LOCUS       NM_001108999            2765 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ankyrin repeat and kinase domain containing 1
            (Ankk1), mRNA.
ACCESSION   NM_001108999 XM_001070278 XM_345937
VERSION     NM_001108999.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Kaminskaite,M., Jokubka,R., Janaviciute,J., Lelyte,I.,
            Sinkariova,L., Pranckeviciene,A., Borutaite,V. and Bunevicius,A.
  TITLE     Epistatic effect of Ankyrin repeat and kinase domain containing 1 -
            Dopamine receptor D2 and catechol-o-methyltransferase single
            nucleotide polymorphisms on the risk for hazardous use of alcohol
            in Lithuanian population
  JOURNAL   Gene 765, 145107 (2021)
   PUBMED   32889058
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Tsou,C.C., Chou,H.W., Ho,P.S., Kuo,S.C., Chen,C.Y., Huang,C.C.,
            Liang,C.S., Lu,R.B. and Huang,S.Y.
  TITLE     DRD2 and ANKK1 genes associate with late-onset heroin dependence in
            men
  JOURNAL   World J Biol Psychiatry 20 (8), 605-615 (2019)
   PUBMED   28854834
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Zhang,J., Yan,P., Li,Y., Cai,X., Yang,Z., Miao,X., Chen,B., Li,S.,
            Dang,W., Jia,W. and Zhu,Y.
  TITLE     A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated
            with heroin dependence in Han Chinese males
  JOURNAL   Brain Res 1688, 54-64 (2018)
   PUBMED   29550268
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Espana-Serrano,L., Guerra Martin-Palanco,N., Montero-Pedrazuela,A.,
            Perez-Santamarina,E., Vidal,R., Garcia-Consuegra,I., Valdizan,E.M.,
            Pazos,A., Palomo,T., Jimenez-Arriero,M.A., Guadano-Ferraz,A. and
            Hoenicka,J.
  TITLE     The Addiction-Related Protein ANKK1 is Differentially Expressed
            During the Cell Cycle in Neural Precursors
  JOURNAL   Cereb Cortex 27 (5), 2809-2819 (2017)
   PUBMED   27166167
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Quraishi,R., Jain,R., Mishra,A.K. and Ambekar,A.
  TITLE     Association of ankyrin repeats & kinase domain containing 1 (ANKK1)
            gene polymorphism with co-morbid alcohol & nicotine dependence: A
            pilot study from a tertiary care treatment centre in north India
  JOURNAL   Indian J Med Res 145 (1), 33-38 (2017)
   PUBMED   28574012
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Doehring,A., Hentig,Nv., Graff,J., Salamat,S., Schmidt,M.,
            Geisslinger,G., Harder,S. and Lotsch,J.
  TITLE     Genetic variants altering dopamine D2 receptor expression or
            function modulate the risk of opiate addiction and the dosage
            requirements of methadone substitution
  JOURNAL   Pharmacogenet Genomics 19 (6), 407-414 (2009)
   PUBMED   19373123
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Huang,W., Payne,T.J., Ma,J.Z., Beuten,J., Dupont,R.T., Inohara,N.
            and Li,M.D.
  TITLE     Significant association of ANKK1 and detection of a functional
            polymorphism with nicotine dependence in an African-American sample
  JOURNAL   Neuropsychopharmacology 34 (2), 319-330 (2009)
   PUBMED   18354387
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Yang,B.Z., Kranzler,H.R., Zhao,H., Gruen,J.R., Luo,X. and
            Gelernter,J.
  TITLE     Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated
            with comorbid alcohol and drug dependence
  JOURNAL   Alcohol Clin Exp Res 32 (12), 2117-2127 (2008)
   PUBMED   18828801
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Ponce,G., Hoenicka,J., Jimenez-Arriero,M.A., Rodriguez-Jimenez,R.,
            Aragues,M., Martin-Sune,N., Huertas,E. and Palomo,T.
  TITLE     DRD2 and ANKK1 genotype in alcohol-dependent patients with
            psychopathic traits: association and interaction study
  JOURNAL   Br J Psychiatry 193 (2), 121-125 (2008)
   PUBMED   18669994
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Gelernter,J., Yu,Y., Weiss,R., Brady,K., Panhuysen,C., Yang,B.Z.,
            Kranzler,H.R. and Farrer,L.
  TITLE     Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1
            loci, is strongly associated to nicotine dependence in two distinct
            American populations
  JOURNAL   Hum Mol Genet 15 (24), 3498-3507 (2006)
   PUBMED   17085484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1 and BM384954.1.
            
            On Sep 10, 2019 this sequence version replaced NM_001108999.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               JAXUCZ010000008.1  58684250-58684489   c
            241-535             JAXUCZ010000008.1  58682346-58682640   c
            536-687             JAXUCZ010000008.1  58681160-58681311   c
            688-737             JAXUCZ010000008.1  58680789-58680838   c
            738-893             JAXUCZ010000008.1  58680164-58680319   c
            894-1017            JAXUCZ010000008.1  58679410-58679533   c
            1018-1078           JAXUCZ010000008.1  58678822-58678882   c
            1079-2745           JAXUCZ010000008.1  58676328-58677994   c
            2746-2764           BM384954.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2765
                     /gene="Ankk1"
                     /note="ankyrin repeat and kinase domain containing 1"
                     /db_xref="GeneID:367080"
                     /db_xref="RGD:1305538"
     exon            1..240
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2374
                     /gene="Ankk1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="ankyrin repeat and protein kinase
                     domain-containing protein 1"
                     /protein_id="NP_001102469.2"
                     /db_xref="GeneID:367080"
                     /db_xref="RGD:1305538"
                     /translation="MVPHRARRLPDPMAVRPLEQQLGSLTVFTRDDFEEEWHLVASGG
                     FSQVFQARHKRWRTQYAIKCSPCLQKETTSSEVSCLFEEAVKMEKIKFQYIVSIYGVC
                     KQPLGIVMEFMANGSLEKILPTHSLCWQLKFRIIHETSLAMNFLHSIKPPLLHLDLKP
                     GNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPE
                     YDVYSFGIVVWEILTQKKPYAGLNMMTIIIQVAAGMRPSLHDVSAEWPEEAHQMVDLM
                     KLCWDQDPKKRPCFLNVIIETDMLLSLFQTPVADPEYEALTRKVSYKSSLSQPHRWIP
                     TLHNTLQVSKEVSQEIADSADSDDSLKWILQLSDSKSLVPSDIYENKVTPLHFLVARG
                     SLEQVRLLLSHEVDVDCQTASGYTPLLIATQDQQPDLCALLLAHGADTNLADEDGWAP
                     LHFAAQSGDDHTARLLLDHGALVNAREHEGWTPLHLAAQNNFENIARLLVSRQADLNP
                     CEAEGKTPLHVAAYFGHIGLVKLLTGQGAELDAQQRNLRTPLHLAVEKGKVRAIQHLL
                     KRGALPDVLDHNGYSPLHIAAAKGKYLIFKMLLRHGASLELCTQQGWAPLHLATYKGH
                     LEIIHLLAKSHADLDALGSMQWTPLHLAAFCGEEGMMLALLQCGANPNAAEQSGWTPL
                     HLAVHKGTFLGIVHLLEHGADVHACNKVGWTPAHLAALKGNTEILKVLVKACARLDAK
                     DGVGCTPLQLALRSLKQSAVALLQDKEPSLAILGDSKPVPLMDD"
     exon            241..535
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..687
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..737
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..893
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1017
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1079
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..2747
                     /gene="Ankk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaggcaca ggggagtgta tggtgccaca cagggccagg aggcttccgg accccatggc
       61 agtcaggccc ttggagcagc agctgggcag cctcaccgtc ttcacccgtg atgattttga
      121 ggaagaatgg cacctagtag ccagcggtgg cttcagccag gtgttccagg caaggcacaa
      181 gcgctggagg acgcagtatg ccatcaagtg ctccccatgc ctccagaagg aaaccaccag
      241 ctctgaagtg agttgcctct ttgaagaagc agtcaaaatg gagaagatta agtttcaata
      301 cattgtgtcc atctatgggg tctgcaagca gcccctgggc atcgtgatgg agttcatggc
      361 taacggttcc ctggagaaga tactacctac ccacagcctc tgctggcagc tcaagttccg
      421 catcatccac gagacaagct tggccatgaa cttcctccac agcattaagc cacccctgct
      481 ccacctggac cttaagccag gcaacatcct gctggacaat aacatgcatg tcaagatttc
      541 agattttggc ctgtccaagt ggatggagca atcaacccag aagcagtaca ttgagagatc
      601 agctctgagg ggtacactca gctacatacc tcctgaaatg ttcctggaaa ataacaaggc
      661 tccggggcct gaatatgatg tgtacagctt tgggattgtc gtctgggaga ttctcactca
      721 gaagaaacct tatgcagggc tcaatatgat gaccattatc atccaggtgg ctgcaggcat
      781 gaggccctcc ttgcacgatg tctctgctga gtggccagag gaggcccatc agatggtgga
      841 cctgatgaag ctctgctggg accaagaccc caagaagagg ccatgcttcc taaatgtgat
      901 cattgagaca gacatgctac tgtccctgtt ccagacccct gtggcagatc ctgagtatga
      961 agccctgacc cggaaggtgt cttacaagtc atcgctgagc cagccccaca ggtggatacc
     1021 caccctgcac aatactttgc aggtcagcaa ggaggtcagc caggagattg cagacagtgc
     1081 agactcagat gactccttga agtggattct acagctctct gacagcaaga gcttggtccc
     1141 aagtgatatc tatgagaaca aggtgactcc cctacacttt ctagtggcca ggggcagctt
     1201 ggaacaagtg aggctgctgc tgtcccatga ggtcgatgta gactgccaga cagcttctgg
     1261 ctatacacca ctccttattg ccacccagga ccagcagcct gacctctgtg ccctgcttct
     1321 ggcccatggt gctgatacca acctggcaga tgaagatggc tgggccccac tgcatttcgc
     1381 agcccagagt ggggatgacc acactgcccg tctgctcctg gaccatggcg ccctggtgaa
     1441 tgcacgggag catgagggtt ggaccccact ccacctggct gcacagaaca actttgagaa
     1501 tattgcacgg cttctggtct cccgtcaggc tgatctcaac ccatgtgagg cagagggcaa
     1561 gactcccctc catgttgccg cctactttgg ccacattggc ttggtcaagc tgctgacagg
     1621 acagggagct gagctggatg ctcagcagag aaacctgagg acacccctgc acctggcagt
     1681 ggagaaggga aaagtgagag ccattcagca cctgctaaaa cgtggggcac tccctgatgt
     1741 gcttgaccac aatggctaca gtcctttgca cattgctgca gccaagggca agtaccttat
     1801 ctttaaaatg cttctgagac atggggccag ccttgagcta tgcacacaac agggatgggc
     1861 acccctgcac ctagcaactt acaagggcca cctggagatt atccatctgt tggccaagag
     1921 ccatgcagac ctagatgctc ttggaagtat gcaatggact cccctgcacc tggctgcctt
     1981 ctgtggggag gagggaatga tgctggcatt gctgcagtgt ggggccaatc ccaatgccgc
     2041 tgagcagtca ggttggactc ctctccacct ggcagtgcat aaagggacct tcctgggtat
     2101 cgtccacctt ctggagcacg gtgctgatgt ccacgcttgc aacaaagtgg gctggacacc
     2161 tgcccacctg gctgctctca agggcaacac agaaatcctc aaagttctag tcaaagcttg
     2221 tgcgcgactg gatgccaagg atggagttgg ctgtactccc ttgcagctag ccctccgcag
     2281 cctaaagcag agtgctgttg ccctcttgca ggacaaggaa ccttcactag ccattctggg
     2341 agattctaaa cctgtgcccc tgatggatga ttaggtgtag cagtgttcct ttgcttggaa
     2401 ggggaggggc ttgtgaaagt gaaacttgtc atgtgagaga ccacttcctg cctgtccatt
     2461 tgaccttgag aggaaccagt gtcctagatg acagaaggaa gctgaggggt tccagtgaac
     2521 tgaggaagct actgactgcc tgaaaaactg atcttagctc ccctgcagtc atctgtagac
     2581 aaaccatgtt ctcccctttc tttaaatgag ctcatgtgtc caagataagc tttgttccca
     2641 gcctcaagac tcctttcccc atttgttgct ttcctttgaa tcatggagtc tcatgcccca
     2701 aggaactccc aaaataaaga aaaagcctca aaatgaggag aaagggcaaa aaaaaaaaaa
     2761 aaaaa
//
