LOCUS       NM_053546               1890 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus angiopoietin 1 (Angpt1), mRNA.
ACCESSION   NM_053546 XM_346797
VERSION     NM_053546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Zhong,Z., Li,H.Y., Zhong,H., Lin,W., Lin,S. and Zhou,T.
  TITLE     All-trans retinoic acid regulating angiopoietins-1 and alleviating
            extracellular matrix accumulation in interstitial fibrosis rats
  JOURNAL   Ren Fail 43 (1), 658-663 (2021)
   PUBMED   33820492
  REMARK    GeneRIF: All-trans retinoic acid regulating angiopoietins-1 and
            alleviating extracellular matrix accumulation in interstitial
            fibrosis rats.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Moxon,J.V., Trollope,A.F., Dewdney,B., de Hollander,C.,
            Nastasi,D.R., Maguire,J.M. and Golledge,J.
  TITLE     The effect of angiopoietin-1 upregulation on the outcome of acute
            ischaemic stroke in rodent models: A meta-analysis
  JOURNAL   J Cereb Blood Flow Metab 39 (12), 2343-2354 (2019)
   PUBMED   31581897
  REMARK    GeneRIF: published rodent data suggest that angiopoietin-1
            upregulation improves outcome following temporary cerebral
            ischaemia by reducing cerebral infarction size and improving
            blood-brain barrier integrity.
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Li,S., Zou,H., Gong,M., Chen,Y., Yan,X., Yu,L. and Yang,Y.
  TITLE     Angiopoietin-1 Promotes the Integrity of Neovascularization in the
            Subcutaneous Matrigel of Type 1 Diabetic Rats
  JOURNAL   Biomed Res Int 2019, 2016972 (2019)
   PUBMED   30729120
  REMARK    GeneRIF: Hyperglycemia could induce pathological angiogenesis in
            subcutaneous Matrigel of diabetic rats, and Ang-1 could upregulate
            the expression of intercellular junction protein in subcutaneous
            Matrigel of diabetic rats and promote the integrity of
            neovascularization in the subcutaneous Matrigel of diabetic rats
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Sabirzhanov,B., Faden,A.I., Aubrecht,T., Henry,R., Glaser,E. and
            Stoica,B.A.
  TITLE     MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates
            Neuronal Cell Death
  JOURNAL   J Neurotrauma 35 (20), 2462-2481 (2018)
   PUBMED   29774773
  REMARK    GeneRIF: miR-711-dependent downregulation of Ang-1...may play a
            role in neuronal cell death after neuronal injury in vitro and
            after experimental traumatic brain injury.
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Lu,Z., Wang,Q., Chen,C., Gao,Y., He,J., Liu,W., Li,Z. and Zhao,Z.
  TITLE     Overexpression of Angiopoietin-1 Potentiates Endothelial Progenitor
            Cells for the Treatment of Aneurysm
  JOURNAL   Ann Vasc Surg 48, 214-221 (2018)
   PUBMED   29197611
  REMARK    GeneRIF: Overexpression of Ang-1 enhanced the tube formation,
            migration, and proliferation ability of endothelial progenitor
            cells. EPC transplantation facilitated occlusion of carotid
            aneurysms.
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Mandriota,S.J. and Pepper,M.S.
  TITLE     Regulation of angiopoietin-2 mRNA levels in bovine microvascular
            endothelial cells by cytokines and hypoxia
  JOURNAL   Circ Res 83 (8), 852-859 (1998)
   PUBMED   9776732
REFERENCE   7  (bases 1 to 1890)
  AUTHORS   Witzenbichler,B., Maisonpierre,P.C., Jones,P., Yancopoulos,G.D. and
            Isner,J.M.
  TITLE     Chemotactic properties of angiopoietin-1 and -2, ligands for the
            endothelial-specific receptor tyrosine kinase Tie2
  JOURNAL   J Biol Chem 273 (29), 18514-18521 (1998)
   PUBMED   9660821
REFERENCE   8  (bases 1 to 1890)
  AUTHORS   Koblizek,T.I., Weiss,C., Yancopoulos,G.D., Deutsch,U. and Risau,W.
  TITLE     Angiopoietin-1 induces sprouting angiogenesis in vitro
  JOURNAL   Curr Biol 8 (9), 529-532 (1998)
   PUBMED   9560344
REFERENCE   9  (bases 1 to 1890)
  AUTHORS   Suri,C., Jones,P.F., Patan,S., Bartunkova,S., Maisonpierre,P.C.,
            Davis,S., Sato,T.N. and Yancopoulos,G.D.
  TITLE     Requisite role of angiopoietin-1, a ligand for the TIE2 receptor,
            during embryonic angiogenesis
  JOURNAL   Cell 87 (7), 1171-1180 (1996)
   PUBMED   8980224
REFERENCE   10 (bases 1 to 1890)
  AUTHORS   Davis,S., Aldrich,T.H., Jones,P.F., Acheson,A., Compton,D.L.,
            Jain,V., Ryan,T.E., Bruno,J., Radziejewski,C., Maisonpierre,P.C.
            and Yancopoulos,G.D.
  TITLE     Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by
            secretion-trap expression cloning
  JOURNAL   Cell 87 (7), 1161-1169 (1996)
   PUBMED   8980223
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053546.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB080023.1, SRR26643290.26249.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840108,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               JAXUCZ010000007.1  75668109-75668696   c
            589-744             JAXUCZ010000007.1  75524951-75525106   c
            745-866             JAXUCZ010000007.1  75513701-75513822   c
            867-1096            JAXUCZ010000007.1  75498546-75498775   c
            1097-1224           JAXUCZ010000007.1  75479656-75479783   c
            1225-1326           JAXUCZ010000007.1  75471217-75471318   c
            1327-1493           JAXUCZ010000007.1  75462824-75462990   c
            1494-1624           JAXUCZ010000007.1  75436654-75436784   c
            1625-1890           JAXUCZ010000007.1  75418218-75418483   c
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..1890
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /note="angiopoietin 1"
                     /db_xref="GeneID:89807"
                     /db_xref="RGD:628896"
     exon            1..588
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1785
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /codon_start=1
                     /product="angiopoietin-1 precursor"
                     /protein_id="NP_445998.2"
                     /db_xref="GeneID:89807"
                     /db_xref="RGD:628896"
                     /translation="MTVFLSFAFFAAILTHIGCSNQRRSPENGGRRYNRIQHGQCAYT
                     FILPEHDGNCRESATEQYNTNALQRDAPHVETDFSSQKLQHLEHVMENYTQWLQKLEN
                     YIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLE
                     IQLLENSLSTYKLEKQLLQQTNEILKIQEKNSLLEHKILEMEGKHKEELDTLKEEKEN
                     LQGLVTRQTFIIQELEKQLSRATNNNSVLQKQQLELMDTVHNLVSLCTKEVLLKGGKR
                     EEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNGGGWTVIQHREDGSL
                     DFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFH
                     IGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDA
                     CGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF"
     exon            589..744
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..866
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1096
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1224
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1326
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1493
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1624
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1890
                     /gene="Angpt1"
                     /gene_synonym="Agpt; Agpt1; Ang-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctccacg ctgaacggtt acacagagag gaaacaataa atctaagcta ctattgcaat
       61 aaatatctca agttttaacg aaggaaacta tcattacagt aattttttta agtaacgcgt
      121 tttagaacaa agctaacaaa tggctagttt tctgtggatc ttcttcaaat gctttcttta
      181 acggggagag cgtcaaacaa gcagttttac ctgaaataaa gaactagttt aaaggtcaga
      241 agagaggagc aagctttgca ggaggcacgg aaggcgagtg ctggcagtac aatgacagtt
      301 ttcctttcct ttgcattctt cgctgccatt ctgactcaca tagggtgcag caaccagcgc
      361 cggagtccag aaaacggagg gagaagatat aaccgaattc aacatgggca atgtgcctac
      421 actttcattc ttccagaaca cgacgggaac tgccgtgaga gtgcgacaga gcagtacaac
      481 accaacgctc tgcaaaggga tgctccacac gtggagacgg atttctcttc ccagaaactt
      541 cagcatctgg agcatgtgat ggaaaattat actcagtggc tgcaaaaact tgagaattac
      601 attgtggaaa atatgaagtc ggagatggcc cagatacaac agaatgcggt tcaaaaccac
      661 acggccacca tgctggagat aggaaccagc ctcttgtctc agactgcaga gcagacccga
      721 aagctcacag atgtggagac ccaggtacta aatcaaacat cccgtcttga aatccaactg
      781 ctggagaatt cattatcaac atacaagcta gagaaacagc ttctccaaca gacaaatgaa
      841 attctgaaga ttcaggaaaa aaacagttta ttagagcata aaatcctaga aatggaggga
      901 aaacacaagg aagagctgga caccttgaag gaggagaaag aaaaccttca aggcttggtt
      961 actcgtcaga cattcatcat ccaagaattg gagaagcaac ttagcagagc taccaacaac
     1021 aacagtgttc tgcagaagca acaactggag ctcatggaca cagtccataa ccttgtcagc
     1081 ctttgcacaa aagaagtttt gctaaaggga ggaaaaagag aagaagagaa accatttcga
     1141 gactgtgcag atgtatatca agctggtttt aataagagtg gaatctacac tatttatttt
     1201 aataatatgc cagaacccaa aaaggtattt tgcaatatgg atgtgaatgg aggaggatgg
     1261 acagtaatac aacaccgtga ggatggaagc ctagatttcc agaggggctg gaaggagtat
     1321 aaaatgggtt ttgggaatcc ctctggtgaa tattggcttg ggaacgagtt catttttgca
     1381 ataaccagtc agaggcagta catgctgagg atcgagctga tggactggga agggaaccga
     1441 gcctactcac agtacgacag attccacata ggaaacgaga agcagaacta caggttatat
     1501 ttaaagggtc acacggggac agcaggcaaa cagagcagct tgatcttaca tggtgctgat
     1561 ttcagcacaa aggacgctga taacgacaac tgtatgtgca aatgcgccct tatgctaaca
     1621 ggaggttggt ggtttgatgc ctgtggccct tccaatctaa acggaatgtt ctacactgcg
     1681 gggcaaaacc atggaaaact gaatgggata aagtggcact acttcaaagg acccagttac
     1741 tccttacgtt ccacaaccat gatgatccgg cccttggact tctgaaggcg ctatgccagt
     1801 attagaaacc tgaaaaacaa tctggggatg ttcccgaatg agaagctatc tggaagcttc
     1861 cgaaacaacc agcatcgtct cccttccagc
//
