LOCUS       NP_446166                492 aa            linear   ROD 09-APR-2024
DEFINITION  mineralization regulator ANKH [Rattus norvegicus].
ACCESSION   NP_446166 XP_346619
VERSION     NP_446166.2
DBSOURCE    REFSEQ: accession NM_053714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 492)
  AUTHORS   Chen,B., Zhao,Y., Han,D., Zhao,B., Mao,Y., Cui,Z.K., Chu,Y.C.,
            Feng,L., Yin,S., Wang,C.Y., Wang,X., Xu,M.J. and Zhao,G.
  TITLE     Wnt1 inhibits vascular smooth muscle cell calcification by
            promoting ANKH expression
  JOURNAL   J Mol Cell Cardiol 135, 10-21 (2019)
   PUBMED   31356809
  REMARK    GeneRIF: This work reveals the ANKH regulation of Wnt1 in vascular
            smooth muscle cells is essential for blocking vascular
            calcification (VC). Our findings may contribute to the development
            of medications that target Wnt signaling and/or ANKH to inhibit VC.
REFERENCE   2  (residues 1 to 492)
  AUTHORS   Rosenthal,A.K., Gohr,C.M., Mitton-Fitzgerald,E., Lutz,M.K.,
            Dubyak,G.R. and Ryan,L.M.
  TITLE     The progressive ankylosis gene product ANK regulates extracellular
            ATP levels in primary articular chondrocytes
  JOURNAL   Arthritis Res Ther 15 (5), R154 (2013)
   PUBMED   24286344
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 492)
  AUTHORS   Xu,H.G., Cheng,J.F., Peng,H.X., Lv,K., Wang,H., Liu,P., Zhong,M.
            and Zhang,M.Y.
  TITLE     JNK phosphorylation promotes natural degeneration of cervical
            endplate chondrocytes by down-regulating expression of ANK
  JOURNAL   Eur Rev Med Pharmacol Sci 17 (17), 2335-2344 (2013)
   PUBMED   24065227
  REMARK    GeneRIF: Phosphorylation of JNK promotes natural degeneration of
            cervical endplate chondrocytes, likely by down-regulating ANK
            expression
REFERENCE   4  (residues 1 to 492)
  AUTHORS   Zhao,G., Xu,M.J., Zhao,M.M., Dai,X.Y., Kong,W., Wilson,G.M.,
            Guan,Y., Wang,C.Y. and Wang,X.
  TITLE     Activation of nuclear factor-kappa B accelerates vascular
            calcification by inhibiting ankylosis protein homolog expression
  JOURNAL   Kidney Int 82 (1), 34-44 (2012)
   PUBMED   22437419
  REMARK    GeneRIF: TNF-activated NF-kappaB promotes inflammation-accelerated
            vascular calcification by inhibiting ankylosis protein homolog
            expression and consequent pyrophosphate secretion.
REFERENCE   5  (residues 1 to 492)
  AUTHORS   Xu,H.G., Zhang,X.H., Wang,H., Liu,P., Wang,L.T., Zuo,C.J.,
            Tong,W.X. and Zhang,X.L.
  TITLE     Intermittent Cyclic Mechanical Tension-Induced Calcification and
            downregulation of ankh gene expression of end plate chondrocytes
  JOURNAL   Spine (Phila Pa 1976) 37 (14), 1192-1197 (2012)
   PUBMED   22695244
  REMARK    GeneRIF: Results show that Cyclic Mechanical Tension (ICMT) induced
            the calcification and downregulation of ankh gene expression of end
            plate chondrocytes.
REFERENCE   6  (residues 1 to 492)
  AUTHORS   Pendleton,A., Johnson,M.D., Hughes,A., Gurley,K.A., Ho,A.M.,
            Doherty,M., Dixey,J., Gillet,P., Loeuille,D., McGrath,R.,
            Reginato,A., Shiang,R., Wright,G., Netter,P., Williams,C. and
            Kingsley,D.M.
  TITLE     Mutations in ANKH cause chondrocalcinosis
  JOURNAL   Am J Hum Genet 71 (4), 933-940 (2002)
   PUBMED   12297987
REFERENCE   7  (residues 1 to 492)
  AUTHORS   Reichenberger,E., Tiziani,V., Watanabe,S., Park,L., Ueki,Y.,
            Santanna,C., Baur,S.T., Shiang,R., Grange,D.K., Beighton,P.,
            Gardner,J., Hamersma,H., Sellars,S., Ramesar,R., Lidral,A.C.,
            Sommer,A., Raposo do Amaral,C.M., Gorlin,R.J., Mulliken,J.B. and
            Olsen,B.R.
  TITLE     Autosomal dominant craniometaphyseal dysplasia is caused by
            mutations in the transmembrane protein ANK
  JOURNAL   Am J Hum Genet 68 (6), 1321-1326 (2001)
   PUBMED   11326338
REFERENCE   8  (residues 1 to 492)
  AUTHORS   Nurnberg,P., Thiele,H., Chandler,D., Hohne,W., Cunningham,M.L.,
            Ritter,H., Leschik,G., Uhlmann,K., Mischung,C., Harrop,K.,
            Goldblatt,J., Borochowitz,Z.U., Kotzot,D., Westermann,F.,
            Mundlos,S., Braun,H.S., Laing,N. and Tinschert,S.
  TITLE     Heterozygous mutations in ANKH, the human ortholog of the mouse
            progressive ankylosis gene, result in craniometaphyseal dysplasia
  JOURNAL   Nat Genet 28 (1), 37-41 (2001)
   PUBMED   11326272
REFERENCE   9  (residues 1 to 492)
  AUTHORS   Ho,A.M., Johnson,M.D. and Kingsley,D.M.
  TITLE     Role of the mouse ank gene in control of tissue calcification and
            arthritis
  JOURNAL   Science 289 (5477), 265-270 (2000)
   PUBMED   10894769
REFERENCE   10 (residues 1 to 492)
  AUTHORS   Sweet,H.O. and Green,M.C.
  TITLE     Progressive ankylosis, a new skeletal mutation in the mouse
  JOURNAL   J Hered 72 (2), 87-93 (1981)
   PUBMED   7276519
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NP_446166.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393241.1, SRR26643298.10132.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q22"
     Protein         1..492
                     /product="mineralization regulator ANKH"
                     /note="progressive ankylosis protein homolog; progressive
                     ankylosis homolog; ankylosis, progressive homolog; solute
                     carrier family 61 member 1; ATP carrier protein ANKH"
                     /calculated_mol_wt=54164
     Region          1..345
                     /region_name="ANKH"
                     /note="Progressive ankylosis protein (ANKH); pfam07260"
                     /db_xref="CDD:429370"
     Site            86..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            132..152
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            159..179
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            190..210
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            327..347
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            351..371
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            404..426
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Site            430..452
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     Region          458..492
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P58366.1)"
     CDS             1..492
                     /gene="Ankh"
                     /gene_synonym="Ank; SLC61A1"
                     /coded_by="NM_053714.2:295..1773"
                     /db_xref="GeneID:114506"
                     /db_xref="RGD:619925"
ORIGIN      
        1 mvkfpalthy wplirflvpl gitniaidfg eqalnrgiaa vkedavemla syglayslmk
       61 fftgpmsdfk nvglvfvnsk rdrakavlcm vvagaiaavf htliaysdlg yyiinklhhv
      121 desvgsktrr aflylaafpf mdamawthag illkhkysfl vgcasisdvi aqvvfvaill
      181 hshlecrepl lipilslymg alvrcttlcl gyyrnihdii pdrsgpelgg datirkmlsf
      241 wwplalilat qrisrpivnl fvsrdlggss aateavailt atypvghmpy gwlteiravy
      301 pafdknnpsn klantnntvt sahikkftfv cmalsltlcf vmfwtpnvse kilidiigvd
      361 fafaelcvip lrifsffpvp vtvrahltgw lmtlkktfvl apssvlriiv litslvvlpy
      421 lgvhgatlgv gsllagfvge stmvalaacy vyrkqkkkme nesategeds amtdmppaee
      481 vtdivemree ne
//
