LOCUS       NM_001395562            8230 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ankyrin 1 (Ank1), transcript variant 1, mRNA.
ACCESSION   NM_001395562 XM_039094575
VERSION     NM_001395562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8230)
  AUTHORS   Hori,S., Tateyama,M., Shirai,T., Kubo,Y. and Saitoh,O.
  TITLE     Two single-point mutations in Ankyrin Repeat one drastically change
            the threshold temperature of TRPV1
  JOURNAL   Nat Commun 14 (1), 2415 (2023)
   PUBMED   37169739
  REMARK    GeneRIF: Two single-point mutations in Ankyrin Repeat one
            drastically change the threshold temperature of TRPV1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8230)
  AUTHORS   Desmond,P.F., Muriel,J., Markwardt,M.L., Rizzo,M.A. and Bloch,R.J.
  TITLE     Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic
            Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal
            Muscle
  JOURNAL   J Biol Chem 290 (46), 27854-27867 (2015)
   PUBMED   26405035
  REMARK    GeneRIF: these results suggest that sAnk1 interacts with SERCA1
            through its TM and cytoplasmic domains to regulate SERCA1 activity
            and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum
            lumen.
REFERENCE   3  (bases 1 to 8230)
  AUTHORS   Huang,H., Zhao,P., Arimatsu,K., Tabeta,K., Yamazaki,K., Krieg,L.,
            Fu,E., Zhang,T. and Du,X.
  TITLE     A deep intronic mutation in the ankyrin-1 gene causes diminished
            protein expression resulting in hemolytic anemia in mice
  JOURNAL   G3 (Bethesda) 3 (10), 1687-1695 (2013)
   PUBMED   23934996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8230)
  AUTHORS   Yuki,K.E., Eva,M.M., Richer,E., Chung,D., Paquet,M., Cellier,M.,
            Canonne-Hergaux,F., Vaulont,S., Vidal,S.M. and Malo,D.
  TITLE     Suppression of hepcidin expression and iron overload mediate
            Salmonella susceptibility in ankyrin 1 ENU-induced mutant
  JOURNAL   PLoS One 8 (2), e55331 (2013)
   PUBMED   23390527
REFERENCE   5  (bases 1 to 8230)
  AUTHORS   Willis,C.D., Oashi,T., Busby,B., Mackerell,A.D. Jr. and Bloch,R.J.
  TITLE     Hydrophobic residues in small ankyrin 1 participate in binding to
            obscurin
  JOURNAL   Mol Membr Biol 29 (2), 36-51 (2012)
   PUBMED   22416964
  REMARK    GeneRIF: Site-directed mutagenesis, blot overlays and surface
            plasmon resonance assays were used to study the contribution of the
            hydrophobic residues, V70, F71, I102 and I103 of small ankyrin-1
            (sAnk1), to two different 30-mers of obscurin that bind sAnk1.
REFERENCE   6  (bases 1 to 8230)
  AUTHORS   White,R.A., Birkenmeier,C.S., Lux,S.E. and Barker,J.E.
  TITLE     Ankyrin and the hemolytic anemia mutation, nb, map to mouse
            chromosome 8: presence of the nb allele is associated with a
            truncated erythrocyte ankyrin
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3117-3121 (1990)
   PUBMED   2139228
REFERENCE   7  (bases 1 to 8230)
  AUTHORS   Kordeli,E., Davis,J., Trapp,B. and Bennett,V.
  TITLE     An isoform of ankyrin is localized at nodes of Ranvier in
            myelinated axons of central and peripheral nerves
  JOURNAL   J Cell Biol 110 (4), 1341-1352 (1990)
   PUBMED   2139035
REFERENCE   8  (bases 1 to 8230)
  AUTHORS   Bodine,D.M. 4th, Birkenmeier,C.S. and Barker,J.E.
  TITLE     Spectrin deficient inherited hemolytic anemias in the mouse:
            characterization by spectrin synthesis and mRNA activity in
            reticulocytes
  JOURNAL   Cell 37 (3), 721-729 (1984)
   PUBMED   6234993
REFERENCE   9  (bases 1 to 8230)
  AUTHORS   Bennett,V. and Stenbuck,P.J.
  TITLE     The membrane attachment protein for spectrin is associated with
            band 3 in human erythrocyte membranes
  JOURNAL   Nature 280 (5722), 468-473 (1979)
   PUBMED   379653
REFERENCE   10 (bases 1 to 8230)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039094575.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               JAXUCZ010000016.1  75757046-75757464   c
            420-521             JAXUCZ010000016.1  75664749-75664850   c
            522-620             JAXUCZ010000016.1  75646960-75647058   c
            621-719             JAXUCZ010000016.1  75644786-75644884   c
            720-818             JAXUCZ010000016.1  75643914-75644012   c
            819-1004            JAXUCZ010000016.1  75643283-75643468   c
            1005-1103           JAXUCZ010000016.1  75642276-75642374   c
            1104-1202           JAXUCZ010000016.1  75641666-75641764   c
            1203-1301           JAXUCZ010000016.1  75641288-75641386   c
            1302-1499           JAXUCZ010000016.1  75638088-75638285   c
            1500-1598           JAXUCZ010000016.1  75636725-75636823   c
            1599-1697           JAXUCZ010000016.1  75636201-75636299   c
            1698-1796           JAXUCZ010000016.1  75635552-75635650   c
            1797-1994           JAXUCZ010000016.1  75634322-75634519   c
            1995-2093           JAXUCZ010000016.1  75633378-75633476   c
            2094-2192           JAXUCZ010000016.1  75632689-75632787   c
            2193-2390           JAXUCZ010000016.1  75627324-75627521   c
            2391-2489           JAXUCZ010000016.1  75622889-75622987   c
            2490-2588           JAXUCZ010000016.1  75621031-75621129   c
            2589-2687           JAXUCZ010000016.1  75620726-75620824   c
            2688-2780           JAXUCZ010000016.1  75619802-75619894   c
            2781-2853           JAXUCZ010000016.1  75619403-75619475   c
            2854-2877           JAXUCZ010000016.1  75618687-75618710   c
            2878-2974           JAXUCZ010000016.1  75617611-75617707   c
            2975-3053           JAXUCZ010000016.1  75617179-75617257   c
            3054-3151           JAXUCZ010000016.1  75615553-75615650   c
            3152-3376           JAXUCZ010000016.1  75615245-75615469   c
            3377-3531           JAXUCZ010000016.1  75614525-75614679   c
            3532-3743           JAXUCZ010000016.1  75613894-75614105   c
            3744-3948           JAXUCZ010000016.1  75613404-75613608   c
            3949-4045           JAXUCZ010000016.1  75613018-75613114   c
            4046-4274           JAXUCZ010000016.1  75612631-75612859   c
            4275-4400           JAXUCZ010000016.1  75611132-75611257   c
            4401-4520           JAXUCZ010000016.1  75610881-75611000   c
            4521-4599           JAXUCZ010000016.1  75609764-75609842   c
            4600-4674           JAXUCZ010000016.1  75609413-75609487   c
            4675-4806           JAXUCZ010000016.1  75606701-75606832   c
            4807-4953           JAXUCZ010000016.1  75605079-75605225   c
            4954-5491           JAXUCZ010000016.1  75596613-75597150   c
            5492-5768           JAXUCZ010000016.1  75593759-75594035   c
            5769-5852           JAXUCZ010000016.1  75589421-75589504   c
            5853-5918           JAXUCZ010000016.1  75588433-75588498   c
            5919-6043           JAXUCZ010000016.1  75588020-75588144   c
            6044-8230           JAXUCZ010000016.1  75578824-75581010   c
FEATURES             Location/Qualifiers
     source          1..8230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..8230
                     /gene="Ank1"
                     /note="ankyrin 1"
                     /db_xref="GeneID:306570"
                     /db_xref="RGD:1309620"
     exon            1..419
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..6017
                     /gene="Ank1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin 1, erythroid; ankyrin 1, erythrocytic"
                     /codon_start=1
                     /product="ankyrin-1 isoform 1"
                     /protein_id="NP_001382491.1"
                     /db_xref="GeneID:306570"
                     /db_xref="RGD:1309620"
                     /translation="MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKAD
                     AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI
                     ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
                     KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD
                     TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL
                     HIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAK
                     TKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD
                     KGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHL
                     PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLH
                     CAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMT
                     KKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVQLLLPR
                     GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTE
                     MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLHV
                     ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSS
                     NGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETVDEILDVSEDEGTA
                     HISLTGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIR
                     SEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRH
                     NGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPV
                     IVEIPHFASHGRGDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELE
                     KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVK
                     LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSG
                     EGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAE
                     AVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEV
                     ARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVKVRDSSREPG
                     GFLSFLRKPMKYEDAQHILCHLNVTMPPCTKGSGAEDRRRTLTPLTLRYSILSESRLG
                     FTSDTDRVEMKMAVIREHLGLSWAELARELQFSVEDINRIRVENPNSLLDQSTALLTL
                     WVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPDRRHGDREYSLSPSQV
                     NGYSSLQDELLSPASLHYALPSPLCADQYWNEVAVIDAIPLAATEHDTMLEMSDMQVW
                     SSGLTPSLVTAEDSSLECSKAEDSDAIPEWKLEGAHSEDTQGPELGSQDLVEDDTVDS
                     DATNGLADLLGQEEGQRSEKKSQEVSGTEQDTETEVSLVSGQQRVHARITDSPSVRQV
                     LDRSQARTVDWYKQGSAASYPQEAAQSSWQEEVTQGPQSFQRRITTIQGPEPGTLQEY
                     EQVVVSTREHVQRGPPESDSPKAGKDPSLWASESAFSQEVQGDELQNIPGEQVTEEQF
                     TDEQGNIVTKKIIRKVVRQVDSSGAIDTQQHEEVELRGSGLQPDLIEGRKGAQIVKRA
                     SLKRGKQ"
     exon            420..521
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..620
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..719
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..818
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1004
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1103
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1202
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1301
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1499
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1598
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1697
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1796
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1994
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2093
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2192
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2390
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2489
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2588
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2687
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2780
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2853
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2877
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2974
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3053
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3151
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3376
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3531
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3743
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3948
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4045
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4274
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4400
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4520
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4521..4599
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4674
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4806
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4953
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5491
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..5768
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5769..5852
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5853..5918
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            5919..6043
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
     exon            6044..8230
                     /gene="Ank1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggcgc ggcgagggcg cgcggcgagc ccagagccgg tgcggggcgc gggcgagcga
       61 gctccggccg cggcgggagg cgccaccccg gggctcgggt agccgcgcgc cggcctctcc
      121 tcgccctccg ccccgcgccc cgggccccct ggcgccgcag ccttcgcctc cgcgggggag
      181 aagctcgtgc cctgcgcagc tgagggagcc ggctcttccc gggagggtgt cgtcgccgcc
      241 ggctcgcaga gggcgcgggc ccgggaggcg gggaccgagc accgcgaccc gccatggctc
      301 aggcggccaa acagctgaag aaaatcaaag acatcgaggc gcaggccctc caggagcaga
      361 aggagaagga ggaatccaac aggaagcggc ggaaccgctc ccgtgaccgc aagaagaagg
      421 ccgatgctgc taccagcttt ttgcgggcgg cacgctcagg aaacctggac aaggctttgg
      481 atcacctacg caatggagtg gacattaaca cctgtaacca gaacgggttg aatggcttgc
      541 atctggcctc caaagaaggc catgtgaaga tggtggttga acttctgcac aaagagatca
      601 ttctagaaac aacaaccaag aaggggaaca ctgctctgca tatcgctgcc cttgctggtc
      661 aggacgaggt ggtccgggag ctggtcaact atggagccaa tgtcaatgcc cagtcccaga
      721 aaggcttcac tcccctgtac atggctgctc aagagaatca cttggaggtg gtgaagtttc
      781 tcctggagaa tggagccaat cagaatgtag ccacagagga tggcttcact ccgctggctg
      841 tggctctgca gcagggccat gagaatgtgg tggctcacct catcaactat ggaacgaaag
      901 gaaaagtgcg cctccctgcc ctgcacatcg cggcccgcaa cgatgacaca cggacagccg
      961 cagtccttct gcagaatgac cccaacccag atgtgctttc caagacggga ttcacacccc
     1021 tccacatcgc agcacactac gagaacctca acgtggccca gctgctcctc aaccggggag
     1081 ccagcgtcaa cttcacacct cagaatggta ttactccact gcacatcgcc tcccgcaggg
     1141 gaaatgtgat catggtgaga ctcctgctgg accgaggggc tcagatagaa acgaggacca
     1201 aggatgaact gacaccactc cactgtgcag ctcggaatgg acacgtgaga atctcagaga
     1261 tcctgctgga ccacggggca cccatccaag ccaaaaccaa gaatggcttg tcccccatcc
     1321 acatggcggc tcagggagac cacctcgact gtgtccgact tctattgcaa tacaacgccg
     1381 agatagatga catcacctta gatcacctga ctcctctcca cgtggcagcc cactgcggcc
     1441 accacagggt ggctaaggtt cttttggata aaggggccaa gccgaactcc agagccctga
     1501 atggctttac cccactacac atcgcctgca agaagaacca catacgtgtc atggagctgc
     1561 tgctgaagac aggagcctct attgacgcag tcactgagtc tggcctgaca cctctccatg
     1621 tagcctcctt catgggacac cttcctattg tgaagaactt attacagagg ggagcgtcac
     1681 ccaatgtctc caatgtgaaa gtagaaaccc cattgcacat ggcagcccga gcagggcata
     1741 cagaagtggc caaatatttg ctccagaaca aagccaaagc caatgccaag gccaaggacg
     1801 accagacacc acttcactgt gctgctcgca tcggccacac gagcatggtg aagctcctgc
     1861 tggagaatga cgccagcccc aacctggcta ccactgctgg ccacacacct ctgcacaccg
     1921 cagcccgtga gggtcacgtg gacacagccc tggccctgct ggaaaaggag gcatcccaag
     1981 cctgcatgac caagaaagga tttacccctc tccacgtggc tgccaagtat gggaaggtcc
     2041 ggctggcaga gctgctgctg gaacatgatg cccatcccaa cgcggccgga aagaacggct
     2101 tgactcccct gcatgtggcc gtccatcaca acaacttgga cattgtccag cttctccttc
     2161 cccgaggtgg ctccccgcac agccctgcct ggaatggcta cacccctttg cacatcgcag
     2221 ccaagcagaa ccagatagag gtggcccgca gtctactgca atacggaggg tccgcgaatg
     2281 cagagtctgt acaaggagtg accccgcttc acctggctgc ccaagagggc cacacggaaa
     2341 tggtcgctct tctcctgtca aagcaagcca atggcaacct ggggaacaag agtggactca
     2401 ctcctctcca cctggtagca caagaaggcc atgttccagt ggcggatgtg ctgattaaac
     2461 atggcgtcac agtggatgct acgacccgga tgggttacac cccactccac gtggccagtc
     2521 actacggaaa catcaagctg gtgaagttcc tgctacagca ccaggcagat gtcaacgcca
     2581 agaccaagct agggtacagc cccttgcacc aggcagctca gcaaggacac acggacattg
     2641 tgacattgct cctgaagaat ggtgcttctc caaatgaggt cagctcgaac ggaaccacac
     2701 ctctggcaat agccaaacgt ttgggctaca tctctgtaac agacgtgctc aaggtggtca
     2761 cagatgaaac cagtgtggtg ttagtcagtg acaaacaccg gatgagctac cctgagacag
     2821 tggatgagat cctggatgtg tctgaagatg aaggaactgc tcacatatct ttaacgggtg
     2881 acgaacttgt cggctcgaag gctgaaaggc gggactcccg ggatgtgggt gaggagaaag
     2941 agctgttgga ttttgtgccg aagctagacc aagtggtgga atccccagcc atcccaagga
     3001 tcccttgtgt cacgcctgag actgttgtga tccgatccga agatcaggaa caagcatcta
     3061 aagagtatga tgaggactca ctcattccca gtagcccagc cacagagacc tcagacaaca
     3121 tcagccccgt ggctagcccc gtccacacag ggtttctggt gagcttcatg gtcgatgccc
     3181 ggggaggatc catgagagga agtcgtcata atggcctaag ggtggtgatc cctccccgga
     3241 catgcgcagc acccactcgc atcacctgcc gcctggttaa gccccagaag ctaagcacac
     3301 cgcccccgct ggctgaggag gagggcctag ccagcaggat cattgcactg ggtcctacgg
     3361 gggcccagtt ccttagccct gtgatcgtgg aaatccccca ctttgcctcc catggccgcg
     3421 gggaccgtga gctggtggtt ctgaggagcg agaacggctc cgtgtggaag gagcacaaga
     3481 gccgctatgg agaaagctac ctggaccaga tcctgaacgg catggacgaa gagctgggga
     3541 gcctggagga gctggagaag aagcgcgtgt gtcgcatcat taccaccgac ttccccctgt
     3601 actttgtcat catgtcccgg ctctgccagg actacgacac catcggtcct gaagggggct
     3661 ccctgagaag caagctggtg cccctggtac aggcgacgtt ccccgaaaac gcggtgacca
     3721 agaaagtgaa gctggctctg caggcccagc ctgtcccaga cgagctggtg accaagctcc
     3781 tgggcaacca ggccaccttc agccccattg ttactgttga gccaaggcgt cggaagttcc
     3841 accgtcccat tgggctgcga atcccactcc ctccctcatg gactgacaac cccagggaca
     3901 gcggggaggg agacaccacc agcctacgct tactgtgcag cgtcatcggt ggaactgacc
     3961 aagcccagtg ggaagatata acgggaacaa ccaagcttgt atacgccaat gagtgcgcca
     4021 actttaccac caacgtctca gccagattct ggctgtcgga ctgtcctcgg accgctgagg
     4081 ccgtacactt tgccactctc ttgtacaaag agctcacggc agttccctac atggccaagt
     4141 ttgtcatttt cgccaagatg aacgaccccc gggaaggacg gctacgctgc tactgcatga
     4201 cagatgacaa ggtggacaag accctggaac agcatgaaaa cttcgtggag gtggcccgga
     4261 gcagggacat agaggttcta gaagggatgc ctctgtttgc agaactctct gggaacttgg
     4321 tgcctgtcaa gaaagcggcc cagcagcgaa gcttccattt ccagtcattt cgagagaatc
     4381 gcctggccat ccccgtgaag gtgagggaca gcagccgcga gccaggaggg ttcttgtcgt
     4441 tcctgcggaa gccgatgaaa tatgaagacg cacagcacat cctctgccac ttgaatgtca
     4501 ccatgccccc ctgtaccaag ggcagtggag cagaagacag gagaaggacc ctgacgccct
     4561 tgactcttcg ctatagcatt ctcagcgagt cccggctggg ttttaccagt gacacagacc
     4621 gtgttgaaat gaagatggct gtcatcaggg agcacctcgg cctcagctgg gcagagctgg
     4681 cccgggagct gcagttcagc gtggaggaca tcaaccggat ccgtgtagaa aaccctaact
     4741 ccttgttgga tcagagtaca gccctgctga ccctctgggt ggaccgtgaa ggcgaaaatg
     4801 caaagatgga gaatctgtac acggccctgc ggaacatcga cagaagtgag attgttaaca
     4861 tgttggaggg ctccggcagg cagagcagaa acctcaaacc agaccggagg catggggacc
     4921 gggagtactc attgtcaccc tcccaggtga atggttactc ctcgctgcag gacgagctgc
     4981 tgtcccccgc ctccctgcac tacgcacttc cctctccact gtgtgcagac cagtactgga
     5041 acgaagtggc cgtcatagac gccatccccc tggcggccac ggagcatgac accatgctgg
     5101 agatgtctga catgcaggtg tggtcttcgg gcctcacacc ctccctggtc actgctgagg
     5161 actcctctct ggagtgcagc aaggccgagg actctgacgc cataccagag tggaagttgg
     5221 agggggcaca ctcagaggac acgcagggcc cggagctggg ctctcaggac ctggtggagg
     5281 acgacacagt ggattcagat gccacaaatg gcctggcaga tttgctaggt caggaggaag
     5341 gtcagaggtc agaaaagaag agtcaggaag tctcaggcac agagcaggac acagagactg
     5401 aagtgtctct tgtttcaggc cagcagcgag ttcacgcccg aatcacagac tcaccctcag
     5461 tgaggcaggt gctggacaga agccaggcca gaacagtgga ctggtataaa cagggttcag
     5521 cagcatcata tccacaagag gccgcacaaa gttcctggca agaggaggtc acgcaaggcc
     5581 cacagtcatt ccagagaagg atcaccacca tccaagggcc ggagcccggc acacttcagg
     5641 aatatgagca ggtggtggtg tccaccaggg agcatgtgca gagggggcca cctgagagcg
     5701 acagccccaa ggccgggaag gacccaagtc tgtgggcatc ggagagtgcc ttctctcaag
     5761 aggtgcaggg ggatgagctt cagaatattc caggagagca ggtgacagag gaacaattca
     5821 cagacgaaca gggcaacatt gtcaccaaga agatcattcg aaaagtcgtc cgacaggtgg
     5881 actcctctgg tgccatcgac acccagcagc acgaggaggt ggagctaaga gggagtggac
     5941 tccagccgga cctgatagaa ggcaggaagg gggctcaaat agtgaagcgg gccagcttga
     6001 aaaggggcaa acagtgacct ctcctcaagt agccccttgg gaggatcaca cctcaacacc
     6061 caaaccctga actccacaca ctcttgtcat gcacacggga ggagacctgg accagagggc
     6121 tactgaaggg tcgcacgcgt tctgagctcc ccggcatgac ctctgtaagg agtttccttt
     6181 agtctcctat tcgcatgaat gactggctgt agacgcatga cctacagtct tcagtcctgc
     6241 ctctagcgac tatggatctc tgtgggaatc aggacaaagg cggcgagaga agggagcgga
     6301 taaggagccc caaagagcac acgggtgcag acacgaataa gggcttaccg tggctgggat
     6361 ggttgatccg tttgtttgcg ttttgttttg atttttgact tcaaactcat ttgtaagaaa
     6421 ttcacacgat ctttctggac cgagggaacg ggaaacggcg tgaaatcagt ttagcccttt
     6481 gtcctcgtgt accagtctcc tatacccccc cacacaccac atgccactcg tccccgcccc
     6541 acccccaccc ccgtggaggg actgctcttc ccagaatgac atgacacagg tgcacacacg
     6601 caggtcttcc cttcactcag tctacactga ttttactgtg acctctgaag ccgtatggat
     6661 aaactggatt tatttttttt ttttatgttg tctctcagtt tcagtattaa ctcaccttcc
     6721 agtgggagat catcaccctg agagtgcact cggggttcct tgtgttagaa atttaagaac
     6781 tgaggcaagg agcccctagg ctttgctgta gggctcaaag gggagccagg gtcccatctc
     6841 gaagttctct gctggggaag gacctgtggc tgtccgagga tcgcaccagc atgtccgata
     6901 gaggaagggg ttttctaaac cgtcaagtac ttctataata gtctgtgttc aaagtgtaaa
     6961 ctgttacagt aatcagcctt gtgtatatga aaacaataaa tactatgcaa accaatagaa
     7021 acacgttagc agtatgtaca gagccctaaa gagctcagct ccagaggact tctccaggct
     7081 gtgggaggag ctaaaggctg tctttcactg aatgaggaag ggagtagggc tgtgaatgta
     7141 cctgccagtt cctaggtcag accaccctga ggtctcccag agccaacttg gtgcttgaag
     7201 tgcagtgcaa gtggccgcag tctggaggtc ctgacacaga cagctgggct caggctggtc
     7261 ggccaagtgc ctggctctga ccacgggccc agcgcaagga gagccggagc aggatagaac
     7321 tgctgaccag gaggctgagg agagaccctc ttctatctag actcagggcc aggccaggaa
     7381 gggaaccctc aactggctgg tcttgccttg gagccctcag ggaagagcct taacgtcaca
     7441 ctagagtctc ctgcagaggg aggcccgaat cagcacaatc cggctccgcc atgcccgggc
     7501 ggcgccccct agggccagga gagagactgg caggctcttc tcgctctccc ggagccactg
     7561 gtggacagcg gtcaccttcc tcgcctgccg ctcttcgggg tgtcgtcggg acacaataaa
     7621 aaccttccaa gtagcacaga cgcccctcca tgcccgtacc cccacgccct ggaggccctc
     7681 ccggggactc cagcccgcgc gcgctctagc cccgggccgg tgcgcgagtt gggggggggg
     7741 ggaggatgct gtggtccgcg ggcgtggctg gcttccctgg gggggagggg gcggcggccc
     7801 ccggagggcg ggcgaggatt ggcgcggggt cgccccgcct cgccccgccc cctccgccca
     7861 gtagcgcctc ctagcgccct gcgcggccga ctccgctttg gcaccctccg ctcggtctgg
     7921 cttggctgct tggcacgccg cccccgccca cggcggcatg gctgcgcgct cccgttgcta
     7981 gtaggagctg ttttaggagg agtttggggt ctccacttga tgcctagaga atgctgcagt
     8041 ctgcacctta gacgcttttt agaagttttg aaatgatttt tttaattgtt atgaaaaaaa
     8101 tgaactatgt cttggctctc tctcacatgc tctgttactg agagagacca gcccacccta
     8161 ctctgatgta tagaccattc tccctacacc agctaaacaa atgtcaaatt aataaagaaa
     8221 tggactcatg
//
