LOCUS       NM_207595               1846 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ankyrin repeat family A member 2 (Ankra2),
            transcript variant 1, mRNA.
ACCESSION   NM_207595 XM_215457
VERSION     NM_207595.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1846)
  AUTHORS   Nie,J., Xu,C., Jin,J., Aka,J.A., Tempel,W., Nguyen,V., You,L.,
            Weist,R., Min,J., Pawson,T. and Yang,X.J.
  TITLE     Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M
            syndrome protein CCDC8
  JOURNAL   Structure 23 (4), 700-712 (2015)
   PUBMED   25752541
REFERENCE   2  (bases 1 to 1846)
  AUTHORS   Xu,C., Jin,J., Bian,C., Lam,R., Tian,R., Weist,R., You,L., Nie,J.,
            Bochkarev,A., Tempel,W., Tan,C.S., Wasney,G.A., Vedadi,M.,
            Gish,G.D., Arrowsmith,C.H., Pawson,T., Yang,X.J. and Min,J.
  TITLE     Sequence-specific recognition of a PxLPxI/L motif by an ankyrin
            repeat tumbler lock
  JOURNAL   Sci Signal 5 (226), ra39 (2012)
   PUBMED   22649097
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1846)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   4  (bases 1 to 1846)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
REFERENCE   5  (bases 1 to 1846)
  AUTHORS   Lim,H.H. and Park,C.S.
  TITLE     Identification and functional characterization of ankyrin-repeat
            family protein ANKRA as a protein interacting with BKCa channel
  JOURNAL   Mol Biol Cell 16 (3), 1013-1025 (2005)
   PUBMED   15616191
  REMARK    GeneRIF: ANKRA could modulate the excitability of neurons by
            binding directly to endogenous BKCa channel and altering its gating
            kinetics in a calcium-dependent manner
REFERENCE   6  (bases 1 to 1846)
  AUTHORS   Rader,K., Orlando,R.A., Lou,X. and Farquhar,M.G.
  TITLE     Characterization of ANKRA, a novel ankyrin repeat protein that
            interacts with the cytoplasmic domain of megalin
  JOURNAL   J Am Soc Nephrol 11 (12), 2167-2178 (2000)
   PUBMED   11095640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 16, 2023 this sequence version replaced NM_207595.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566568.1, BC081975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000002.1  31347158-31347490
            334-720             JAXUCZ010000002.1  31349818-31350204
            721-879             JAXUCZ010000002.1  31350979-31351137
            880-945             JAXUCZ010000002.1  31352884-31352949
            946-1043            JAXUCZ010000002.1  31355206-31355303
            1044-1169           JAXUCZ010000002.1  31355767-31355892
            1170-1236           JAXUCZ010000002.1  31356363-31356429
            1237-1317           JAXUCZ010000002.1  31356886-31356966
            1318-1846           JAXUCZ010000002.1  31357474-31358002
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1846
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /note="ankyrin repeat family A member 2"
                     /db_xref="GeneID:294679"
                     /db_xref="RGD:1303108"
     exon            1..333
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            334..720
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1373
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin-repeat family A protein; ankyrin repeat family A
                     protein 2; ankyrin repeat family A protein 2-like;
                     SLO-interacting ankyrin-containing protein; ankyrin
                     repeat, family A (RFXANK-like), 2"
                     /codon_start=1
                     /product="ankyrin repeat family A protein 2 isoform 1"
                     /protein_id="NP_997478.1"
                     /db_xref="GeneID:294679"
                     /db_xref="RGD:1303108"
                     /translation="MATSANLDIGAQLVVEECPSSYGLSGMPDIKIEHQPDPNSDEGS
                     AQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIH
                     TSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQG
                     EMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA
                     LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHGKCVKMLLENGADPTI
                     ETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE"
     exon            721..879
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            880..945
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1043
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1169
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1236
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1317
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1846
                     /gene="Ankra2"
                     /gene_synonym="ANKRA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgaggcg acctttagtt ctgcgagagg atggggcgcg gagcgctagg gaaaccagaa
       61 gagatcactt gtagtcgtct cgccttcact gaacgctcta gtttttttcc agaagagata
      121 aaaaatagga agtgacgtct gggcccgaag ccgaccgagc tcgggaccaa tccactgctg
      181 gccctggcca ggcccgagcc gctctcccgc tgcgctctgg gtagtcatat cacccgccgg
      241 accggcccct gtccccggaa ccgctcaccg tgcgggagcg ggtgtcaccc cgcggccata
      301 gagcgggaac gcccgccggg acacctgtcg cttatacttt actatctcaa ttccagtaaa
      361 atactggata acacccttgg gggaaaaaaa agaaaaagaa atcatgaaga aatgttttaa
      421 ttattaaaac catggctaca tctgcaaatc tggacattgg ggcccaactg gtcgtggaag
      481 agtgtcccag cagctatggc ctctctggga tgccagacat caaaatagag caccagccag
      541 acccaaactc agatgaaggg tcagctcagg gagtcgccat ggggatgaag ttcatactgc
      601 caaaccgatt tgatatgaac gtgtgctctc gctttgtgaa gtccttaaac gaagaggata
      661 gtaaaaatat tcaagatcaa gttaactctg acctggaggt ggcgtctgtc ttatttaaag
      721 ctgaatgcaa tatccatacc tctccttctc ctggaattca agtaaggcac gtctacacac
      781 cctctacaac taaacatttc tcacccataa aacagtcaac tactttaacc aacaagcaca
      841 ggggaaacga ggtctccacc acacctctgt tagcaaattc tctgtctgtt caccagttgg
      901 cagctcaggg agagatgctc tacctggcta ctcgtattga acaagaaaat gttatcaatc
      961 acacggatga agaaggattt actcccctga tgtgggctgc ggcacacggg caaatagctg
     1021 tggtagaatt cctccttcag aacggtgcag atccccagct cttaggaaaa ggtcgagaaa
     1081 gtgccctgtc gttggcctgc agtaagggct acacagacat tgtcaaaatg ctgctagact
     1141 gtggagttga cgtaaatgag tatgactgga acggaggcac ccctttgctt tatgctgtcc
     1201 acgggaacca cgggaagtgc gtgaagatgc tgttggaaaa tggagctgac ccaacaattg
     1261 aaacagactc tggctataat tctatggact tggctgtagc tctgggctac agaagtgttc
     1321 aacaggtcat tgagtcacac ctgctgaagc tgcttcagaa catcaaggag tgacgattcc
     1381 tcagaaaagg ccacctgccc ttctcagccc tgggtcctta atgatagttt tgtttacgtg
     1441 taaattttta tagttctgtt tgagtgtaaa tttttatctc agttgcaata tttgctggtt
     1501 tttagtgagt tttaatacat attcctctgg ataattcact tgtctataat aaaattaatc
     1561 ctgatttttt aaataaatgt gtcttactat atattaagat tattaattaa tgttttctgg
     1621 catgtaacct tttatggtac aggtgtttgt gtgttttgta tcaaggatca caatgacact
     1681 ttaagaaaac tccatcttgt ttctctccac tcctgtatta actttgactt tcacaggact
     1741 cactgtaagt ctgtggggaa aataatgttc ttgttgaatt aaagagtact cagtgtgatg
     1801 gtttacaaaa tcatgtttaa ataaagtacc tttctgtctg tctgca
//
