LOCUS       NM_199115               1871 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus angiopoietin-like 4 (Angptl4), mRNA.
ACCESSION   NM_199115 XM_343182
VERSION     NM_199115.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Kondo,S., Kojima,K., Nakamura,N., Miyabe,M., Kikuchi,T., Ohno,T.,
            Sawada,N., Minato,T., Saiki,T., Ito,M., Sasajima,S., Matsubara,T.,
            Mitani,A. and Naruse,K.
  TITLE     Increased expression of angiopoietin-like protein 4 regulates
            matrix metalloproteinase-13 expression in Porphyromonas gingivalis
            lipopolysaccharides-stimulated gingival fibroblasts and
            ligature-induced experimental periodontitis
  JOURNAL   J Periodontal Res 58 (1), 43-52 (2023)
   PUBMED   36409042
  REMARK    GeneRIF: Increased expression of angiopoietin-like protein 4
            regulates matrix metalloproteinase-13 expression in Porphyromonas
            gingivalis lipopolysaccharides-stimulated gingival fibroblasts and
            ligature-induced experimental periodontitis.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Qiu,W., Huang,L., Li,Y., Liu,Q. and Lv,Y.
  TITLE     Dysregulation of Angiopoietin-like-4 Associated with
            Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway
  JOURNAL   Curr Pharm Des 29 (4), 300-309 (2023)
   PUBMED   36537603
  REMARK    GeneRIF: Dysregulation of Angiopoietin-like-4 Associated with
            Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway.
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Shen,X., Zhang,Y., Lin,C., Weng,C., Wang,Y., Feng,S., Wang,C.,
            Shao,X., Lin,W., Li,B., Wang,H., Chen,J. and Jiang,H.
  TITLE     Calcineurin inhibitors ameliorate PAN-induced podocyte injury
            through the NFAT-Angptl4 pathway
  JOURNAL   J Pathol 252 (3), 227-238 (2020)
   PUBMED   32686149
  REMARK    GeneRIF: Calcineurin inhibitors ameliorate PAN-induced podocyte
            injury through the NFAT-Angptl4 pathway.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Guo,K., Pan,P., Wu,M., Ma,Y., Lu,J. and Chen,H.
  TITLE     Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes
            via beta1 Integrin/FAK signaling in diabetic nephropathy
  JOURNAL   Mol Cell Endocrinol 505, 110730 (2020)
   PUBMED   31981598
  REMARK    GeneRIF: Hyposialylated angiopoietin-like-4 induces apoptosis of
            podocytes via beta1 Integrin/FAK signaling in diabetic nephropathy.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Yang,X., Cao,J., Du,Y., Gong,Q., Cheng,Y. and Su,G.
  TITLE     Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment
            Epithelial Barrier Breakdown by Activating Signal Transducer and
            Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells
            Under Hypoxic Condition and Diabetic Rats
  JOURNAL   Med Sci Monit 25, 6742-6754 (2019)
   PUBMED   31494661
  REMARK    GeneRIF: ANGPTL4 partially modulates STAT3 and could serve as an
            effective diabetic retinopathy treatment strategy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Xu,A., Lam,M.C., Chan,K.W., Wang,Y., Zhang,J., Hoo,R.L., Xu,J.Y.,
            Chen,B., Chow,W.S., Tso,A.W. and Lam,K.S.
  TITLE     Angiopoietin-like protein 4 decreases blood glucose and improves
            glucose tolerance but induces hyperlipidemia and hepatic steatosis
            in mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 6086-6091 (2005)
   PUBMED   15837923
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Ge,H., Yang,G., Huang,L., Motola,D.L., Pourbahrami,T. and Li,C.
  TITLE     Oligomerization and regulated proteolytic processing of
            angiopoietin-like protein 4
  JOURNAL   J Biol Chem 279 (3), 2038-2045 (2004)
   PUBMED   14570927
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Yoshida,K., Shimizugawa,T., Ono,M. and Furukawa,H.
  TITLE     Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing
            factor in mice and inhibitor of lipoprotein lipase
  JOURNAL   J Lipid Res 43 (11), 1770-1772 (2002)
   PUBMED   12401877
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Yoon,J.C., Chickering,T.W., Rosen,E.D., Dussault,B., Qin,Y.,
            Soukas,A., Friedman,J.M., Holmes,W.E. and Spiegelman,B.M.
  TITLE     Peroxisome proliferator-activated receptor gamma target gene
            encoding a novel angiopoietin-related protein associated with
            adipose differentiation
  JOURNAL   Mol Cell Biol 20 (14), 5343-5349 (2000)
   PUBMED   10866690
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Kim,I., Kim,H.G., Kim,H., Kim,H.H., Park,S.K., Uhm,C.S., Lee,Z.H.
            and Koh,G.Y.
  TITLE     Hepatic expression, synthesis and secretion of a novel
            fibrinogen/angiopoietin-related protein that prevents
            endothelial-cell apoptosis
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 603-610 (2000)
   PUBMED   10698685
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078944.1.
            
            On Aug 8, 2004 this sequence version replaced NM_199115.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078944.1, AY393999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1871
                     /gene="Angptl4"
                     /note="angiopoietin-like 4"
                     /db_xref="GeneID:362850"
                     /db_xref="RGD:735058"
     exon            1..455
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1358
                     /gene="Angptl4"
                     /note="angiopoietin-related protein 4; HFARP; hepatic
                     fibrinogen/angiopoietin-related protein; angiopoietin-like
                     protein 4"
                     /codon_start=1
                     /product="angiopoietin-related protein 4 precursor"
                     /protein_id="NP_954546.1"
                     /db_xref="GeneID:362850"
                     /db_xref="RGD:735058"
                     /translation="MRCAPTAGAALVLCAATAGLLSAQGRPAQPEPPRFASWDEMNLL
                     AHGLLQLGHGLREHVERTRGQLGALERRMAACGNACQGPKGTDPKDRVPEGQAPETLQ
                     SLQTQLKAQNSKIQQLFQKVAQQQRYLSKQNLRIQNLQSQIDLLTPTHLDNGVDKTSR
                     GKRLPKMAQLIGLTPNATRLHRPPRDCQELFQEGERHSGLFQIQPLGSPPFLVNCEMT
                     SDGGWTVIQRRLNGSVDFNQSWEAYKDGFGDPQGEFWLGLEKMHSITGDRGSQLAVQL
                     QDWDGNAKLLQFPIHLGGEDTAYSLQLTEPTANELGATNVSPNGLSLPFSTWDQDHDL
                     RGDLNCAKSLSGGWWFGTCSHSNLNGQYFHSIPRQRQQRKKGIFWKTWKGRYYPLQAT
                     TLLIQPMEATAAS"
     exon            456..566
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     exon            567..684
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     exon            685..798
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     exon            799..894
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1176
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1846
                     /gene="Angptl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgcgat ctacaggctt tcttctgcac cagagcaagt ctaagtctga gccggcttcc
       61 ccagaactcc agctactggg tcttgaactc ctgcgtcccg aagtcctagc gttgctgcac
      121 ccaaggccat ccccggaatc atgcgctgcg ctccgaccgc aggcgctgct ctagtgctat
      181 gcgcagctac tgcggggctg ctgagcgcgc aagggcgccc tgcacagccg gagccgccgc
      241 gcttcgcatc ctgggatgaa atgaacttgc tggctcacgg gctgctgcag ctcggtcacg
      301 ggctgcggga acacgtggag cgcacccgtg gacagctggg cgcgctggaa cgccgcatgg
      361 ctgcctgcgg taacgcttgc caggggccca aggggacaga cccgaaggat agagtccccg
      421 aaggccaggc tcctgagact ctgcagagtt tacagactca actcaaggct cagaacagca
      481 agatccagca actgttccag aaggtagccc agcagcagag atacctatca aagcagaatc
      541 tgagaataca gaatcttcag agccagattg acctcttgac ccccacacac ctagacaatg
      601 gggtagacaa gacttcgagg ggaaagaggc ttcccaagat ggcccagctc attggcttga
      661 ctcccaacgc cacccgctta cacaggcctc cccgggactg ccaggaactc tttcaagaag
      721 gggagcggca cagtggactt ttccagatcc agcctctggg atctccacca tttttggtca
      781 actgtgagat gacttcagat ggaggctgga cggtgattca gagacgcctg aacggctctg
      841 tggacttcaa tcagtcttgg gaagcctaca aagatggctt cggagatccc caaggcgagt
      901 tctggctggg cctagagaag atgcacagca tcacagggga ccgaggaagc cagttggctg
      961 tgcagctcca ggactgggat ggcaatgcca aattgctcca atttcctatc catttggggg
     1021 gtgaggacac agcctacagc ctgcagctca ccgagcccac ggccaatgag ctgggtgcca
     1081 ccaatgtttc ccccaatggc ctttccctgc ccttctctac ctgggaccaa gaccacgacc
     1141 tccgagggga ccttaactgt gccaagagcc tctctggtgg ctggtggttt ggcacctgca
     1201 gccattccaa tctaaatgga caatacttcc actctattcc acggcaacgg cagcagcgta
     1261 aaaaggggat cttctggaaa acatggaagg gccgctacta tccactacag gctaccaccc
     1321 tgttgatcca gcccatggag gctacagcag cctcctagcc tcctcactgg agcctggttc
     1381 caggcctaag aagacagtga ctttggttgt gaccttaaga tatggctgtt ttctgctgag
     1441 agcaggagct ctaagtaggg ctatctggag tctcgtggac agagaagaag cccataactg
     1501 gagtgactgg aggacccctt ttccgtgttg gggtctgcaa gcactgttgt ctgaaacagt
     1561 cagagcaaca ggaaacaaat ggcccagacc cagaaaacgt gggctcaagg ggcattgact
     1621 ctcacttctc gcctaccaga gaagttggag atgcagaggg accatttcag tccaactagc
     1681 tgggccctta atggcggact cggtcatatt gaccgactgg agatagggtt cccaggagcc
     1741 ctggatacac tcaatggtgc tcttgtgggt gctgtggatg aacaggtgcc aactgtggtt
     1801 ccaaggcaca gctcacaaca ttcttacaat aaaaacaacc tcagaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa a
//
