LOCUS       NP_001360938            2639 aa            linear   ROD 01-APR-2024
DEFINITION  ankyrin repeat domain-containing protein 11 [Rattus norvegicus].
ACCESSION   NP_001360938 XP_008770888
VERSION     NP_001360938.1
DBSOURCE    REFSEQ: accession NM_001374009.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2639)
  AUTHORS   Ockeloen,C.W., Willemsen,M.H., de Munnik,S., van Bon,B.W., de
            Leeuw,N., Verrips,A., Kant,S.G., Jones,E.A., Brunner,H.G., van
            Loon,R.L., Smeets,E.E., van Haelst,M.M., van Haaften,G.,
            Nordgren,A., Malmgren,H., Grigelioniene,G., Vermeer,S., Louro,P.,
            Ramos,L., Maal,T.J., van Heumen,C.C., Yntema,H.G., Carels,C.E. and
            Kleefstra,T.
  TITLE     Further delineation of the KBG syndrome phenotype caused by ANKRD11
            aberrations
  JOURNAL   Eur J Hum Genet 23 (9), 1176-1185 (2015)
   PUBMED   25424714
  REMARK    Erratum:[Eur J Hum Genet. 2015 Sep;23(9):1270. PMID: 26269249]
REFERENCE   2  (residues 1 to 2639)
  AUTHORS   Sirmaci,A., Spiliopoulos,M., Brancati,F., Powell,E., Duman,D.,
            Abrams,A., Bademci,G., Agolini,E., Guo,S., Konuk,B., Kavaz,A.,
            Blanton,S., Digilio,M.C., Dallapiccola,B., Young,J., Zuchner,S. and
            Tekin,M.
  TITLE     Mutations in ANKRD11 cause KBG syndrome, characterized by
            intellectual disability, skeletal malformations, and macrodontia
  JOURNAL   Am J Hum Genet 89 (2), 289-294 (2011)
   PUBMED   21782149
REFERENCE   3  (residues 1 to 2639)
  AUTHORS   Barbaric,I., Perry,M.J., Dear,T.N., Rodrigues Da Costa,A.,
            Salopek,D., Marusic,A., Hough,T., Wells,S., Hunter,A.J.,
            Cheeseman,M. and Brown,S.D.
  TITLE     An ENU-induced mutation in the Ankrd11 gene results in an
            osteopenia-like phenotype in the mouse mutant Yoda
  JOURNAL   Physiol Genomics 32 (3), 311-321 (2008)
   PUBMED   17986521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1 and CA504097.1.
            
            On Sep 6, 2019 this sequence version replaced XP_008770888.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760389, SAMEA5760400
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..2639
                     /product="ankyrin repeat domain-containing protein 11"
                     /note="ankyrin repeat domain 11"
                     /calculated_mol_wt=295647
     Region          <158..>287
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(167,169,173..174,177..179,181..182,186,189,198,200,
                     202,206..207,210..212,214..215,219,222,231,233,235,
                     239..240,243..245,247..248,252,255)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          167..198
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          200..231
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          233..261
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <732..1634
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          <1602..1947
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <1858..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..2639
                     /gene="Ankrd11"
                     /coded_by="NM_001374009.1:459..8378"
                     /db_xref="GeneID:365023"
                     /db_xref="RGD:1306679"
ORIGIN      
        1 mpkggcsktp qqedcslsnd mvekqtgkkd kdkvsltktp kldrtdggke vrervtkrkl
       61 pftvgangeq kdsdtekqgp erkrikkepv prksgllfgm glsgiragyp lserqqvall
      121 mqmtaeesan spvdttpkhp sqstvcqkgt pnsasktkdk vnkrnerget rlhraairgd
      181 arrikelise gadvnvkdfa gwtalheacn rgyydiakql laagaevntk gldddtplhd
      241 aannghykvv klllryggnp qqsnrkgetp lkvansptmv nlllgkgtyt sseesstess
      301 eeedapsfap sssvdgnntd sefekglklk aknpepqktv tpvkdeyefd eddeqdrvpp
      361 vddkhllkkd yrreaksnsf isipkmevrs ysknntlapk kaahrilsdt sdeedvsasi
      421 gageklrlsa htmlpsskar essssrqqke knklkkkrkk etkgkevrfg krsdkfcssg
      481 sesessesee ddgdsvgssg clkgsplvlk dpslfsslsa sstsshgsav aqkhssghtd
      541 qhtkhwrtdn wkaisspaws evsslsdssr tgltsesdcs segssveslk ptrrkqehrk
      601 rgslqsmper rgtfhpcadg avpkldkegk vvkkhktkhk hkhkekgpcs vsqelklksf
      661 tyeyedskqk pdkaillend vstenklkvl khdrdklskt ksedkewlfk dekalkrmkd
      721 vskdtsrafr eerdrpskte rerstkeksp keeklrlyke erkkkskdrp fklekkndmk
      781 evskekekaf redkeklkke klcrddaafd dycnksqfld hedtkfslsd dqqerwfsdl
      841 sdssfdfkge dswdsvtdyr diksdsvakl iletvkedsk ekkrdnktre krdfrdsffr
      901 krdrdcvdrn sekrrdhtek qrsfpsylse kdkkrresae ggrdrrdtle gsrerrdgri
      961 rseevhredl kecgcdstfk dksdcdftkt lepwerphaa rekekkdale kdrkekgrae
     1021 kykdksgere rneksilekc qkdkefekcf kekkdgkekh kdthskdrkt pfdqlrekke
     1081 kafsslised fserkddrkg kekswyiadi ftdesedeke ecvassfktg etgdsqraes
     1141 lqekedgreh psdrhrkass drqhtekprd kepkekrkdr gaaeggkdkk ekifekhkek
     1201 kdkecaekyk erkdrasvds apekknkqkl pekvekkhfv edkakskhke kpekdhsrer
     1261 kssrgpdvek sllekleeea lhdyredsnd kisevssdsf adhgqepsls tllevsfsep
     1321 paedkarest clseklkere rerhrhssss skksherera kkekadkkek gedykdgggg
     1381 rkdasqyekd fadaeafggs yttkadteed ldkaielfss ekkdrndser epakklekel
     1441 kpygsstisi lkekkkrekh rekwreekek hrdkhidgfl rhhkdepkpa akdkdnppnc
     1501 fkeksreesl klseaklkek fkenaerekg dsvkmsngnd kplpsrdank kdsrprekll
     1561 gdgdlmmtsf ermlsqkdle ieerhkrhke rmkqmekmrh rsgdpklkek kptddgrkks
     1621 ldfpskkalg ldkkvkepap vlptgegkph sgpgteskdw lagqplkevl pasprteqgr
     1681 ptgvptptsv vscpsyeevm htprtpscsa ddypdlvfdc tdsqhsmpvs ttstsacspp
     1741 ffdrfsvass vvaenagqtp trpistnlyr sisvdirrtp eeefsvgdkl frqqsvpaas
     1801 sfdspvqhll eekaplppvp aekfaclspe yyspdygips pkvdtlhcpp tavvsatppp
     1861 dsvfsnlppk sspsprgell tpaiegalpp dlglpldate dqqataailp pepsylepld
     1921 egpfntvite epvewthsaa eqslpsslia sasetpvswp vgselmlksp qrfaespkhf
     1981 cpgeplhstt pgpfsaaept ypvspgsypl papepaleev kdggtgaipv aiaaaegaap
     2041 ytaptrlesf fsnckphpda pldtapepas vttvaqveal gplessflds shsisalsqv
     2101 epvswheaft speddldlgp fslpelplqa kdasdveaet aeaspappve sppgptgvls
     2161 ggdvpastte eppapppqea spqlstepep seetkldvvl eaaaetevla ddsapeasis
     2221 nlvpapsppe qqrpagggde eteaedpsaa pccapdgptt dglaqapnsa eaacvvaave
     2281 gppgniqpea tdpepkptse apkapkveev pqrmtrnraq mlasqskqgi patekdsmpa
     2341 pasrakgrap eeedaqaqhp rkrrfqrsgq qlqqqlntst qqtreviqqt laaivdaikl
     2401 daiepyhsdr snpyfeylqi rkkieekrki lccitpqapq cyaeyvtytg sylldgkpls
     2461 klhipviapp pslaeplkel fkqqeavrgk lrlqhsiere klivsceqei lrvhcraart
     2521 ianqavpfsa ctmlldsevy nmplesqgde nksvrdrfna rqfiswlqdv ddkydrmktc
     2581 llmrqqheaa alnavqrmew qlkaqeldpa ghkslcvnev psfyvpmvdv nddfvllpa
//
