LOCUS       NM_001033984            7889 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus ankyrin 3 (Ank3), transcript variant 2, mRNA.
ACCESSION   NM_001033984
VERSION     NM_001033984.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7889)
  AUTHORS   Jung,G., Hernandez-Illan,E., Lozano,J.J., Sidorova,J., Munoz,J.,
            Okada,Y., Quintero,E., Hernandez,G., Jover,R., Carballal,S.,
            Cuatrecasas,M., Moreno,L., Diaz,M., Ocana,T., Sanchez,A.,
            Rivero,L., Ortiz,O., Llach,J., Castells,A., Pellise,M., Goel,A.,
            Batlle,E. and Balaguer,F.
  TITLE     Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals
            HLA-F Hypermethylation as a Biomarker Candidate for Serrated
            Polyposis Syndrome
  JOURNAL   J Mol Diagn 24 (6), 674-686 (2022)
   PUBMED   35447336
REFERENCE   2  (bases 1 to 7889)
  AUTHORS   Toma,C., Shaw,A.D., Heath,A., Pierce,K.D., Mitchell,P.B.,
            Schofield,P.R. and Fullerton,J.M.
  TITLE     A linkage and exome study of multiplex families with bipolar
            disorder implicates rare coding variants of ANK3 and additional
            rare alleles at 10q11-q21
  JOURNAL   J Psychiatry Neurosci 46 (2), E247-E257 (2021)
   PUBMED   33729739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7889)
  AUTHORS   Yang,H.Q., Perez-Hernandez,M., Sanchez-Alonso,J., Shevchuk,A.,
            Gorelik,J., Rothenberg,E., Delmar,M. and Coetzee,W.A.
  TITLE     Ankyrin-G mediates targeting of both Na+ and KATP channels to the
            rat cardiac intercalated disc
  JOURNAL   Elife 9, e52373 (2020)
   PUBMED   31934859
  REMARK    GeneRIF: Ankyrin-G mediates targeting of both Na(+) and KATP
            channels to the rat cardiac intercalated disc.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7889)
  AUTHORS   Freal,A., Rai,D., Tas,R.P., Pan,X., Katrukha,E.A., van de
            Willige,D., Stucchi,R., Aher,A., Yang,C., Altelaar,A.F.M.,
            Vocking,K., Post,J.A., Harterink,M., Kapitein,L.C., Akhmanova,A.
            and Hoogenraad,C.C.
  TITLE     Feedback-Driven Assembly of the Axon Initial Segment
  JOURNAL   Neuron 104 (2), 305-321 (2019)
   PUBMED   31474508
REFERENCE   5  (bases 1 to 7889)
  AUTHORS   Haaland,O.A., Romanowska,J., Gjerdevik,M., Lie,R.T., Gjessing,H.K.
            and Jugessur,A.
  TITLE     A genome-wide scan of cleft lip triads identifies parent-of-origin
            interaction effects between ANK3 and maternal smoking, and between
            ARHGEF10 and alcohol consumption
  JOURNAL   F1000Res 8, 960 (2019)
   PUBMED   31372216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7889)
  AUTHORS   Zhou,D., Lambert,S., Malen,P.L., Carpenter,S., Boland,L.M. and
            Bennett,V.
  TITLE     AnkyrinG is required for clustering of voltage-gated Na channels at
            axon initial segments and for normal action potential firing
  JOURNAL   J Cell Biol 143 (5), 1295-1304 (1998)
   PUBMED   9832557
REFERENCE   7  (bases 1 to 7889)
  AUTHORS   Zhang,X. and Bennett,V.
  TITLE     Restriction of 480/270-kD ankyrin G to axon proximal segments
            requires multiple ankyrin G-specific domains
  JOURNAL   J Cell Biol 142 (6), 1571-1581 (1998)
   PUBMED   9744885
REFERENCE   8  (bases 1 to 7889)
  AUTHORS   Thevananther,S., Kolli,A.H. and Devarajan,P.
  TITLE     Identification of a novel ankyrin isoform (AnkG190) in kidney and
            lung that associates with the plasma membrane and binds alpha-Na,
            K-ATPase
  JOURNAL   J Biol Chem 273 (37), 23952-23958 (1998)
   PUBMED   9727010
REFERENCE   9  (bases 1 to 7889)
  AUTHORS   Kordeli,E., Ludosky,M.A., Deprette,C., Frappier,T. and Cartaud,J.
  TITLE     AnkyrinG is associated with the postsynaptic membrane and the
            sarcoplasmic reticulum in the skeletal muscle fiber
  JOURNAL   J Cell Sci 111 (Pt 15), 2197-2207 (1998)
   PUBMED   9664041
REFERENCE   10 (bases 1 to 7889)
  AUTHORS   Peters,L.L., John,K.M., Lu,F.M., Eicher,E.M., Higgins,A.,
            Yialamas,M., Turtzo,L.C., Otsuka,A.J. and Lux,S.E.
  TITLE     Ank3 (epithelial ankyrin), a widely distributed new member of the
            ankyrin gene family and the major ankyrin in kidney, is expressed
            in alternatively spliced forms, including forms that lack the
            repeat domain
  JOURNAL   J Cell Biol 130 (2), 313-330 (1995)
   PUBMED   7615634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF102552.1 and AJ812023.1.
            
            Transcript Variant: This variant (2) represents the longest variant
            and it encodes the longest protein (isoform 2). Isoform 2 is also
            known as '270 kDa ankyrin-G'.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               AF102552.1         1-723
            724-822             AJ812023.1         1017-1115
            823-1214            AF102552.1         823-1214
            1215-1317           AJ812023.1         1508-1610
            1318-1713           AF102552.1         1318-1713
            1714-1812           AJ812023.1         2007-2105
            1813-1911           AF102552.1         1813-1911
            1912-2575           AJ812023.1         2205-2868
            2576-7867           AF102552.1         2576-7867
            7868-7889           AJ812023.1         5788-5809
FEATURES             Location/Qualifiers
     source          1..7889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..7889
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /note="ankyrin 3"
                     /db_xref="GeneID:361833"
                     /db_xref="RGD:620157"
     CDS             1..7869
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin 3 (G); ankyrin 3, epithelial; ankyrin-G; ankyrin
                     3, node of Ranvier (ankyrin G)"
                     /codon_start=1
                     /product="ankyrin-3 isoform 2"
                     /protein_id="NP_001029156.1"
                     /db_xref="GeneID:361833"
                     /db_xref="RGD:620157"
                     /translation="MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRKKKSDANAS
                     YLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDA
                     ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLL
                     DNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAA
                     ALLLQNDTNADIESKMVVNRATESGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND
                     ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP
                     ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK
                     VLLDKKANPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAF
                     MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ
                     TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL
                     SITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL
                     LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQE
                     GHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT
                     PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN
                     ELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNEVLDMSD
                     DEVGKASAPEKLSDGEYISDGEEGEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFS
                     LGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLPFTREFDSDSLRHYS
                     WAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITC
                     RLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL
                     RSENGETWKEHQFDSKNEDLSELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVS
                     RIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNK
                     ATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPSLRLLCSITGGTSP
                     AQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMA
                     KFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCY
                     GNLAPLTKGGQQLVFNFYSFKENRLPFSIKVRDTSQEPCGRLSFLKEPKTTKGLPQTA
                     VCNLNITLPAHKKAEKADRRQSFTSLALRKRYSYLTEPSMKTVERSSGTARSLPTTYS
                     HKPFFSTRPYQSWTTTPITVPGPAKSGSLSSSPSNTPSASPLKSIWSVSTPSPIKSTL
                     GASTTSSVKSISDVASPIRSFRTISSPIRTVASPSPYNTQVASGTLGRVPTITEATPI
                     KGVAPNSTLSSRTSPVTTAGSLLEKSSITMTPPASPKANITMYSSSLPFKSIITSAAP
                     LISSPLKSVVSPTKSAADVISTAKAAMASTLSSPLKQMSGHAEVALVNGSVSPLKYPS
                     SSALINGCKATATLQDKISTATNAVSSVVSAAPDTVEKALSTTTAMPFSPLRSYVSAA
                     APSAFQSLRAPSASALYNSLGPSVGVTTSSVTSSIITVPVYSVGNVLAEPALKKLPDS
                     NSLTKSAAALLSPIKTLTTETRPQPHFNRTSSPVKSSLFLASSALKPSVPSSLSSSQE
                     ILKDVAEMKEDLMRMTAILQTDVPEEKPFQTDLPREGRIDDEEPFKIVEKVKEDLVKV
                     SEILKKDVCVESKGPPKSPKSDKGHSPEDDWTEFSSEEIREARQAAASHAPSLPERVH
                     GKANLTRVIDYLTNDIGSSSLTNLKYKFEEAKKEGEERQKRILKPAMALQEHKLKMPP
                     ASMRPSTSEKELCKMADSFFGTDAILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAP
                     QSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYEPSTGEIPQSQPEDPVSPKPPPT
                     FMELEPKPTALSIKEKVKAFQMKASSEEEDHSRVLSKGMRVKEETHITTTTRMVYHSP
                     PGSECASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAMSPDVAKSAAETSAQH
                     AEKDNQMKPKLERIIEVHIEKGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDE
                     INQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFD
                     YGNISGTRSFADENNVFHDPVDGWQNETPSGSLESPAQARRITGGLLDRLDDSSDQVR
                     DPITSYLTGEAGKFEANGNHAEVIPEAKAKAYFPESQNDIGKQSIKENLKPKTHGCGR
                     AEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTPADGKARLNLQEEEGSA
                     RSEPKQGEGYKVKTKKEIRNVEKKAH"
     exon            1..114
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            115..216
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..315
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..414
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..513
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..699
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            700..723
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..822
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..921
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1020
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1218
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1317
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1416
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1515
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1713
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1812
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1911
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2109
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2208
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2307
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2406
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2502
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2575
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2638
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2762
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2865
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2972
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3197
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3352
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3564
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3772
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3869
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4098
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4224
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4347
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4429
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..6982
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6983..7057
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7058..7189
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7190..7333
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7334..7424
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7425..7803
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7804..7889
                     /gene="Ank3"
                     /gene_synonym="ANK-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctcatg ccgcttccca gttaaagaaa aacagggatt tagaaatcaa tgcggaagaa
       61 gagaccgaga aaaaaaagaa gcaccgtaaa cggtcccggg atcgcaagaa aaagtcggat
      121 gccaatgcaa gttacttgag agcagctcgg gcggggcacc tggaaaaggc ccttgactac
      181 atcaaaaatg gagtggacgt caacatctgt aaccagaatg ggttgaatgc gctccatctt
      241 gcttccaaag aaggccatgt ggaagtggtc tccgagctgc tgcagagaga agccaacgtc
      301 gatgcagcca caaagaaagg aaacacagcc ttacacatcg catccttggc tggacaagcg
      361 gaagtggtca aggtcttggt tacgaacgga gcgaacgtca acgcacagtc tcagaatggc
      421 ttcacgccgc tgtatatggc ggcccaggag aaccacctgg aagtcgtcag gtttcttctg
      481 gacaatggtg ccagccaaag cctggctaca gaggatggct tcacgccatt ggccgtggct
      541 cttcaacaag gtcacgacca agtcgtatcc ctcctgctcg agaacgacac gaagggaaaa
      601 gtgcgcctcc cagccctcca catcgcggcc cggaaagatg acaccaaagc ggcagctctg
      661 ctcctacaga acgacaccaa tgcagacata gagtcaaaga tggtggtgaa tagagcaact
      721 gagagtggct tcaccccact ccacatagct gcccactacg ggaatatcaa tgtggccacg
      781 ttgctgttaa accgagcggc tgccgtggac ttcaccgcac ggaatgacat cactcctttg
      841 catgttgcct cgaaacgggg aaacgcaaat atggtaaagc tgttgctcga ccggggtgcg
      901 aagatcgacg ccaagaccag ggacggtctg accccgctgc actgcggggc gagaagtggc
      961 cacgagcagg tggtagagat gttgctggac agagccgccc ccatcctttc gaaaaccaag
     1021 aatggactgt ccccactgca catggccaca caaggagacc atttaaactg cgtccaactc
     1081 ctcctccagc acaacgtgcc cgtggatgac gtcaccaacg actacctgac cgccctccac
     1141 gtggcggccc actgcggcca ttacaaagtt gccaaggttc ttttggataa gaaagctaac
     1201 cccaatgcca aagctctgaa tggcttcacc cctctccata tcgcctgcaa aaagaaccga
     1261 atccgagtaa tggaactcct tttgaagcac ggtgcatcta ttcaagccgt aaccgagtcg
     1321 ggccttaccc caatccatgt cgctgccttc atgggacatg taaatatcgt gtcacagcta
     1381 atgcatcatg gagcctcccc aaacaccacc aacgtgagag gagaaacagc attgcatatg
     1441 gcggctcggt cggggcaagc agaagtggtg cggtatttgg tacaagatgg agctcaggta
     1501 gaagcaaaag ctaaggatga ccagacccca ctccacattt cagcccgact cgggaaggct
     1561 gacatagtgc aacaactgtt acagcaagga gcgtccccga atgcagcaac aacttccggg
     1621 tacacccccc ttcacctttc ggccagagag gggcatgagg atgtagctgc cttccttctg
     1681 gaccatggag catctttatc cataacaaca aagaagggat tcacgcctct gcacgtggct
     1741 gcaaaatatg ggaagcttga agtggcaagt ctcctgctgc agaagagtgc gtctcctgat
     1801 gccgctggga agagcgggct aactccactg catgtagcag cacattacga taatcagaaa
     1861 gtggcccttc tgcttttgga ccagggagcc tcaccccacg cagctgcaaa gaacggttat
     1921 acgccactgc acatcgccgc caagaagaac cagatggaca tagccacgtc cctgctggag
     1981 tacggagctg atgcaaacgc cgttacccgg caagggattg cgtccgtcca ccttgcagcg
     2041 caggaagggc acgtggacat ggtgtcgctg ctcctcagta gaaatgcgaa cgtcaacttg
     2101 agcaataaga gcggcctcac cccactccac ctggcggctc aagaagaccg agtgaacgtg
     2161 gctgaggtcc ttgtcaacca aggggcccac gtggatgcac agacaaagat gggctacacg
     2221 ccgctccatg tgggctgtca ctatggaaac atcaaaatag tcaattttct gctgcagcat
     2281 tctgcgaaag ttaatgccaa gacaaagaat ggatacacgc cactgcacca ggcagcccag
     2341 cagggccaca cacacatcat caacgtcctg ctccagaaca acgcttcccc caatgaactc
     2401 actgtgaatg ggaacacagc cctggccatc gcccgacgcc ttggctacat ctcggtggtt
     2461 gacaccctaa aggtcgtgac agaggaaatt atgaccacca ctaccatcac ggagaagcac
     2521 aaaatgaatg tcccagaaac gatgaatgaa gtcctcgaca tgtcagacga tgaagttggt
     2581 aaagccagcg cccccgaaaa gctcagtgat ggggaatata tctcagatgg tgaagaaggt
     2641 gaagatgcca tcacagggga cactgacaag tatctcgggc cacaggacct caaggagctg
     2701 ggcgatgact ccctgcctgc cgagggctat gtgggcttca gtctcggagc ccgttctgcc
     2761 agccttcgct ccttcagttc ggataggtcc tacaccctga acagaagctc ctatgcgcgg
     2821 gacagcatga tgatcgagga gcttctggtg ccatccaaag agcagcacct tccattcacg
     2881 agggagtttg actccgactc cctcagacac tacagttggg cagcagacac actggacaat
     2941 gtgaacctgg tctccagccc tgtgcattct gggtttctgg ttagctttat ggtggacgcg
     3001 agagggggct ccatgcgagg aagccgccac cacgggatgc ggatcatcat ccctccgcgc
     3061 aagtgtacgg cccccacccg catcacttgc cgcctggtaa agagacataa actggccaac
     3121 ccacccccca tggtggaagg agagggatta gccagtaggc tggtagaaat gggtcctgcg
     3181 ggggcacaat ttttaggccc ggtcatagtg gaaatccctc attttgggtc catgagagga
     3241 aaggagaggg aactcattgt cctccggagc gagaacggag agacctggaa ggaacaccag
     3301 tttgacagca aaaacgaaga cctctcggag ctcctcaatg gcatggacga agaacttgac
     3361 agcccagaag agttgggcac aaagcgcatc tgcagaatca tcacgaagga tttcccccag
     3421 tatttcgctg tggtttcccg gattaagcag gaaagcaacc agattggtcc cgaaggtggg
     3481 attctgagca gcaccacggt ccccctcgtc caggcgtctt tcccagaggg tgccttaacc
     3541 aaaaggatcc gtgtgggtct gcaggctcag cccgtaccag aggagactgt gaaaaagatc
     3601 cttggaaaca aagcaacgtt tagcccaatt gtcacggtgg agccgaggag gaggaaattc
     3661 cataagccga tcaccatgac catcccggtg cccccaccct cgggagaagg cgtgtccaat
     3721 gggtacaagg gggacaccac gcccagcctg cgactcctct gcagcattac aggagggacc
     3781 tcgccggctc agtgggaaga catcacaggc acaaccccgc tgaccttcat aaaggactgt
     3841 gtgtctttca caaccaatgt ttcagccagg ttctggctgg cggactgcca tcaggtgtta
     3901 gaaaccgtag ggctagcctc gcagctgtac agagagttga tatgtgtccc ctacatggcc
     3961 aagtttgttg tttttgccaa aacaaacgac ccagtggaat cctccctaag gtgcttctgt
     4021 atgacagacg acagagtgga caaaaccctg gagcagcagg agaatttcga ggaggttgcc
     4081 agaagcaaag acatcgaggt tctggaagga aagcccatct atgttgattg ctatggaaac
     4141 ctggctcctc tgaccaaagg agggcagcag cttgttttta acttctattc tttcaaagaa
     4201 aacagactgc cattttccat caaggttaga gacaccagcc aagagccctg cggccgtctg
     4261 tctttcctga aggagccgaa aacaacaaaa ggattacccc aaacggctgt ttgcaactta
     4321 aatattactc taccggcgca taaaaaggct gagaaggcag acagacgcca gagcttcaca
     4381 tccctagcct tacgtaagcg ctacagctac ttgactgagc ccagcatgaa aacagttgaa
     4441 cggagttcag gaacagcaag atcccttccc actacttatt cacacaagcc attcttttct
     4501 acaagaccat accagtcctg gactacgact cccataacag tgcccgggcc ggccaaatca
     4561 ggctccttat ccagctcccc ctctaacacg ccgtcagcgt ctccgttaaa atccatatgg
     4621 tctgtttcaa cgccttctcc gatcaaatcc acgctaggcg cctcaactac gtcatcagtc
     4681 aaatccatta gtgatgtggc gtctcctatt agatctttcc ggacaatttc ttcgccaata
     4741 agaacggtgg catcgccgtc tccatacaat acccaagtag cctctggtac ccttgggagg
     4801 gtacccacca tcacagaggc cacacctata aagggggtgg ctcccaactc aactttgtcc
     4861 tctcgaactt ctcctgtgac gaccgcaggg tctctgttgg agaagtcgtc catcaccatg
     4921 acaccccctg cctcccccaa agccaacatc accatgtatt cctccagctt gccatttaag
     4981 tccattatca cgtcagcggc accgctgatc tcctcccctt taaagtcagt ggtgtctccg
     5041 accaagtctg cagctgatgt catctcaaca gctaaagctg cgatggcatc gactctctcc
     5101 tcccccttaa agcagatgtc tggacatgca gaagtagcgc tagtcaatgg gtctgtttct
     5161 cctctgaagt atccttcctc ttccgcttta attaacggat gcaaagccac tgccacatta
     5221 caggacaaaa tttctacagc cacaaatgct gtgagctcgg tggtgagcgc ggcccctgac
     5281 acggtggaga aagcgctctc caccacaaca gccatgccct tttccccact caggtcttac
     5341 gtttccgctg cagcgccctc tgcttttcag tcccttagag ctccctctgc cagtgcactc
     5401 tacaactccc tcgggccttc agtaggtgtt actacctcat ccgtaacttc atcgataatc
     5461 acagtgccag tatactcggt aggcaatgtt ttggcagaac cagcattgaa gaaacttcca
     5521 gactctaact cgctcacaaa atcggcagcg gctttgctgt cgcccattaa aacattgact
     5581 acggagacac gtcctcagcc ccatttcaat cgaacgtcat ctcccgtcaa gtcctctctg
     5641 ttcctggcat cctcggccct taagccgtca gtaccatctt ctttatcttc cagtcaggag
     5701 atcttaaaag atgtggccga gatgaaggag gacctcatga gaatgaccgc catactgcag
     5761 acggatgtgc ctgaggagaa gccattccag accgacctcc cccgagaagg gaggatagac
     5821 gacgaagagc ctttcaaaat cgttgagaaa gtgaaggaag acttagtcaa agtcagtgag
     5881 atactcaaaa aggacgtgtg tgtcgagagc aaagggccac ccaagtcccc aaagagtgac
     5941 aaaggacact ctccagaaga tgactggacg gaatttagtt ctgaggaaat acgagaagcc
     6001 aggcaggctg ctgccagtca cgccccatcc ctgcccgaga gagtacatgg aaaggccaac
     6061 ctcaccagag tcatagacta cctgaccaat gacatcggga gcagttcact gaccaactta
     6121 aagtacaagt ttgaagaggc taagaaggaa ggagaggaga gacagaagag aattttaaag
     6181 ccagccatgg ccttgcagga gcataaactc aaaatgccgc cagcctccat gagaccttcc
     6241 acctccgaga aggaactgtg caagatggcg gactcctttt ttggaacaga tgccatccta
     6301 gagtctcccg atgacttttc tcaacatgac caagacaaaa gtcccttgtc cgacagtggc
     6361 tttgaaaccc gaagtgagaa aacaccttca gccccccaaa gtgccgagag caccggccct
     6421 aagccactat ttcatgaagt ccccatcccc cctgtcatca cagagacgag aactgaagta
     6481 gtccacgtga tcaggagcta cgagccctct actggggaga tcccccagtc ccagccagag
     6541 gaccccgtgt ctcccaaacc tccccctaca tttatggagt tggaaccaaa gcccaccgcc
     6601 cttagcatta aggaaaaagt gaaagcattc caaatgaaag ccagtagcga ggaagaggac
     6661 cacagtcggg ttttaagcaa aggcatgcgt gtcaaagaag agactcacat caccacaacc
     6721 acgaggatgg tgtatcactc cccgcctggc agtgagtgtg cctccgagag gattgaggag
     6781 accatgtcag tccatgacat tatgaaggct tttcagtccg ggcgagaccc ttccaaagag
     6841 ctggcggggc tgtttgaaca caagtcggcc atgtctccgg atgttgccaa gtctgctgct
     6901 gagacctcgg cccagcacgc agagaaggac aaccaaatga aacccaaact ggagcgtatt
     6961 atagaggtcc acatcgaaaa aggtccacag agtccttgtg agcggacgga tatcaggatg
     7021 gcaatagtag ccgatcacct gggacttagt tggacagagc tggcaaggga actgaatttt
     7081 tcagtggatg aaatcaacca aatacgagtg gaaaatccca attctttaat ttctcagagc
     7141 ttcatgttat taaaaaagtg ggtgacgaga gacgggaaga atgccacaac tgatgcctta
     7201 acttcggtct taacaaaaat taaccgaata gacatagtaa ctctgctgga aggaccaata
     7261 tttgattatg ggaatatttc aggcaccaga agctttgcag atgaaaacaa tgttttccat
     7321 gacccagttg atggttggca gaacgagacg ccaagtggaa gcctagagtc cccggcgcaa
     7381 gcgcgaagaa taaccggtgg gttactggac cgtctggacg acagctctga ccaggttcgg
     7441 gatcccatta cctcatacct cacaggagaa gctgggaagt tcgaagcaaa cggaaaccac
     7501 gcagaagtca ttccagaagc aaaggccaag gcctactttc ctgaatccca aaacgatata
     7561 gggaaacaga gcatcaagga gaacttgaaa ccaaaaacac acggatgtgg tcgcgctgag
     7621 gaaccagtgt cgcccctcac agcctaccag aaatctctag aagaaaccag caagcttgtc
     7681 atagaagacg cacctaaacc ctgtgtgcct gtcggcatga aaaagatgac caggactccg
     7741 gctgacggca aagccaggct caacctccag gaagaggagg ggtccgccag gtcagagcct
     7801 aagcagggag aaggctataa ggtgaaaaca aagaaggaaa tccggaatgt ggagaagaaa
     7861 gcccactagt gacggtgacg tcagtccag
//
