LOCUS       NP_001094002             836 aa            linear   ROD 03-APR-2024
DEFINITION  anaphase-promoting complex subunit 2 [Rattus norvegicus].
ACCESSION   NP_001094002 XP_001072691 XP_215994
VERSION     NP_001094002.1
DBSOURCE    REFSEQ: accession NM_001100532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Kaur,I., Kaur,J., Sooraj,K., Goswami,S., Saxena,R., Chauhan,V.S.
            and Sihota,R.
  TITLE     Comparative evaluation of the aqueous humor proteome of primary
            angle closure and primary open angle glaucomas and age-related
            cataract eyes
  JOURNAL   Int Ophthalmol 39 (1), 69-104 (2019)
   PUBMED   29332228
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Wang,J., Yin,M.Z., Zhao,K.W., Ke,F., Jin,W.J., Guo,X.L., Liu,T.H.,
            Liu,X.Y., Gu,H., Yu,X.M., Li,Z., Mu,L.L., Hong,D.L., Chen,J. and
            Chen,G.Q.
  TITLE     APC/C is essential for hematopoiesis and impaired in aplastic
            anemia
  JOURNAL   Oncotarget 8 (38), 63360-63369 (2017)
   PUBMED   28968996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Rahimi,H., Ahmadzadeh,A., Yousef-amoli,S., Kokabee,L.,
            Shokrgozar,M.A., Mahdian,R. and Karimipoor,M.
  TITLE     The expression pattern of APC2 and APC7 in various cancer cell
            lines and AML patients
  JOURNAL   Adv Med Sci 60 (2), 259-263 (2015)
   PUBMED   26046517
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Ruis-Gonzalez,M.D., Canete,M.D., Gomez-Chaparro,J.L., Abril,N.,
            Canete,R. and Lopez-Barea,J.
  TITLE     Alterations of protein expression in serum of infants with
            intrauterine growth restriction and different gestational ages
  JOURNAL   J Proteomics 119, 169-182 (2015)
   PUBMED   25724728
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Almuriekhi,M., Shintani,T., Fahiminiya,S., Fujikawa,A.,
            Kuboyama,K., Takeuchi,Y., Nawaz,Z., Nadaf,J., Kamel,H., Kitam,A.K.,
            Samiha,Z., Mahmoud,L., Ben-Omran,T., Majewski,J. and Noda,M.
  TITLE     Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features
  JOURNAL   Cell Rep 10 (9), 1585-1598 (2015)
   PUBMED   25753423
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Hoogenraad,C.C., Feliu-Mojer,M.I., Spangler,S.A., Milstein,A.D.,
            Dunah,A.W., Hung,A.Y. and Sheng,M.
  TITLE     Liprinalpha1 degradation by calcium/calmodulin-dependent protein
            kinase II regulates LAR receptor tyrosine phosphatase distribution
            and dendrite development
  JOURNAL   Dev Cell 12 (4), 587-602 (2007)
   PUBMED   17419996
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Dube,P., Herzog,F., Gieffers,C., Sander,B., Riedel,D., Muller,S.A.,
            Engel,A., Peters,J.M. and Stark,H.
  TITLE     Localization of the coactivator Cdh1 and the cullin subunit Apc2 in
            a cryo-electron microscopy model of vertebrate APC/C
  JOURNAL   Mol Cell 20 (6), 867-879 (2005)
   PUBMED   16364912
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Bonner,A.E., Lemon,W.J., Devereux,T.R., Lubet,R.A. and You,M.
  TITLE     Molecular profiling of mouse lung tumors: association with tumor
            progression, lung development, and human lung adenocarcinomas
  JOURNAL   Oncogene 23 (5), 1166-1176 (2004)
   PUBMED   14647414
REFERENCE   9  (residues 1 to 836)
  AUTHORS   Miura,K., Bowman,E.D., Simon,R., Peng,A.C., Robles,A.I.,
            Jones,R.T., Katagiri,T., He,P., Mizukami,H., Charboneau,L.,
            Kikuchi,T., Liotta,L.A., Nakamura,Y. and Harris,C.C.
  TITLE     Laser capture microdissection and microarray expression analysis of
            lung adenocarcinoma reveals tobacco smoking- and prognosis-related
            molecular profiles
  JOURNAL   Cancer Res 62 (11), 3244-3250 (2002)
   PUBMED   12036940
REFERENCE   10 (residues 1 to 836)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166796.1.
            
            On or before Jun 1, 2008 this sequence version replaced
            XP_215994.4, XP_001072691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166796.1, FQ224461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     Protein         1..836
                     /product="anaphase-promoting complex subunit 2"
                     /calculated_mol_wt=95242
     Region          <526..708
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          771..831
                     /region_name="APC2"
                     /note="Anaphase promoting complex (APC) subunit 2;
                     smart01013"
                     /db_xref="CDD:198081"
     CDS             1..836
                     /gene="Anapc2"
                     /coded_by="NM_001100532.1:6..2516"
                     /db_xref="GeneID:296558"
                     /db_xref="RGD:1305546"
ORIGIN      
        1 meaegvavsv aaaaaattti vatddcdsrp gqelvvawnt vstglvppaa lglassrtsg
       61 avppkeeelr aavevlrahg lhsvleewfv evlqndlqgn iatefwnais lrensvdepq
      121 clvllldafg llesrldpyl hslellekwt rlgllmgaga qglrekvhtm lrgvlffstp
      181 rtfqemvqrl ygrflrvymq skrkgeggtd pelegeldsr yarrryyrll qsplcagcgs
      241 dkqqcwcrqa leqfnqlsqv lhrlsllerv saeavtttlh qvtrermedr crgeyersfl
      301 refhkwierv vgwlgkvflq dnpsrptspe agntlrrwrc hvqrffyriy aslrieelfs
      361 iirdfpdsrp aiedlkycle rtdqrqqllv slkvaletrl lhpgvntcdi itlyisaika
      421 lrvldpsmvi levacepirr ylrtredtvr qivagltgds dgtgdlavel sktdpaclet
      481 gqdseddsge pedwvpdpvd adpakssskr rssdiisllv siygskdlfi neyrslladr
      541 llhqfsfspe reirnvellk lrfgeapmhf cevmlkdmad srrinanire edekrpveeq
      601 ppfgvyavil ssefwppfkd eklevpedir aaldvyckky eklkamrtls wkhtlglvtm
      661 dveladrtls vavtpvqavv llyfqdqasw tleelskvvk mpvallrrrm svwlqqgvlr
      721 eeppgtfsvi eeerpqdrdn mvlidsddes dsgmasqadq keeelllfwt yiqamltnle
      781 slsleriysm lrmfvmtgpa laeidlqelq gylqkkvrdq qliysagvyr lpkncn
//
