LOCUS       NM_001106526            2331 bp    mRNA    linear   ROD 23-MAY-2023
DEFINITION  Rattus norvegicus angiopoietin 4 (Angpt4), mRNA.
ACCESSION   NM_001106526 XM_001061004 XM_215890
VERSION     NM_001106526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Wu Z, Shi Y, Cui Y, Xing X, Zhang L, Liu D, Zhang Y, Dong J, Jin L,
            Pang M, Xiao RP, Zhu Z, Xiong JW, Tong X, Zhang Y, Wang S, Tang F
            and Zhang B.
  TITLE     Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM
            cellular coordination cascade during heart regeneration
  JOURNAL   Protein Cell 14 (5), 350-368 (2023)
   PUBMED   37155312
  REMARK    GeneRIF: Single-cell analysis reveals an Angpt4-initiated
            EPDC-EC-CM cellular coordination cascade during heart regeneration.
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Fouillade C, Baron-Menguy C, Domenga-Denier V, Thibault C, Takamiya
            K, Huganir R and Joutel A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Olsen MW, Ley CD, Junker N, Hansen AJ, Lund EL and Kristjansen PE.
  TITLE     Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid
            pressure
  JOURNAL   Neoplasia 8 (5), 364-372 (2006)
   PUBMED   16790085
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Saharinen P, Kerkela K, Ekman N, Marron M, Brindle N, Lee GM,
            Augustin H, Koh GY and Alitalo K.
  TITLE     Multiple angiopoietin recombinant proteins activate the Tie1
            receptor tyrosine kinase and promote its interaction with Tie2
  JOURNAL   J Cell Biol 169 (2), 239-243 (2005)
   PUBMED   15851516
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Lee HJ, Cho CH, Hwang SJ, Choi HH, Kim KT, Ahn SY, Kim JH, Oh JL,
            Lee GM and Koh GY.
  TITLE     Biological characterization of angiopoietin-3 and angiopoietin-4
  JOURNAL   FASEB J 18 (11), 1200-1208 (2004)
   PUBMED   15284220
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY,
            Kuriyama T, Cheng SH, Gregory RJ and Jiang C.
  TITLE     Hypoxia-inducible factor-1 mediates activation of cultured vascular
            endothelial cells by inducing multiple angiogenic factors
  JOURNAL   Circ Res 93 (7), 664-673 (2003)
   PUBMED   12958144
REFERENCE   7  (bases 1 to 2331)
  AUTHORS   Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H,
            McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T,
            Papadopoulos N, Maisonpierre PC, Davis S and Yancopoulos GD.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
REFERENCE   8  (bases 1 to 2331)
  AUTHORS   Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN and Koh GY.
  TITLE     Molecular cloning and characterization of a novel angiopoietin
            family protein, angiopoietin-3
  JOURNAL   FEBS Lett 443 (3), 353-356 (1999)
   PUBMED   10025962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474050.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061004.1, XM_215890.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2331
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /note="angiopoietin 4"
                     /db_xref="GeneID:296269"
                     /db_xref="RGD:1307539"
     exon            1..460
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1654
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /codon_start=1
                     /product="angiopoietin-4 precursor"
                     /protein_id="NP_001099996.1"
                     /db_xref="GeneID:296269"
                     /db_xref="RGD:1307539"
                     /translation="MLRPPAMLLDGLLLLATMAAAQHRGPEASGRRQIHRVQHGQCSY
                     TFVLPEPDICQLAPVAPEGLGGSNSLQRDLPAARHHLTDWRAQRAQRAQRVSQLEKIL
                     ENNTQWLLKLEQSIQMNLRSDLAQAQQHTIQNQTTTMLALGANLMNQTMAQTHKLTAV
                     EAQVLNHTSRVKTQMLESSLSTNKLERQMLMQSRELQRLQGRNRALETRLQALEAQHQ
                     AQLNSLQDKREQLQSLLGHQTGALANLKHSLRALSSNSSSLQQQQQQLMELVQRLVRI
                     VAQDQHPVSLKTPKPLFRDCAEIKRSGANTSGVYTIHGANMTKPLKVFCDMETDGGGW
                     TLIQRREDGSLNFQRTWEEYKEGFGNVAREHWLGNEAVHSLTSRTAYLLRVELHDWEG
                     HQTSIQYENFQLGSERQRYSLSVNDSSISARLKNSLAPQGTKFSTKDMDNDNCMCKCA
                     QMLSGGWWFDACGLSNLNGIYYPVHQHLHKINGIRWHYFRGPSYSLHGTRMMLRPMGA
                     "
     exon            461..616
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..738
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            739..977
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1093
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1195
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1362
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1493
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2331
                     /gene="Angpt4"
                     /gene_synonym="Agpt4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcacagcagt gagactttgc agccaggtct tcacaggccc cagctgcaca gcacatctgg
       61 gctggctgct ggtagttacc tgccctggta cctctgacaa gacctcctca tcaccgcttg
      121 gtctcggatg ctccgcccgc cagctatgct actagatggc ctcctcctgc tggccaccat
      181 ggctgcagcc cagcacagag ggccagaagc cagtgggcgc cgccagattc accgggtcca
      241 gcacggccag tgtagctaca cctttgtgct gcctgagcca gatatctgcc agctggcgcc
      301 ggtggcacct gagggtttgg ggggctccaa tagcctccag agggacttgc ctgccgcaag
      361 gcaccaccta acagactggc gagcccagcg ggcccagcgg gcccagcgtg tgagccagct
      421 ggagaagatt ctagagaata acactcagtg gctgctgaag ctggagcagt ccatccagat
      481 gaacttgagg tcagacctgg ctcaggccca acagcacaca atccagaacc agacgaccac
      541 catgctggca ctgggcgcca acctcatgaa ccagaccatg gctcagaccc acaagctgac
      601 tgctgtggag gcacaggtcc taaaccacac atctcgcgtg aagacccaaa tgctggagag
      661 ctcactgtcc accaacaagc tggagaggca gatgctgatg cagagccgcg agctgcagcg
      721 gctgcagggc cgcaacaggg ccctggagac caggctgcag gcattggagg cacagcatca
      781 ggcccagctt aacagcctcc aagacaagag ggaacaactg caaagcctcc tgggccatca
      841 gactggggcc ctggctaacc tgaagcacag tctgcgagcc ctcagcagca attccagctc
      901 cctgcagcag cagcagcagc agctgatgga gctggtacag cgcctggtgc ggattgtagc
      961 ccaggaccag cacccagttt ccttaaagac gcctaagccg ctgttccggg attgtgcaga
     1021 gatcaagcgc tctggagcca acaccagtgg tgtctatacc atccatgggg ccaacatgac
     1081 aaagcctctc aaggtgttct gtgacatgga gactgatgga ggtggctgga ccctcatcca
     1141 gcgcagggag gatggaagct tgaatttcca gaggacttgg gaggaataca aagagggttt
     1201 tggtaatgtg gctagagaac actggctggg caatgaggct gtgcacagcc tcaccagcag
     1261 aacggcctac ttgctacgtg tggagctgca tgactgggaa ggccaccaga cctccatcca
     1321 gtatgagaac ttccagctgg gcagcgagag gcagcggtac agcctctctg tgaatgacag
     1381 cagcatctca gcaaggctca agaacagcct ggctcctcag ggcaccaagt tcagtaccaa
     1441 agacatggac aatgataact gcatgtgcaa atgtgctcag atgctgtctg gagggtggtg
     1501 gtttgacgcc tgtggcctct ccaacctcaa cggcatctac tatccggttc atcaacactt
     1561 gcataagatc aatggcatcc gctggcacta cttccgaggc cccagctact cactgcatgg
     1621 cacacgcatg atgctgcggc caatgggtgc ctgacacaca gccctacaga gactgatgct
     1681 caaggaggat tctcaaccca gatggctctg tgcaagctgg atcctgccca gaagtcagtg
     1741 cccagggctc atcttgacat tccgggacac cagaaccagc ttatcttgca cctgaattat
     1801 gagagtcact tgcctccctg tgcccctcta gtgtgaaatg ctgggtgctt gaggcacctg
     1861 cctctgtggg acccatgctc ctgctgcatg caggggctcc ctgtcacggt ctgaggcaga
     1921 ctgaacttga cacctcagag ggaggggttg cagcaggcgg ggaaaatctt gcagactggg
     1981 gtgccctcct ccaggagcgt ctgagagacg atcctatccc ccttttataa tttcaagttt
     2041 ctctagcctt gagttgtctg aagacttcct tccaaggctg gtgaacactg ttcccacttc
     2101 cagcccccca gggctagcca ttatttccca gggctctgtg gctcctgggc ttcaatgact
     2161 gacagtcaga cctggtctct cggaggcttc tagaaatagg agaagggatc ctttcactcc
     2221 agtgtgccgt agagtgtgtt ccgtaggtac taaggctcct ctctaaggta ctttggatga
     2281 agtaagagag aaacagcagg ttaaataaag agaatagagt ttcttaacgg c
//
