LOCUS       NM_001414940            8048 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ankyrin repeat and sterile alpha motif domain
            containing 1B (Anks1b), transcript variant 1, mRNA.
ACCESSION   NM_001414940 XM_017594829
VERSION     NM_001414940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8048)
  AUTHORS   Dosemeci,A., Toy,D., Burch,A., Bayer,K.U. and Tao-Cheng,J.H.
  TITLE     CaMKII-mediated displacement of AIDA-1 out of the postsynaptic
            density core
  JOURNAL   FEBS Lett 590 (17), 2934-2939 (2016)
   PUBMED   27477489
  REMARK    GeneRIF: CaMKII-mediated redistribution of AIDA-1 is similar to
            that observed for SynGAP. CaMKII-mediated removal of two abundant
            PSD-95-binding proteins from the PSD core during activity is
            expected to initiate a molecular reorganization at the PSD.
REFERENCE   2  (bases 1 to 8048)
  AUTHORS   Dosemeci,A., Toy,D., Reese,T.S. and Tao-Cheng,J.H.
  TITLE     AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory
            Conditions
  JOURNAL   PLoS One 10 (9), e0137216 (2015)
   PUBMED   26356309
  REMARK    GeneRIF: localization as well as the activity-induced
            redistribution of AIDA-1 at the postsynaptic density, was examined.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8048)
  AUTHORS   Tindi,J.O., Chavez,A.E., Cvejic,S., Calvo-Ochoa,E., Castillo,P.E.
            and Jordan,B.A.
  TITLE     ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic
            Transmission by Regulating GluN2B Subunit Localization
  JOURNAL   J Neurosci 35 (24), 8986-8996 (2015)
   PUBMED   26085624
REFERENCE   4  (bases 1 to 8048)
  AUTHORS   Kroker,K.S., Mathis,C., Marti,A., Cassel,J.C., Rosenbrock,H. and
            Dorner-Ciossek,C.
  TITLE     PDE9A inhibition rescues amyloid beta-induced deficits in synaptic
            plasticity and cognition
  JOURNAL   Neurobiol Aging 35 (9), 2072-2078 (2014)
   PUBMED   24746365
  REMARK    GeneRIF: It impairs hippocampallong-term potentiation.
REFERENCE   5  (bases 1 to 8048)
  AUTHORS   Jacob,A.L., Jordan,B.A. and Weinberg,R.J.
  TITLE     Organization of amyloid-beta protein precursor intracellular
            domain-associated protein-1 in the rat brain
  JOURNAL   J Comp Neurol 518 (16), 3221-3236 (2010)
   PUBMED   20575057
  REMARK    GeneRIF: data suggest that AIDA-1 serves as a direct signaling link
            between synapses and the nucleus in adult rat brain.
REFERENCE   6  (bases 1 to 8048)
  AUTHORS   Shin,J., Gu,C., Park,E. and Park,S.
  TITLE     Identification of phosphotyrosine binding domain-containing
            proteins as novel downstream targets of the EphA8 signaling
            function
  JOURNAL   Mol Cell Biol 27 (23), 8113-8126 (2007)
   PUBMED   17875921
REFERENCE   7  (bases 1 to 8048)
  AUTHORS   Jordan,B.A., Fernholz,B.D., Khatri,L. and Ziff,E.B.
  TITLE     Activity-dependent AIDA-1 nuclear signaling regulates nucleolar
            numbers and protein synthesis in neurons
  JOURNAL   Nat Neurosci 10 (4), 427-435 (2007)
   PUBMED   17334360
REFERENCE   8  (bases 1 to 8048)
  AUTHORS   Jordan,B.A., Fernholz,B.D., Boussac,M., Xu,C., Grigorean,G.,
            Ziff,E.B. and Neubert,T.A.
  TITLE     Identification and verification of novel rodent postsynaptic
            density proteins
  JOURNAL   Mol Cell Proteomics 3 (9), 857-871 (2004)
   PUBMED   15169875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 15, 2022 this sequence version replaced XM_017594829.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-924               JAXUCZ010000007.1  26200649-26201572
            925-1005            JAXUCZ010000007.1  26388023-26388103
            1006-1162           JAXUCZ010000007.1  26396576-26396732
            1163-1459           JAXUCZ010000007.1  26403708-26404004
            1460-1535           JAXUCZ010000007.1  26416743-26416818
            1536-1637           JAXUCZ010000007.1  26417929-26418030
            1638-1754           JAXUCZ010000007.1  26420866-26420982
            1755-1921           JAXUCZ010000007.1  26424270-26424436
            1922-2065           JAXUCZ010000007.1  26515620-26515763
            2066-2231           JAXUCZ010000007.1  26623196-26623361
            2232-2368           JAXUCZ010000007.1  26683614-26683750
            2369-2549           JAXUCZ010000007.1  26725624-26725804
            2550-3136           JAXUCZ010000007.1  26888363-26888949
            3137-3197           JAXUCZ010000007.1  26890596-26890656
            3198-3304           JAXUCZ010000007.1  26960314-26960420
            3305-3403           JAXUCZ010000007.1  27034265-27034363
            3404-3556           JAXUCZ010000007.1  27068357-27068509
            3557-3664           JAXUCZ010000007.1  27288822-27288929
            3665-3844           JAXUCZ010000007.1  27290919-27291098
            3845-3916           JAXUCZ010000007.1  27308213-27308284
            3917-4045           JAXUCZ010000007.1  27314470-27314598
            4046-4117           JAXUCZ010000007.1  27316688-27316759
            4118-4129           JAXUCZ010000007.1  27333273-27333284
            4130-4216           JAXUCZ010000007.1  27334408-27334494
            4217-4354           JAXUCZ010000007.1  27341726-27341863
            4355-4522           JAXUCZ010000007.1  27359213-27359380
            4523-8048           JAXUCZ010000007.1  27363025-27366550
FEATURES             Location/Qualifiers
     source          1..8048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..8048
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 1B"
                     /db_xref="GeneID:314721"
                     /db_xref="RGD:1565556"
     exon            1..924
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     CDS             791..4633
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ankyrin repeat and sterile alpha motif domain-containing
                     protein 1B; E2A-PBX1-associated protein; amyloid-beta
                     protein intracellular domain-associated protein 1"
                     /codon_start=1
                     /product="ankyrin repeat and sterile alpha motif
                     domain-containing protein 1B isoform 1"
                     /protein_id="NP_001401869.1"
                     /db_xref="GeneID:314721"
                     /db_xref="RGD:1565556"
                     /translation="MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLL
                     SIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQFEASTNVADNKGYFPIHLAAWK
                     GDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK
                     LETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGM
                     DVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQ
                     IATLLQDYLEGVGRSVVLEEEHAQEDTAQETRLSSPAQSPSQKTKSETVTGELSKLLD
                     EIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVED
                     EEEDPNSCGPTGLWEALTPCNGCRNLGFPMLAQESYPKKRNYPMEIVPSASLDTFPSE
                     NENFLCELVDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTGHHRNSSTGPTPDCS
                     PPSPDTALKNIVKVIRPQPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPPV
                     SPPTSSVETTEIKNEGAEHTDDLSQQEDDEHPKEYDAGQFAGLLHGSSPACEAPENPF
                     HLYGKRNQGEDGQEEASLANSPLPFKQTPIENNPEPSVKKIKPKVVSRTIFHKRSHQL
                     ENHTIVGTRMSRGGSRNGDQWGVNPGGFVERACTLGRIRSLPKALIDMHLSKNVSKSD
                     SDLIAYPSKDKARVNWSKSSTAERSSKDNSERTPSFTSEWEEIDKIMNSIDVGINSEL
                     EGMNGPRCPVQTVGQWLESIGLPQYENHLTANGFDNVQFMGSNVMEDQDLLEIGILNS
                     GHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKK
                     IWELELINVLKISLIGHRKRILASLGDRLHEDPPQKPPRSITLREPSGNHTPPQLSPS
                     LSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQSSVCEIWTNQNA
                     GFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLG
                     SMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDAANKNIIA
                     EHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEV
                     AYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVE
                     PGQEAKRGINTKYETTIF"
     exon            925..1005
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1162
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1459
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1535
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1637
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1754
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1921
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2065
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2231
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2368
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2549
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..3136
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3197
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3304
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3403
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3556
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3664
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3844
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..3916
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4045
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4117
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4129
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4216
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4354
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..4522
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..8048
                     /gene="Anks1b"
                     /gene_synonym="AIDA-1; EB-1; RGD1565556"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggccggcc ccgggccgca cctgccgcgc gcacacgccc cccgcgcgcc gagcctccga
       61 gctgccgccg ccgccgccct ccgcacgcac ccgccgcggc tcgcccgcac agcccgcaca
      121 gcccagcctc ggcgcgggcc gcagccaccc cagccgcggc tgccgcgctt cttgcagcca
      181 cgggccgcgg ccatcgccgc cctgaaagag ccgagcctgc cgggcgcaga acccagtagg
      241 gtccaggctg ggcgctcgta agcacgggcc gcctctgccg ttgtggttcg ctaccctcta
      301 gctcccggga ggacgcgctt gactcgctcc tcatcagcct cagagctccg tgttgctcct
      361 cagtgccgga gcatccttcc ctgtgctcag catcctcctg tcagcgccgg agcatcctgc
      421 ccagtgcttg gcattctctg tgctcagcgt cctcctccga gctctgcatc ctccttccgt
      481 tcctcggcag cacccgggcc cagtccccac ccgctcgcac cccacccgcg ggaaggaggc
      541 ctcgggaatg caggggagtg gctgtggggg cgcgtcgccg ctcggccagc ccctctaccc
      601 aaacacgggc tgctccccat tgtaaagctg ctccgggaga aggaggacgg cgtgctgctc
      661 cctgtgcggg gctgcgggga atctcagcgt ccttttaggg tggggcgggg agggccctgg
      721 cttttgggga gtggacctgg aggaggaccg gagcagggaa aggactctgt agcggactcg
      781 gtgagagact atggggaagg accaggagct gctagaggct gctcgtactg gcaatgtggc
      841 tctggtcgag aaactcctat ctggcaggaa aggagggatc ctgggtggtg gatccggacc
      901 tctgcccctg tctaatctgc taagcatctg gcgaggtccc aacgtgaact gcacagacag
      961 ttcgggttac accgctttgc accacgcagc cttaaatgga cataaggaca tagttctcaa
     1021 actacttcaa ttcgaggcgt ccaccaatgt cgcagacaac aaaggttact tccccattca
     1081 cctggctgcc tggaaaggag acgtggagat tgtgaagatt cttatccatc acgggccttc
     1141 acattccaga gtcaatgaac agaacaacga gaacgaaact gccctccact gtgcagcgca
     1201 atacggacac tcagaagtag tggctgttct cctagaggag ctcaccgatc ccaccattag
     1261 gaacagcaag ctcgaaacac cgctggactt ggcagcgctc tacggaaggc tgagggtggt
     1321 gaagatgatc atcagcgcgc acccaaactt aatgagctgt aacacgcgga agcacacgcc
     1381 gctccacctc gcggcccgca atggtcacaa ggccgtggtg caggtgctgc tggaggcggg
     1441 gatggacgtg agctgtcaaa cagagaaggg gagtgctctt cacgaagcgg cgttgtttgg
     1501 gaaggtggat gtggtgcgag ttctgttaga aacaggaatt gatgccaaca taaaggacag
     1561 cctaggtaga accgtcttag acattctgaa agagcacccg tctcagaagt ctctccagat
     1621 tgcaacgctc ctgcaagact atttggaagg cgtgggaagg tcggtggtcc tcgaggaaga
     1681 gcatgctcag gaagacacag cacaagagac acgcctttcg tctcctgccc agtctccttc
     1741 tcaaaagact aaaagtgaaa ctgtcactgg agaactatcg aaactcctgg atgaaataaa
     1801 actctgtcaa gaaaaggatt attcctttga agatctgtgc catacaatct cagaccacta
     1861 cttagataat ttgagcaaga tctcagagga agaacttggg aaaaatggaa gccagagtgt
     1921 aagaacttca tctacaataa atttgtcacc aggagaagtg gaagacgaag aggaggatcc
     1981 aaactcttgt ggacccacgg gactttggga agcgctaact ccttgtaacg gatgtaggaa
     2041 ccttggcttt cccatgctcg cacaggagtc ttatccaaag aagaggaatt accccatgga
     2101 aattgtacca tctgcttctc tggacacatt cccttcagaa aatgagaact ttctttgtga
     2161 actcgtggac acagctgtta caaagaagcc ctgttcctta gaaatcgcaa gggcaccttc
     2221 tccgagaact gataatgcct ctgaggtagc aattactgct ccaggaactg gtcaccatag
     2281 aaacagctct acaggcccaa cacctgactg ctcacctcca tcccccgaca ctgccctaaa
     2341 aaatatcgta aaagttatcc gacctcagcc aaaacaacga acatctattg tgtcgtctct
     2401 ggatttccag cgaatgaatc ataaccaaga atactttgaa atcagcacat ctacaggctg
     2461 taccagcttt acttcgagcc ctccagtgag cccacccacc tcctctgtgg aaaccacaga
     2521 aatcaagaac gagggagctg aacacacaga tgacctctct cagcaggaag atgacgaaca
     2581 cccaaaagag tatgatgctg ggcaattcgc aggccttctc cacgggtcct ctccagcctg
     2641 tgaggctcca gaaaatccgt ttcacctgta tgggaaaaga aatcaaggtg aagacggaca
     2701 agaggaagcc agcttggcca acagtccttt gcctttcaaa cagactccaa tagaaaataa
     2761 cccagagcct tcagtgaaga aaattaaacc caaagtggtc agtagaacga ttttccacaa
     2821 aagaagccac caacttgaga accataccat cgttggcaca agaatgtcca ggggtggatc
     2881 ccgcaacggc gaccaatggg gtgtgaatcc agggggcttc gtggagagag cgtgcactct
     2941 agggagaata aggtcattgc ctaaagccct gatcgacatg catttatcca aaaatgtctc
     3001 caagtccgat tccgatctta ttgcgtaccc ttccaaggac aaagcgagag ttaactggag
     3061 caaatcgtca actgcagagc gcagttccaa agataattct gaaagaacgc cttccttcac
     3121 atctgaatgg gaagaaatcg acaaaataat gaactcgatt gacgttggaa tcaacagcga
     3181 acttgaaggg atgaacggac ccagatgccc tgtccaaaca gtaggacaat ggttggaaag
     3241 cattgggcta cctcagtacg agaaccacct gacggctaat ggatttgaca atgtacagtt
     3301 tatgggaagc aatgttatgg aagatcagga tttgttggaa attggaatcc ttaactctgg
     3361 tcacagacaa agaattctac aggcgatcca gctgcttcca aagatgaggc ccatcggcca
     3421 cgatggctac catcccacct ctgtagctga gtggctggat tccatcgagc tgggcgacta
     3481 cacgaaagcc tttctcatca atggctacac gtcgatggac ctgttgaaaa agatctggga
     3541 gcttgaactt attaacgttt taaaaatcag tttgattggc cacaggaagc gcattttggc
     3601 atctctggga gacagactgc acgaggaccc tccacagaag ccccctcggt ccatcaccct
     3661 cagggaaccc agtggtaatc acactcctcc tcagttgtct ccatcactta gccaaagcac
     3721 ttacaccact ggtggctccc tagacgtccc tcacattatc atgcagggcg atgcaaggag
     3781 gagaagaaat gaaaactact ttgatgatat tccccgatca aagctggaga gacagatggc
     3841 tcagtcgtct gtctgtgaaa tctggaccaa tcagaatgct ggatttcctt tctcagcgat
     3901 ccatcaggtt cataatacag gggactgggg agaaccttcc atcaccttgc gacctcctaa
     3961 tgaagccaca gcctcaactc cagtccagta ctggcagcat cacccagaaa agctcatctt
     4021 ccagtcgtgt gactacaaag ccttttattt aggttctatg ctgataaaag agctgagggg
     4081 aacggaatca acacaggacg cttgcgcaaa gatgcgggct aactgtcaga agtctacgga
     4141 gcaaatgaag aaagtcccca ctatcattct ttctgtctca tataaaggag tcaaatttat
     4201 tgatgcggca aataagaaca taattgccga gcatgaaatt cgtaatatct cttgtgctgc
     4261 ccaggaccca gaagacctct caacctttgc ttatatcaca aaagatctga agtccaacca
     4321 ccactactgt cacgtgttta ctgcctttga tgtgaattta gcctatgaaa tcatcctaac
     4381 gctggggcag gcatttgagg tcgcttacca gctagctcta caagcaagaa aagggggcca
     4441 ttcctccacg cttccggaga gctttgagaa caagccctcg aaacccatcc caaagccccg
     4501 agttagcatt cgcaagtcag tgcagatcga cccttctgag caaaagactc tggccaatct
     4561 gccgtggatt gtggagccgg ggcaagaagc caagaggggc attaatacca agtatgaaac
     4621 cacgattttc tgatacccgc cgccccgtcc tcgcggtgcc ttgctcgcca agcagtcccc
     4681 gcagcaggct ttccttcgcg cctccgtgtc cacccacccc gggaggaaga ccgctccagc
     4741 tcgcgtggcc tcgtcacggg cggaagggcg acggccatcc ctagggagcc ttctgccagc
     4801 gagactttga cgccccttag aggcgcgagg ggggctgcgc ggggcgcccc aactccgcta
     4861 ccaccgcctc cttcgaggta ctgctcaact gccccgtatt tgctttgctt tagttggggg
     4921 gagaatacct ttttaaaagt gaagggtggg gagagggagg gtctccagta ctgcctaaaa
     4981 gtctaaacat cttgggttaa gttttcactg tcagccattt cgaagggaaa gtcagaacag
     5041 tactacacac ccctccaacc cccccaaaag catctgtaaa atcattgtat tactgagtac
     5101 aatttcatgc aaaaagacaa agcaaccctc accaggaaat tctgccccca ccccacccga
     5161 tttctatatt tgtggatttt atatgtaatc aactatgtca gataaaggaa acctttattg
     5221 aatgattcaa aaatttaaaa agtgatttaa aacagaggaa tttattatgc acagaaaaaa
     5281 tgtgtcttgt attaaatatt tttattaaaa gaatgtttca ttaatgcatt catatgaaaa
     5341 ctaggttttg ttgtgcggga tgtttctggt ttcgtttcaa atgactacat tcctacagct
     5401 acttgccctg aggacctggc ttagttgtgg tgaaaccctg ttgtccttgc ctccagagcg
     5461 gaagaaaagg ctaggctcag gggtgacccg aagtgctgac tcacccatag cctgcataag
     5521 tggttttttt gggggggttg ctttgggttt ttttcgtttt gttttgtttt gttttagcct
     5581 ttgaggtgtt ttaatgaaca tgtttaacga aaataaaagc tagggctcct gctgtcaaga
     5641 tttctgtcaa ggaaaccttg tttgagaacg gtgttaataa aattctattg caaaattctt
     5701 ttctagaaaa aaaaataaat aacacaaaaa agaagaaatt ccaaagtaat aaaaactttt
     5761 cttgaaacag atttaaaaaa agatgtttgc ttactatttg attaaataaa tttacttacg
     5821 tttctttaag gtattttaat ttttttaatg tctctgtgga gtatttgtat gataccataa
     5881 tgtatatttc tgtagaaaca aattatataa acagtatcaa tatcattata gaaaaataac
     5941 attttaatgt atattgttct aaccaatcat attgtgaatc attttgaagt tcattatagc
     6001 gatattgata aattgtgaac ttgtcttaat gttttttttt tattaaccaa tatcatttta
     6061 aacctgagat tatcacattc atcaggtggt gagttttaaa gacaaactaa atttcatttc
     6121 aactgacaaa tgtatatggt tttagttcag tattgaagaa ttttaataca atattaaatt
     6181 acttgaactg aatagttcct tgtatatatt ttgcctattc cctgttgata tgtatgtagt
     6241 aaacagagaa gagaataacg ttaaaatatg gttaccaaaa ggaacttgta taggaggagc
     6301 aaagcagcca acagctttgc tgggacacaa gcatatgtgt aaacaagctt gggcttccag
     6361 atataaattt tgtaattttt gtcattattt atatcctata ttaaaaaaaa gcacacaaaa
     6421 taaaacagaa gttgtacagt ggctggtgcc tggcatcgtg ttgtgagcac ctcctctctt
     6481 ccactgagga gcaggaccaa aggcccagcc ctcttcacag atagagactt gtttttcaat
     6541 tggcgacatc agtgaggggg gaaaagaaaa ggcttgctca tttccaagtt cacgcagtct
     6601 gaaaaaggaa tactgtcttc cgaagcttga atctcagcca taagccacca ggtctttgca
     6661 ttgtctcttt aaaagtggtg tataaggggg aaattggcaa gacagacatt tctaaacaga
     6721 ggggaacaca gacagacaga cagacagaca gacacacaaa cacacacaca cacacacaca
     6781 cacacacaca cacaccccag actgcgtatg tggcataaca tacagcttgc atgggaagca
     6841 gccccctgca cattgcttat acatcctcga gtcctttcat cttttttcct aaaacgtgtg
     6901 cacccgctat aaagtgggtg atgggctcgt cagagctggg ctgattctgt ggccggtgac
     6961 caccatgcct caggtccctc aacctccatc acccatggcc caatccataa ctgccaccct
     7021 tgaaaaccca aagcagtctg agggtgctct ctgcctgtca ctcagaggcc tgggacgttg
     7081 aacccaaaaa agctaaactt atgaaagccg ggctgaaatg gggcccgggg cctgggatag
     7141 ctcaggcagg ggttttccac tctgatgttt ccactgggcc agtttgtttc tttgtctcta
     7201 ttttctctgt tcatcccgct gagtgtttgt atccatgatg attccagcat gaagtacgta
     7261 gcacactcca gttaggagaa attttttaaa gatacaagac tagcgtggtg gtgagatgag
     7321 atagtcttct cgtgctcgca gcaacctgaa ggggcaataa ggacaaagaa ggccatgtgg
     7381 cagggttagc cccctccaga ccaggggtac aacggacagt tgtggtgagc ctcggaaagg
     7441 caggggtaac cttccctctc cgttcttcac ccatggccag agcaaggcag gtagtgaaag
     7501 ggatatgcct gatgcagaaa agccagctca ggcatggcag gtgggattta tagctggttt
     7561 tgtttaaagc gaaggcctga tatttgataa atgcagtaac cagcggttga gagtgacaag
     7621 cccttaaatg cgaacattaa tcaaaggaga acttaaacgg ccccctttac agaaggactt
     7681 gaattcaatc gatccattta atttttttct tattaaaccg tgctctgtaa taaatctgag
     7741 tgaatggacc ctatgaaaac tctgctgggc ttattaataa gtcatggaag tggtttttct
     7801 caagtcggac tgcttgggaa tgttgccagc ctatctgatg tttggatgag acggaataga
     7861 cgtttaagca taaagggcat atgaccacag tctcgaaaat cagtcaacat ttgcacttgg
     7921 actccaagta aatgttactc ctacttctaa aatgaattga agatttgggg agtagtctag
     7981 tttccggtga gctagaatgt aacgcctacg ttcagaaatc tgtactggaa taaaagcctc
     8041 tttgctga
//
