LOCUS       NM_001402356            2267 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus angiopoietin-like 1 (Angptl1), mRNA.
ACCESSION   NM_001402356
VERSION     NM_001402356.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Horton,B.N., Solanki,R.B., Rajneesh,K.F., Kulesza,P. and
            Ardelt,A.A.
  TITLE     Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent
            ependyma and adjacent blood vessels suggests functional
            relationships
  JOURNAL   J Histochem Cytochem 58 (1), 53-60 (2010)
   PUBMED   19786610
  REMARK    GeneRIF: No gross E2 effect on the ependymal pattern of Angpt1 or
            cerebral Angpt1 protein content is observed.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Valenzuela,D.M., Griffiths,J.A., Rojas,J., Aldrich,T.H.,
            Jones,P.F., Zhou,H., McClain,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Huang,T., Papadopoulos,N., Maisonpierre,P.C.,
            Davis,S. and Yancopoulos,G.D.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Kim,I., Kwak,H.J., Ahn,J.E., So,J.N., Liu,M., Koh,K.N. and Koh,G.Y.
  TITLE     Molecular cloning and characterization of a novel angiopoietin
            family protein, angiopoietin-3
  JOURNAL   FEBS Lett 443 (3), 353-356 (1999)
   PUBMED   10025962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.41611.1,
                                           SRR26643290.42561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               JAXUCZ010000013.1  71513347-71513648
            303-1147            JAXUCZ010000013.1  71518888-71519732
            1148-1341           JAXUCZ010000013.1  71527654-71527847
            1342-1612           JAXUCZ010000013.1  71529446-71529716
            1613-2267           JAXUCZ010000013.1  71531156-71531810
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2267
                     /gene="Angptl1"
                     /note="angiopoietin-like 1"
                     /db_xref="GeneID:679942"
                     /db_xref="RGD:1598128"
     exon            1..302
                     /gene="Angptl1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..1147
                     /gene="Angptl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1800
                     /gene="Angptl1"
                     /note="angiopoietin-related protein 1"
                     /codon_start=1
                     /product="angiopoietin-related protein 1 precursor"
                     /protein_id="NP_001389285.1"
                     /db_xref="GeneID:679942"
                     /db_xref="RGD:1598128"
                     /translation="MKTFVWILSVVLFLLGIGHCKGGQFKIKKTTQRRYPRATDGKEE
                     TKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQ
                     LVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNV
                     TTEMLKMATRYRELEVKYASLTDLVNNQSVMITVLEEQCLRLFSRQDPHVSPPLVQVV
                     PRHIPNSHQDTPGLLAGNEIQRDPGYPRDLMPPPDLATAPTKSPFKIPAVTFINEGPF
                     KDCQQAKEAGHSASGIYMIKPENSHGPVQLWCENSLDPGGWTVIQKRTDGSVNFFRNW
                     ENYKKGFGNIDGEYWLGLDNIYKLSNQDNYKLMIELEDWSEKKVYAEYSSFRLEPESD
                     YYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYTGNCAHFHKGGWWYNACAHSNLN
                     GVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMVKPID"
     exon            1148..1341
                     /gene="Angptl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1612
                     /gene="Angptl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..2267
                     /gene="Angptl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctggact gtgtggacag tctgtcggct gcagcgggtc actgcctttc cccacgcagc
       61 agacagcaca ggcacaatgc cttctcggct gcattagaga aagtccacag tcacaaatta
      121 cataggtggc ccaacaattc agtcaatcgg tgctgcaaag agacgttcct tactgcctgg
      181 attcaccggt cagaacaaaa atgcagttac cactgaagtc agagacgaac aaacttccac
      241 actgatctca gagagctcgg caaggacgca agctcacgga cacgcttttt tcaacaccaa
      301 agacgctgtg gtagaattca cttcaaaatg aagacttttg tctggatcct aagtgtggta
      361 ctcttcctac tgggcattgg tcactgcaaa ggaggacaat tcaaaataaa aaaaacaacc
      421 caaaggagat atccccgtgc tacagatggt aaagaggaaa caaagaaatg ttcatataca
      481 ttcttggtac ccgaacagaa aataacaggg ccaatctgtg tcaacaccaa aggtcaggat
      541 gcgggcacta ttaaagacat gatcaccagg atggaccttg agaacctgaa ggatgtgctc
      601 tctaggcaga aacgagagat agatgtcctg cagctggtgg tggatgtgga tgggaacatt
      661 gtgaatgagg tgaagctgct gagaaaggag agccggaaca tgaactccag agtcactcaa
      721 ctctatatgc agctactaca tgagatcatc cgtaagagag ataactcact cgaactttcc
      781 cagctggaaa acaaaatcct caatgtcacc acagaaatgc tcaagatggc aacacgatac
      841 cgggagctag aggtgaaata tgcttccttg actgatcttg tcaataacca gtctgtgatg
      901 atcactgtac tggaagagca gtgcttgagg ctattttccc gacaagaccc ccacgtgtct
      961 ccccctcttg tccaggtggt accacgacac attcctaaca gccaccagga cacccctggt
     1021 ctgctggcag gcaatgagat acagagggat ccaggttatc ccagagactt aatgccacca
     1081 cctgatctgg caacagctcc cacaaaaagc cctttcaaga ttccagcagt gactttcatc
     1141 aatgaaggac cattcaaaga ctgtcagcaa gcaaaagaag ccgggcactc agccagtggg
     1201 atttacatga ttaaacccga aaacagccac ggtccggtgc agttatggtg tgagaacagt
     1261 ctggaccctg ggggttggac tgttattcag aaaagaacag atggctctgt caatttcttc
     1321 agaaactggg aaaactataa gaaagggttt ggaaacattg atggagagta ctggcttgga
     1381 ctggataata tctacaagct tagtaatcaa gacaattata agctgatgat tgaattagaa
     1441 gactggagtg agaagaaggt ctatgcggaa tacagcagct ttcgcctgga gcctgaaagt
     1501 gactactaca gactgcgcct ggggacttac caggggaatg ctggggattc tatgatgtgg
     1561 cataatggta aacaattcac cacgctggac agagataaag atatgtatac aggaaactgc
     1621 gcccactttc ataaaggagg ctggtggtac aatgcctgtg cacactctaa cctcaacggt
     1681 gtatggtata gaggtggcca ttacagaagc aagcaccagg atggaatttt ctgggctgag
     1741 tacagaggcg ggtcctactc cttgagagca gtgcagatga tggtcaaacc cattgactga
     1801 cggctccaag taaatggcac agagcttcac gtccggttcc ccaagtctaa acatcatgtt
     1861 actttgcaca actcattttt acaggtacag tttgtaaaat acattgtact actataagaa
     1921 tgtatctgtg aatacagttc cattttcctt caacgtgcta cagaagatta ttcaagtcct
     1981 tgttatttta aaaattatat tgactgaata ttggtaaatg taaatatttg ccacaatctt
     2041 agctttattc tgaatcaaat ccaaatacat gttcaagata ctttgattta tttaaaaaaa
     2101 tataagactg ctctaatttc cactgaaaaa aatattttaa gagttcagcc aactagtgca
     2161 ttttatttat gaaaatacag acaggaaact agagaaaaaa tgtctagttt tgccactaga
     2221 aaatgttttc cactaaataa atctttaaaa taaaaattta aattgaa
//
