LOCUS       NM_001014004            2126 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus aminomethyltransferase (Amt), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001014004 XM_224997
VERSION     NM_001014004.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Okamura-Ikeda,K., Hosaka,H., Yoshimura,M., Yamashita,E., Toma,S.,
            Nakagawa,A., Fujiwara,K., Motokawa,Y. and Taniguchi,H.
  TITLE     Crystal structure of human T-protein of glycine cleavage system at
            2.0 A resolution and its implication for understanding non-ketotic
            hyperglycinemia
  JOURNAL   J Mol Biol 351 (5), 1146-1159 (2005)
   PUBMED   16051266
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Kure,S., Mandel,H., Rolland,M.O., Sakata,Y., Shinka,T., Drugan,A.,
            Boneh,A., Tada,K., Matsubara,Y. and Narisawa,K.
  TITLE     A missense mutation (His42Arg) in the T-protein gene from a large
            Israeli-Arab kindred with nonketotic hyperglycinemia
  JOURNAL   Hum Genet 102 (4), 430-434 (1998)
   PUBMED   9600239
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Kure,S., Shinka,T., Sakata,Y., Osamu,N., Takayanagi,M., Tada,K.,
            Matsubara,Y. and Narisawa,K.
  TITLE     A one-base deletion (183delC) and a missense mutation (D276H) in
            the T-protein gene from a Japanese family with nonketotic
            hyperglycinemia
  JOURNAL   J Hum Genet 43 (2), 135-137 (1998)
   PUBMED   9621520
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   Nanao,K., Okamura-Ikeda,K., Motokawa,Y., Danks,D.M.,
            Baumgartner,E.R., Takada,G. and Hayasaka,K.
  TITLE     Identification of the mutations in the T-protein gene causing
            typical and atypical nonketotic hyperglycinemia
  JOURNAL   Hum Genet 93 (6), 655-658 (1994)
   PUBMED   8005589
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Lowry,M., Hall,D.E. and Brosnan,J.T.
  TITLE     Increased activity of renal glycine-cleavage-enzyme complex in
            metabolic acidosis
  JOURNAL   Biochem J 231 (2), 477-480 (1985)
   PUBMED   3877504
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001014004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083803.1, SRR26360172.2174908.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000008.1  117860437-117860720
            285-452             JAXUCZ010000008.1  117860823-117860990
            453-533             JAXUCZ010000008.1  117861422-117861502
            534-665             JAXUCZ010000008.1  117862557-117862688
            666-744             JAXUCZ010000008.1  117864108-117864186
            745-890             JAXUCZ010000008.1  117864456-117864601
            891-1071            JAXUCZ010000008.1  117865005-117865185
            1072-1227           JAXUCZ010000008.1  117865540-117865695
            1228-2126           JAXUCZ010000008.1  117865794-117866692
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2126
                     /gene="Amt"
                     /note="aminomethyltransferase"
                     /db_xref="GeneID:306586"
                     /db_xref="RGD:1359408"
     exon            1..284
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1406
                     /gene="Amt"
                     /EC_number="2.1.2.10"
                     /note="aminomethyltransferase (glycine cleavage system
                     protein T)"
                     /codon_start=1
                     /product="aminomethyltransferase, mitochondrial"
                     /protein_id="NP_001014026.1"
                     /db_xref="GeneID:306586"
                     /db_xref="RGD:1359408"
                     /translation="MQRTVRVVAPLGFRLQAQPLVQSRPFSSVQDGLRRTPLYDFHLA
                     HGGKMVAFAGWSLPVQYRDSHVDSHLHTRRHCSLFDVSHMLQTKIFGCDRVRLMENIV
                     VGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCRDKDLALMQDKV
                     KEFQNRGLDVGLEVVDNALLALQGPTAAQVLQAGVTDDMRKLPFMTSAVMEVFGVSGC
                     RVTRCGYTGEDGVEISVPAAGAVHLATALLKNPEVKLAGLAARDSLRLEAGLCLYGND
                     IDEHTTPVEGSLSWTLGKRRRVAMDFPGAKIIIPQLKGEVQRRRVGLICEGAPMRAHS
                     PILNTEGAVIGTVTSGCPSPSLKKNVAMGYVAFKYSRPGTQLLVEVRRKQQMTVVSKM
                     PFVPTKYYTLK"
     exon            285..452
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            453..533
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            534..665
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            666..744
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            745..890
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1071
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1227
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..2126
                     /gene="Amt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgaggaa gagcctgagg ccatccagag tccgcctcag ttttaaatcc cagcctgccc
       61 tatgggcttc ccgccccttt cccatcccct tcagactaga aagacctgtc caagctgagg
      121 tttggactac atctcccagc gtgcctggca gagaagtggc ctcagtgtgc cggctgcacc
      181 agttgcgggt gacaatgcag cggacagtca gggtggtagc ccctctgggt tttcgccttc
      241 aggcacaacc cttggtccag agtcgtccat tcagttctgt acaggatgga ctccgcagga
      301 ctccactcta tgacttccac ctagcccatg gagggaaaat ggtggcgttt gcagggtgga
      361 gtctgcctgt gcaataccgg gacagtcatg ttgattcaca cctgcacaca cgccgtcact
      421 gctctctctt tgatgtgtcc cacatgctac agaccaagat atttggctgt gaccgagtga
      481 ggctgatgga gaatatagtg gttggagaca ttgcggaact aaggcctaac cagggaacgc
      541 tgtctctgtt tactaatgaa gctggaggca tcctagacga cttgattgtg accaatactt
      601 ctgaggggca cctgtatgta gtatccaatg ctggctgccg ggacaaggac ttggctctca
      661 tgcaggacaa ggtcaaggag ttccagaaca ggggccttga tgtaggcctg gaggtggtag
      721 ataatgccct gttagctctg caaggaccca ctgcagcaca ggtcttacag gctggggtga
      781 cagatgatat gaggaaactg cccttcatga ccagtgctgt gatggaggtg ttcggtgtgt
      841 ctggctgtcg tgtgacccgc tgtggctaca caggagagga tggtgttgag atatcagtgc
      901 cagcggcagg agcagtccac ttggccactg ctctgctgaa aaacccagag gtaaagctgg
      961 caggactagc agcccgagat agcctgcgcc tggaggctgg cctctgtctg tatgggaatg
     1021 acatcgatga acataccaca cctgtggagg gcagcctcag ctggacactg ggaaagcgcc
     1081 gccgagttgc tatggacttc ccaggagcca aaatcatcat cccccagctg aagggtgagg
     1141 tgcagaggcg acgtgtgggg ttgatatgcg aaggggctcc aatgagagca cacagtccta
     1201 ttttgaacac agaaggcgca gtgattggta cagtgaccag tggctgccct tcacccagcc
     1261 tgaagaagaa tgtggcgatg ggttatgtgg ccttcaagta cagtcggcca gggacacagc
     1321 tgctggtgga agttcggcgg aagcagcaaa tgacggtggt tagcaaaatg ccctttgtgc
     1381 ccacgaagta ctatactctc aagtgaaaca gcccatggaa aagcccgtcc tcccgcagtg
     1441 tttctctaga gggctttcca tagtgcttag tcagatcagt ggagtagcac cccctccccg
     1501 gcatggaagc tgaatgaggt ttgctgggtc tgcttagggg tgggggagag aatcccatct
     1561 agactctccc ttacgagcca ctccaatttt agggcccaat ttttcaatga tgaatcacca
     1621 tacttaatgt ttgtcctatt ttaagtccac aatcccacta accttcatct gcctggtgct
     1681 ggctatggaa caaaggtttg ctctgtgtgg aggataacac ctgtcccacc tacctcacta
     1741 tggcttccct aatttcaaag gactattact gtgggcagtg tgggcttagg caccttctcc
     1801 actttgcttt ccatgaatgt acactgaagc cttttcttag atagaaatga ctcctgactc
     1861 tgtgttggct gaggctgttc ctgtgtgcaa acacagggat ggctaagcaa acatgggact
     1921 cacccttcca cattcccaag tcaacccagc ctactgtgca gtcaagacat ggcagggtta
     1981 gtacttgcac tgacctcggt cggctgttgt cagtaattat actttactaa ctcttttttt
     2041 tttttccgga gctggggacc aaacctaggg ctaaatcccc aacccccttt actaactctt
     2101 gaaaattaaa gtttctttcc ttctta
//
