LOCUS       NM_001107589            1116 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ankyrin repeat domain 2 (Ankrd2), mRNA.
ACCESSION   NM_001107589 XM_001055096 XM_219881
VERSION     NM_001107589.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Wette SG, Smith HK, Lamb GD and Murphy RM.
  TITLE     Characterization of muscle ankyrin repeat proteins in human
            skeletal muscle
  JOURNAL   Am J Physiol Cell Physiol 313 (3), C327-C339 (2017)
   PUBMED   28615162
  REMARK    GeneRIF: These data are not consistent with the proposal that Ankrd
            2, per se, or pAnkrd 2-Ser99 mediates stretch-induced signaling in
            skeletal muscle, dissociating from titin and translocating to the
            nucleus, because the majority of these forms of Ankrd 2 are already
            free in the cytosol.
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Bean C, Verma NK, Yamamoto DL, Chemello F, Cenni V, Filomena MC,
            Chen J, Bang ML and Lanfranchi G.
  TITLE     Ankrd2 is a modulator of NF-kappaB-mediated inflammatory responses
            during muscle differentiation
  JOURNAL   Cell Death Dis 5 (1), e1002 (2014)
   PUBMED   24434510
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1116)
  AUTHORS   Mohamed JS, Lopez MA, Cox GA and Boriek AM.
  TITLE     Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3
            cooperatively inhibit myoblast differentiation by physical
            interaction
  JOURNAL   J Biol Chem 288 (34), 24560-24568 (2013)
   PUBMED   23824195
REFERENCE   4  (bases 1 to 1116)
  AUTHORS   Wu Y, Ruggiero CL, Bauman WA and Cardozo C.
  TITLE     Ankrd1 is a transcriptional repressor for the androgen receptor
            that is downregulated by testosterone
  JOURNAL   Biochem Biophys Res Commun 437 (3), 355-360 (2013)
   PUBMED   23811403
  REMARK    GeneRIF: Ankrd2 does not bind the human androgen receptor (AR) or
            alter testosterone-induced changes in reporter gene activity,
            indicating that it is not a direct transcriptional effector for the
            AR.
REFERENCE   5  (bases 1 to 1116)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   6  (bases 1 to 1116)
  AUTHORS   Bean C, Facchinello N, Faulkner G and Lanfranchi G.
  TITLE     The effects of Ankrd2 alteration indicate its involvement in cell
            cycle regulation during muscle differentiation
  JOURNAL   Biochim Biophys Acta 1783 (6), 1023-1035 (2008)
   PUBMED   18302940
REFERENCE   7  (bases 1 to 1116)
  AUTHORS   Tsukamoto Y, Hijiya N, Yano S, Yokoyama S, Nakada C, Uchida T,
            Matsuura K and Moriyama M.
  TITLE     Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins
            (MARPs), translocates from the I-band to the nucleus after muscle
            injury
  JOURNAL   Histochem Cell Biol 129 (1), 55-64 (2008)
   PUBMED   17926058
REFERENCE   8  (bases 1 to 1116)
  AUTHORS   Witt CC, Ono Y, Puschmann E, McNabb M, Wu Y, Gotthardt M, Witt SH,
            Haak M, Labeit D, Gregorio CC, Sorimachi H, Granzier H and Labeit
            S.
  TITLE     Induction and myofibrillar targeting of CARP, and suppression of
            the Nkx2.5 pathway in the MDM mouse with impaired titin-based
            signaling
  JOURNAL   J Mol Biol 336 (1), 145-154 (2004)
   PUBMED   14741210
REFERENCE   9  (bases 1 to 1116)
  AUTHORS   Fujiwara M, Tsukamoto Y, Miyazaki A, Moriyama M and Satoh H.
  TITLE     Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to
            mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Genome Res 105 (1), 159 (2004)
   PUBMED   15222314
  REMARK    GeneRIF: assignment of Ankrd2 to rat chromosome 1q51-q53.
REFERENCE   10 (bases 1 to 1116)
  AUTHORS   Tsukamoto Y, Senda T, Nakano T, Nakada C, Hida T, Ishiguro N, Kondo
            G, Baba T, Sato K, Osaki M, Mori S, Ito H and Moriyama M.
  TITLE     Arpp, a new homolog of carp, is preferentially expressed in type 1
            skeletal muscle fibers and is markedly induced by denervation
  JOURNAL   Lab Invest 82 (5), 645-655 (2002)
   PUBMED   12004005
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055096.1, XM_219881.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216123.1, FQ216298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1116
                     /gene="Ankrd2"
                     /note="ankyrin repeat domain 2"
                     /db_xref="GeneID:309374"
                     /db_xref="RGD:1305104"
     exon            1..85
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..997
                     /gene="Ankrd2"
                     /note="ankyrin repeat domain 2 (stretch responsive
                     muscle)"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 2"
                     /protein_id="NP_001101059.1"
                     /db_xref="GeneID:309374"
                     /db_xref="RGD:1305104"
                     /translation="MEGPEAVQRATELIEQRLAEEEETEKLRRATPGKTSMDMLVLED
                     EKRLGVQSPALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAA
                     QEPPPEPEEITGPVDEETFLKAAVEGKIKVIDKYLADGGSADTCDEFRRTALHRASLE
                     GHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSRGANTDVRDKLLST
                     PLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHGADMM
                     AKNMAGKTPTDLVQLWQADTRHALEHPEPESEQNGLERPGSGRETPQPVPAQ"
     exon            86..187
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..346
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..454
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..553
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..652
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..751
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..850
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1116
                     /gene="Ankrd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggcacc atggagggtc ccgaggctgt gcagagagcc acagagctca tcgagcagcg
       61 gcttgccgag gaggaagaga ctgagaaact tcgaagagcc actcctggga agacgtccat
      121 ggacatgcta gtgctagagg acgagaagcg cctcggggtg cagagtcctg ctttacaaaa
      181 ggttaagggc caagagcgcg tgcgcaagac atccctggac ttgcgacgtg agatcattga
      241 cgtgggcggg atccagaacc tcatagaact gaggaaaaaa cgcaagcaga aaaagcgaga
      301 tgcccttgcc gcagcgcagg aaccacctcc ggagccggag gagatcactg gcccagtaga
      361 tgaggagaca ttcctgaaag ctgcggtgga ggggaaaatc aaagtcattg acaagtacct
      421 ggcagacgga ggttcggcag acacctgtga tgagttccgt cggacagcac tgcatcgggc
      481 ctccctggag ggacacatgg agatactgga gaaacttctg gagaatgggg ccaccgtgga
      541 cttccaggat cggctggact gcacagccat gcactgggcc tgccgtggag gccacctgga
      601 ggtggtgaaa ctcttgcaaa gtcggggggc caacaccgac gtgagagaca agctactgag
      661 cactcccctg catgtggccg tccgtactgg acacgtggag attgtggaac attttctctc
      721 cctgggcttg gatatcaatg ccaaagacag agaaggggac agtgccctgc atgatgccgt
      781 gagactcaac cgctacaaaa tcatcaaact gctgctcttg catggggcag acatgatggc
      841 taagaatatg gcggggaaga cccctaccga cctggtccag ctgtggcaag cagacacccg
      901 gcatgccctg gagcaccctg aaccagaatc agagcagaac ggattggaga ggcctgggag
      961 tggccgggag acaccccagc ctgtaccagc ccagtaaata tctacccgga gctgggcacc
     1021 cgacccggag caccagaccc ctactatgag ctgcctgaag ccaagctagc aggaacatcc
     1081 ccagattcaa caacacaata aagtgctggc tttgct
//
