LOCUS       NM_133569               2129 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus angiopoietin-like 2 (Angptl2), mRNA.
ACCESSION   NM_133569 XM_346650
VERSION     NM_133569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Yang,H., Liu,J., Chen,X. and Li,G.
  TITLE     Angptl2 gene knockdown is critical for abolishing angiotensin
            II-induced vascular smooth muscle cell proliferation and migration
  JOURNAL   Biochem Cell Biol 100 (1), 59-67 (2022)
   PUBMED   34860608
  REMARK    GeneRIF: Angptl2 gene knockdown is critical for abolishing
            angiotensin II-induced vascular smooth muscle cell proliferation
            and migration.
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Chen,W., Wang,J., Wang,X., Chang,P. and Liang,M.
  TITLE     Knockdown of hypoxia-inducible factor 1-alpha (HIF1alpha)
            interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate
            high glucose-triggered hypoxia/reoxygenation injury in
            cardiomyocytes
  JOURNAL   Bioengineered 13 (1), 1476-1490 (2022)
   PUBMED   34974813
  REMARK    GeneRIF: Knockdown of hypoxia-inducible factor 1-alpha (HIF1alpha)
            interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate
            high glucose-triggered hypoxia/reoxygenation injury in
            cardiomyocytes.
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Wang,D., Guo,Y., Chai,S., Shen,K., Li,Y. and Zhao,R.
  TITLE     Expression of angiopoietin-like protein 2 in ovarian tissue of rat
            polycystic ovarian syndrome model and its correlation study
  JOURNAL   Reprod Biol Endocrinol 18 (1), 94 (2020)
   PUBMED   32988397
  REMARK    GeneRIF: Expression of angiopoietin-like protein 2 in ovarian
            tissue of rat polycystic ovarian syndrome model and its correlation
            study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Yang,S., Zhang,J., Wang,S., Shi,J. and Zhao,X.
  TITLE     Knockdown of Angiopoietin-Like Protein 2 Ameliorates Diabetic
            Nephropathy by Inhibiting TLR4
  JOURNAL   Cell Physiol Biochem 43 (2), 685-696 (2017)
   PUBMED   28946139
  REMARK    GeneRIF: ANGPTL2 knockdown ameliorates Diabetic Nephropathy by
            inhibiting TLR4 expression, an observation contributing to a better
            understanding of Diabetic Nephropathy pathogenesis.
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Pan,Z., Shao,Y., Dong,W., Liu,C., Chen,Y., Jin,H., Tang,L., Qiu,J.
            and Su,L.
  TITLE     Xuebijing attenuates hypotension through the upregulation of
            angiotensin II type 1 receptor-associated protein 1 in rats
            suffering from heat stroke
  JOURNAL   Int J Mol Med 34 (6), 1699-1705 (2014)
   PUBMED   25270312
  REMARK    GeneRIF: Data indicate that AT1 receptor-associated protein 1
            (Arap1) were decreased during heatstroke (HS).
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133569.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159049.1, SRR26360172.2341161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000003.1  36914876-36915212
            338-1203            JAXUCZ010000003.1  36926564-36927429
            1204-1397           JAXUCZ010000003.1  36940465-36940658
            1398-1668           JAXUCZ010000003.1  36941921-36942191
            1669-2129           JAXUCZ010000003.1  36944255-36944715
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2129
                     /gene="Angptl2"
                     /note="angiopoietin-like 2"
                     /db_xref="GeneID:171100"
                     /db_xref="RGD:620004"
     exon            1..337
                     /gene="Angptl2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..1203
                     /gene="Angptl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1868
                     /gene="Angptl2"
                     /note="angiopoietin-related protein 2"
                     /codon_start=1
                     /product="angiopoietin-related protein 2 precursor"
                     /protein_id="NP_598253.2"
                     /db_xref="GeneID:171100"
                     /db_xref="RGD:620004"
                     /translation="MRPLCMTYWWLGLLATVGAATGPEADVEGAEDGSQREYIYLNRY
                     KRAGESPDKCTYTFIVPQQRVTGAICVNSKEPEVHLENRVHKQELELLNNELLKQKRQ
                     IETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLEN
                     RILNQTADMLQLASKYKDLEHKFQHLAMLAHNQSEVIAQLEEHCQRVPAARPVPQPPP
                     ATPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPSLPTMPALTSLPSSTDKPSGPWR
                     DCLQALEDGHSTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWE
                     TYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEY
                     YKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNG
                     VWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH"
     exon            1204..1397
                     /gene="Angptl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1668
                     /gene="Angptl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..2129
                     /gene="Angptl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgaggct gctgctgtcg gcctggggat ggaccccaag ccctgagtgg tgctgttgga
       61 cccaggacct gcaaggagca cgcactaagg cagctacgga ccacgctgtg agggagagca
      121 ggttgggagc agccccagtg acaccagagc cagcctcatc cctaagagct tctaagagca
      181 tagactgctg ccagctgagg ccagtaaggc agggctgctt ggcggccagt ccagcctaag
      241 actcgggacc tctcctggag gccacggcca ggctgtcccg ctgatggcac cgtgaagcat
      301 gtgagaccct gctccagggc caagcaggag agaagaggct ttcagagacc tcattcataa
      361 agaccaagga gcacactgca aggaccatga ggccactgtg tatgacctac tggtggcttg
      421 gactgctggc caccgtggga gctgctacag gcccagaggc tgatgttgag ggcgcagagg
      481 atggttcgca gagagagtac atttacctca acaggtacaa gagggcaggt gagtccccag
      541 acaagtgcac ctacactttc attgtgcccc agcagcgggt cacaggtgcc atttgtgtca
      601 actccaaaga gcccgaggtg cacctggaga accgtgtgca caagcaggag ctggagctgc
      661 tcaacaatga gctgcttaag cagaagcggc agatcgagac gctgcagcag ctggtagagg
      721 tagatggcgg catcgtgagc gaggtgaagc tgctgcgcaa ggagagccgc aacatgaact
      781 ctcgggtcac acagctgtac atgcagcttc tacacgagat cattcgcaag cgagacaatg
      841 cgctggagct ttcccagctg gagaacagga tcctgaacca gacagctgac atgctgcagc
      901 tggcgagcaa gtacaaggac ctggagcaca agttccagca cctggctatg ctggcacaca
      961 accaatcaga ggtcattgcc cagcttgaag agcactgcca acgtgtacct gcagccaggc
     1021 ctgtgcccca gccaccccca gccacgccac ctcgggtcta ccagccacca acctacaacc
     1081 gcatcatcaa ccagatctcc actaatgaga tccagagtga ccagaatctg aaggtgctgc
     1141 caccctccct gcccaccatg cctgccctta ccagtctccc atcttccact gataagccat
     1201 caggtccatg gagagattgt ctacaggccc tagaggatgg tcacagcacc agctccatct
     1261 acctggtgaa gccggagaat accaaccgcc ttatgcaggt gtggtgcgac cagagacatg
     1321 accctggggg ttggactgtc atccagagac gcctggatgg ctctgtcaac ttcttcagga
     1381 actgggagac ctataagcaa gggtttggga acatcgacgg cgaatactgg ctgggcctgg
     1441 agaacatcta ctggctgacg aaccaaggca actacaaatt gcttgtaacc atggaggact
     1501 ggtctggccg gaaggtcttt gcagagtatg ctagcttccg actggagcca gaaagcgagt
     1561 actataagct gcggctgggg cgttatcacg gcaacgcagg cgactccttt acctggcaca
     1621 acggcaaaca gttcaccacc ctggacaggg accatgatgt ctacacagga aactgtgccc
     1681 actatcagaa gggaggatgg tggtacaatg cctgtgctca ctccaacctc aatggggtct
     1741 ggtaccgtgg gggccattac cggagccgat accaggatgg ggtctactgg gctgagttcc
     1801 gaggaggatc ttactcactc aagaaggtgg tgatgatgat tcggcccaac cccaacactt
     1861 tccattaagc tctctctgcc tggccactta cggcattgcc agaagccatc ccaactgtgc
     1921 gacgtcagca cagctcttca ctggcccacc tcaggctggg aggacagagt gctggactct
     1981 gctctccaag tggctgtcag atgatggaga tgaaagggct tctctgcccc tcctgccttc
     2041 ttttacaccc agccatccct gtattccagg acaggacaga actgcaatct tccaatcagt
     2101 taagtcttaa taaaaatttc aactgccaa
//
