LOCUS       NM_001271264            4280 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ankyrin repeat domain 27 (Ankrd27), mRNA.
ACCESSION   NM_001271264 XM_001079798 XM_341843
VERSION     NM_001271264.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Sleiman,P.M., Wang,M.L., Cianferoni,A., Aceves,S., Gonsalves,N.,
            Nadeau,K., Bredenoord,A.J., Furuta,G.T., Spergel,J.M. and
            Hakonarson,H.
  TITLE     GWAS identifies four novel eosinophilic esophagitis loci
  JOURNAL   Nat Commun 5, 5593 (2014)
   PUBMED   25407941
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Hesketh,G.G., Perez-Dorado,I., Jackson,L.P., Wartosch,L.,
            Schafer,I.B., Gray,S.R., McCoy,A.J., Zeldin,O.B., Garman,E.F.,
            Harbour,M.E., Evans,P.R., Seaman,M.N.J., Luzio,J.P. and Owen,D.J.
  TITLE     VARP is recruited on to endosomes by direct interaction with
            retromer, where together they function in export to the cell
            surface
  JOURNAL   Dev Cell 29 (5), 591-606 (2014)
   PUBMED   24856514
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Ohbayashi,N., Yatsu,A., Tamura,K. and Fukuda,M.
  TITLE     The Rab21-GEF activity of Varp, but not its Rab32/38 effector
            function, is required for dendrite formation in melanocytes
  JOURNAL   Mol Biol Cell 23 (4), 669-678 (2012)
   PUBMED   22171327
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Sieroslawska,A. and Rymuszka,A.
  TITLE     Evaluation of genotoxic potential of neurotoxin anatoxin-a with the
            use of umuC test
  JOURNAL   Neuro Endocrinol Lett 31 Suppl 2, 16-20 (2010)
   PUBMED   21187829
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Burgo,A., Sotirakis,E., Simmler,M.C., Verraes,A., Chamot,C.,
            Simpson,J.C., Lanzetti,L., Proux-Gillardeaux,V. and Galli,T.
  TITLE     Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in
            neurite growth
  JOURNAL   EMBO Rep 10 (10), 1117-1124 (2009)
   PUBMED   19745841
  REMARK    GeneRIF: show that TI-VAMP interacts with the Vps9 domain and
            ankyrin-repeat-containing protein Varp, a guanine nucleotide
            exchange factor of the small GTPase Rab21, through a specific
            domain herein called the interacting domain.
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Tamura,K., Ohbayashi,N., Maruta,Y., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Varp is a novel Rab32/38-binding protein that regulates Tyrp1
            trafficking in melanocytes
  JOURNAL   Mol Biol Cell 20 (12), 2900-2908 (2009)
   PUBMED   19403694
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Zhang,X., He,X., Fu,X.Y. and Chang,Z.
  TITLE     Varp is a Rab21 guanine nucleotide exchange factor and regulates
            endosome dynamics
  JOURNAL   J Cell Sci 119 (Pt 6), 1053-1062 (2006)
   PUBMED   16525121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and CO574455.1.
            
            On or before Sep 12, 2012 this sequence version replaced
            XM_341843.5, XM_001079798.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2519195.1,
                                           SRR26360176.1826234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000001.1  97388126-97388231
            107-238             JAXUCZ010000001.1  97393510-97393641
            239-349             JAXUCZ010000001.1  97402103-97402213
            350-506             JAXUCZ010000001.1  97403266-97403422
            507-661             JAXUCZ010000001.1  97404543-97404697
            662-721             JAXUCZ010000001.1  97405564-97405623
            722-775             JAXUCZ010000001.1  97405707-97405760
            776-841             JAXUCZ010000001.1  97405843-97405908
            842-918             JAXUCZ010000001.1  97406196-97406272
            919-1040            JAXUCZ010000001.1  97407552-97407673
            1041-1119           JAXUCZ010000001.1  97408744-97408822
            1120-1252           JAXUCZ010000001.1  97409950-97410082
            1253-1345           JAXUCZ010000001.1  97414529-97414621
            1346-1473           JAXUCZ010000001.1  97416310-97416437
            1474-1556           JAXUCZ010000001.1  97416880-97416962
            1557-1672           JAXUCZ010000001.1  97417672-97417787
            1673-1765           JAXUCZ010000001.1  97418664-97418756
            1766-1963           JAXUCZ010000001.1  97421193-97421390
            1964-2023           JAXUCZ010000001.1  97423315-97423374
            2024-2143           JAXUCZ010000001.1  97423492-97423611
            2144-2188           JAXUCZ010000001.1  97425059-97425103
            2189-2311           JAXUCZ010000001.1  97428537-97428659
            2312-2509           JAXUCZ010000001.1  97430269-97430466
            2510-2629           JAXUCZ010000001.1  97431544-97431663
            2630-3265           CO574455.1         111-746
            3266-4280           JAXUCZ010000001.1  97439487-97440501
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4280
                     /gene="Ankrd27"
                     /note="ankyrin repeat domain 27"
                     /db_xref="GeneID:361555"
                     /db_xref="RGD:1307106"
     exon            1..106
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            107..238
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3298
                     /gene="Ankrd27"
                     /note="ankyrin repeat domain 27 (VPS9 domain); ankyrin
                     repeat domain-containing protein 27-like"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 27"
                     /protein_id="NP_001258193.1"
                     /db_xref="GeneID:361555"
                     /db_xref="RGD:1307106"
                     /translation="MALYDEDLLRNPFYLALQKWRPDLCSKVAQIHGIVLVPCRGSLP
                     SNVQASCQFESYVLVPMEGHFQTLDGKAVLIEGNRVKLGAGFACLLSVPILFEETFYN
                     EKEESFSILCIAHPLEKRETSEEPSAPSDPFSLKTIKDVREFLGRHSERFDKHIASFH
                     RTFRECERKSLRHLIDSVNALYTKCLQQLLRDSHLKVLAKQEAQMNLMKQAVEMYVHH
                     DIYDLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELGQLNK
                     CTSPQQKLLCLRKVVQLMTQSPSQRVNLETVCADDLLSVLLYLLVKTEIPNWMANLSY
                     IKNFRFSSSPKDELGYCLTSVEAAIEYIRQGSLSAQPPDAEGFGDRLFLKQRMNLLSQ
                     MSSTPIDCLFKHIASGNQKEVERLLSQDDQDKDAMQKMCHPLCSCEDCEKLVSGRLND
                     PSVVTPFSRDDRGQTPLHVAALCGQASLIDFLVSKGAVVNATDYHGSTPLHLACQKGF
                     QSVTLLLLHYKANTEVQDNNGNTPLHLACTYGQEDCVKALVYYDVQACRLDIGNEKGD
                     TALHIAARWGYEGIIETLLQNGAPTAIQNRLKETPLKCALNSKILSAMEAYHLSSDRR
                     PKPSEVPAPSPTRSADSISQGSSTSSFSSVSVSFRPEEVKKDYREVEKLLRAVADGDL
                     EMVRYLLEWTEDDLDDMDEAISTVDLEFCHPLCQCPKCAPAQKKLARIPANGLSVNVT
                     NQDGFSPLHMAALHGRTDLVPLLLKHGAYSGARNTSQAVPLHLACQQGHFQVAKCLLD
                     SNAKPNKRDLSGNTPLICACSAGHHEVAALLLQHGAAINACNNKGNTALHEAVMGRHV
                     LVVELLLFYGASVDILNKRQYTAVDCAEQDSKIMELLQVVPSCVAASPNNVVVVQETE
                     HEDYVTVEIRKKWNPKMYNLPEEPFRRQFCLINPGGRFQERTKSWETMGRDRSVPDLT
                     GGLQEPEKQRVTGKQNDLSDQSRCQTSEEGNKGLPGRPVPRQAVPGHRPMVRRHTVND
                     AAILQVPEVTGHLTTQEAGVSRS"
     exon            239..349
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            350..506
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            507..661
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            662..721
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            722..775
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            776..841
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            842..918
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1040
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1119
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1252
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1345
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1473
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1556
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1672
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1765
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1963
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2023
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2143
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2188
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2311
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2509
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2629
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2791
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2915
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..2994
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3067
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..4280
                     /gene="Ankrd27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgaagag tggaaccacc gcacccgggt ggtgggcact caggtcccag cccaggatcc
       61 gagaggtgct gtcgtagcac agaggtgaaa ctatgtagcc tcttaagaag ctcacgtgga
      121 tccccctgaa gtccatatgg ctctgtatga tgaagatctc ctgagaaacc ctttctacct
      181 ggcccttcag aagtggcgcc ccgacttgtg cagtaaggtg gcccagatcc atggcattgt
      241 cctagtgcct tgcagaggaa gcttgccgag caacgtgcag gcctcctgcc agttcgagtc
      301 ctatgttttg gtacccatgg aaggacactt tcagacctta gatggaaagg ctgtcctcat
      361 agaaggaaac agggttaagc taggagcagg ctttgcttgc cttctctctg tgcccatcct
      421 ctttgaagag actttctaca acgaaaagga agagagtttc agcattctct gcatcgctca
      481 tcctttggag aagagggaga catcagaaga accttcagca ccctcagatc ctttctctct
      541 gaaaaccatc aaagatgtga gagaattttt gggaagacac tcagagagat tcgacaagca
      601 catcgcgtct ttccaccgga cattccgaga atgtgaaaga aagagcctcc gccatctcat
      661 agactccgta aatgctctct acaccaaatg cctccagcag cttctcagag actctcacct
      721 gaaggttctt gccaagcagg aggcccagat gaacctgatg aagcaggcag tagagatgta
      781 tgtccatcat gatatttacg acctgatctt caaatacgtg gggaccatgg aggcgagcga
      841 ggatgccgcc tttaacaaaa tcacaagaag ccttcaagat ctccagcaga aagacattgg
      901 cgtgaaacct gagttcagct tcaacattcc tcgggcaaag agagagctgg gacagctgaa
      961 caagtgtaca tccccacagc agaagctgct gtgtctgcgg aaggtggtcc agctcatgac
     1021 acagtctccc agccagagag tgaatttgga gaccgtctgt gctgatgatc ttctttccgt
     1081 cctgttatat ctgcttgtga aaacagagat ccctaactgg atggcgaatt tgagttacat
     1141 caaaaacttc agatttagca gctcgcccaa agatgagcta ggatactgcc tgacctcagt
     1201 cgaggctgcg attgaataca tccggcaagg aagcctctct gcacagccgc ctgacgctga
     1261 gggatttggc gacagactct ttctcaagca acggatgaac ttattgtccc agatgtcatc
     1321 aacacccatc gactgcctgt ttaagcacat cgcttctggc aaccaaaagg aagtagaaag
     1381 acttctgagt caagatgacc aagacaaaga cgccatgcaa aagatgtgcc acccgctttg
     1441 ctcctgtgag gactgtgaga agcttgtctc tggaaggctg aatgatccgt cggttgtcac
     1501 tcctttctcc agagatgaca gaggtcaaac acccctccat gtggctgctc tctgtggtca
     1561 ggcatccctc attgacttcc tggtctccaa aggtgccgta gtgaacgcca cagactatca
     1621 tgggtctact cccttacatc tggcatgtca gaaaggcttc caaagtgtga cgctgctgct
     1681 gctacactac aaggccaaca ctgaggtgca agacaacaac ggcaacaccc cgctgcacct
     1741 ggcctgcacc tacgggcagg aggattgtgt gaaggccctg gtctactatg atgtccaggc
     1801 ctgcagattg gatattggta acgagaaagg agacacagcc ctgcacattg cagctcgctg
     1861 gggttacgag ggcatcatag agacgctgct gcagaatgga gccccaacag caattcagaa
     1921 cagactgaag gaaacaccac tcaagtgtgc actgaactcg aagattctgt ctgccatgga
     1981 agcgtatcat ctatcctctg acaggaggcc aaagccttct gaggtccctg caccgtcccc
     2041 tacacgctct gcggattcca tcagccaggg ctcctctacc tccagctttt cttcggtatc
     2101 ggtgagcttc aggccagaag aggtcaaaaa ggactacagg gaggtagaaa agcttctcag
     2161 agcagttgcc gatggcgacc tagaaatggt gcgatacctt ttggagtgga cggaggacga
     2221 cctagacgat atggacgaag ccatcagcac ggtggatctt gaattctgtc accctttgtg
     2281 ccagtgcccc aagtgtgctc cagcccagaa gaaactggca aggatccctg ccaatgggct
     2341 cagtgtgaat gtgaccaacc aggacggctt ctctcccctg catatggctg ccctgcatgg
     2401 caggacagac cttgtccccc tcctgctgaa gcatggagcc tactcaggtg ccagaaacac
     2461 aagccaagct gtcccgctcc acctggcctg ccaacagggc cactttcagg tggcaaaatg
     2521 tctcttagac tccaatgcaa aacctaataa aagggacctc agtgggaaca cgcccctcat
     2581 ttgcgcctgc tctgccggcc atcatgaagt cgctgcactg ttgctacagc acggggccgc
     2641 catcaatgct tgcaacaaca aaggcaacac ggccctgcac gaggccgtga tgggaaggca
     2701 cgtcttggtg gtggaactgc ttctgtttta tggcgcatct gttgacatcc tgaacaagag
     2761 gcagtacacg gcggtggact gtgcagagca ggactcaaag ataatggagt tgctgcaagt
     2821 cgtcccaagt tgcgttgctg cttctccaaa caacgtcgtt gtcgtccagg agacagaaca
     2881 cgaggattat gtgactgtgg agatcaggaa aaaatggaac cccaaaatgt acaacctgcc
     2941 agaggaacct tttcggagac agttttgcct cattaaccca ggggggcggt tccaggagag
     3001 gacgaagtca tgggagacta tgggaaggga tagaagtgta ccagatctta ccggaggtct
     3061 ccaggagcca gagaagcaaa gagtcacagg gaagcagaat gatttgtcag accagagcag
     3121 gtgtcagacc tctgaggaag gaaacaaggg gctccctggg aggcctgtgc cgagacaggc
     3181 tgttccagga caccggccaa tggtccgcag acacacagtc aatgacgcag ccatacttca
     3241 ggtcccagag gtgactggcc acctgaccac ccaagaggct ggtgtttctc ggtcttagca
     3301 ggaagggact ggaaaatctg ctgctgagac acgagtctac agtaagctgg gaagcatgaa
     3361 cccagtgtag agctaagtat acgttgaaca cccggcttga gggccagccc ctcggattta
     3421 ccaccctctc ctcttcaaag cgaactaaca cacttgaata ggaatgggag ggagtgaacg
     3481 agccctcatc tcagcatttg ggtttcctgg tcgccatcag ctctgacctc ctttggctgg
     3541 aaggtgctaa atgtctggga agtggataag ggggagcctt atatccggga gaagtcagag
     3601 aaggaatgcc ggttacggaa cggtggatgc caggcagaga agcatcccgt tgggatgacg
     3661 aaacggagcc tgggaaacac ttgaactgga agatgcccga acgctgtttt gatgtccgtc
     3721 ccagtgaaaa ggacctacca ttctgccttg ttctacacca catgtatggg caaagttggc
     3781 cgtcactttc ccaacaacac agacccctgg gtcactgcac gtttacctgt atccatttct
     3841 gctcactctc cttcccgtta agagcctccc gacacagcgt acctgacgat ggttaccaga
     3901 gagcagcttt ggcacacctt atgtcttttg attcaaattc aaaacttaca gcacaaacca
     3961 ggtcggagtt taagttggaa tttgttgcca ttgattcctt tttataactt tctatagatt
     4021 ctattatttt tttatgttcc cgatcctaaa gttgcagaca tgggttcatc ctgagtccgt
     4081 tttcaaagga ctttgtaaag gggaagtggt tttgtgcaca ttattgggaa tacttgtgaa
     4141 tgtatagaag ggaggggctg attatttttc tacaaagtaa tttatgattt ctaattttct
     4201 aatgtgcctt ggatatgtgc caaatgatgg aaaagaaaac agtaaacttt gactcttgat
     4261 tgtgtcctgc catttttaaa
//
