LOCUS       NM_001100532            2681 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus anaphase promoting complex subunit 2 (Anapc2),
            mRNA.
ACCESSION   NM_001100532 XM_001072691 XM_215994
VERSION     NM_001100532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Kaur,I., Kaur,J., Sooraj,K., Goswami,S., Saxena,R., Chauhan,V.S.
            and Sihota,R.
  TITLE     Comparative evaluation of the aqueous humor proteome of primary
            angle closure and primary open angle glaucomas and age-related
            cataract eyes
  JOURNAL   Int Ophthalmol 39 (1), 69-104 (2019)
   PUBMED   29332228
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Wang,J., Yin,M.Z., Zhao,K.W., Ke,F., Jin,W.J., Guo,X.L., Liu,T.H.,
            Liu,X.Y., Gu,H., Yu,X.M., Li,Z., Mu,L.L., Hong,D.L., Chen,J. and
            Chen,G.Q.
  TITLE     APC/C is essential for hematopoiesis and impaired in aplastic
            anemia
  JOURNAL   Oncotarget 8 (38), 63360-63369 (2017)
   PUBMED   28968996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Rahimi,H., Ahmadzadeh,A., Yousef-amoli,S., Kokabee,L.,
            Shokrgozar,M.A., Mahdian,R. and Karimipoor,M.
  TITLE     The expression pattern of APC2 and APC7 in various cancer cell
            lines and AML patients
  JOURNAL   Adv Med Sci 60 (2), 259-263 (2015)
   PUBMED   26046517
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Ruis-Gonzalez,M.D., Canete,M.D., Gomez-Chaparro,J.L., Abril,N.,
            Canete,R. and Lopez-Barea,J.
  TITLE     Alterations of protein expression in serum of infants with
            intrauterine growth restriction and different gestational ages
  JOURNAL   J Proteomics 119, 169-182 (2015)
   PUBMED   25724728
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Almuriekhi,M., Shintani,T., Fahiminiya,S., Fujikawa,A.,
            Kuboyama,K., Takeuchi,Y., Nawaz,Z., Nadaf,J., Kamel,H., Kitam,A.K.,
            Samiha,Z., Mahmoud,L., Ben-Omran,T., Majewski,J. and Noda,M.
  TITLE     Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features
  JOURNAL   Cell Rep 10 (9), 1585-1598 (2015)
   PUBMED   25753423
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Hoogenraad,C.C., Feliu-Mojer,M.I., Spangler,S.A., Milstein,A.D.,
            Dunah,A.W., Hung,A.Y. and Sheng,M.
  TITLE     Liprinalpha1 degradation by calcium/calmodulin-dependent protein
            kinase II regulates LAR receptor tyrosine phosphatase distribution
            and dendrite development
  JOURNAL   Dev Cell 12 (4), 587-602 (2007)
   PUBMED   17419996
REFERENCE   7  (bases 1 to 2681)
  AUTHORS   Dube,P., Herzog,F., Gieffers,C., Sander,B., Riedel,D., Muller,S.A.,
            Engel,A., Peters,J.M. and Stark,H.
  TITLE     Localization of the coactivator Cdh1 and the cullin subunit Apc2 in
            a cryo-electron microscopy model of vertebrate APC/C
  JOURNAL   Mol Cell 20 (6), 867-879 (2005)
   PUBMED   16364912
REFERENCE   8  (bases 1 to 2681)
  AUTHORS   Bonner,A.E., Lemon,W.J., Devereux,T.R., Lubet,R.A. and You,M.
  TITLE     Molecular profiling of mouse lung tumors: association with tumor
            progression, lung development, and human lung adenocarcinomas
  JOURNAL   Oncogene 23 (5), 1166-1176 (2004)
   PUBMED   14647414
REFERENCE   9  (bases 1 to 2681)
  AUTHORS   Miura,K., Bowman,E.D., Simon,R., Peng,A.C., Robles,A.I.,
            Jones,R.T., Katagiri,T., He,P., Mizukami,H., Charboneau,L.,
            Kikuchi,T., Liotta,L.A., Nakamura,Y. and Harris,C.C.
  TITLE     Laser capture microdissection and microarray expression analysis of
            lung adenocarcinoma reveals tobacco smoking- and prognosis-related
            molecular profiles
  JOURNAL   Cancer Res 62 (11), 3244-3250 (2002)
   PUBMED   12036940
REFERENCE   10 (bases 1 to 2681)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166796.1.
            
            On or before Jun 1, 2008 this sequence version replaced
            XM_215994.4, XM_001072691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166796.1, FQ224461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2681
                     /gene="Anapc2"
                     /note="anaphase promoting complex subunit 2"
                     /db_xref="GeneID:296558"
                     /db_xref="RGD:1305546"
     exon            1..164
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2516
                     /gene="Anapc2"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 2"
                     /protein_id="NP_001094002.1"
                     /db_xref="GeneID:296558"
                     /db_xref="RGD:1305546"
                     /translation="MEAEGVAVSVAAAAAATTTIVATDDCDSRPGQELVVAWNTVSTG
                     LVPPAALGLASSRTSGAVPPKEEELRAAVEVLRAHGLHSVLEEWFVEVLQNDLQGNIA
                     TEFWNAISLRENSVDEPQCLVLLLDAFGLLESRLDPYLHSLELLEKWTRLGLLMGAGA
                     QGLREKVHTMLRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKRKGEGGTDPELEGELD
                     SRYARRRYYRLLQSPLCAGCGSDKQQCWCRQALEQFNQLSQVLHRLSLLERVSAEAVT
                     TTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDNPSRPTSPEAGNT
                     LRRWRCHVQRFFYRIYASLRIEELFSIIRDFPDSRPAIEDLKYCLERTDQRQQLLVSL
                     KVALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVR
                     QIVAGLTGDSDGTGDLAVELSKTDPACLETGQDSEDDSGEPEDWVPDPVDADPAKSSS
                     KRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEA
                     PMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLE
                     VPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLL
                     YFQDQASWTLEELSKVVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDN
                     MVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLERIYSMLRMFVMTG
                     PALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPKNCN"
     exon            165..787
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..920
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1095
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1215
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1333
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1515
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1657
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1733
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1937
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2067
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2303
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2667
                     /gene="Anapc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgatgga ggccgagggt gtggcggtat cggtggcggc ggcggcggcg gcgacaacga
       61 caattgtcgc cacggatgac tgcgactcta ggcctggaca ggagctcgtg gttgcctgga
      121 atactgtgag caccggtctg gtgccgccgg ctgcgctggg gctggcatct tcccggacca
      181 gcggtgcagt tccaccaaag gaggaagagc ttcgtgcagc ggtagaagtt ctgagggccc
      241 acggtctgca ctctgtcctg gaggagtggt tcgtggaagt gctgcagaat gaccttcaag
      301 gcaacattgc cacggagttc tggaatgcca tctcccttcg cgaaaactct gtcgatgaac
      361 cccaatgcct tgtgctgctc ctggatgcgt tcggtctgct ggaaagccgc ttggatccct
      421 atctgcatag cctagaactc ctagagaaat ggactcgtct gggcttgctg atgggcgctg
      481 gagctcaggg tcttcgggag aaagttcaca ctatgttgcg gggagtcctg tttttttcca
      541 cccctaggac attccaggag atggtccagc gcctctatgg tcgtttcctg agagtctata
      601 tgcagagcaa gagaaaagga gaagggggca cagatccaga actagaggga gagctggaca
      661 gccggtatgc ccgccgcagg tactaccgac ttttgcagag ccctctgtgt gcaggatgtg
      721 gcagtgacaa gcagcagtgc tggtgccggc aggccctgga gcagttcaac cagctcagcc
      781 aggtcctgca taggctcagt ctgctggagc gggttagcgc tgaggccgtg accaccaccc
      841 tgcatcaggt gacccgggaa aggatggaag accgctgccg aggagagtat gagcgctctt
      901 tcttgcgtga gttccacaag tggatcgaga gagtggttgg ttggcttggc aaagtgttcc
      961 ttcaggacaa ccccagcaga ccaacttctc cagaagctgg gaacacactg cgtcgttggc
     1021 gctgtcacgt acagagattc ttctaccgaa tctatgccag cctacgtatt gaggagcttt
     1081 tcagcatcat ccgagacttc ccagactctc ggccagccat tgaggacctt aagtactgct
     1141 tggagaggac ggatcagagg cagcagctcc tcgtgtccct caaagtggcc ctagagactc
     1201 gactcctcca cccaggtgtc aacacgtgtg acatcatcac actctacatt tctgccatca
     1261 aggcattacg tgtgctagat ccctctatgg tcatcctgga ggtggcctgt gagcccatcc
     1321 gtcgctacct gaggacacgg gaggacacag tacggcagat tgtggctggg ctaaccgggg
     1381 actcggatgg gactggggac ttggctgttg agctgtctaa gactgacccg gcctgcctgg
     1441 agaccggcca ggacagtgag gatgactctg gcgagcccga ggactgggtc cctgaccctg
     1501 tggatgctga tccagcaaag tcaagttcca agcgacgctc ttcagacatc atcagcctgc
     1561 tggtcagcat ctatggcagc aaagacctgt ttatcaatga gtaccgctcc ctcctggccg
     1621 atcgcctcct ccaccagttc agcttcagtc cggagaggga gattcgtaat gtggagctgt
     1681 tgaagctgcg ctttggagaa gcccccatgc acttctgtga ggtcatgctc aaggacatgg
     1741 cagattcccg ccgcatcaat gccaatatcc gtgaggagga tgagaagcgg cctgtggaag
     1801 aacagccacc atttggggtc tatgccgtca tattgtccag tgaattttgg cctcccttca
     1861 aagatgagaa gctggaggtc cctgaggaca tcagggcagc cctggatgtt tactgcaaga
     1921 agtatgagaa actgaaggct atgcggacac tcagttggaa gcataccctg ggcctggtga
     1981 cgatggacgt ggagctggct gaccgcaccc tgtctgttgc ggtcacccca gtgcaggcag
     2041 tggttttgct gtatttccag gaccaagcca gctggacctt ggaggagctg agcaaggtgg
     2101 tgaagatgcc cgtggcactc ctacgaagac gcatgtcagt gtggctgcag cagggtgtgc
     2161 tgcgggagga gcctcccggc actttctctg tcattgagga agagcggcct caggataggg
     2221 acaacatggt gctgattgac agtgatgatg aaagtgactc gggcatggcc tcccaggctg
     2281 accagaagga agaggagcta ctgctctttt ggacatacat ccaggccatg ttgaccaacc
     2341 tagagagcct ctctctggag cgcatctaca gcatgctccg aatgtttgta atgactggcc
     2401 ctgcactggc tgagattgac ctgcaggaac tacagggcta cttgcagaag aaggtccgag
     2461 accagcagct catctactct gcaggtgtct accgcctgcc taagaactgc aactgatgtt
     2521 ccccttccag gctctgacct gcagcattca tgcctgtgca acccctggat ggacagctag
     2581 ggtaccttct gtccccatgt tcctgtgccc agcccctacc tgttccctgc ctaacaccta
     2641 aagaacaaat taaagcatat tagctcaaaa aaaaaaaaaa a
//
