LOCUS       NM_001271710             878 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus angiopoietin-like 8 (Angptl8), mRNA.
ACCESSION   NM_001271710 XM_002726997 XM_002729877
VERSION     NM_001271710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 878)
  AUTHORS   Aydin,S., Kilinc,F., Ugur,K., Aydin,M.A., Yalcin,M.H., Kuloglu,T.,
            Kaya Tektemur,N., Albayrak,S., Emre,E., Yardim,M., Akkoc,R.F.,
            Hancer,S., Sahin,I., Cinar,V., Akbulut,T., Demircan,S., Evren,B.,
            Gencer,B.T., Aksoy,A., Yilmaz Bozoglan,M., Aydemir,I. and Aydin,S.
  TITLE     Effects of irisin and exercise on adropin and betatrophin in a new
            metabolic syndrome model
  JOURNAL   Biotech Histochem 99 (1), 21-32 (2024)
   PUBMED   37933453
  REMARK    GeneRIF: Effects of irisin and exercise on adropin and betatrophin
            in a new metabolic syndrome model.
REFERENCE   2  (bases 1 to 878)
  AUTHORS   Zhang,D., Yu,Y.J., Xu,F.S., Yuan,J.H., Wang,R., Zhang,C.S.,
            Wang,L.X., Liu,Y., Song,L.M., Liu,J.L. and Dong,J.
  TITLE     Recombinant betatrophin (Angptl-8/lipasin) ameliorates
            streptozotocin-induced hyperglycemia and beta-cell destruction in
            neonatal rats
  JOURNAL   Mol Med Rep 20 (5), 4523-4532 (2019)
   PUBMED   31702044
  REMARK    GeneRIF: These results suggest that early administration of
            betatrophin promotes betacell proliferation in STZinduced diabetic
            neonates and prevents the development of diabetes in adults.
REFERENCE   3  (bases 1 to 878)
  AUTHORS   Amri,J., Parastesh,M., Sadegh,M., Latifi,S.A. and Alaee,M.
  TITLE     High-intensity interval training improved fasting blood glucose and
            lipid profiles in type 2 diabetic rats more than endurance
            training; possible involvement of irisin and betatrophin
  JOURNAL   Physiol Int 106 (3), 213-224 (2019)
   PUBMED   31578075
  REMARK    GeneRIF: A significant increase in the serum concentration of
            irisin (p < 0.05), betatrophin (p < 0.05), and insulin (p < 0.001)
            and significant decrease in the FBG (P < 0.01) and lipid profiles
            (p < 0.01) were observed.
REFERENCE   4  (bases 1 to 878)
  AUTHORS   Izumi,R., Kusakabe,T., Noguchi,M., Iwakura,H., Tanaka,T.,
            Miyazawa,T., Aotani,D., Hosoda,K., Kangawa,K. and Nakao,K.
  TITLE     CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma
            triglyceride concentrations and adiposity in rats
  JOURNAL   J Lipid Res 59 (9), 1575-1585 (2018)
   PUBMED   30042156
  REMARK    GeneRIF: Angptl8 KO in rats resulted in lower body weight and
            plasma TG levels without affecting glucose metabolism
REFERENCE   5  (bases 1 to 878)
  AUTHORS   Chen,J., Chen,S., Huang,P., Meng,X.L., Clayton,S., Shen,J.S. and
            Grayburn,P.A.
  TITLE     In vivo targeted delivery of ANGPTL8 gene for beta cell
            regeneration in rats
  JOURNAL   Diabetologia 58 (5), 1036-1044 (2015)
   PUBMED   25720603
  REMARK    GeneRIF: ANGPTL8 induced adult and aged beta cell regeneration in a
            rat model.
REFERENCE   6  (bases 1 to 878)
  AUTHORS   Jiao,Y., Le Lay,J., Yu,M., Naji,A. and Kaestner,K.H.
  TITLE     Elevated mouse hepatic betatrophin expression does not increase
            human beta-cell replication in the transplant setting
  JOURNAL   Diabetes 63 (4), 1283-1288 (2014)
   PUBMED   24353178
REFERENCE   7  (bases 1 to 878)
  AUTHORS   Wang,Y., Quagliarini,F., Gusarova,V., Gromada,J., Valenzuela,D.M.,
            Cohen,J.C. and Hobbs,H.H.
  TITLE     Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride
            metabolism without impaired glucose homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16109-16114 (2013)
   PUBMED   24043787
REFERENCE   8  (bases 1 to 878)
  AUTHORS   Quagliarini,F., Wang,Y., Kozlitina,J., Grishin,N.V., Hyde,R.,
            Boerwinkle,E., Valenzuela,D.M., Murphy,A.J., Cohen,J.C. and
            Hobbs,H.H.
  TITLE     Atypical angiopoietin-like protein that regulates ANGPTL3
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19751-19756 (2012)
   PUBMED   23150577
REFERENCE   9  (bases 1 to 878)
  AUTHORS   Zhang,R.
  TITLE     Lipasin, a novel nutritionally-regulated liver-enriched factor that
            regulates serum triglyceride levels
  JOURNAL   Biochem Biophys Res Commun 424 (4), 786-792 (2012)
   PUBMED   22809513
REFERENCE   10 (bases 1 to 878)
  AUTHORS   Ren,G., Kim,J.Y. and Smas,C.M.
  TITLE     Identification of RIFL, a novel adipocyte-enriched insulin target
            gene with a role in lipid metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 303 (3), E334-E351 (2012)
   PUBMED   22569073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Nov 10, 2012 this sequence version replaced
            XM_002729877.1, XM_002726997.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ201125.1, BI274505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               JAXUCZ010000008.1  28652555-28652872
            319-480             JAXUCZ010000008.1  28653010-28653171
            481-590             JAXUCZ010000008.1  28654076-28654185
            591-878             JAXUCZ010000008.1  28654294-28654581
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..878
                     /gene="Angptl8"
                     /note="angiopoietin-like 8"
                     /db_xref="GeneID:100361444"
                     /db_xref="RGD:2320121"
     exon            1..318
                     /gene="Angptl8"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..618
                     /gene="Angptl8"
                     /note="lipasin; betatrophin; rCG31799-like;
                     angiopoietin-like protein 8"
                     /codon_start=1
                     /product="angiopoietin-like protein 8 precursor"
                     /protein_id="NP_001258639.1"
                     /db_xref="GeneID:100361444"
                     /db_xref="RGD:2320121"
                     /translation="MVVPILCLLWAIATAVRPAPVAPLGGPEPAQYEELTLLFHGALQ
                     LGQALNGVYKATEARLTEAGRNLGLFDQALEFLGREVNQGRDATRELRTSLSEIQAEE
                     DTLHLRAEATARSLREVARAQHALRNSVRRLQVQLRGAWLGQAHQEFENLKDRADKQN
                     HLLWALTGHVQRQQREMAEQQQWLRQIQQRLHMAALPA"
     exon            319..480
                     /gene="Angptl8"
                     /inference="alignment:Splign:2.1.0"
     exon            481..590
                     /gene="Angptl8"
                     /inference="alignment:Splign:2.1.0"
     exon            591..878
                     /gene="Angptl8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacccccga gactgtccac catggttgtg cctattctct gcctcctatg ggccatagca
       61 acagcagtgc gacctgcccc agtggcccct ctcggtggtc cagagccggc ccaatatgaa
      121 gagttgaccc tgctctttca cggggcccta cagctaggtc aggccctcaa tggtgtgtac
      181 aaagccacgg aagctcgcct gacagaagct gggcgcaacc tgggcctttt tgaccaagca
      241 ctggaatttc tgggaagaga ggtcaatcag ggccgggatg caacacggga gcttcgcacc
      301 agcttgtcgg agattcaggc agaagaggac actttacacc ttcgagcaga agccacagcc
      361 cgatcgctga gggaagtggc ccgggcccag catgctctgc ggaacagtgt acggagacta
      421 caagtgcagc tgagaggtgc ctggctaggc caagcccacc aagaatttga gaatttaaag
      481 gatcgagccg ataagcagaa ccacctcttg tgggctctca ctggccacgt gcagcgacag
      541 cagcgtgaga tggcagagca gcaacagtgg ctgcggcaga tccagcagag actccacatg
      601 gcagccctcc cagcctgaga ctacctggat gccactgagg accagttgtg ctgcagggaa
      661 cactgaatgc gctccaccgg gcctatctat gagcagggcc gacagagctg gctgcccatc
      721 agctagactt ggccggtgca ccccgcttcc tggcagagca gagacagaag caagcaggcg
      781 ggatggaagg cagaagacag ccccgtggag aaggctggag aaggacatga gctcccttat
      841 gccccacacc ccacaataaa aaagaggcaa tctataaa
//
