LOCUS       NM_001393843            5173 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ankyrin repeat and LEM domain containing 2
            (Ankle2), mRNA.
ACCESSION   NM_001393843 XM_008769342
VERSION     NM_001393843.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Yamamoto,S., Jaiswal,M., Charng,W.L., Gambin,T., Karaca,E.,
            Mirzaa,G., Wiszniewski,W., Sandoval,H., Haelterman,N.A., Xiong,B.,
            Zhang,K., Bayat,V., David,G., Li,T., Chen,K., Gala,U., Harel,T.,
            Pehlivan,D., Penney,S., Vissers,L.E.L.M., de Ligt,J.,
            Jhangiani,S.N., Xie,Y., Tsang,S.H., Parman,Y., Sivaci,M.,
            Battaloglu,E., Muzny,D., Wan,Y.W., Liu,Z., Lin-Moore,A.T.,
            Clark,R.D., Curry,C.J., Link,N., Schulze,K.L., Boerwinkle,E.,
            Dobyns,W.B., Allikmets,R., Gibbs,R.A., Chen,R., Lupski,J.R.,
            Wangler,M.F. and Bellen,H.J.
  TITLE     A drosophila genetic resource of mutants to study mechanisms
            underlying human genetic diseases
  JOURNAL   Cell 159 (1), 200-214 (2014)
   PUBMED   25259927
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Asencio,C., Davidson,I.F., Santarella-Mellwig,R., Ly-Hartig,T.B.,
            Mall,M., Wallenfang,M.R., Mattaj,I.W. and Gorjanacz,M.
  TITLE     Coordination of kinase and phosphatase activities by Lem4 enables
            nuclear envelope reassembly during mitosis
  JOURNAL   Cell 150 (1), 122-135 (2012)
   PUBMED   22770216
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000229.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393843.2.
            
            On Mar 18, 2021 this sequence version replaced XM_008769342.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.147438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               JACYVU010000229.1  9044007-9044416     c
            411-887             JACYVU010000229.1  9040988-9041464     c
            888-1094            JACYVU010000229.1  9039387-9039593     c
            1095-1291           JACYVU010000229.1  9037691-9037887     c
            1292-1480           JACYVU010000229.1  9037407-9037595     c
            1481-1603           JACYVU010000229.1  9029605-9029727     c
            1604-1670           JACYVU010000229.1  9027598-9027664     c
            1671-1840           JACYVU010000229.1  9023162-9023331     c
            1841-1947           JACYVU010000229.1  9022011-9022117     c
            1948-2138           JACYVU010000229.1  9021346-9021536     c
            2139-2766           JACYVU010000229.1  9017260-9017887     c
            2767-2898           JACYVU010000229.1  9016604-9016735     c
            2899-5173           JACYVU010000229.1  9013951-9016225     c
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..5173
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /note="ankyrin repeat and LEM domain containing 2"
                     /db_xref="GeneID:360829"
                     /db_xref="RGD:1310191"
     exon            1..410
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..3118
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /note="liver regeneration-related protein LRRG057; LEM
                     domain-containing protein 4"
                     /codon_start=1
                     /product="ankyrin repeat and LEM domain-containing protein
                     2"
                     /protein_id="NP_001380772.1"
                     /db_xref="GeneID:360829"
                     /db_xref="RGD:1310191"
                     /translation="MLWQRLAVVEWAALAWELLGASVLLIAVRWLVRRLEKRPRDPNR
                     CGTLSSLPGASAAVSAQPGEVMTMDAMLARLKLLNPDDLRQEVMKAGLKCGPITSTTR
                     FIFEKKLAQALLEQGGLLTSSLPKHSEVTGTAFIHGTSRTPAFVDRKQTQQACLSEDR
                     DFGYSVGLNPPEEEAVTSSVHPIPFSASTRNDNHKAGVTTAKEPLLYYGVCPVYEDGL
                     VRHERIHVYEDKKEALQAVKLIKGSRFKAFPTREDAEKFARGICDYLPSPSKNMSLLS
                     PVKAMPLCSNDGPKADGLCLAESETVNKERANSYKNPRTQDLTAKLRKAVERGEEHTF
                     SDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASVCQLTLETLENPEFMRLM
                     YPDDNMDMLQKRILYIVDLYLNTPDKVGFDTPLHFACKFGNVDVVNVLSSHPLIVKNP
                     RNKYGKTPEDVICERSKNKSVELRERIREYLMGHYYVPLLRAEDTSPVIGELWSSDQK
                     AEASSADHCRSSPRDPVMTLRAFVGPLSPSKAEDFRKLWKTPPRKKAGLFHSIRKSDP
                     ERGIERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLIQKELNQKAQHEI
                     GEEEGCLQDRTSDFGSGKKYSNSISVGAFLDGGDDISLEEVKNQQNTVPSQSQPSVDK
                     FQNSKSGSPSLGQKADPGEAAVGFYPDNSRNGFCYPLNSRTADGRETEATNGEEALPP
                     PVSILTQEFDKLNLQSLGDNLFETPNKNRELEDKILASSKGVVESGLASPAAIARLEN
                     KQVRTNSEVSEAMAEMSLGPNSPQLGVQAGLEPGFSSATADPTKRLFLSGEEPSKLDR
                     DVLAALECAIIDPGLYPAVHRWKSTVMGYSPSDRQSWPSPALKGKFTTELVDLDCCHS
                     CSGRSSPAGSSPSKPGHTTFSSGLHSPGRYSPAHGRHFQRVACMARLAAL"
     exon            411..887
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1094
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1291
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1480
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1603
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1670
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1840
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1947
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2138
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2766
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2898
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..5173
                     /gene="Ankle2"
                     /gene_synonym="Ab2-034; RGD1310191"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagccgcct gaggctgggg tcctggcgcg ttctggcctt ggtcgttggg acacgggagg
       61 ctccgcactg cgcgcgcagc gcgcctggtt ttcccacggc cggggaggag gcctgaggca
      121 ggcgcggctc cggcggccgg gcgagcggcc tacagagggc cccaggcggg cgcgggcggt
      181 ggctgcggcg gccgcgctcg aggcgtcggc gccggcggtg gcgatgctgt ggcagcggtt
      241 ggctgtggtg gagtgggcgg ccctggcctg ggagctcctg ggcgcctcgg tgctgctcat
      301 cgccgtgcgc tggctggtcc ggcgcctgga gaagcggccg cgggacccga accgctgcgg
      361 gacactctcc tctctgcctg gcgcgtctgc agcggtgtcc gctcagcccg gtgaagtgat
      421 gacaatggac gctatgttgg ctcgactgaa actcttgaat ccagatgacc tcagacaaga
      481 agttatgaaa gctggactga aatgtgggcc cattacatca actacaagat ttatttttga
      541 gaagaaatta gcgcaggcct tactagaaca aggtggactg ctgacttcct ctcttccaaa
      601 gcacagtgag gtgactggca cggcatttat ccatggcact tcaaggactc ctgcatttgt
      661 ggacaggaaa caaactcagc aggcctgttt atctgaagac agagattttg gttatagtgt
      721 gggcttgaac cctccagaag aggaagctgt aacatccagt gtgcacccca taccctttag
      781 tgcctccacc aggaatgaca accacaaggc tggagtgaca actgctaagg agccccttct
      841 gtactatgga gtgtgtccag tgtatgagga tggccttgtg agacacgaaa ggatccatgt
      901 ttacgaagat aaaaaggaag ccttacaagc tgtcaaattg atcaaagggt cccggtttaa
      961 agcttttcca acaagagaag atgctgagaa atttgctaga gggatatgtg attacttacc
     1021 ttctcccagc aaaaatatgt ccttactgtc tcctgtaaag gcaatgcccc tctgcagcaa
     1081 tgatgggcca aaagcagatg gcttgtgcct ggctgaatca gaaacagtaa acaaagaacg
     1141 agcaaacagt tataaaaacc cccgtacaca ggaccttact gccaagctgc ggaaagctgt
     1201 tgaaagaggg gaggaacaca ccttttctga tcttatctgg agtaatcctc gatatctaat
     1261 tggttctggg gacaacccaa ccattgtgca agaaggatgt aggtacaatg tcatgcatgt
     1321 tgctgccaaa gagaatcagg cgtctgtgtg ccagctgaca ttagagactc tggagaaccc
     1381 tgaatttatg cgtcttatgt acccagatga taacatggac atgctacaga aacgtatcct
     1441 ctacattgtc gacctgtatc ttaatactcc tgacaaagtg ggctttgaca caccattgca
     1501 ttttgcttgt aaatttggga atgtggatgt agtcaacgtg ctttcttccc accctttgat
     1561 tgtgaaaaac ccaaggaata aatatggtaa aacacctgaa gacgtaattt gtgaaagaag
     1621 caaaaacaaa tctgtagaac tgagagaaag gattagagaa tacttaatgg gtcactacta
     1681 tgtaccactt ctgagagccg aagacacctc tcctgtcatt ggggagctgt ggtcctcaga
     1741 ccagaaagct gaagcatcca gtgccgacca ctgcagaagt agccccaggg atcctgtgat
     1801 gacactgaga gcttttgtgg ggcctctgag tccatccaaa gcagaagatt ttcgaaagct
     1861 ttggaaaact ccacctcgaa aaaaagcagg cctcttccac agcatcagga agtctgaccc
     1921 agaaagaggc attgagagag ttggaaggga gctagctcat gagctggggt atccttgggt
     1981 tgaatactgg gaatttctgg gatgttttgt tgatctgtct tcccaggaag gcttgcaaag
     2041 actagaagaa taccttatcc agaaggagtt aaaccaaaag gctcaacatg aaataggaga
     2101 agaggaaggc tgccttcagg acagaacctc agattttggc agtggaaaga agtacagcaa
     2161 ctccatctcc gtgggagcgt ttctagatgg gggtgatgac attagcttgg aagaagttaa
     2221 aaatcagcaa aatacagttc caagtcagag tcagccctca gtcgacaaat tccaaaactc
     2281 caaaagtggt tccccttcct tgggacagaa ggcggaccct ggagaagccg cagttggatt
     2341 ttacccagat aacagcagaa atgggttttg ttatcctctg aacagcagga ctgcagatgg
     2401 aagggaaaca gaggccacca atggagagga ggcccttcca ccacctgttt ctattttgac
     2461 tcaagagttt gataaactga atttgcaaag tctaggagat aaccttttcg agacaccaaa
     2521 taaaaatagg gaactagagg ataagatact ggcttcaagt aaaggtgtag tagaaagtgg
     2581 cttggcatct cctgctgcaa tagcaagact tgaaaataag caagtcagga ccaacagtga
     2641 ggtgtcagag gcaatggctg aaatgtcttt gggccccaac agcccccaac ttggggttca
     2701 ggctggtctg gaacctgggt tctcatctgc cacagcagat cccaccaaga ggctcttcct
     2761 gtctggagag gagccatcaa aactagatcg agatgtttta gcagcccttg agtgtgcgat
     2821 tattgaccct ggtctgtacc cagcagtcca cagatggaaa agtaccgtca tgggctactc
     2881 gccctcagac agacagagtt ggccaagtcc tgcactcaaa gggaagttca caactgagtt
     2941 ggtggatctt gattgctgtc atagctgctc aggacgaagc agcccggctg ggagcagccc
     3001 cagtaagcct ggccacacca ccttctcttc tggcctgcac agccctggac gctacagtcc
     3061 agcacatggg agacacttcc aaagagtggc atgcatggcc cgacttgcag ctctgtagag
     3121 ccagccagta tgctcactcc tgggattcat ttacttcttt gttttttaaa gaagagtaat
     3181 gcttattggt aaaaattcca taaaagaatt gtataatcct cactttgagg gtaccagaat
     3241 tttagaaaat aacaatgttc tggtagaatt tgaatgtctg atattttgga agaagttaat
     3301 gaaagcaaac tcagatacaa attgtttgaa agtgtggcta tagtaatgat tcagactttt
     3361 caggtggaaa cttctgattt tgaagtggag caaagataca aaggcagttg acaagtgagg
     3421 tgctgctctg attggatgtg ttagcagcag ctctgcagca tgtgccagca cacccagttt
     3481 ctgagaccga tgaattatgt gctgtctctc tttggggagg gacagctttc tgatatgcaa
     3541 ttgcaaatct gtcacttcat cccaattgtt ccaacagtga gaaagcaggt gtcagagaag
     3601 cagatgggcc ttgactgtct cagacttcag taacaatgct caaaacactg ccaggaagtg
     3661 gggcggggag acttaaagcc actgagaatc atgccagtaa tcatagaaaa ctcagcagca
     3721 gtaactaaac acagaaccat ttctcagtgc tcgtcaatga ataagcaatc tgggagttgt
     3781 tccctagtct taacatttat cctgagatgt cactgagcat gattaacatg acagatgtat
     3841 cccatattca ctcgagacct gagttcattt cagtggcttg aggtgtttac ttttggctat
     3901 cccaggagat gtgtgaagag tggcactgca aaccctaagg caccaagata aagccacctt
     3961 gctaacgctg ggtcctggct atgtggcacg gccgcttgca caaagccagt agtgttctac
     4021 agacacttgc agtcttaatc ccactacaga agtacaccac tgattttacc aacttcagtg
     4081 ccttttgtga gtcatttttt aatttttcca aatttagatt ttgagactat agtgctaaat
     4141 gggtgttacc aggcactctt ttaaccccat cacccattag gcagaagcag ggggttctca
     4201 gagctttgag gccagcctgg tcttcatagt gagttctagg acatctagaa ctacacagag
     4261 atcttgtctc aaaaacaaaa aacaaaacaa acaaacaaaa aaacaataaa gtaaaaattc
     4321 tgagctcaaa tgtttaggtc cttttttttt ttgaagcatt ttaatgtggt aggaaatatc
     4381 agaattgaga ttttggactt tggattcagt ttgttttcat tccccttgta agcagctgag
     4441 ctctaagtac aagacagcca ataacgtgac ctggaaacag tcccaaaggg aatctttgtt
     4501 ctcaaaagaa accaaacccc acacattaga tccagctatg atcttgtttt ctctaaagtc
     4561 ttattgtcct gtggggttat ttttgttgtt tttccatact caaataaaaa ccaaagtact
     4621 agttttgccc ttttttaact ttttcttttt tttccggagc tggggaccga acccagggcc
     4681 ttgcttgcat tcgctaggca ttaactctta tttctttttt tttttttttt tttttttttg
     4741 gttctttttt tcggagctgg ggaccaaacc cagggccttg cgcttcctag gtaagcgctc
     4801 taccgctgag ctaaatcccc agccctaact cttatttctt aatgacattt acgtaagaca
     4861 acttttggga gtcagttctt ataccatgta ggtctcaggg atccaactca ggtcactgga
     4921 attgagtttt acttgctgag cccatcttgc tggcccattt taaactttaa gccacctttg
     4981 gactagacta tttttccact agtgtgaaga atatatgatg cctgttagta acacatgatt
     5041 ctatatcata aacactgttt aattgatctt tctcaaagtg ttgtataaga aatgattcct
     5101 tgttatctgg acagaatccc cttcttagta aaactgtaaa caatattttc attaaaaagt
     5161 acattgagta tca
//
