LOCUS       NM_031502               1575 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus amylase 2a3 (Amy2a3), mRNA.
ACCESSION   NM_031502
VERSION     NM_031502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Unno,T., Matsumoto,Y. and Yamamoto,Y.
  TITLE     Gallated form of tea catechin, not nongallated form, increases
            fecal starch excretion in rats
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 58 (1), 45-49 (2012)
   PUBMED   23007066
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Zhang,W., Wang,X.P., Yu,Z.W., Wang,L.S., Zhu,Y., Yu,X.F., Wu,K.,
            Zeng,Y. and Xu,M.Y.
  TITLE     Hyperlipidemic versus healthy pancreases: a proteomic analysis
            using an animal model
  JOURNAL   IUBMB Life 62 (10), 781-789 (2010)
   PUBMED   20981735
  REMARK    GeneRIF: Comparative proteomic analysis revealed that amylase
            levels were decreased by twofold in pancreases from hyperlipidemic
            rats compared with control rats.Pancreatic amylase protein levels
            were also decreased in tissue from hyperlipidemic rats.
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Nashida,T., Imai,A., Shimomura,H., Yoshie,S., Yokosuka,H. and
            Kumakura,M.
  TITLE     Unstimulated amylase secretion is proteoglycan-dependent in rat
            parotid acinar cells
  JOURNAL   Arch Biochem Biophys 469 (2), 165-173 (2008)
   PUBMED   17980695
  REMARK    GeneRIF: analysis of how amylase secretion is
            proteoglycan-dependent in rat parotid acinar cells
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Kleene,R., Classen,B., Zdzieblo,J. and Schrader,M.
  TITLE     SH3 binding sites of ZG29p mediate an interaction with amylase and
            are involved in condensation-sorting in the exocrine rat pancreas
  JOURNAL   Biochemistry 39 (32), 9893-9900 (2000)
   PUBMED   10933808
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   MacDonald,R.J., Crerar,M.M., Swain,W.F., Pictet,R.L. and
            Rutter,W.J.
  TITLE     Pancreas-specific genes: structure and expression
  JOURNAL   Cancer 47 (6 Suppl), 1497-1504 (1981)
   PUBMED   6168351
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   MacDonald,R.J., Crerar,M.M., Swain,W.F., Pictet,R.L., Thomas,G. and
            Rutter,W.J.
  TITLE     Structure of a family of rat amylase genes
  JOURNAL   Nature 287 (5778), 117-122 (1980)
   PUBMED   6159531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031502.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J00703.2, FQ233367.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760386,
                                           SAMEA5760400 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000002.1  204014229-204014412 c
            185-331             JAXUCZ010000002.1  204013750-204013896 c
            332-520             JAXUCZ010000002.1  204012807-204012995 c
            521-751             JAXUCZ010000002.1  204011882-204012112 c
            752-885             JAXUCZ010000002.1  204010128-204010261 c
            886-1008            JAXUCZ010000002.1  204009366-204009488 c
            1009-1108           JAXUCZ010000002.1  204009174-204009273 c
            1109-1227           JAXUCZ010000002.1  204007919-204008037 c
            1228-1353           JAXUCZ010000002.1  204007686-204007811 c
            1354-1575           JAXUCZ010000002.1  204005840-204006061 c
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1575
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /note="amylase 2a3"
                     /db_xref="GeneID:497039"
                     /db_xref="RGD:1593187"
     exon            1..184
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1543
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /EC_number="3.2.1.1"
                     /note="pancreatic alpha-amylase; pancreatic amylase; PA;
                     1,4-alpha-D-glucan glucanohydrolase; amylase 2,
                     pancreatic; pancreatic alpha-amylase-like"
                     /codon_start=1
                     /product="pancreatic alpha-amylase precursor"
                     /protein_id="NP_113690.2"
                     /db_xref="GeneID:497039"
                     /db_xref="RGD:1593187"
                     /translation="MKFVLLLSLIGFCWAQYDPHTADGRTAIVHLFEWRWADIAKECE
                     RYLAPKGFGGVQVSPPNENIIINNPSRPWWERYQPISYKICSRSGNENEFKDMVTRCN
                     NVGVRIYVDAVINHMCGSGNSAGTHSTCGSYFNPNNREFSAVPYSAWDFNDNKCNGEI
                     NNYNDANQVRNCRLSGLLDLALDKDYVRTKVADYMNNLIDIGVAGFRLDAAKHMWPGD
                     IKAVLDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAIKGSEYFGNGRVTEFKYGAKLGT
                     VIRKWNGEKMSYLKNWGEGWGFVPTDRALVFVDNHDNQRGHGAGGASILTFWDARMYK
                     MAVGFMLAHPYGFTRVMSSYRWARNFQNGKDVNDWIGPPNNNGVTKEVTINPDTTCGN
                     DWVCEHRWRQIRNMVAFRNVVNGQPFANWWDNGSNQVAFSRGNRGFIVFNNDDWALSS
                     TLQTGLPAGTYCDVISGDKVNGNCTGLKVNVGSDGKAHFSISNSAEDPFIAIHADSKL
                     "
     exon            185..331
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..520
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..751
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..885
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1008
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1108
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1227
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1353
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1575
                     /gene="Amy2a3"
                     /gene_synonym="Amy2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaacttcaa agcaaaatga agttcgttct gctgctttcc ctcattgggt tctgctgggc
       61 tcaatatgac ccacacactg cggatgggag gactgctatt gtccacctgt tcgagtggcg
      121 ctgggctgat attgccaagg aatgtgagcg gtacttagca cctaagggat ttggaggggt
      181 gcaggtctct ccacccaatg aaaatattat aattaataat ccatcaaggc cttggtggga
      241 aagatatcaa ccaatcagct acaaaatttg ctcaaggtct ggaaatgaaa atgaattcaa
      301 agacatggtg acgaggtgca acaatgttgg tgtccggatt tatgtggatg ctgtcattaa
      361 tcacatgtgt ggctcgggca atagtgcagg aacacacagt acctgtggaa gttacttcaa
      421 tcctaataac agggaattct cagcagttcc atactctgct tgggatttta acgataataa
      481 atgtaatgga gaaattaata actacaatga tgccaatcag gtcagaaatt gtcgtctgtc
      541 tggccttctg gatcttgcac tcgataaaga ttatgttcga accaaggtgg ctgactatat
      601 gaacaatctc attgacattg gtgtagcagg gttcagactt gatgctgcta agcacatgtg
      661 gcctggagac ataaaggcag ttttggacaa actacataat ctaaatacaa aatggttctc
      721 ccaaggaagc agacctttca ttttccaaga ggtcattgat cttggtggtg aagcaattaa
      781 aggtagtgag tactttggaa atggccgcgt gacagaattc aagtatggtg caaaacttgg
      841 cacagttatt cgcaaatgga atggagagaa gatgtcttac ttaaagaact ggggagaagg
      901 ttggggtttt gtgcctactg acagagccct tgtgtttgtg gacaaccatg acaatcagcg
      961 aggacatggt gctggaggag catccatcct gacattctgg gatgctagaa tgtataaaat
     1021 ggcagttgga tttatgttgg ctcatcctta tggattcacc agagtaatgt caagttaccg
     1081 atgggcaaga aatttccaga atggaaaaga tgtgaatgac tggattggac cacctaataa
     1141 caatggagta acaaaagaag tgaccattaa tccagacact acttgtggta atgactgggt
     1201 ctgtgaacat cgatggcgtc aaatcaggaa catggttgcc ttcaggaatg tagtcaacgg
     1261 tcagcctttt gcaaactggt gggataatgg cagcaaccaa gtggctttta gcagaggaaa
     1321 cagaggattc attgtcttta acaatgatga ctgggctttg tcaagcactc tacagactgg
     1381 tcttcctgct ggcacatact gtgatgtcat ttcaggagat aaagtcaatg gcaattgcac
     1441 tggacttaaa gtaaatgttg gcagtgatgg caaagctcac ttctctatta gtaactctgc
     1501 tgaagaccca ttcattgcaa tccatgccga ctcaaagttg taagagtcaa attaaagaga
     1561 tttagattga gcacc
//
