LOCUS       NM_031805               7401 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus ankyrin 3 (Ank3), transcript variant 1, mRNA.
ACCESSION   NM_031805
VERSION     NM_031805.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7401)
  AUTHORS   Jung,G., Hernandez-Illan,E., Lozano,J.J., Sidorova,J., Munoz,J.,
            Okada,Y., Quintero,E., Hernandez,G., Jover,R., Carballal,S.,
            Cuatrecasas,M., Moreno,L., Diaz,M., Ocana,T., Sanchez,A.,
            Rivero,L., Ortiz,O., Llach,J., Castells,A., Pellise,M., Goel,A.,
            Batlle,E. and Balaguer,F.
  TITLE     Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals
            HLA-F Hypermethylation as a Biomarker Candidate for Serrated
            Polyposis Syndrome
  JOURNAL   J Mol Diagn 24 (6), 674-686 (2022)
   PUBMED   35447336
REFERENCE   2  (bases 1 to 7401)
  AUTHORS   Toma,C., Shaw,A.D., Heath,A., Pierce,K.D., Mitchell,P.B.,
            Schofield,P.R. and Fullerton,J.M.
  TITLE     A linkage and exome study of multiplex families with bipolar
            disorder implicates rare coding variants of ANK3 and additional
            rare alleles at 10q11-q21
  JOURNAL   J Psychiatry Neurosci 46 (2), E247-E257 (2021)
   PUBMED   33729739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7401)
  AUTHORS   Yang,H.Q., Perez-Hernandez,M., Sanchez-Alonso,J., Shevchuk,A.,
            Gorelik,J., Rothenberg,E., Delmar,M. and Coetzee,W.A.
  TITLE     Ankyrin-G mediates targeting of both Na+ and KATP channels to the
            rat cardiac intercalated disc
  JOURNAL   Elife 9, e52373 (2020)
   PUBMED   31934859
  REMARK    GeneRIF: Ankyrin-G mediates targeting of both Na(+) and KATP
            channels to the rat cardiac intercalated disc.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7401)
  AUTHORS   Freal,A., Rai,D., Tas,R.P., Pan,X., Katrukha,E.A., van de
            Willige,D., Stucchi,R., Aher,A., Yang,C., Altelaar,A.F.M.,
            Vocking,K., Post,J.A., Harterink,M., Kapitein,L.C., Akhmanova,A.
            and Hoogenraad,C.C.
  TITLE     Feedback-Driven Assembly of the Axon Initial Segment
  JOURNAL   Neuron 104 (2), 305-321 (2019)
   PUBMED   31474508
REFERENCE   5  (bases 1 to 7401)
  AUTHORS   Haaland,O.A., Romanowska,J., Gjerdevik,M., Lie,R.T., Gjessing,H.K.
            and Jugessur,A.
  TITLE     A genome-wide scan of cleft lip triads identifies parent-of-origin
            interaction effects between ANK3 and maternal smoking, and between
            ARHGEF10 and alcohol consumption
  JOURNAL   F1000Res 8, 960 (2019)
   PUBMED   31372216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7401)
  AUTHORS   Zhou,D., Lambert,S., Malen,P.L., Carpenter,S., Boland,L.M. and
            Bennett,V.
  TITLE     AnkyrinG is required for clustering of voltage-gated Na channels at
            axon initial segments and for normal action potential firing
  JOURNAL   J Cell Biol 143 (5), 1295-1304 (1998)
   PUBMED   9832557
REFERENCE   7  (bases 1 to 7401)
  AUTHORS   Zhang,X. and Bennett,V.
  TITLE     Restriction of 480/270-kD ankyrin G to axon proximal segments
            requires multiple ankyrin G-specific domains
  JOURNAL   J Cell Biol 142 (6), 1571-1581 (1998)
   PUBMED   9744885
REFERENCE   8  (bases 1 to 7401)
  AUTHORS   Thevananther,S., Kolli,A.H. and Devarajan,P.
  TITLE     Identification of a novel ankyrin isoform (AnkG190) in kidney and
            lung that associates with the plasma membrane and binds alpha-Na,
            K-ATPase
  JOURNAL   J Biol Chem 273 (37), 23952-23958 (1998)
   PUBMED   9727010
REFERENCE   9  (bases 1 to 7401)
  AUTHORS   Kordeli,E., Ludosky,M.A., Deprette,C., Frappier,T. and Cartaud,J.
  TITLE     AnkyrinG is associated with the postsynaptic membrane and the
            sarcoplasmic reticulum in the skeletal muscle fiber
  JOURNAL   J Cell Sci 111 (Pt 15), 2197-2207 (1998)
   PUBMED   9664041
REFERENCE   10 (bases 1 to 7401)
  AUTHORS   Peters,L.L., John,K.M., Lu,F.M., Eicher,E.M., Higgins,A.,
            Yialamas,M., Turtzo,L.C., Otsuka,A.J. and Lux,S.E.
  TITLE     Ank3 (epithelial ankyrin), a widely distributed new member of the
            ankyrin gene family and the major ankyrin in kidney, is expressed
            in alternatively spliced forms, including forms that lack the
            repeat domain
  JOURNAL   J Cell Biol 130 (2), 313-330 (1995)
   PUBMED   7615634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 10, 2021 this sequence version replaced NM_031805.1.
            
            Transcript Variant: This variant (1) has a different 5' UTR and
            multiple differences in the coding region but maintains the reading
            frame, compared to variant 2. This variant encodes isoform 1 which
            is shorter than isoform 2. Isoform 1 is also known as AnkG217.
            
            Sequence Note: This RefSeq record was created from genomic and
            transcript sequence data from multiple strains to make it
            consistent with the reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ812024.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               JAXUCZ010000020.1  19084618-19085056   c
            440-541             JAXUCZ010000020.1  18823040-18823141   c
            542-640             JAXUCZ010000020.1  18822510-18822608   c
            641-739             JAXUCZ010000020.1  18822234-18822332   c
            740-838             JAXUCZ010000020.1  18813971-18814069   c
            839-1024            JAXUCZ010000020.1  18808007-18808192   c
            1025-1123           JAXUCZ010000020.1  18805986-18806084   c
            1124-1222           JAXUCZ010000020.1  18779005-18779103   c
            1223-1321           JAXUCZ010000020.1  18762719-18762817   c
            1322-1519           JAXUCZ010000020.1  18759486-18759683   c
            1520-1618           JAXUCZ010000020.1  18755903-18756001   c
            1619-1717           JAXUCZ010000020.1  18752800-18752898   c
            1718-1816           JAXUCZ010000020.1  18750915-18751013   c
            1817-2014           JAXUCZ010000020.1  18748512-18748709   c
            2015-2113           JAXUCZ010000020.1  18746571-18746669   c
            2114-2212           JAXUCZ010000020.1  18746132-18746230   c
            2213-2410           JAXUCZ010000020.1  18737033-18737230   c
            2411-2509           JAXUCZ010000020.1  18735940-18736038   c
            2510-2608           JAXUCZ010000020.1  18732476-18732574   c
            2609-2707           JAXUCZ010000020.1  18732289-18732387   c
            2708-2803           JAXUCZ010000020.1  18731510-18731605   c
            2804-2876           JAXUCZ010000020.1  18726237-18726309   c
            2877-3000           JAXUCZ010000020.1  18702821-18702944   c
            3001-3012           JAXUCZ010000020.1  18701168-18701179   c
            3013-3100           JAXUCZ010000020.1  18698067-18698154   c
            3101-3207           JAXUCZ010000020.1  18679860-18679966   c
            3208-3432           JAXUCZ010000020.1  18674977-18675201   c
            3433-3587           JAXUCZ010000020.1  18672150-18672304   c
            3588-3799           JAXUCZ010000020.1  18659238-18659449   c
            3800-4007           JAXUCZ010000020.1  18657547-18657754   c
            4008-4104           JAXUCZ010000020.1  18656213-18656309   c
            4105-4333           JAXUCZ010000020.1  18655429-18655657   c
            4334-4459           JAXUCZ010000020.1  18654696-18654821   c
            4460-4582           JAXUCZ010000020.1  18653729-18653851   c
            4583-4628           JAXUCZ010000020.1  18652044-18652089   c
            4629-4703           JAXUCZ010000020.1  18639599-18639673   c
            4704-4835           JAXUCZ010000020.1  18636161-18636292   c
            4836-4979           JAXUCZ010000020.1  18634923-18635066   c
            4980-5658           JAXUCZ010000020.1  18631751-18632429   c
            5659-6037           JAXUCZ010000020.1  18628728-18629106   c
            6038-6124           JAXUCZ010000020.1  18618019-18618105   c
            6125-6208           JAXUCZ010000020.1  18612718-18612801   c
            6209-6265           JAXUCZ010000020.1  18612526-18612582   c
            6266-6351           JAXUCZ010000020.1  18611167-18611252   c
            6352-7401           JAXUCZ010000020.1  18601821-18602870   c
FEATURES             Location/Qualifiers
     source          1..7401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..7401
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /note="ankyrin 3"
                     /db_xref="GeneID:361833"
                     /db_xref="RGD:620157"
     exon            1..439
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..6331
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin 3 (G); ankyrin 3, epithelial; ankyrin-G; ankyrin
                     3, node of Ranvier (ankyrin G)"
                     /codon_start=1
                     /product="ankyrin-3 isoform 1"
                     /protein_id="NP_113993.1"
                     /db_xref="GeneID:361833"
                     /db_xref="RGD:620157"
                     /translation="MSEEAKEKTAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYI
                     KNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ
                     AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPL
                     AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADIESKSG
                     FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK
                     IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ
                     LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK
                     KNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE
                     TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP
                     NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASL
                     LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK
                     NQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLT
                     PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN
                     AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTL
                     KVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEGEDAITGDTDKYLGPQDLKELGD
                     DSLPAEGYVGFSLGARSASPKISSDRSYTLNRSSYARDSMMIEELLVPSKEQHLPFTR
                     EFDSDSLRHYSWAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPP
                     RKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGS
                     MRGKERELIVLRSENGETWKEHQFDSKNEDLSELLNGMDEELDSPEELGTKRICRIIT
                     KDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVP
                     EETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPSLR
                     LLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQL
                     YRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEV
                     LEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKVRDTSQEPCGRLSFLKE
                     PKTTKGLPQTAVCNLNITLPAHKKAEKADRRQSFTSLALRPQSPCERTDIRMAIVADH
                     LGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVL
                     TKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGHPSFQVELETPMGLYCT
                     PPTPFQQDDHFSDNSSIESPFRTPSRLSDGLMPSQGSIEHPAGGPPVVTAEDTSLEDS
                     KMDDSVTVTETADPLDVDESQLKDLCQSECAHCWASVPGVPSGGPQAEPLRAQTRKVG
                     VSSEQQEKGDSGPEEEMADDKVRSLFEDIQLEEVEAEEMTEDEGQAILNRVPRAELAM
                     SSLAGWQNETPSGSLESPAQARRITGGLLDRLDDSSDQVRDPITSYLTGEAGKFEANG
                     NHAEVIPEAKAKAYFPESQNDIGKQSIKENLKPKTHGCGRAEEPVSPLTAYQKSLEET
                     SKLVIEDAPKPCVPVGMKKMTRTPADGKARLNLQEEEGSARSEPKDLRHSESDSSSEE
                     ERRVTTRVIRRRVIIKGEEAKTIPGESVTEEQFTDEEGNLITRKITRKVIRRIGPQER
                     KQDDVQGEGYKVKTKKEIRNVEKKAH"
     exon            440..541
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            542..640
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..739
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..838
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1024
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1123
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1222
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1321
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1519
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1618
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1717
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1816
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2014
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2113
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2212
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2410
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2509
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2608
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2707
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2803
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2876
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3000
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3012
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3100
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3207
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3432
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3587
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3799
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..4007
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4104
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4333
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4459
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4582
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4583..4628
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4703
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4835
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..4979
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5658
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5659..6037
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6038..6124
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6125..6208
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6209..6265
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6266..6351
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6352..7401
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggagaag caagccctga aatcttgtca agatcttatc ttggggtaat gacttgctga
       61 caaaaaaaaa aaaaaaaaaa aaaagaagaa gaagaaaaag aaagcaagga aggaagaaaa
      121 caaagggttg aaatattgat ttttctttgg aggaataacc agggctttgc tggagagaac
      181 acccagtttc tccccgaggc aagctgagtt gtccgtgaca gcagccaggg ctggcttgaa
      241 gcagccgctc tgcctgggga gctccctaaa tggactttgg tctcaatgct gtgactcttt
      301 gtcgggggtt tggatgtggg aacaccacgg aaggtgatct cctgtctcgt ctcaactccc
      361 ctgatctcaa ggaaagatga gcgaagaggc aaaggagaaa accgccaagc ctgctcatag
      421 gaagaggaaa gggaaaaagt cggatgccaa tgcaagttac ttgagagcag ctcgggcggg
      481 gcacctggaa aaggcccttg actacatcaa aaatggagtg gacgtcaaca tctgtaacca
      541 gaatgggttg aatgcgctcc atcttgcttc caaagaaggc catgtggaag tggtctccga
      601 gctgctgcag agagaagcca acgtcgatgc agccacaaag aaaggaaaca cagccttaca
      661 catcgcatcc ttggctggac aagcggaagt ggtcaaggtc ttggttacga acggagcgaa
      721 cgtcaacgca cagtctcaga atggcttcac gccgctgtat atggcggccc aggagaacca
      781 cctggaagtc gtcaggtttc ttctggacaa tggtgccagc caaagcctgg ctacagagga
      841 tggcttcacg ccattggccg tggctcttca acaaggtcac gaccaagtcg tatccctcct
      901 gctcgagaac gacacgaagg gaaaagtgcg cctcccagcc ctccacatcg cggcccggaa
      961 agatgacacc aaagcggcag ctctgctcct acagaacgac accaatgcag acatagagtc
     1021 aaagagtggc ttcaccccac tccacatagc tgcccactac gggaatatca atgtggccac
     1081 gttgctgtta aaccgagcgg ctgccgtgga cttcaccgca cggaatgaca tcactccttt
     1141 gcatgttgcc tcgaaacggg gaaacgcaaa tatggtaaag ctgttgctcg accggggtgc
     1201 gaagatcgac gccaagacca gggacggtct gaccccgctg cactgcgggg cgagaagtgg
     1261 ccacgagcag gtggtagaga tgttgctgga cagagccgcc cccatccttt cgaaaaccaa
     1321 gaatggactg tccccactgc acatggccac acaaggagac catttaaact gcgtccaact
     1381 cctcctccag cacaacgtgc ccgtggatga cgtcaccaac gactacctga ccgccctcca
     1441 cgtggcggcc cactgcggcc attacaaagt tgccaaggtt cttttggata agaaagctaa
     1501 ccccaatgcc aaagctctga atggcttcac ccctctccat atcgcctgca aaaagaaccg
     1561 aatccgagta atggaactcc ttttgaagca cggtgcatct attcaagccg taaccgagtc
     1621 gggccttacc ccaatccatg tcgctgcctt catgggacat gtaaatatcg tgtcacagct
     1681 aatgcatcat ggagcctccc caaacaccac caacgtgaga ggagaaacag cattgcatat
     1741 ggcggctcgg tcggggcaag cagaagtggt gcggtatttg gtacaagatg gagctcaggt
     1801 agaagcaaaa gctaaggatg accagacccc actccacatt tcagcccgac tcgggaaggc
     1861 tgacatagtg caacaactgt tacagcaagg agcgtccccg aatgcagcaa caacttccgg
     1921 gtacaccccc cttcaccttt cggccagaga ggggcatgag gatgtagctg ccttccttct
     1981 ggaccatgga gcatctttat ccataacaac aaagaaggga ttcacgcctc tgcacgtggc
     2041 tgcaaaatat gggaagcttg aagtggcaag tctcctgctg cagaagagtg cgtctcctga
     2101 tgccgctggg aagagcgggc taactccact gcatgtagca gcacattacg ataatcagaa
     2161 agtggccctt ctgcttttgg accagggagc ctcaccccac gcagctgcaa agaacggtta
     2221 tacgccactg cacatcgccg ccaagaagaa ccagatggac atagccacgt ccctgctgga
     2281 gtacggagct gatgcaaacg ccgttacccg gcaagggatt gcgtccgtcc accttgcagc
     2341 gcaggaaggg cacgtggaca tggtgtcgct gctcctcagt agaaatgcga acgtcaactt
     2401 gagcaataag agcggcctca ccccactcca cctggcggct caagaagacc gagtgaacgt
     2461 ggctgaggtc cttgtcaacc aaggggccca cgtggatgca cagacaaaga tgggctacac
     2521 gccgctccat gtgggctgtc actatggaaa catcaaaata gtcaattttc tgctgcagca
     2581 ttctgcgaaa gttaatgcca agacaaagaa tggatacacg ccactgcacc aggcagccca
     2641 gcagggccac acacacatca tcaacgtcct gctccagaac aacgcttccc ccaatgaact
     2701 cactgtgaat gggaacacag ccctggccat cgcccgacgc cttggctaca tctcggtggt
     2761 tgacacccta aaggtcgtga cagaggaaat tatgaccacc actaccatca cggagaagca
     2821 caaaatgaat gtcccagaaa cgatgaatga agtcctcgac atgtcagacg atgaaggtga
     2881 agatgccatc acaggggaca ctgacaagta tctcgggcca caggacctca aggagctggg
     2941 cgatgactcc ctgcctgccg agggctatgt gggcttcagt ctcggagccc gttctgccag
     3001 tcccaagata agttcggata ggtcctacac cctgaacaga agctcctatg cgcgggacag
     3061 catgatgatc gaggagcttc tggtgccatc caaagagcag caccttccat tcacgaggga
     3121 gtttgactcc gactccctca gacactacag ttgggcagca gacacactgg acaatgtgaa
     3181 cctggtctcc agccctgtgc attctgggtt tctggttagc tttatggtgg acgcgagagg
     3241 gggctccatg cgaggaagcc gccaccacgg gatgcggatc atcatccctc cgcgcaagtg
     3301 tacggccccc acccgcatca cttgccgcct ggtaaagaga cataaactgg ccaacccacc
     3361 ccccatggtg gaaggagagg gattagccag taggctggta gaaatgggtc ctgcgggggc
     3421 acaattttta ggcccggtca tagtggaaat ccctcatttt gggtccatga gaggaaagga
     3481 gagggaactc attgtcctcc ggagcgagaa cggagagacc tggaaggaac accagtttga
     3541 cagcaaaaac gaagacctct cggagctcct caatggcatg gacgaagaac ttgacagccc
     3601 agaagagttg ggcacaaagc gcatctgcag aatcatcacg aaggatttcc cccagtattt
     3661 cgctgtggtt tcccggatta agcaggaaag caaccagatt ggtcccgaag gtgggattct
     3721 gagcagcacc acggtccccc tcgtccaggc gtctttccca gagggtgcct taaccaaaag
     3781 gatccgtgtg ggtctgcagg ctcagcccgt accagaggag actgtgaaaa agatccttgg
     3841 aaacaaagca acgtttagcc caattgtcac ggtggagccg aggaggagga aattccataa
     3901 gccgatcacc atgaccatcc cggtgccccc accctcggga gaaggcgtgt ccaatgggta
     3961 caagggggac accacgccca gcctgcgact cctctgcagc attacaggag ggacctcgcc
     4021 ggctcagtgg gaagacatca caggcacaac cccgctgacc ttcataaagg actgtgtgtc
     4081 tttcacaacc aatgtttcag ccaggttctg gctggcggac tgccatcagg tgttagaaac
     4141 cgtagggcta gcctcgcagc tgtacagaga gttgatatgt gtcccctaca tggccaagtt
     4201 tgttgttttt gccaaaacaa acgacccagt ggaatcctcc ctaaggtgct tctgtatgac
     4261 agacgacaga gtggacaaaa ccctggagca gcaggagaat ttcgaggagg ttgccagaag
     4321 caaagacatc gaggttctgg aaggaaagcc catctatgtt gattgctatg gaaacctggc
     4381 tcctctgacc aaaggagggc agcagcttgt ttttaacttc tattctttca aagaaaacag
     4441 actgccattt tccatcaagg ttagagacac cagccaagag ccctgcggcc gtctgtcttt
     4501 cctgaaggag ccgaaaacaa caaaaggatt accccaaacg gctgtttgca acttaaatat
     4561 tactctaccg gcgcataaaa aggctgagaa ggcagacaga cgccagagct tcacatccct
     4621 agccttacgt ccacagagtc cttgtgagcg gacggatatc aggatggcaa tagtagccga
     4681 tcacctggga cttagttgga cagagctggc aagggaactg aatttttcag tggatgaaat
     4741 caaccaaata cgagtggaaa atcccaattc tttaatttct cagagcttca tgttattaaa
     4801 aaagtgggtg acgagagacg ggaagaatgc cacaactgat gccttaactt cggtcttaac
     4861 aaaaattaac cgaatagaca tagtaactct gctggaagga ccaatatttg attatgggaa
     4921 tatttcaggc accagaagct ttgcagatga aaacaatgtt ttccatgacc cagttgatgg
     4981 tcacccttcc tttcaagtgg agctggagac cccaatgggg ttgtactgca caccacccac
     5041 ccctttccag caagatgacc attttagtga taactctagc atagagtctc cctttaggac
     5101 ccccagtaga ctgagtgacg ggctgatgcc ttcccaggga agcatagagc atccagcagg
     5161 tggacctcca gtggtaactg cagaagacac ttctttagaa gacagcaaaa tggacgattc
     5221 agtaacggta acagaaacgg ctgacccact ggacgtagat gagagccagt tgaaggacct
     5281 gtgtcagagc gagtgtgctc actgctgggc gagtgtgccc ggggtcccaa gcggcggtcc
     5341 gcaggcagag ccactgagag cgcagactag aaaagtaggc gtgagctctg aacagcagga
     5401 gaaaggagac tctggtcctg aggaggagat ggcggacgac aaggtcagat ctctgtttga
     5461 ggacattcaa cttgaagaag tagaggctga ggagatgaca gaagacgagg ggcaggctat
     5521 acttaaccgt gttccgcgag cagaactggc aatgtcttca cttgcaggtt ggcagaacga
     5581 gacgccaagt ggaagcctag agtccccggc gcaagcgcga agaataaccg gtgggttact
     5641 ggaccgtctg gacgacagct ctgaccaggt tcgggatccc attacctcat acctcacagg
     5701 agaagctggg aagttcgaag caaacggaaa ccacgcagaa gtcattccag aagcaaaggc
     5761 caaggcctac tttcctgaat cccaaaacga tatagggaaa cagagcatca aggagaactt
     5821 gaaaccaaaa acacacggat gtggtcgcgc tgaggaacca gtgtcgcccc tcacagccta
     5881 ccagaaatct ctagaagaaa ccagcaagct tgtcatagaa gacgcaccta aaccctgtgt
     5941 gcctgtcggc atgaaaaaga tgaccaggac tccggctgac ggcaaagcca ggctcaacct
     6001 ccaggaagag gaggggtccg ccaggtcaga gcctaaggac ttgagacaca gtgagagtga
     6061 ttcaagctca gaggaggagc ggagggtcac tacccgggtc atacgacggc gtgtgattat
     6121 aaagggagag gaagccaaaa ccatccctgg tgaatctgtc acagaagagc aatttaccga
     6181 tgaagaaggc aacctcatca ctagaaaaat cactcggaag gtaataagac ggattggtcc
     6241 acaagagagg aagcaggatg atgtgcaggg agaaggctat aaggtgaaaa caaagaagga
     6301 aatccggaat gtggagaaga aagcccacta gtgacggtga cgtcagtcca ggaccacgcg
     6361 ttcgtactgc cagtattgag aaactcacca gagatcagca gggaggagaa tctctagcaa
     6421 gagcggagtg tggatctgcc accccacaca tcagtgacat gtttggggtt ttgggttttt
     6481 ttggtttttt tttttaatgc agaaggataa agaaaatcac cttttttttt atttagcatg
     6541 agccaattta cagagcatgg agactcactt tcattcccgg cgctgacacg cgtgcactaa
     6601 gcaagtgcaa tgtaagatac aagaagccat gttgttcaga ctcagcctca agtaatttgg
     6661 tgtcactttc ggagaagaca gacaaacaac gacacctgtg ccaccggaag gagggacagc
     6721 acaagatgga gcgatcaaat ccagaagaca cactgaaatt actaaatcca caacagctcg
     6781 ccttattttt cttggaccca aactaactgt cagggtataa acactgtttg tttctttttt
     6841 ttttttttaa agaaaaaata ataataaaaa aaatcaatag ttttgctgta aataataaca
     6901 ctgtaaattc taacagaaga aactacaata aagaattata aggcacctgc ctcacggaac
     6961 acaaagatac cacaaacgcg tccaatgaca ggcgtaccaa gtggcctcac cctggacaag
     7021 gacgggaatc tggcgcgtgc gggacgctct ctcactgact cctgtatatt agcaattatg
     7081 atgtttgtac acgcaaaact gctcgcttgg ttttaaaaag aaaatgcaaa tctttaaaaa
     7141 aaaaaaaaaa gaaatctgct gcaaaattta aataattccc ccagcgagga ggaattctgt
     7201 agttctgtga agagaagaat ttttttcctt cagaatatac taatattttg atgcatgcat
     7261 atctccttat tttgattaaa ccttttccaa ttttgcaaac actacagtct cctgcaacac
     7321 gggagatttt acctgtaaac acaaagccct tcatgtaata tttattgcta ttgccaattt
     7381 tttcaatgaa atgaccaaaa a
//
