca tcttgcttca gctctgcagc
     3901 tggttcattt ttctctcatc agtcacagca tcatttctac acagggactc agtccttgga
     3961 aagatttttg cttgccagac cacgtctatt aaaaatgggg agtctgcccc ctgtctctgt
     4021 gctctcgagg gcatcacatg ccgcccaggg ttcctatcaa atagctaaca tgcagggtgt
     4081 tcccctgcac tcccttaccc catctccaca gcaagtgctg aggcagctgg aaccttttat
     4141 tccggtcagt ttggtgactg tgacacacga tggtaaccca gctaaggagg gacactggtt
     4201 tggatgcagg tctcacctca gagtcgtctt cctgatgtca gcaacgagta acccagccag
     4261 caaccaaaca caaacaaatg acactttgtc atttcctctt tgaggttcat ttacagtggg
     4321 gagggggtgc aaagtgctat aaatggcttg gagattcttg tttctgg
//
