LOCUS       NM_001395563            7970 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ankyrin 1 (Ank1), transcript variant 2, mRNA.
ACCESSION   NM_001395563 XM_039094563
VERSION     NM_001395563.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7970)
  AUTHORS   Hori,S., Tateyama,M., Shirai,T., Kubo,Y. and Saitoh,O.
  TITLE     Two single-point mutations in Ankyrin Repeat one drastically change
            the threshold temperature of TRPV1
  JOURNAL   Nat Commun 14 (1), 2415 (2023)
   PUBMED   37169739
  REMARK    GeneRIF: Two single-point mutations in Ankyrin Repeat one
            drastically change the threshold temperature of TRPV1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7970)
  AUTHORS   Desmond,P.F., Muriel,J., Markwardt,M.L., Rizzo,M.A. and Bloch,R.J.
  TITLE     Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic
            Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal
            Muscle
  JOURNAL   J Biol Chem 290 (46), 27854-27867 (2015)
   PUBMED   26405035
  REMARK    GeneRIF: these results suggest that sAnk1 interacts with SERCA1
            through its TM and cytoplasmic domains to regulate SERCA1 activity
            and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum
            lumen.
REFERENCE   3  (bases 1 to 7970)
  AUTHORS   Huang,H., Zhao,P., Arimatsu,K., Tabeta,K., Yamazaki,K., Krieg,L.,
            Fu,E., Zhang,T. and Du,X.
  TITLE     A deep intronic mutation in the ankyrin-1 gene causes diminished
            protein expression resulting in hemolytic anemia in mice
  JOURNAL   G3 (Bethesda) 3 (10), 1687-1695 (2013)
   PUBMED   23934996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7970)
  AUTHORS   Yuki,K.E., Eva,M.M., Richer,E., Chung,D., Paquet,M., Cellier,M.,
            Canonne-Hergaux,F., Vaulont,S., Vidal,S.M. and Malo,D.
  TITLE     Suppression of hepcidin expression and iron overload mediate
            Salmonella susceptibility in ankyrin 1 ENU-induced mutant
  JOURNAL   PLoS One 8 (2), e55331 (2013)
   PUBMED   23390527
REFERENCE   5  (bases 1 to 7970)
  AUTHORS   Willis,C.D., Oashi,T., Busby,B., Mackerell,A.D. Jr. and Bloch,R.J.
  TITLE     Hydrophobic residues in small ankyrin 1 participate in binding to
            obscurin
  JOURNAL   Mol Membr Biol 29 (2), 36-51 (2012)
   PUBMED   22416964
  REMARK    GeneRIF: Site-directed mutagenesis, blot overlays and surface
            plasmon resonance assays were used to study the contribution of the
            hydrophobic residues, V70, F71, I102 and I103 of small ankyrin-1
            (sAnk1), to two different 30-mers of obscurin that bind sAnk1.
REFERENCE   6  (bases 1 to 7970)
  AUTHORS   White,R.A., Birkenmeier,C.S., Lux,S.E. and Barker,J.E.
  TITLE     Ankyrin and the hemolytic anemia mutation, nb, map to mouse
            chromosome 8: presence of the nb allele is associated with a
            truncated erythrocyte ankyrin
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3117-3121 (1990)
   PUBMED   2139228
REFERENCE   7  (bases 1 to 7970)
  AUTHORS   Kordeli,E., Davis,J., Trapp,B. and Bennett,V.
  TITLE     An isoform of ankyrin is localized at nodes of Ranvier in
            myelinated axons of central and peripheral nerves
  JOURNAL   J Cell Biol 110 (4), 1341-1352 (1990)
   PUBMED   2139035
REFERENCE   8  (bases 1 to 7970)
  AUTHORS   Bodine,D.M. 4th, Birkenmeier,C.S. and Barker,J.E.
  TITLE     Spectrin deficient inherited hemolytic anemias in the mouse:
            characterization by spectrin synthesis and mRNA activity in
            reticulocytes
  JOURNAL   Cell 37 (3), 721-729 (1984)
   PUBMED   6234993
REFERENCE   9  (bases 1 to 7970)
  AUTHORS   Bennett,V. and Stenbuck,P.J.
  TITLE     The membrane attachment protein for spectrin is associated with
            band 3 in human erythrocyte membranes
  JOURNAL   Nature 280 (5722), 468-473 (1979)
   PUBMED   379653
REFERENCE   10 (bases 1 to 7970)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039094563.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000016.1  75696633-75696740   c
            109-210             JAXUCZ010000016.1  75664749-75664850   c
            211-309             JAXUCZ010000016.1  75646960-75647058   c
            310-408             JAXUCZ010000016.1  75644786-75644884   c
            409-507             JAXUCZ010000016.1  75643914-75644012   c
            508-693             JAXUCZ010000016.1  75643283-75643468   c
            694-792             JAXUCZ010000016.1  75642276-75642374   c
            793-891             JAXUCZ010000016.1  75641666-75641764   c
            892-990             JAXUCZ010000016.1  75641288-75641386   c
            991-1188            JAXUCZ010000016.1  75638088-75638285   c
            1189-1287           JAXUCZ010000016.1  75636725-75636823   c
            1288-1386           JAXUCZ010000016.1  75636201-75636299   c
            1387-1485           JAXUCZ010000016.1  75635552-75635650   c
            1486-1683           JAXUCZ010000016.1  75634322-75634519   c
            1684-1782           JAXUCZ010000016.1  75633378-75633476   c
            1783-1881           JAXUCZ010000016.1  75632689-75632787   c
            1882-2079           JAXUCZ010000016.1  75627324-75627521   c
            2080-2178           JAXUCZ010000016.1  75622889-75622987   c
            2179-2277           JAXUCZ010000016.1  75621031-75621129   c
            2278-2376           JAXUCZ010000016.1  75620726-75620824   c
            2377-2469           JAXUCZ010000016.1  75619802-75619894   c
            2470-2542           JAXUCZ010000016.1  75619403-75619475   c
            2543-2639           JAXUCZ010000016.1  75617611-75617707   c
            2640-2718           JAXUCZ010000016.1  75617179-75617257   c
            2719-2816           JAXUCZ010000016.1  75615553-75615650   c
            2817-3041           JAXUCZ010000016.1  75615245-75615469   c
            3042-3196           JAXUCZ010000016.1  75614525-75614679   c
            3197-3408           JAXUCZ010000016.1  75613894-75614105   c
            3409-3613           JAXUCZ010000016.1  75613404-75613608   c
            3614-3710           JAXUCZ010000016.1  75613018-75613114   c
            3711-3939           JAXUCZ010000016.1  75612631-75612859   c
            3940-4065           JAXUCZ010000016.1  75611132-75611257   c
            4066-4185           JAXUCZ010000016.1  75610881-75611000   c
            4186-4264           JAXUCZ010000016.1  75609764-75609842   c
            4265-4339           JAXUCZ010000016.1  75609413-75609487   c
            4340-4471           JAXUCZ010000016.1  75606701-75606832   c
            4472-4618           JAXUCZ010000016.1  75605079-75605225   c
            4619-5156           JAXUCZ010000016.1  75596613-75597150   c
            5157-5433           JAXUCZ010000016.1  75593759-75594035   c
            5434-5517           JAXUCZ010000016.1  75589421-75589504   c
            5518-5658           JAXUCZ010000016.1  75588358-75588498   c
            5659-5783           JAXUCZ010000016.1  75588020-75588144   c
            5784-7970           JAXUCZ010000016.1  75578824-75581010   c
FEATURES             Location/Qualifiers
     source          1..7970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..7970
                     /gene="Ank1"
                     /note="ankyrin 1"
                     /db_xref="GeneID:306570"
                     /db_xref="RGD:1309620"
     exon            1..108
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..5757
                     /gene="Ank1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin 1, erythroid; ankyrin 1, erythrocytic"
                     /codon_start=1
                     /product="ankyrin-1 isoform 2"
                     /protein_id="NP_001382492.1"
                     /db_xref="GeneID:306570"
                     /db_xref="RGD:1309620"
                     /translation="MGFCKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG
                     LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA
                     QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI
                     NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA
                     QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAA
                     RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDH
                     LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGAS
                     IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK
                     YLLQNKAKANAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAR
                     EGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGL
                     TPLHVAVHHNNLDIVQLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSA
                     NAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV
                     LIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ
                     GHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKH
                     RMSYPETVDEILDVSEDEGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIP
                     RIPCVTPETVVIRSEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFM
                     VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRII
                     ALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHKSRYGESYLDQILN
                     GMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQ
                     ATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIP
                     LPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVS
                     ARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKV
                     DKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
                     IPVKVRDSSREPGGFLSFLRKPMKYEDAQHILCHLNVTMPPCTKGSGAEDRRRTLTPL
                     TLRYSILSESRLGFTSDTDRVEMKMAVIREHLGLSWAELARELQFSVEDINRIRVENP
                     NSLLDQSTALLTLWVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPDRR
                     HGDREYSLSPSQVNGYSSLQDELLSPASLHYALPSPLCADQYWNEVAVIDAIPLAATE
                     HDTMLEMSDMQVWSSGLTPSLVTAEDSSLECSKAEDSDAIPEWKLEGAHSEDTQGPEL
                     GSQDLVEDDTVDSDATNGLADLLGQEEGQRSEKKSQEVSGTEQDTETEVSLVSGQQRV
                     HARITDSPSVRQVLDRSQARTVDWYKQGSAASYPQEAAQSSWQEEVTQGPQSFQRRIT
                     TIQGPEPGTLQEYEQVVVSTREHVQRGPPESDSPKAGKDPSLWASESAFSQEVQGDEL
                     QNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQVDSSGAIDTQQHEEVIVEGPLADPGD
                     LEADIESFMKLTKVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ"
     exon            109..210
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..309
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..408
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..507
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..693
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..792
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..891
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..990
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1188
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1287
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1386
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1485
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1683
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1782
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1881
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2079
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2178
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2277
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2376
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2469
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2542
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2639
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2718
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2816
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3041
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3196
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3408
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3613
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3710
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3939
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4065
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4185
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4264
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4339
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4471
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4618
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..5156
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5433
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5517
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5518..5658
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5659..5783
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5784..7970
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggctagtc tcctggggcg agcctgttct tgctgctctg acagctctcc cgccctccgg
       61 cccgccggcg gggtcctggt cctgagcaac aagatgggct tctgtaaagc cgatgctgct
      121 accagctttt tgcgggcggc acgctcagga aacctggaca aggctttgga tcacctacgc
      181 aatggagtgg acattaacac ctgtaaccag aacgggttga atggcttgca tctggcctcc
      241 aaagaaggcc atgtgaagat ggtggttgaa cttctgcaca aagagatcat tctagaaaca
      301 acaaccaaga aggggaacac tgctctgcat atcgctgccc ttgctggtca ggacgaggtg
      361 gtccgggagc tggtcaacta tggagccaat gtcaatgccc agtcccagaa aggcttcact
      421 cccctgtaca tggctgctca agagaatcac ttggaggtgg tgaagtttct cctggagaat
      481 ggagccaatc agaatgtagc cacagaggat ggcttcactc cgctggctgt ggctctgcag
      541 cagggccatg agaatgtggt ggctcacctc atcaactatg gaacgaaagg aaaagtgcgc
      601 ctccctgccc tgcacatcgc ggcccgcaac gatgacacac ggacagccgc agtccttctg
      661 cagaatgacc ccaacccaga tgtgctttcc aagacgggat tcacacccct ccacatcgca
      721 gcacactacg agaacctcaa cgtggcccag ctgctcctca accggggagc cagcgtcaac
      781 ttcacacctc agaatggtat tactccactg cacatcgcct cccgcagggg aaatgtgatc
      841 atggtgagac tcctgctgga ccgaggggct cagatagaaa cgaggaccaa ggatgaactg
      901 acaccactcc actgtgcagc tcggaatgga cacgtgagaa tctcagagat cctgctggac
      961 cacggggcac ccatccaagc caaaaccaag aatggcttgt cccccatcca catggcggct
     1021 cagggagacc acctcgactg tgtccgactt ctattgcaat acaacgccga gatagatgac
     1081 atcaccttag atcacctgac tcctctccac gtggcagccc actgcggcca ccacagggtg
     1141 gctaaggttc ttttggataa aggggccaag ccgaactcca gagccctgaa tggctttacc
     1201 ccactacaca tcgcctgcaa gaagaaccac atacgtgtca tggagctgct gctgaagaca
     1261 ggagcctcta ttgacgcagt cactgagtct ggcctgacac ctctccatgt agcctccttc
     1321 atgggacacc ttcctattgt gaagaactta ttacagaggg gagcgtcacc caatgtctcc
     1381 aatgtgaaag tagaaacccc attgcacatg gcagcccgag cagggcatac agaagtggcc
     1441 aaatatttgc tccagaacaa agccaaagcc aatgccaagg ccaaggacga ccagacacca
     1501 cttcactgtg ctgctcgcat cggccacacg agcatggtga agctcctgct ggagaatgac
     1561 gccagcccca acctggctac cactgctggc cacacacctc tgcacaccgc agcccgtgag
     1621 ggtcacgtgg acacagccct ggccctgctg gaaaaggagg catcccaagc ctgcatgacc
     1681 aagaaaggat ttacccctct ccacgtggct gccaagtatg ggaaggtccg gctggcagag
     1741 ctgctgctgg aacatgatgc ccatcccaac gcggccggaa agaacggctt gactcccctg
     1801 catgtggccg tccatcacaa caacttggac attgtccagc ttctccttcc ccgaggtggc
     1861 tccccgcaca gccctgcctg gaatggctac acccctttgc acatcgcagc caagcagaac
     1921 cagatagagg tggcccgcag tctactgcaa tacggagggt ccgcgaatgc agagtctgta
     1981 caaggagtga ccccgcttca cctggctgcc caagagggcc acacggaaat ggtcgctctt
     2041 ctcctgtcaa agcaagccaa tggcaacctg gggaacaaga gtggactcac tcctctccac
     2101 ctggtagcac aagaaggcca tgttccagtg gcggatgtgc tgattaaaca tggcgtcaca
     2161 gtggatgcta cgacccggat gggttacacc ccactccacg tggccagtca ctacggaaac
     2221 atcaagctgg tgaagttcct gctacagcac caggcagatg tcaacgccaa gaccaagcta
     2281 gggtacagcc ccttgcacca ggcagctcag caaggacaca cggacattgt gacattgctc
     2341 ctgaagaatg gtgcttctcc aaatgaggtc agctcgaacg gaaccacacc tctggcaata
     2401 gccaaacgtt tgggctacat ctctgtaaca gacgtgctca aggtggtcac agatgaaacc
     2461 agtgtggtgt tagtcagtga caaacaccgg atgagctacc ctgagacagt ggatgagatc
     2521 ctggatgtgt ctgaagatga aggtgacgaa cttgtcggct cgaaggctga aaggcgggac
     2581 tcccgggatg tgggtgagga gaaagagctg ttggattttg tgccgaagct agaccaagtg
     2641 gtggaatccc cagccatccc aaggatccct tgtgtcacgc ctgagactgt tgtgatccga
     2701 tccgaagatc aggaacaagc atctaaagag tatgatgagg actcactcat tcccagtagc
     2761 ccagccacag agacctcaga caacatcagc cccgtggcta gccccgtcca cacagggttt
     2821 ctggtgagct tcatggtcga tgcccgggga ggatccatga gaggaagtcg tcataatggc
     2881 ctaagggtgg tgatccctcc ccggacatgc gcagcaccca ctcgcatcac ctgccgcctg
     2941 gttaagcccc agaagctaag cacaccgccc ccgctggctg aggaggaggg cctagccagc
     3001 aggatcattg cactgggtcc tacgggggcc cagttcctta gccctgtgat cgtggaaatc
     3061 ccccactttg cctcccatgg ccgcggggac cgtgagctgg tggttctgag gagcgagaac
     3121 ggctccgtgt ggaaggagca caagagccgc tatggagaaa gctacctgga ccagatcctg
     3181 aacggcatgg acgaagagct ggggagcctg gaggagctgg agaagaagcg cgtgtgtcgc
     3241 atcattacca ccgacttccc cctgtacttt gtcatcatgt cccggctctg ccaggactac
     3301 gacaccatcg gtcctgaagg gggctccctg agaagcaagc tggtgcccct ggtacaggcg
     3361 acgttccccg aaaacgcggt gaccaagaaa gtgaagctgg ctctgcaggc ccagcctgtc
     3421 ccagacgagc tggtgaccaa gctcctgggc aaccaggcca ccttcagccc cattgttact
     3481 gttgagccaa ggcgtcggaa gttccaccgt cccattgggc tgcgaatccc actccctccc
     3541 tcatggactg acaaccccag ggacagcggg gagggagaca ccaccagcct acgcttactg
     3601 tgcagcgtca tcggtggaac tgaccaagcc cagtgggaag atataacggg aacaaccaag
     3661 cttgtatacg ccaatgagtg cgccaacttt accaccaacg tctcagccag attctggctg
     3721 tcggactgtc ctcggaccgc tgaggccgta cactttgcca ctctcttgta caaagagctc
     3781 acggcagttc cctacatggc caagtttgtc attttcgcca agatgaacga cccccgggaa
     3841 ggacggctac gctgctactg catgacagat gacaaggtgg acaagaccct ggaacagcat
     3901 gaaaacttcg tggaggtggc ccggagcagg gacatagagg ttctagaagg gatgcctctg
     3961 tttgcagaac tctctgggaa cttggtgcct gtcaagaaag cggcccagca gcgaagcttc
     4021 catttccagt catttcgaga gaatcgcctg gccatccccg tgaaggtgag ggacagcagc
     4081 cgcgagccag gagggttctt gtcgttcctg cggaagccga tgaaatatga agacgcacag
     4141 cacatcctct gccacttgaa tgtcaccatg cccccctgta ccaagggcag tggagcagaa
     4201 gacaggagaa ggaccctgac gcccttgact cttcgctata gcattctcag cgagtcccgg
     4261 ctgggtttta ccagtgacac agaccgtgtt gaaatgaaga tggctgtcat cagggagcac
     4321 ctcggcctca gctgggcaga gctggcccgg gagctgcagt tcagcgtgga ggacatcaac
     4381 cggatccgtg tagaaaaccc taactccttg ttggatcaga gtacagccct gctgaccctc
     4441 tgggtggacc gtgaaggcga aaatgcaaag atggagaatc tgtacacggc cctgcggaac
     4501 atcgacagaa gtgagattgt taacatgttg gagggctccg gcaggcagag cagaaacctc
     4561 aaaccagacc ggaggcatgg ggaccgggag tactcattgt caccctccca ggtgaatggt
     4621 tactcctcgc tgcaggacga gctgctgtcc cccgcctccc tgcactacgc acttccctct
     4681 ccactgtgtg cagaccagta ctggaacgaa gtggccgtca tagacgccat ccccctggcg
     4741 gccacggagc atgacaccat gctggagatg tctgacatgc aggtgtggtc ttcgggcctc
     4801 acaccctccc tggtcactgc tgaggactcc tctctggagt gcagcaaggc cgaggactct
     4861 gacgccatac cagagtggaa gttggagggg gcacactcag aggacacgca gggcccggag
     4921 ctgggctctc aggacctggt ggaggacgac acagtggatt cagatgccac aaatggcctg
     4981 gcagatttgc taggtcagga ggaaggtcag aggtcagaaa agaagagtca ggaagtctca
     5041 ggcacagagc aggacacaga gactgaagtg tctcttgttt caggccagca gcgagttcac
     5101 gcccgaatca cagactcacc ctcagtgagg caggtgctgg acagaagcca ggccagaaca
     5161 gtggactggt ataaacaggg ttcagcagca tcatatccac aagaggccgc acaaagttcc
     5221 tggcaagagg aggtcacgca aggcccacag tcattccaga gaaggatcac caccatccaa
     5281 gggccggagc ccggcacact tcaggaatat gagcaggtgg tggtgtccac cagggagcat
     5341 gtgcagaggg ggccacctga gagcgacagc cccaaggccg ggaaggaccc aagtctgtgg
     5401 gcatcggaga gtgccttctc tcaagaggtg cagggggatg agcttcagaa tattccagga
     5461 gagcaggtga cagaggaaca attcacagac gaacagggca acattgtcac caagaagatc
     5521 attcgaaaag tcgtccgaca ggtggactcc tctggtgcca tcgacaccca gcagcacgag
     5581 gaggtgattg ttgagggacc cctggcagac cctggggatc tggaagcgga cattgagtcc
     5641 tttatgaaac ttactaaggt ggagctaaga gggagtggac tccagccgga cctgatagaa
     5701 ggcaggaagg gggctcaaat agtgaagcgg gccagcttga aaaggggcaa acagtgacct
     5761 ctcctcaagt agccccttgg gaggatcaca cctcaacacc caaaccctga actccacaca
     5821 ctcttgtcat gcacacggga ggagacctgg accagagggc tactgaaggg tcgcacgcgt
     5881 tctgagctcc ccggcatgac ctctgtaagg agtttccttt agtctcctat tcgcatgaat
     5941 gactggctgt agacgcatga cctacagtct tcagtcctgc ctctagcgac tatggatctc
     6001 tgtgggaatc aggacaaagg cggcgagaga agggagcgga taaggagccc caaagagcac
     6061 acgggtgcag acacgaataa gggcttaccg tggctgggat ggttgatccg tttgtttgcg
     6121 ttttgttttg atttttgact tcaaactcat ttgtaagaaa ttcacacgat ctttctggac
     6181 cgagggaacg ggaaacggcg tgaaatcagt ttagcccttt gtcctcgtgt accagtctcc
     6241 tatacccccc cacacaccac atgccactcg tccccgcccc acccccaccc ccgtggaggg
     6301 actgctcttc ccagaatgac atgacacagg tgcacacacg caggtcttcc cttcactcag
     6361 tctacactga ttttactgtg acctctgaag ccgtatggat aaactggatt tatttttttt
     6421 ttttatgttg tctctcagtt tcagtattaa ctcaccttcc agtgggagat catcaccctg
     6481 agagtgcact cggggttcct tgtgttagaa atttaagaac tgaggcaagg agcccctagg
     6541 ctttgctgta gggctcaaag gggagccagg gtcccatctc gaagttctct gctggggaag
     6601 gacctgtggc tgtccgagga tcgcaccagc atgtccgata gaggaagggg ttttctaaac
     6661 cgtcaagtac ttctataata gtctgtgttc aaagtgtaaa ctgttacagt aatcagcctt
     6721 gtgtatatga aaacaataaa tactatgcaa accaatagaa acacgttagc agtatgtaca
     6781 gagccctaaa gagctcagct ccagaggact tctccaggct gtgggaggag ctaaaggctg
     6841 tctttcactg aatgaggaag ggagtagggc tgtgaatgta cctgccagtt cctaggtcag
     6901 accaccctga ggtctcccag agccaacttg gtgcttgaag tgcagtgcaa gtggccgcag
     6961 tctggaggtc ctgacacaga cagctgggct caggctggtc ggccaagtgc ctggctctga
     7021 ccacgggccc agcgcaagga gagccggagc aggatagaac tgctgaccag gaggctgagg
     7081 agagaccctc ttctatctag actcagggcc aggccaggaa gggaaccctc aactggctgg
     7141 tcttgccttg gagccctcag ggaagagcct taacgtcaca ctagagtctc ctgcagaggg
     7201 aggcccgaat cagcacaatc cggctccgcc atgcccgggc ggcgccccct agggccagga
     7261 gagagactgg caggctcttc tcgctctccc ggagccactg gtggacagcg gtcaccttcc
     7321 tcgcctgccg ctcttcgggg tgtcgtcggg acacaataaa aaccttccaa gtagcacaga
     7381 cgcccctcca tgcccgtacc cccacgccct ggaggccctc ccggggactc cagcccgcgc
     7441 gcgctctagc cccgggccgg tgcgcgagtt gggggggggg ggaggatgct gtggtccgcg
     7501 ggcgtggctg gcttccctgg gggggagggg gcggcggccc ccggagggcg ggcgaggatt
     7561 ggcgcggggt cgccccgcct cgccccgccc cctccgccca gtagcgcctc ctagcgccct
     7621 gcgcggccga ctccgctttg gcaccctccg ctcggtctgg cttggctgct tggcacgccg
     7681 cccccgccca cggcggcatg gctgcgcgct cccgttgcta gtaggagctg ttttaggagg
     7741 agtttggggt ctccacttga tgcctagaga atgctgcagt ctgcacctta gacgcttttt
     7801 agaagttttg aaatgatttt tttaattgtt atgaaaaaaa tgaactatgt cttggctctc
     7861 tctcacatgc tctgttactg agagagacca gcccacccta ctctgatgta tagaccattc
     7921 tccctacacc agctaaacaa atgtcaaatt aataaagaaa tggactcatg
//
