LOCUS       NP_001015028             885 aa            linear   ROD 03-APR-2024
DEFINITION  ankyrin repeat and SAM domain-containing protein 6 [Rattus
            norvegicus].
ACCESSION   NP_001015028 XP_342834
VERSION     NP_001015028.2
DBSOURCE    REFSEQ: accession NM_001015028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 885)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   2  (residues 1 to 885)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 885)
  AUTHORS   Delestre,L., Bakey,Z., Prado,C., Hoffmann,S., Bihoreau,M.T.,
            Lelongt,B. and Gauguier,D.
  TITLE     ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is
            Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice
  JOURNAL   PLoS One 10 (9), e0136781 (2015)
   PUBMED   26327442
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 885)
  AUTHORS   Ramachandran,H., Engel,C., Muller,B., Dengjel,J., Walz,G. and
            Yakulov,T.A.
  TITLE     Anks3 alters the sub-cellular localization of the Nek7 kinase
  JOURNAL   Biochem Biophys Res Commun 464 (3), 901-907 (2015)
   PUBMED   26188091
REFERENCE   5  (residues 1 to 885)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (residues 1 to 885)
  AUTHORS   Stagner,E.E., Bouvrette,D.J., Cheng,J. and Bryda,E.C.
  TITLE     The polycystic kidney disease-related proteins Bicc1 and SamCystin
            interact
  JOURNAL   Biochem Biophys Res Commun 383 (1), 16-21 (2009)
   PUBMED   19324013
  REMARK    GeneRIF: Bicc1 and SamCystin interact at the protein level
            suggesting that they function in a common molecular pathway that
            when perturbed, is involved in cystogenesis.
REFERENCE   7  (residues 1 to 885)
  AUTHORS   Kaisaki,P.J., Bergmann,C., Brown,J.H., Outeda,P., Lens,X.M.,
            Peters,D.J., Gretz,N., Gauguier,D. and Bihoreau,M.T.
  TITLE     Genomic organization and mutation screening of the human ortholog
            of Pkdr1 associated with polycystic kidney disease in the rat
  JOURNAL   Eur J Med Genet 51 (4), 325-331 (2008)
   PUBMED   18434273
  REMARK    GeneRIF: Susceptibility to renal cyst formation in the (cy/+) rat
            is caused by a missense mutation in Pkdr1 encoding the novel
            protein SamCystin.
REFERENCE   8  (residues 1 to 885)
  AUTHORS   Brown,J.H., Bihoreau,M.T., Hoffmann,S., Kranzlin,B.,
            Tychinskaya,I., Obermuller,N., Podlich,D., Boehn,S.N.,
            Kaisaki,P.J., Megel,N., Danoy,P., Copley,R.R., Broxholme,J.,
            Witzgall,R., Lathrop,M., Gretz,N. and Gauguier,D.
  TITLE     Missense mutation in sterile alpha motif of novel protein SamCystin
            is associated with polycystic kidney disease in (cy/+) rat
  JOURNAL   J Am Soc Nephrol 16 (12), 3517-3526 (2005)
   PUBMED   16207829
REFERENCE   9  (residues 1 to 885)
  AUTHORS   Bihoreau,M.T., Ceccherini,I., Browne,J., Kranzlin,B., Romeo,G.,
            Lathrop,G.M., James,M.R. and Gretz,N.
  TITLE     Location of the first genetic locus, PKDr1, controlling autosomal
            dominant polycystic kidney disease in Han:SPRD cy/+ rat
  JOURNAL   Hum Mol Genet 6 (4), 609-613 (1997)
   PUBMED   9097967
REFERENCE   10 (residues 1 to 885)
  AUTHORS   Schafer,K., Gretz,N., Bader,M., Oberbaumer,I., Eckardt,K.U.,
            Kriz,W. and Bachmann,S.
  TITLE     Characterization of the Han:SPRD rat model for hereditary
            polycystic kidney disease
  JOURNAL   Kidney Int 46 (1), 134-152 (1994)
   PUBMED   7933831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY661303.1.
            
            On or before Dec 3, 2005 this sequence version replaced
            XP_342834.2, NP_001015028.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY661303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..885
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..885
                     /product="ankyrin repeat and SAM domain-containing protein
                     6"
                     /note="samcystin; polycystic kidney disease protein 1;
                     sterile alpha motif domain-containing protein 6; SAM
                     domain-containing protein 6"
                     /calculated_mol_wt=93662
     Region          8..37
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          9..66
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <43..268
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          68..97
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          69..99
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(70,74..75,78..80,82..83,87,90,99,101,103,107..108,
                     111..113,115..116,120,123,132,134,136,140..141,144..146,
                     148..149,153,156,165)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          101..132
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          101..130
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Site            129
                     /site_type="hydroxylation"
                     /note="3-hydroxyasparagine.
                     /evidence=ECO:0000269|PubMed:23793029; propagated from
                     UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          134..165
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..163
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          167..210
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          181..210
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          214..244
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          215..244
                     /region_name="ANK 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          282..312
                     /region_name="ANK 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          287..380
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Site            order(292..294,296..297,301,304,314,316,318,322..323,
                     326..328,330..331,335,338,347,350,352,356..357,360..362,
                     364..365,369,372)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          316..347
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          316..345
                     /region_name="ANK 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          350..380
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          350..379
                     /region_name="ANK 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          355..>420
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          383..414
                     /region_name="ANK 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          383..411
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          415..439
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          491..522
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          563..775
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     Site            650
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68DC2; propagated from
                     UniProtKB/Swiss-Prot (P0C0T2.2)"
     Site            734
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68DC2; propagated from
                     UniProtKB/Swiss-Prot (P0C0T2.2)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q68DC2; propagated from
                     UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          771..835
                     /region_name="SAM_ANKS6"
                     /note="SAM domain of ANKS6 (or SamCystin) subfamily;
                     cd09518"
                     /db_xref="CDD:188917"
     Site            823
                     /site_type="other"
                     /note="Essential for ANKS3 interaction.
                     /evidence=ECO:0000269|PubMed:26327442; propagated from
                     UniProtKB/Swiss-Prot (P0C0T2.2)"
     Region          855..885
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0T2.2)"
     CDS             1..885
                     /gene="Anks6"
                     /gene_synonym="Pkdr1; Samd6"
                     /coded_by="NM_001015028.2:152..2809"
                     /db_xref="GeneID:362515"
                     /db_xref="RGD:3334"
ORIGIN      
        1 mgegalapgl qlllraceqg dtdtarrlle pggepvagse agaepagpea araveagtpv
       61 pvdcsdeagn salqlaaagg heplvrfllr rgasvnsrnh ygwsalmqaa rcghasvahl
      121 lldhgadvna qnrlgasvlt vasrgghlgv vkllleagat vdhrnpsges tasggsrdel
      181 lgitalmaav qhgheavvrl lmewgadpnh tartvgwspl mlaallgkls vvqqlvekga
      241 npdhlgvlek tafevaldrk hrdladyldp lttvrpktde ekrrpdifha lkmgnfqlvk
      301 eiadedpnhv nlvngdgatp lmlaavtgql plvqllvekh admnkqdsvh gwtalmqaty
      361 hgnkeivkyl lnqgadvtlr akngytafdl vmllndpdte lvrllasvcm qvnkdrggrp
      421 shrpplphsk arqpwsipml pddkgglksw wsrmsnrfrk lklmqtlprg laanqplpfs
      481 depelaldst mrappqdrtn hlgppeaaha akdsgpgnpr rekddvlltt mlrngapfpr
      541 lpsdklkavi ppflppssfe lwssdrsrtc pngkadpmkt vlpprasrah pvgcvgtdga
      601 agrpvkfpsi srsptspass gnfnhsphss ggasgvgsms rlggelhnrs ggsvdsvlsq
      661 iaaqrkkaag lceqkppcqq sspvgpatgs sppelpasll gsgsgssnvt ssskkldpgk
      721 rppsgtsats kstsptltps pspkghtaes svssssshrq skssggsssg titdedeltg
      781 ilkklsleky qpifeeqevd meafltltdg dlqelgiktd gsrqqilaai selnagkgre
      841 rqilqetihn fhssfessas ntrapgnsps magwvrpeet vssrr
//
