LOCUS       NM_134454               2296 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus angiopoietin 2 (Angpt2), mRNA.
ACCESSION   NM_134454 XM_001065522 XM_344544
VERSION     NM_134454.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Cabrera-Becerra,S.E., Vera-Juarez,G., Garcia-Rubio,V.G.,
            Ocampo-Ortega,S.A., Blancas-Napoles,C.M., Aguilera-Mendez,A.,
            Romero-Nava,R., Huang,F., Hong,E. and Villafana,S.
  TITLE     siRNA knockdown of angiopoietin 2 significantly reduces
            neovascularization in diabetic rats
  JOURNAL   J Drug Target 30 (6), 673-686 (2022)
   PUBMED   35289235
  REMARK    GeneRIF: siRNA knockdown of angiopoietin 2 significantly reduces
            neovascularization in diabetic rats.
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Smadja,D.M., Guerin,C.L., Chocron,R., Yatim,N., Boussier,J.,
            Gendron,N., Khider,L., Hadjadj,J., Goudot,G., Debuc,B., Juvin,P.,
            Hauw-Berlemont,C., Augy,J.L., Peron,N., Messas,E., Planquette,B.,
            Sanchez,O., Charbit,B., Gaussem,P., Duffy,D., Terrier,B.,
            Mirault,T. and Diehl,J.L.
  TITLE     Angiopoietin-2 as a marker of endothelial activation is a good
            predictor factor for intensive care unit admission of COVID-19
            patients
  JOURNAL   Angiogenesis 23 (4), 611-620 (2020)
   PUBMED   32458111
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Swiatlowska,P., Sanchez-Alonso,J.L., Mansfield,C., Scaini,D.,
            Korchev,Y., Novak,P. and Gorelik,J.
  TITLE     Short-term angiotensin II treatment regulates cardiac nanomechanics
            via microtubule modifications
  JOURNAL   Nanoscale 12 (30), 16315-16329 (2020)
   PUBMED   32720664
  REMARK    GeneRIF: Short-term angiotensin II treatment regulates cardiac
            nanomechanics via microtubule modifications.
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Xu,J., Yang,G., Li,T. and Liu,L.
  TITLE     Myoendothelial gap junctions mediate regulation of
            angiopoietin-2-induced vascular hyporeactivity after hypoxia
            through connexin 43-gated cAMP transfer
  JOURNAL   Am J Physiol Cell Physiol 313 (3), C262-C273 (2017)
   PUBMED   28637680
  REMARK    GeneRIF: Based on these findings, we propose that Cx43 was the Cx
            isoform involved in MEGJ-mediated VEC-dependent regulation of
            Ang-2, which induces iNOS protein expression and vascular
            hyporeactivity after hypoxia.
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Morooka,N., Futaki,S., Sato-Nishiuchi,R., Nishino,M., Totani,Y.,
            Shimono,C., Nakano,I., Nakajima,H., Mochizuki,N. and Sekiguchi,K.
  TITLE     Polydom Is an Extracellular Matrix Protein Involved in Lymphatic
            Vessel Remodeling
  JOURNAL   Circ Res 120 (8), 1276-1288 (2017)
   PUBMED   28179430
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Holash,J., Maisonpierre,P.C., Compton,D., Boland,P.,
            Alexander,C.R., Zagzag,D., Yancopoulos,G.D. and Wiegand,S.J.
  TITLE     Vessel cooption, regression, and growth in tumors mediated by
            angiopoietins and VEGF
  JOURNAL   Science 284 (5422), 1994-1998 (1999)
   PUBMED   10373119
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Takakura,N., Huang,X.L., Naruse,T., Hamaguchi,I., Dumont,D.J.,
            Yancopoulos,G.D. and Suda,T.
  TITLE     Critical role of the TIE2 endothelial cell receptor in the
            development of definitive hematopoiesis
  JOURNAL   Immunity 9 (5), 677-686 (1998)
   PUBMED   9846489
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Mandriota,S.J. and Pepper,M.S.
  TITLE     Regulation of angiopoietin-2 mRNA levels in bovine microvascular
            endothelial cells by cytokines and hypoxia
  JOURNAL   Circ Res 83 (8), 852-859 (1998)
   PUBMED   9776732
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Witzenbichler,B., Maisonpierre,P.C., Jones,P., Yancopoulos,G.D. and
            Isner,J.M.
  TITLE     Chemotactic properties of angiopoietin-1 and -2, ligands for the
            endothelial-specific receptor tyrosine kinase Tie2
  JOURNAL   J Biol Chem 273 (29), 18514-18521 (1998)
   PUBMED   9660821
REFERENCE   10 (bases 1 to 2296)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., McClain,J.,
            Aldrich,T.H., Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and
            Yancopoulos,G.D.
  TITLE     Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo
            angiogenesis
  JOURNAL   Science 277 (5322), 55-60 (1997)
   PUBMED   9204896
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161931.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_344544.3, XM_001065522.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2296
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /note="angiopoietin 2"
                     /db_xref="GeneID:89805"
                     /db_xref="RGD:621861"
     exon            1..359
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1562
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /codon_start=1
                     /product="angiopoietin-2 precursor"
                     /protein_id="NP_604449.1"
                     /db_xref="GeneID:89805"
                     /db_xref="RGD:621861"
                     /translation="MWQIVFLTFGCDLVLASAYNNFRKSVDSTGRRQYQVQNGPCSYT
                     FLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQ
                     DNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQL
                     LQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHSVQLQSMKEQKDQLQV
                     LVSKQSSVIDELEKKLVTATVNNSVLQKQQHDLMETVNSLLTMMSSPDYKSSVAVPKE
                     EKTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEVKAYCDMDMGGGGWTVIQHREDGSVD
                     FQRTWKEYKEGFGSPLGEYWLGNEFVSQLTSGHRYVLKIQLKDWEGSEAHSLYEHFYL
                     SGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLTGGWWFDAC
                     GPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF"
     exon            360..515
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..637
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..870
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1001
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1103
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1270
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1401
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2270
                     /gene="Angpt2"
                     /gene_synonym="Agpt2; Ang-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagggctc aggactccta tgtgcctgca agtttgctga actcacagtt tagaacccaa
       61 agagagaaag aatgtggcag attgttttcc taacttttgg ctgtgatctt gtcttggcct
      121 cagcctacaa taactttagg aagagcgtgg acagcacggg caggaggcag taccaggtcc
      181 agaacggacc ctgcagctac acattcctgc tgccggagac cgacagctgc cgatcttcct
      241 ccagccccta catgtctaac gccgtgcaga gggatgcacc cctcgactac gacgactcag
      301 tgcaaaggct gcaggtgctg gagaacattc tagagaacaa cacacagtgg ctgatgaagc
      361 tggagaacta catccaggac aacatgaaga aggagatggt ggagatccag cagaatgtgg
      421 tgcagaacca gacggctgtg atgatcgaga ttggaaccag tttgctcaac cagacggcgg
      481 cacaaactcg gaaactgact gatgtggaag cccaagtact aaaccagacg acaagactcg
      541 agttgcagct tcttcaacat tctatttcta ccaacaaatt ggaaaagcag attttggacc
      601 agaccagtga aataaacaaa ctacaagata agaacagctt cctagaaaag aaagtgctgg
      661 acatggagga caagcacagt gtgcagctgc agtccatgaa ggagcagaag gaccagcttc
      721 aggtgctggt gtccaagcag agctccgtca tcgatgagct ggagaagaag ctggtgacgg
      781 ccacagtcaa caactcagtc cttcagaagc agcagcatga tctaatggag acggtcaaca
      841 gcttgctgac catgatgtca tcgcccgact ataagagctc tgttgctgtc cctaaagaag
      901 agaaaaccac cttcagagac tgtgcagaaa tcttcaagtc aggactcacc accagtggca
      961 tctacacgct gaccttcccc aactccacag aggaggtcaa ggcctactgt gacatggaca
     1021 tgggtggagg agggtggacg gtcatccaac accgggaaga tggcagcgtt gacttccaga
     1081 gaacgtggaa agagtacaaa gagggcttcg ggagccctct gggagagtat tggctgggca
     1141 acgagtttgt ctcccagctg accagtgggc atcgctacgt gctgaagatc cagctgaagg
     1201 actgggaagg cagcgaggca cactctctgt atgagcactt ctacctgtcc ggcgaggagt
     1261 ccaactacag gattcacctt acaggactca caggcacggc gggcaaaatc agtagcatca
     1321 gccaaccagg aagtgatttt agcacaaagg attcggacaa tgacaaatgc atctgcaagt
     1381 gttcccagat gctcacagga ggctggtggt tcgacgcatg tggtccttcc aacttgaatg
     1441 gacagtacta cccacaaaag cagaatacga ataagttcaa cggtatcaag tggtactact
     1501 ggaaggggtc cggttactcg ctcaaggcca cgaccatgat gatccggcca gcagatttct
     1561 aaatgcctgc ctacattatc agaagaactt gctgcatcca aagattaact ctgaggcact
     1621 gagagacacc aatgcacagt agccccttcc cacatcagga ggtgctcctg ggggcggggg
     1681 aggatctgtg tgttccagac tgacgcacat cacttaggcc tgcaccgcta accaaccaaa
     1741 ggagacccaa aggcactgcg ggtctggaga aatacctatg agaaggccat ggttagaatc
     1801 acagggacag catgcattcg gactctgtca caagcaagaa tgttacgtgg gagttcatca
     1861 gtaaataact ggaaaacaga accctcagat ggtgcagata aatcccggga ccacattact
     1921 cggagcacgt ttctacagtg tacacagaca cagctcagct gtcctggaac cacagcagtc
     1981 agtctccagg gacttctaag tagtggttac aggttatcat ctggataagc acagttcgtt
     2041 gttccgtctt gtgcttgaca tgttcatttg gaaacaacac atttacctat ctgacggctt
     2101 agtttttaat ggctggacac tattactata cggcaaaaat gcctacatct ctggagtagc
     2161 caccaagcgg gcgccatgtc agtgcatgtg gagactgtac tgtttttgtt ttctttctgg
     2221 ctgttaaata tgaaggtatt tttagtaatt aaatataagt tattagctga aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaa
//
