LOCUS       NM_001399252            1620 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus angiopoietin-like 3 (Angptl3), transcript variant
            1, mRNA.
ACCESSION   NM_001399252 XM_006238440
VERSION     NM_001399252.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Zhao,Y., Goto,M., Vaziri,N.D., Khazaeli,M., Liu,H., Farahanchi,N.,
            Khanifar,E., Farzaneh,T., Haslett,P.A., Moradi,H. and
            Soundarapandian,M.M.
  TITLE     RNA Interference Targeting Liver Angiopoietin-Like Protein 3
            Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of
            Pathologic Hypertriglyceridemia
  JOURNAL   J Pharmacol Exp Ther 376 (3), 428-435 (2021)
   PUBMED   33443084
  REMARK    GeneRIF: RNA Interference Targeting Liver Angiopoietin-Like Protein
            3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration
            of Pathologic Hypertriglyceridemia.
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Essalmani,R., Susan-Resiga,D., Chamberland,A., Asselin,M.C.,
            Canuel,M., Constam,D., Creemers,J.W., Day,R., Gauthier,D., Prat,A.
            and Seidah,N.G.
  TITLE     Furin is the primary in vivo convertase of angiopoietin-like 3 and
            endothelial lipase in hepatocytes
  JOURNAL   J Biol Chem 288 (37), 26410-26418 (2013)
   PUBMED   23918928
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Quagliarini,F., Wang,Y., Kozlitina,J., Grishin,N.V., Hyde,R.,
            Boerwinkle,E., Valenzuela,D.M., Murphy,A.J., Cohen,J.C. and
            Hobbs,H.H.
  TITLE     Atypical angiopoietin-like protein that regulates ANGPTL3
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19751-19756 (2012)
   PUBMED   23150577
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Sonnenburg,W.K., Yu,D., Lee,E.C., Xiong,W., Gololobov,G., Key,B.,
            Gay,J., Wilganowski,N., Hu,Y., Zhao,S., Schneider,M., Ding,Z.M.,
            Zambrowicz,B.P., Landes,G., Powell,D.R. and Desai,U.
  TITLE     GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition
            by angiopoietin-like 3 and angiopoietin-like 4
  JOURNAL   J Lipid Res 50 (12), 2421-2429 (2009)
   PUBMED   19542565
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Shimamura,M., Matsuda,M., Yasumo,H., Okazaki,M., Fujimoto,K.,
            Kono,K., Shimizugawa,T., Ando,Y., Koishi,R., Kohama,T., Sakai,N.,
            Kotani,K., Komuro,R., Ishida,T., Hirata,K., Yamashita,S.,
            Furukawa,H. and Shimomura,I.
  TITLE     Angiopoietin-like protein3 regulates plasma HDL cholesterol through
            suppression of endothelial lipase
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (2), 366-372 (2007)
   PUBMED   17110602
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Inaba,T., Matsuda,M., Shimamura,M., Takei,N., Terasaka,N., Ando,Y.,
            Yasumo,H., Koishi,R., Makishima,M. and Shimomura,I.
  TITLE     Angiopoietin-like protein 3 mediates hypertriglyceridemia induced
            by the liver X receptor
  JOURNAL   J Biol Chem 278 (24), 21344-21351 (2003)
   PUBMED   12672813
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Ando,Y., Shimizugawa,T., Takeshita,S., Ono,M., Shimamura,M.,
            Koishi,R. and Furukawa,H.
  TITLE     A decreased expression of angiopoietin-like 3 is protective against
            atherosclerosis in apoE-deficient mice
  JOURNAL   J Lipid Res 44 (6), 1216-1223 (2003)
   PUBMED   12671033
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Shimamura,M., Matsuda,M., Kobayashi,S., Ando,Y., Ono,M., Koishi,R.,
            Furukawa,H., Makishima,M. and Shimomura,I.
  TITLE     Angiopoietin-like protein 3, a hepatic secretory factor, activates
            lipolysis in adipocytes
  JOURNAL   Biochem Biophys Res Commun 301 (2), 604-609 (2003)
   PUBMED   12565906
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Shimizugawa,T., Ono,M., Shimamura,M., Yoshida,K., Ando,Y.,
            Koishi,R., Ueda,K., Inaba,T., Minekura,H., Kohama,T. and
            Furukawa,H.
  TITLE     ANGPTL3 decreases very low density lipoprotein triglyceride
            clearance by inhibition of lipoprotein lipase
  JOURNAL   J Biol Chem 277 (37), 33742-33748 (2002)
   PUBMED   12097324
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Camenisch,G., Pisabarro,M.T., Sherman,D., Kowalski,J., Nagel,M.,
            Hass,P., Xie,M.H., Gurney,A., Bodary,S., Liang,X.H., Clark,K.,
            Beresini,M., Ferrara,N. and Gerber,H.P.
  TITLE     ANGPTL3 stimulates endothelial cell adhesion and migration via
            integrin alpha vbeta 3 and induces blood vessel formation in vivo
  JOURNAL   J Biol Chem 277 (19), 17281-17290 (2002)
   PUBMED   11877390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006238440.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210243.1, SRR26643286.17051.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               JAXUCZ010000005.1  118818494-118819043
            551-661             JAXUCZ010000005.1  118819598-118819708
            662-776             JAXUCZ010000005.1  118820808-118820922
            777-890             JAXUCZ010000005.1  118821943-118822056
            891-986             JAXUCZ010000005.1  118822310-118822405
            987-1253            JAXUCZ010000005.1  118824571-118824837
            1254-1620           JAXUCZ010000005.1  118825165-118825531
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1620
                     /gene="Angptl3"
                     /note="angiopoietin-like 3"
                     /db_xref="GeneID:502970"
                     /db_xref="RGD:1564505"
     exon            1..550
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1423
                     /gene="Angptl3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angiopoietin-related protein 3"
                     /codon_start=1
                     /product="angiopoietin-related protein 3 isoform 1
                     precursor"
                     /protein_id="NP_001386181.1"
                     /db_xref="GeneID:502970"
                     /db_xref="RGD:1564505"
                     /translation="MHTIKLLLFVVPLVISSRVDPDLSPFDSVPSEPKSRFAMLDDVK
                     ILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQCFYDLSLQTNEIKEEEKELRRT
                     TSKLQVKNEEVKNMSLELNSKLESLLEEKMALQHRVRALEEQLTSLVQNPPGAREHPE
                     VTSLKSFVEQQDNSIRELLQSVEEQYKQLSQQHIQIKEIENQLRKTGIQEPTENSLYS
                     KPRAPRTTPPLHLKEAKNIEQDDLPADCSAIYNRGEHTSGVYTIRPSSSQVFNVYCDT
                     QSGTPRTLIQHRKDGSQNFNQTWENYEKGFGRLDGEFWLGLEKIYAIVKQSNYILRLE
                     LQDWKDSKHYAEYSFHLGNHETNYTLHVAEIAANIPEALPEHRDLMFSTWDHRAKGQL
                     YCPESYSGGWWFSDMCGENNLNGKYNKPRAKSKPERRRGISWRPRGGKLYSIKSSKMM
                     LQPTT"
     exon            551..661
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..776
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..890
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..986
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1253
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1620
                     /gene="Angptl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttaccgg aggaagacgt tccaaattgc ttgaaattga ataattgaaa caaaaatgca
       61 cacaattaag ctgctccttt ttgttgttcc tctagtaatt tcgtccagag ttgatccaga
      121 cctttcgcca tttgattctg taccgtcaga gccaaaatca agatttgcta tgttggatga
      181 tgtcaaaatt ttagccaatg gcctcctgca gctgggtcat ggtcttaaag attttgtcca
      241 taagacaaag ggacaaatta atgacatatt tcagaagctc aacatatttg atcagtgttt
      301 ttatgaccta tcacttcaaa ccaatgaaat caaagaagag gaaaaggagc taagaagaac
      361 cacatctaaa ctacaagtta aaaacgaaga ggtgaagaat atgtcacttg aactgaactc
      421 aaagcttgaa agtctactgg aggagaagat ggcgctccaa cacagagtca gggctttgga
      481 ggaacagctg accagcttgg ttcagaaccc gcctggggct cgggagcacc cagaggtaac
      541 gtcacttaaa agttttgtag aacagcaaga taacagcata agagaactcc tccagagtgt
      601 ggaagaacaa tataaacaac taagtcaaca gcacattcag ataaaagaaa tagaaaatca
      661 gctcagaaag actggcattc aagaacccac tgaaaattct ctttattcta aaccaagagc
      721 accaagaact actccccctc ttcatctgaa ggaagcaaaa aatatagaac aagatgatct
      781 gcctgctgac tgctctgcca tttataacag aggtgaacat acaagtggcg tgtatactat
      841 tagaccaagc agctctcaag tgtttaatgt ctactgtgac acccaatcag gcactccacg
      901 gacattaatt caacaccgga aagatggctc tcaaaacttc aaccaaacgt gggaaaacta
      961 cgaaaagggt tttgggaggc ttgatggaga attctggttg ggcctagaga agatctacgc
     1021 tatagtcaaa cagtctaact acatcttacg actggagcta caagactgga aggacagcaa
     1081 gcactatgct gaatattcct ttcatctggg caatcatgaa accaactaca cgctacatgt
     1141 ggctgagatt gctgccaata tccctgaggc cctaccagaa cacagagacc tgatgttttc
     1201 tacatgggat cacagagcaa agggacagct ctactgtcca gaaagttatt caggtggctg
     1261 gtggttcagt gacatgtgtg gagaaaacaa cctaaatggt aaatacaaca aacccagagc
     1321 caaatccaaa ccagagcgga gaagagggat ctcctggagg cctcggggcg gaaagctcta
     1381 ctctatcaaa tcatctaaaa tgatgctcca gccgaccacc taaggaagcg tcagctgaac
     1441 tgagacaaat taaaagacca acacattcaa tattaaaatc cgcccgcaca ctgtagtaca
     1501 gcaatctggt attaaatctt tagtggaaag cttaagaatt gaatttcaat taactttaaa
     1561 gtcattgtta agatcagata tcattgcatc aatataacac aatttatatt ttcaatcaaa
//
