LOCUS       NM_053714               2446 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ANKH inorganic pyrophosphate transport regulator
            (Ankh), mRNA.
ACCESSION   NM_053714 XM_346618
VERSION     NM_053714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Chen,B., Zhao,Y., Han,D., Zhao,B., Mao,Y., Cui,Z.K., Chu,Y.C.,
            Feng,L., Yin,S., Wang,C.Y., Wang,X., Xu,M.J. and Zhao,G.
  TITLE     Wnt1 inhibits vascular smooth muscle cell calcification by
            promoting ANKH expression
  JOURNAL   J Mol Cell Cardiol 135, 10-21 (2019)
   PUBMED   31356809
  REMARK    GeneRIF: This work reveals the ANKH regulation of Wnt1 in vascular
            smooth muscle cells is essential for blocking vascular
            calcification (VC). Our findings may contribute to the development
            of medications that target Wnt signaling and/or ANKH to inhibit VC.
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Rosenthal,A.K., Gohr,C.M., Mitton-Fitzgerald,E., Lutz,M.K.,
            Dubyak,G.R. and Ryan,L.M.
  TITLE     The progressive ankylosis gene product ANK regulates extracellular
            ATP levels in primary articular chondrocytes
  JOURNAL   Arthritis Res Ther 15 (5), R154 (2013)
   PUBMED   24286344
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Xu,H.G., Cheng,J.F., Peng,H.X., Lv,K., Wang,H., Liu,P., Zhong,M.
            and Zhang,M.Y.
  TITLE     JNK phosphorylation promotes natural degeneration of cervical
            endplate chondrocytes by down-regulating expression of ANK
  JOURNAL   Eur Rev Med Pharmacol Sci 17 (17), 2335-2344 (2013)
   PUBMED   24065227
  REMARK    GeneRIF: Phosphorylation of JNK promotes natural degeneration of
            cervical endplate chondrocytes, likely by down-regulating ANK
            expression
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Zhao,G., Xu,M.J., Zhao,M.M., Dai,X.Y., Kong,W., Wilson,G.M.,
            Guan,Y., Wang,C.Y. and Wang,X.
  TITLE     Activation of nuclear factor-kappa B accelerates vascular
            calcification by inhibiting ankylosis protein homolog expression
  JOURNAL   Kidney Int 82 (1), 34-44 (2012)
   PUBMED   22437419
  REMARK    GeneRIF: TNF-activated NF-kappaB promotes inflammation-accelerated
            vascular calcification by inhibiting ankylosis protein homolog
            expression and consequent pyrophosphate secretion.
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Xu,H.G., Zhang,X.H., Wang,H., Liu,P., Wang,L.T., Zuo,C.J.,
            Tong,W.X. and Zhang,X.L.
  TITLE     Intermittent Cyclic Mechanical Tension-Induced Calcification and
            downregulation of ankh gene expression of end plate chondrocytes
  JOURNAL   Spine (Phila Pa 1976) 37 (14), 1192-1197 (2012)
   PUBMED   22695244
  REMARK    GeneRIF: Results show that Cyclic Mechanical Tension (ICMT) induced
            the calcification and downregulation of ankh gene expression of end
            plate chondrocytes.
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Pendleton,A., Johnson,M.D., Hughes,A., Gurley,K.A., Ho,A.M.,
            Doherty,M., Dixey,J., Gillet,P., Loeuille,D., McGrath,R.,
            Reginato,A., Shiang,R., Wright,G., Netter,P., Williams,C. and
            Kingsley,D.M.
  TITLE     Mutations in ANKH cause chondrocalcinosis
  JOURNAL   Am J Hum Genet 71 (4), 933-940 (2002)
   PUBMED   12297987
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Reichenberger,E., Tiziani,V., Watanabe,S., Park,L., Ueki,Y.,
            Santanna,C., Baur,S.T., Shiang,R., Grange,D.K., Beighton,P.,
            Gardner,J., Hamersma,H., Sellars,S., Ramesar,R., Lidral,A.C.,
            Sommer,A., Raposo do Amaral,C.M., Gorlin,R.J., Mulliken,J.B. and
            Olsen,B.R.
  TITLE     Autosomal dominant craniometaphyseal dysplasia is caused by
            mutations in the transmembrane protein ANK
  JOURNAL   Am J Hum Genet 68 (6), 1321-1326 (2001)
   PUBMED   11326338
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Nurnberg,P., Thiele,H., Chandler,D., Hohne,W., Cunningham,M.L.,
            Ritter,H., Leschik,G., Uhlmann,K., Mischung,C., Harrop,K.,
            Goldblatt,J., Borochowitz,Z.U., Kotzot,D., Westermann,F.,
            Mundlos,S., Braun,H.S., Laing,N. and Tinschert,S.
  TITLE     Heterozygous mutations in ANKH, the human ortholog of the mouse
            progressive ankylosis gene, result in craniometaphyseal dysplasia
  JOURNAL   Nat Genet 28 (1), 37-41 (2001)
   PUBMED   11326272
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Ho,A.M., Johnson,M.D. and Kingsley,D.M.
  TITLE     Role of the mouse ank gene in control of tissue calcification and
            arthritis
  JOURNAL   Science 289 (5477), 265-270 (2000)
   PUBMED   10894769
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Sweet,H.O. and Green,M.C.
  TITLE     Progressive ankylosis, a new skeletal mutation in the mouse
  JOURNAL   J Hered 72 (2), 87-93 (1981)
   PUBMED   7276519
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053714.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393241.1, SRR26643298.10132.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               JAXUCZ010000002.1  79883451-79883840
            391-607             JAXUCZ010000002.1  79958800-79959016
            608-726             JAXUCZ010000002.1  79969448-79969566
            727-810             JAXUCZ010000002.1  79972845-79972928
            811-981             JAXUCZ010000002.1  79979822-79979992
            982-1116            JAXUCZ010000002.1  79982002-79982136
            1117-1209           JAXUCZ010000002.1  79984413-79984505
            1210-1305           JAXUCZ010000002.1  79987868-79987963
            1306-1435           JAXUCZ010000002.1  80006892-80007021
            1436-1559           JAXUCZ010000002.1  80007649-80007772
            1560-1659           JAXUCZ010000002.1  80008227-80008326
            1660-2446           JAXUCZ010000002.1  80009817-80010603
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q22"
     gene            1..2446
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /note="ANKH inorganic pyrophosphate transport regulator"
                     /db_xref="GeneID:114506"
                     /db_xref="RGD:619925"
     exon            1..390
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1773
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /note="progressive ankylosis protein homolog; progressive
                     ankylosis homolog; ankylosis, progressive homolog; solute
                     carrier family 61 member 1; ATP carrier protein ANKH"
                     /codon_start=1
                     /product="mineralization regulator ANKH"
                     /protein_id="NP_446166.2"
                     /db_xref="GeneID:114506"
                     /db_xref="RGD:619925"
                     /translation="MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKED
                     AVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHT
                     LIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFL
                     VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHD
                     IIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAV
                     AILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTNNTVTSAHIKKFTFVCMAL
                     SLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLM
                     TLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACY
                     VYRKQKKKMENESATEGEDSAMTDMPPAEEVTDIVEMREENE"
     exon            391..607
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..726
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..810
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..981
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1116
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1209
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1305
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1435
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1559
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1659
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2446
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgtcag cagaagcctc tgctgccgcc gccgccgcca ctgccgctgt ccctgttcct
       61 cctctctttc tccccggcag atctttgttg tgtgggaggg cagcggggat ggacttgagc
      121 tcgcggctct tctgctagag cagccgcgct tggagaggac gccgccgccg cgagcagccg
      181 ccgccccagg ccccgccagc cgcggcctcc gtccccgcgc cgcgctccgc gcgcctccca
      241 gcacagtgcc ctcgcggcgg cagatgagtg tggggtcagc ccacggcggg gactatggtg
      301 aaattcccgg cgctcacgca ctactggccc ctgatccggt tcctggtgcc ccttggcatc
      361 accaacatag ccatcgactt cggggagcag gccttgaacc ggggcattgc tgcagtcaag
      421 gaagatgcag tagagatgct ggccagctat gggctggcgt attctctgat gaagttcttc
      481 acgggaccca tgagtgactt caagaatgtg ggcctggtgt ttgtgaacag caagagagac
      541 agggccaaag ctgtcctgtg catggtggtg gccggtgcca ttgctgcagt cttccacacc
      601 ctgatagcct acagtgactt agggtactac atcatcaaca agctacatca tgtggacgag
      661 tctgtgggga gcaaaacacg aagggccttc ctgtatctcg ctgccttccc ttttatggat
      721 gccatggcgt ggactcatgc tggcattctc ttaaaacaca aatacagttt cctggtggga
      781 tgtgcctcaa tctcagatgt catagctcag gttgtgttcg tagccatttt acttcacagt
      841 cacctggaat gccgagagcc gctgctcatc cccatcctgt ctctgtacat gggtgcactt
      901 gtgcgctgta ccacgctgtg cctgggctac tacaggaaca tccacgacat catccctgac
      961 aggagcggcc cagagctggg gggcgacgca accataagaa agatgctgag cttctggtgg
     1021 cctctggctc tgattctggc cacgcagcgc atcagccggc ccattgtcaa cctctttgtg
     1081 tcccgggatc ttggtggcag ttctgctgct acagaggcag tggccattct gacagctacc
     1141 taccccgtgg gtcacatgcc atatggctgg ttgacagaaa tccgtgctgt ctaccctgct
     1201 tttgacaaga ataaccccag caataaactg gccaacacga acaacacggt cacctcggcc
     1261 cacatcaaga agttcacctt cgtctgcatg gcactgtcac tgacgctctg ttttgtaatg
     1321 ttctggaccc ccaacgtctc tgagaagatt ttgatagaca tcattggagt ggacttcgcc
     1381 tttgcagaac tctgtgtcat tcctctgcgt atcttctcct tcttcccagt gccagtgact
     1441 gtgagagctc atctcactgg atggttgatg acacttaaga aaacctttgt tctggcaccc
     1501 agctccgtgc tgcggatcat cgtcctcatc accagccttg tggttctgcc ttacctgggg
     1561 gtgcatggag ccacactagg tgtgggctcc cttctagcag ggtttgtggg agagtctacc
     1621 atggttgccc tcgcagcatg ctatgtgtat cggaagcaga aaaagaagat ggagaatgag
     1681 tcagccaccg agggggaaga ctcggccatg accgacatgc ctccagcaga ggaggtgaca
     1741 gacatcgtag agatgagaga ggaaaatgag taagcacggg ccaccagggg cactacaggg
     1801 acagtcagga caacagtcgt ctcttccctc ctcctcccac caagttgttt tctgttgttt
     1861 aatttttatt cttggttatg aaagaggcct tgatttagag gtttcgtata aattctctag
     1921 catactgggt atgctcaccg atgcagggac ctgaagaaag gtctttactg tcgctttgta
     1981 actcagaact gctgacttca tgcccctgcc tcacaaaacc caaaagatag agctgcctct
     2041 tggccgacgt ttctacccct tggacaatct ccactttgga accaaaggac ttgggctgtg
     2101 ccgctgcctc ttgggccaga ctcttttccg ttcgtgtttg tctcctaaga atcaacaggt
     2161 tgaagctcag cctctcttga cttgctcccc aataatgtgg ctctaagaca cgtgacccgg
     2221 tggccatcac accccttttc actctagagt caagaactgt ctgcagcgcc cactggtggg
     2281 ccccaggctg cagcccacag tctccctgct cccagaggaa gagctggtag ccatgttggc
     2341 caacataatg ggaaatttaa tctcctgtag aaattggatc agtcacaaac tgacttgatc
     2401 gccagcatct cattgttttc ctggtttcgc tgagttgcca cgcccc
//
