LOCUS       NM_001108211            2335 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ankyrin repeat domain 23 (Ankrd23), mRNA.
ACCESSION   NM_001108211 XM_001056748 XM_006244814 XM_237094
VERSION     NM_001108211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Laughlin,M.H., Yang,H.T., Tharp,D.L., Rector,R.S., Padilla,J. and
            Bowles,D.K.
  TITLE     Vascular cell transcriptomic changes to exercise training differ
            directionally along and between skeletal muscle arteriolar trees
  JOURNAL   Microcirculation 24 (2) (2017)
   PUBMED   27889934
  REMARK    GeneRIF: Ankrd23 mRNA levels increased with increasing branch order
            in the gastrocnemius arteriolar tree . Further research will be
            required to determine whether Ankrd23 plays an important role in
            mechanically induced vascular remodeling of the arterial tree in
            skeletal muscle.
            Review article
REFERENCE   2  (bases 1 to 2335)
  AUTHORS   Barash,I.A., Bang,M.L., Mathew,L., Greaser,M.L., Chen,J. and
            Lieber,R.L.
  TITLE     Structural and regulatory roles of muscle ankyrin repeat protein
            family in skeletal muscle
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C218-C227 (2007)
   PUBMED   17392382
REFERENCE   3  (bases 1 to 2335)
  AUTHORS   Nagueh,S.F., Shah,G., Wu,Y., Torre-Amione,G., King,N.M.,
            Lahmers,S., Witt,C.C., Becker,K., Labeit,S. and Granzier,H.L.
  TITLE     Altered titin expression, myocardial stiffness, and left
            ventricular function in patients with dilated cardiomyopathy
  JOURNAL   Circulation 110 (2), 155-162 (2004)
   PUBMED   15238456
REFERENCE   4  (bases 1 to 2335)
  AUTHORS   Witt,C.C., Ono,Y., Puschmann,E., McNabb,M., Wu,Y., Gotthardt,M.,
            Witt,S.H., Haak,M., Labeit,D., Gregorio,C.C., Sorimachi,H.,
            Granzier,H. and Labeit,S.
  TITLE     Induction and myofibrillar targeting of CARP, and suppression of
            the Nkx2.5 pathway in the MDM mouse with impaired titin-based
            signaling
  JOURNAL   J Mol Biol 336 (1), 145-154 (2004)
   PUBMED   14741210
REFERENCE   5  (bases 1 to 2335)
  AUTHORS   Miller,M.K., Bang,M.L., Witt,C.C., Labeit,D., Trombitas,C.,
            Watanabe,K., Granzier,H., McElhinny,A.S., Gregorio,C.C. and
            Labeit,S.
  TITLE     The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a
            family of titin filament-based stress response molecules
  JOURNAL   J Mol Biol 333 (5), 951-964 (2003)
   PUBMED   14583192
REFERENCE   6  (bases 1 to 2335)
  AUTHORS   Ikeda,K., Emoto,N., Matsuo,M. and Yokoyama,M.
  TITLE     Molecular identification and characterization of a novel nuclear
            protein whose expression is up-regulated in insulin-resistant
            animals
  JOURNAL   J Biol Chem 278 (6), 3514-3520 (2003)
   PUBMED   12456686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 27, 2021 this sequence version replaced
            XM_006244814.4, NM_001108211.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.23933.1,
                                           SRR26643295.34939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000009.1  46274430-46274510   c
            82-228              JAXUCZ010000009.1  46273079-46273225   c
            229-357             JAXUCZ010000009.1  46272750-46272878   c
            358-483             JAXUCZ010000009.1  46271509-46271634   c
            484-582             JAXUCZ010000009.1  46271236-46271334   c
            583-681             JAXUCZ010000009.1  46271045-46271143   c
            682-780             JAXUCZ010000009.1  46270844-46270942   c
            781-879             JAXUCZ010000009.1  46270639-46270737   c
            880-2335            JAXUCZ010000009.1  46269107-46270562   c
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..2335
                     /gene="Ankrd23"
                     /note="ankyrin repeat domain 23"
                     /db_xref="GeneID:316330"
                     /db_xref="RGD:1310398"
     exon            1..81
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..975
                     /gene="Ankrd23"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 23"
                     /protein_id="NP_001101681.1"
                     /db_xref="GeneID:316330"
                     /db_xref="RGD:1310398"
                     /translation="MDFISIQQLVSGERVGRKALEFGRGVPDPGGWPSGWTLGPQEAV
                     AWEKLKLEEEKRKKLERFNSSRLTLDNLTDLENLIQRRRKKRQRHKVPPREPESGAEP
                     QPQVPLEPVGLEMFLKAAAENQEALIDKYLADGGDPNAHDKLHRTALHWACLKGHRQL
                     VNKLLAAGAAIETRDLLDRTPVFWACRGGHLDILKQLLNQGAQINAQDKIWSTPLHVA
                     VRMGHSDCLEHLIECGAHINAQDKEGDTALHEAVRYGHHKATKLLLLYGAKLGMKNGA
                     SLTPVQLARDWQRGIREALQAHVGHPRTRC"
     exon            82..228
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            229..357
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            358..483
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            484..582
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            583..681
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            682..780
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            781..879
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
     exon            880..2335
                     /gene="Ankrd23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagagctg agctcacttg gtcccaggtg ctcatggaga gcaagggggg gaccatggac
       61 ttcatcagca ttcagcagtt ggtaagtgga gaaagagttg gcaggaaagc gttggagttt
      121 ggccgtggag ttcctgatcc tggtggctgg cctagtggct ggacgctggg accccaagag
      181 gctgtggcct gggagaaact aaagttggag gaagagaaga gaaagaaact ggaaagattt
      241 aacagttcca gactgaccct ggacaacctg acagacttgg aaaacttgat tcagagacga
      301 agaaaaaaac gacagagaca caaagtcccc cccagggaac ctgagtctgg ggctgagcct
      361 cagccccagg tcccactgga gccggtgggc ctggaaatgt tcctgaaggc agctgccgag
      421 aatcaggagg ccctgattga caagtacctg gcagacggag gggaccccaa tgcccatgac
      481 aagctccacc gcacagcctt gcactgggcc tgtctgaagg gccacagaca gctagtgaac
      541 aagctgctag cggcaggagc tgctatagaa actcgagatt tgctggacag gacgcctgtg
      601 ttctgggcct gccgtggagg acacctggac attctcaagc agctgcttaa ccagggagct
      661 cagatcaacg cacaagacaa gatctggagc acccctctcc acgtggcagt gcgcatgggc
      721 cactcagact gcctggagca cctcattgag tgtggcgccc atatcaacgc acaggacaag
      781 gaaggggaca cagcactcca cgaggcagtg cgctacgggc accacaaagc cacaaagctg
      841 ctgctgctct atggagccaa gctaggcatg aagaatgggg cctccctgac accggtgcag
      901 ctggcacgag actggcagag gggtatccgg gaagcactcc aggcccatgt ggggcatccc
      961 cgcacccggt gctgatgatg ggcacctgcg ggtcactcag ccaccattcc acacccacag
     1021 accaccccta aatggttccc taccccagtc ccaatttgtc tctgactttg cttcctttcg
     1081 ggcctgaggc aagaggtaga gcagacctgg atttaatttc agtgaggagc actgttccct
     1141 gccagggctg gagcagggac cacagggcag caagaaacaa agggatccag atgagggcta
     1201 aggccagggc acaagtgagc agaccagcgc taccctcagc taggtctagg cctcggtctg
     1261 ccaatcctta ggccaggaga cgggtcttgg cctgttctcc tgtaagcagg cattcagatg
     1321 tggccagcag ctgcatccag ggatgaaaga agcaggctga gtgccaggca ctggagcagg
     1381 cacttctaac ctttgggcag tgtttcccct gggacctcat tcctatcagt agcgaccctg
     1441 gtagtgagtg tgtgcagtag ttctagccat ctctagtctt cagagctctg aaagggtcct
     1501 ggcaggctga ggggcatgtc agcaggactg aggccccact gaagtcagta cctaccaggt
     1561 tgcctcagaa gctggagagt gaggagttgg aactagtgtt accctaggga aactacctaa
     1621 aggctttggg caggcccgct tgcttcatgt gagggtcaag caccgggtgc tggggattgc
     1681 ttgtggccca ctcaactcct ggggcggtgg cccgcaactc cagcttaccc tgaggcccta
     1741 atgccccctg gtgctggaga aagcaccagg actaggctct gtaggccctg cacatggagt
     1801 cctgtacctt gctttgggac aatgccaaca gtgtacatcc ctctccggcc ccctgtgcca
     1861 actggtggtg taaagaggac ctcacacagg ctccccacat ggctgctttt tcctcccagc
     1921 tctgttccta gcttcactgc tggcagggct ggctccttaa atgctaggaa gttgacttaa
     1981 agagctgaag ccgcagctga gcgaggggct gaaaggtgga ggctctgcct cccgcatgga
     2041 gcccccagct gacgcccgtt ttgcagcagc tattttctga ttaactttgg cctctctggc
     2101 cattgttact atgtgaagaa cctgactagt gttcccccct aggggcacgt atctttccat
     2161 ggggcaggcc ctgccctgtt catgccagcc agcgtgcacc gcgacactgg tgccgtgggc
     2221 aacagacatt caagactact caatatgacg actcctcaga aataaggaca cttgacacac
     2281 aaagcaactt tttatacaga tcaatgtttt ctcattaaac tgactactca ccaca
//
