LOCUS       NM_013220               1745 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ankyrin repeat domain 1 (Ankrd1), mRNA.
ACCESSION   NM_013220
VERSION     NM_013220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Lange,S., Gehmlich,K., Lun,A.S., Blondelle,J., Hooper,C.,
            Dalton,N.D., Alvarez,E.A., Zhang,X., Bang,M.L., Abassi,Y.A., Dos
            Remedios,C.G., Peterson,K.L., Chen,J. and Ehler,E.
  TITLE     MLP and CARP are linked to chronic PKCalpha signalling in dilated
            cardiomyopathy
  JOURNAL   Nat Commun 7, 12120 (2016)
   PUBMED   27353086
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Chen,C., Shen,L., Cao,S., Li,X., Xuan,W., Zhang,J., Huang,X.,
            Bin,J., Xu,D., Li,G., Kitakaze,M. and Liao,Y.
  TITLE     Cytosolic CARP promotes angiotensin II- or pressure
            overload-induced cardiomyocyte hypertrophy through calcineurin
            accumulation
  JOURNAL   PLoS One 9 (8), e104040 (2014)
   PUBMED   25089522
  REMARK    GeneRIF: Overexpression of Ankrd1 exacerbates pathological cardiac
            remodeling through the enhancement of cytosolic translocation of
            CARP and up-regulation of calcineurin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Wu,Y., Ruggiero,C.L., Bauman,W.A. and Cardozo,C.
  TITLE     Ankrd1 is a transcriptional repressor for the androgen receptor
            that is downregulated by testosterone
  JOURNAL   Biochem Biophys Res Commun 437 (3), 355-360 (2013)
   PUBMED   23811403
  REMARK    GeneRIF: Ankrd1 binds to and directly regulates the transcriptional
            activity of the human androgen receptor in cultured rat myoblasts,
            whereas Ankrd2 does not.
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Samaras,S.E., Chen,B., Koch,S.R., Sawyer,D.B., Lim,C.C. and
            Davidson,J.M.
  TITLE     26S proteasome regulation of Ankrd1/CARP in adult rat ventricular
            myocytes and human microvascular endothelial cells
  JOURNAL   Biochem Biophys Res Commun 425 (4), 830-835 (2012)
   PUBMED   22892129
  REMARK    GeneRIF: the 26S proteasome is the dominant regulator of
            Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is
            significantly longer in cardiomyocytes (h) than endothelial cells
            (min).
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Chen,B., Zhong,L., Roush,S.F., Pentassuglia,L., Peng,X.,
            Samaras,S., Davidson,J.M., Sawyer,D.B. and Lim,C.C.
  TITLE     Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads
            to sarcomere disarray: implications for anthracycline
            cardiomyopathy
  JOURNAL   PLoS One 7 (4), e35743 (2012)
   PUBMED   22532871
  REMARK    GeneRIF: These data demonstrate co-dependent roles for GATA4 and
            CARP in regulating sarcomere gene expression and maintaining
            sarcomeric organization in cardiomyocytes in culture.
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Munro,E.
  TITLE     Carotid surgery
  JOURNAL   Eur J Vasc Endovasc Surg 16 (2), 170-171 (1998)
   PUBMED   9728441
REFERENCE   7  (bases 1 to 1745)
  AUTHORS   Baumeister,A., Arber,S. and Caroni,P.
  TITLE     Accumulation of muscle ankyrin repeat protein transcript reveals
            local activation of primary myotube endcompartments during muscle
            morphogenesis
  JOURNAL   J Cell Biol 139 (5), 1231-1242 (1997)
   PUBMED   9382869
REFERENCE   8  (bases 1 to 1745)
  AUTHORS   Jeyaseelan,R., Poizat,C., Baker,R.K., Abdishoo,S., Isterabadi,L.B.,
            Lyons,G.E. and Kedes,L.
  TITLE     A novel cardiac-restricted target for doxorubicin. CARP, a nuclear
            modulator of gene expression in cardiac progenitor cells and
            cardiomyocytes
  JOURNAL   J Biol Chem 272 (36), 22800-22808 (1997)
   PUBMED   9278441
REFERENCE   9  (bases 1 to 1745)
  AUTHORS   Zou,Y., Evans,S., Chen,J., Kuo,H.C., Harvey,R.P. and Chien,K.R.
  TITLE     CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5
            homeobox gene pathway
  JOURNAL   Development 124 (4), 793-804 (1997)
   PUBMED   9043061
REFERENCE   10 (bases 1 to 1745)
  AUTHORS   Chu,W., Burns,D.K., Swerlick,R.A. and Presky,D.H.
  TITLE     Identification and characterization of a novel cytokine-inducible
            nuclear protein from human endothelial cells
  JOURNAL   J Biol Chem 270 (17), 10236-10245 (1995)
   PUBMED   7730328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013220.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U50736.1, BC072699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000001.1  243236931-243237014 c
            85-264              JAXUCZ010000001.1  243236375-243236554 c
            265-402             JAXUCZ010000001.1  243235317-243235454 c
            403-510             JAXUCZ010000001.1  243234895-243235002 c
            511-609             JAXUCZ010000001.1  243233843-243233941 c
            610-708             JAXUCZ010000001.1  243232543-243232641 c
            709-807             JAXUCZ010000001.1  243232270-243232368 c
            808-906             JAXUCZ010000001.1  243232044-243232142 c
            907-1745            JAXUCZ010000001.1  243228460-243229298 c
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1745
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /note="ankyrin repeat domain 1"
                     /db_xref="GeneID:27064"
                     /db_xref="RGD:61989"
     exon            1..84
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1017
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /note="cardiac adriamycin-responsive protein; muscle
                     ankyrin repeat protein; cardiac responsive adriamycin
                     protein; ankyrin-like repeat protein; ankyrin repeat
                     domain 1 (cardiac muscle); cardiac ankyrin repeat protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 1"
                     /protein_id="NP_037352.2"
                     /db_xref="GeneID:27064"
                     /db_xref="RGD:61989"
                     /translation="MMVFRVEELVTGKKNSNGSSGEFLPGEFRNGEYEAAVALEKQED
                     LKTLPANSVNLGEEQRKSEKVREAELKKKKLEQRSKLENLEDLEIIVQLKKRKKYKKT
                     KVPVVKEPEPEIITEPVDVPRFLKAALENKLPVVEKFLSDKNSPDVCDEYKRTALHRA
                     CLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWACRGGNLDVLKLLLNKGAKISARDKL
                     LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLMTFGA
                     DLNVKNCAGKTPMDLVLHWQNGTKAIFDSLKENAYKNSRIATF"
     exon            85..264
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            265..402
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            403..510
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            511..609
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            610..708
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            709..807
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            808..906
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1745
                     /gene="Ankrd1"
                     /gene_synonym="Alrp; Carp; Crap; MARP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccagctcc aggggttcag ccacaagagg gaaaaacata gactcacggc tgccaacatg
       61 atggtttttc gagtagagga gctggtaacg ggcaaaaaga acagcaatgg gtcctcaggg
      121 gagttccttc ctggcgagtt cagaaatgga gagtatgaag ctgctgttgc cttggagaaa
      181 caagaggact tgaagacact tccagccaac agtgtgaacc tgggggaaga acaacggaaa
      241 agtgagaaag ttcgagaggc agagctcaaa aagaaaaaac tagaacaaag atcaaagctt
      301 gaaaacttag aagaccttga aataattgtt caactgaaga aaagaaaaaa atacaagaaa
      361 actaaagttc cagttgtgaa ggaaccggag cctgaaatta ttactgaacc tgtggatgtg
      421 ccaaggtttc tgaaagctgc actggagaac aaactgccag ttgtagagaa attcctgtca
      481 gacaagaaca gccccgacgt ctgcgatgag tataaacgga ccgctctcca tagagcatgc
      541 ttagaaggac acttggcgat cgtggagaag ttaatggagg ctggagccca gattgaattc
      601 cgagatatgc tggaatccac agccatccac tgggcatgtc gtggaggaaa cctggatgtc
      661 ctgaaactgt tgctaaacaa aggtgccaaa atcagtgccc gagacaagct gctcagcaca
      721 gcgctgcacg tggcggtgag gaccggtcac tacgagtgtg ctgagcacct catcgcctgc
      781 gaggcggatc tcaatgccaa ggacagagaa ggagacaccc ctctgcatga tgcggtgagg
      841 ttgaatcgct acaagatgat ccggctcttg atgaccttcg gtgcggacct caatgtcaag
      901 aactgtgctg ggaagacccc tatggatctg gtgttgcact ggcagaatgg aaccaaagcg
      961 atattcgaca gcctcaagga gaatgcctac aaaaactcgc gcatagctac gttctgagga
     1021 aagagactcg acaggagctg ttctcagccg ttttcaaaac atttcccagc agcagagcaa
     1081 ccagctataa cacccagctt ttgtttgcca gccaaatagg gagataagct ttaaagacgc
     1141 ttcatggaag ccctgggtta gagatgttaa catgtcctct agcgatgctc accattttta
     1201 tctgctccta tttatttatt tatttatttc atagcactgg tagtcaggtt ttcatgagca
     1261 tcattttggg ggagcaagac ttaatctgtg tgtaacattc ggagtcttcc cgtggctcta
     1321 aaaccgcgtg ggtgaatggt gtctaatcgc acccttttgt gtcctcactt gcattaaagc
     1381 tactcaaggt atttttgaaa ggcaagggtt ggtcggtcgc cgcagccctt ctctggattc
     1441 tcactgctga tatccgaatg aagcagcaga aggtgtacag gaatgcagaa ggggatggga
     1501 gcagttctgc aggacctaag ccgtggctcg ccaggcaccc acaggtgtgg tttgccggat
     1561 cacacagtgc cgaggtgaag gccacgtcag gagcgtgtgt ggagggggat ggagggagta
     1621 ggcaatgggg cctcactaac ctgaggtcga tgagaggaaa agtcaaaagg acatgccctg
     1681 taaatgtgta aatgtgtatt gtgttgtacg catattttat attcctaata aatgcaaact
     1741 aattc
//
