LOCUS       NM_031544               3919 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus adenosine monophosphate deaminase 3 (Ampd3),
            mRNA.
ACCESSION   NM_031544
VERSION     NM_031544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3919)
  AUTHORS   Osanami,A., Sato,T., Toda,Y., Shimizu,M., Kuno,A., Kouzu,H.,
            Yano,T., Ohwada,W., Ogawa,T., Miura,T. and Tanno,M.
  TITLE     Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca2+
            overload in type 2 diabetes rat hearts
  JOURNAL   J Diabetes Investig 14 (4), 560-569 (2023)
   PUBMED   36815317
  REMARK    GeneRIF: Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca[2+]
            overload in type 2 diabetes rat hearts.
REFERENCE   2  (bases 1 to 3919)
  AUTHORS   Tatekoshi,Y., Tanno,M., Kouzu,H., Abe,K., Miki,T., Kuno,A.,
            Yano,T., Ishikawa,S., Ohwada,W., Sato,T., Niinuma,T., Suzuki,H. and
            Miura,T.
  TITLE     Translational regulation by miR-301b upregulates AMP deaminase in
            diabetic hearts
  JOURNAL   J Mol Cell Cardiol 119, 138-146 (2018)
   PUBMED   29733818
  REMARK    GeneRIF: The results indicate that translational regulation by
            miR-301b mediates upregulated expression of cardiac AMPD3 protein
            in OLETF, which potentially reduces the adenine nucleotide pool at
            the time of increased work load. The miR-301b-AMPD3 axis may be a
            novel therapeutic target for intervening enegy metabolism in
            diabetic hearts.
REFERENCE   3  (bases 1 to 3919)
  AUTHORS   Rybakowska,I., Romaszko,P., Zabielska,M., Turyn,J., Kaletha,K.,
            Barton,P.J., Slominska,E.M. and Smolenski,R.T.
  TITLE     Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in
            heart and other organs
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 33 (4-6), 319-322 (2014)
   PUBMED   24940686
REFERENCE   4  (bases 1 to 3919)
  AUTHORS   Daniels,I.S., O Brien,W.G. 3rd, Nath,V., Zhao,Z. and Lee,C.C.
  TITLE     AMP deaminase 3 deficiency enhanced 5'-AMP induction of
            hypometabolism
  JOURNAL   PLoS One 8 (9), e75418 (2013)
   PUBMED   24066180
  REMARK    Erratum:[PLoS One. 2014;9(3):e91311]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3919)
  AUTHORS   Akizu,N., Cantagrel,V., Schroth,J., Cai,N., Vaux,K., McCloskey,D.,
            Naviaux,R.K., Van Vleet,J., Fenstermaker,A.G., Silhavy,J.L.,
            Scheliga,J.S., Toyama,K., Morisaki,H., Sonmez,F.M., Celep,F.,
            Oraby,A., Zaki,M.S., Al-Baradie,R., Faqeih,E.A., Saleh,M.A.,
            Spencer,E., Rosti,R.O., Scott,E., Nickerson,E., Gabriel,S.,
            Morisaki,T., Holmes,E.W. and Gleeson,J.G.
  TITLE     AMPD2 regulates GTP synthesis and is mutated in a potentially
            treatable neurodegenerative brainstem disorder
  JOURNAL   Cell 154 (3), 505-517 (2013)
   PUBMED   23911318
REFERENCE   6  (bases 1 to 3919)
  AUTHORS   Mahnke-Zizelman,D.K., D'cunha,J., Wojnar,J.M., Brogley,M.A. and
            Sabina,R.L.
  TITLE     Regulation of rat AMP deaminase 3 (isoform C) by development and
            skeletal muscle fibre type
  JOURNAL   Biochem J 326 (Pt 2) (Pt 2), 521-529 (1997)
   PUBMED   9291127
REFERENCE   7  (bases 1 to 3919)
  AUTHORS   Wang,X., Morisaki,H., Sermsuvitayawong,K., Mineo,I., Toyama,K.,
            Ogasawara,N., Mukai,T. and Morisaki,T.
  TITLE     Cloning and expression of cDNA encoding heart-type isoform of AMP
            deaminase
  JOURNAL   Gene 188 (2), 285-290 (1997)
   PUBMED   9133604
REFERENCE   8  (bases 1 to 3919)
  AUTHORS   Gross,M.
  TITLE     Molecular biology of AMP deaminase deficiency
  JOURNAL   Pharm World Sci 16 (2), 55-61 (1994)
   PUBMED   8032342
  REMARK    Review article
REFERENCE   9  (bases 1 to 3919)
  AUTHORS   Bausch-Jurken,M.T., Mahnke-Zizelman,D.K., Morisaki,T. and
            Sabina,R.L.
  TITLE     Molecular cloning of AMP deaminase isoform L. Sequence and
            bacterial expression of human AMPD2 cDNA
  JOURNAL   J Biol Chem 267 (31), 22407-22413 (1992)
   PUBMED   1429593
REFERENCE   10 (bases 1 to 3919)
  AUTHORS   Ashby,B. and Holmsen,H.
  TITLE     Platelet AMP deaminase. Purification and kinetic studies
  JOURNAL   J Biol Chem 256 (20), 10519-10523 (1981)
   PUBMED   7287721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031544.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90888.1, SRR26643295.3562.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000001.1  174320033-174320154
            123-348             JAXUCZ010000001.1  174329800-174330025
            349-550             JAXUCZ010000001.1  174341249-174341450
            551-710             JAXUCZ010000001.1  174343712-174343871
            711-930             JAXUCZ010000001.1  174346153-174346372
            931-1060            JAXUCZ010000001.1  174348283-174348412
            1061-1255           JAXUCZ010000001.1  174352946-174353140
            1256-1387           JAXUCZ010000001.1  174354718-174354849
            1388-1551           JAXUCZ010000001.1  174355336-174355499
            1552-1678           JAXUCZ010000001.1  174356037-174356163
            1679-1842           JAXUCZ010000001.1  174356983-174357146
            1843-1963           JAXUCZ010000001.1  174358141-174358261
            1964-2137           JAXUCZ010000001.1  174359937-174360110
            2138-2248           JAXUCZ010000001.1  174361959-174362069
            2249-3919           JAXUCZ010000001.1  174362930-174364600
FEATURES             Location/Qualifiers
     source          1..3919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..3919
                     /gene="Ampd3"
                     /note="adenosine monophosphate deaminase 3"
                     /db_xref="GeneID:25095"
                     /db_xref="RGD:2111"
     exon            1..122
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2425
                     /gene="Ampd3"
                     /EC_number="3.5.4.6"
                     /note="Ampd"
                     /codon_start=1
                     /product="AMP deaminase 3"
                     /protein_id="NP_113732.2"
                     /db_xref="GeneID:25095"
                     /db_xref="RGD:2111"
                     /translation="MRAPVCVGRGGKVIQGTSSTPGEHQRLLVGLATKTEMPRQFPKL
                     NMSDLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPEDCPIGQKEAKERELQKELAEQ
                     KSVETAKRKKSFKMIRSQSMSLQMPTQDWKGPPSVSPAMSPTTPLVLGAASKPGLAPY
                     DMPEYQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLAH
                     QGESVPLEEGLPDFHPPPLPQEDPYCLDNAPPNLGYLVRMQGGVLFVYDNQTMLERQE
                     PHSLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
                     KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKYTYQTEPDRTVAEKLGRKITLRQV
                     FDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEY
                     FARMVKEVARELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVP
                     RIYDIFRSKKLLPSFGKMLENIFLPLFQATINPQDHRELHLFLKYVTGFDSVDDESKH
                     SDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEA
                     GSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPL
                     REFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGL
                     SHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITA
                     LAD"
     exon            123..348
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..550
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..710
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..930
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1060
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1255
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1387
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1551
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1678
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1842
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1963
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2137
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2248
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..3919
                     /gene="Ampd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtgtgtg tgtgtgtaca tgcgcgcgcc cgtgtgtgtt gggaggggcg ggaaggtgat
       61 tcaagggacc agttcaacac ctggagaaca ccaacgcttg ctggtcggtt tagctaccaa
      121 gaccgagatg cctcgccaat tccccaagtt gaacatgtcc gatttggacg aacatgtccg
      181 gctgttggca gagaaggtgt tcgctaaggt gctccgagaa gaggacagca aagatgttat
      241 gtccctgttt actgtccccg aggactgtcc catcggacag aaggaagcca aggagaggga
      301 gctacagaag gagttggcag agcagaagtc tgtggagaca gcaaaaagaa agaagagttt
      361 caagatgatc cggtcgcagt ctatgtccct gcagatgcca acacaagact ggaaaggtcc
      421 tccatctgtc agtccggcca tgtctcctac aacccctctg gtccttggag ctgcttctaa
      481 gcctgggctg gcaccctatg acatgcctga gtatcagcga gtcaccatca gtggagatta
      541 ctgtgcaggg atcactgtgg aagactatga acaggctgcc aagagcctgg ccaaggccct
      601 gatgatccgg gagaagtatg cacggcttgc ctatcaccgc ttccctcgga ccacagccca
      661 gtacctggct catcaggggg aaagtgtgcc tttggaagag ggtctcccag acttccaccc
      721 tcccccactg ccccaggaag acccttattg cctggacaat gcgcccccca acctgggcta
      781 cctggtccgc atgcagggag gtgttctctt tgtgtatgac aatcagacga tgttggaacg
      841 ccaggaaccc cacagcctgc cctaccctga cctggagacc tacatcgtgg acatgagcca
      901 tattctggca ctcatcaccg atggccccac gaaaacctat tgtcaccggc gactgaactt
      961 tctggaatcc aagtttagcc ttcatgagat gttaaatgaa atgtcagagt tcaaggaatt
     1021 gaagagtaat ccccacagag acttttataa tgtgagaaag gtagacacac acatccacgc
     1081 agcggcctgc atgaatcaga agcacctgct gcgtttcatc aagtacacat accagacaga
     1141 gccggacaga actgtggccg agaagctcgg ccggaagatc accctgcggc aggtgtttga
     1201 cagcctgcac atggacccct acgacctcac agtggactcg ctggatgttc atgcgggccg
     1261 gcagacattt caccgcttcg acaagttcaa ctccaagtac aaccctgtgg gggccagtga
     1321 gcttcgggac ctgtatttaa aaactgaaaa ctacctgggg ggagagtact ttgctcgcat
     1381 ggtcaaggaa gtggcccggg aattggagga cagcaagtac cagtactcag aaccccggct
     1441 gtccatctat ggtcgcagtc ctaaggaatg gtctagcctg gcccgctggt tcattcagca
     1501 caaggtctac tcgcccaaca tgcgttggat catccaggtg ccgcggatct atgatatatt
     1561 taggtcaaag aaactactgc caagctttgg gaagatgctg gagaacatct tcctgcccct
     1621 tttccaggct actatcaacc ctcaagacca tcgggagctt cacctcttcc ttaaatacgt
     1681 gacagggttt gacagcgtgg atgatgagtc caagcacagt gaccacatgt tctcagacaa
     1741 gagccccagc ccagacctct ggaccagcga gcagaaccca ccctacagtt actacctgta
     1801 ctacatgtat gccaacatca tggtgctgaa caacctccgc agggaacgag gcctgagcac
     1861 attcttgttc cgacctcact gtggggaagc cggctccatc actcacctag tgtctgcctt
     1921 cctgactgca gacaacattt cccacgggct gctcctcaag aagagtcctg ttttgcagta
     1981 tctctactac cttgctcaga ttcctattgc catgtctcct ctcagcaaca acagcctgtt
     2041 tctggaatat tccaagaacc cacttcggga attcctacac aagggattac acgtctctct
     2101 ctctactgat gaccccatgc agttccacta caccaaggaa gcgctcatgg aggagtacgc
     2161 catcgcagcc caagtgtgga agttgagtac gtgtgacctg tgtgagattg ccaggaacag
     2221 cgtgctgcag agcggcctct cacatcagga gaagcagaag tttttgggtc agaattatta
     2281 caaggaggga ccggagggca atgacatccg aaagacaaat gttgcacaga tccggatggc
     2341 tttccgctac gagaccctgt gtaacgagct cagctttctg tccgatgcca tgaagtcaga
     2401 ggagatcaca gccctggccg actaggccca gcgatccaca cacactttca tcttttggtt
     2461 taatgtcagg tctgctgggg ctaacggtgc cccagatctc aaaccggggc ttccgtctgt
     2521 gacgaggaca cctctgaaga aatctcaagc tcccagtttt ggttgcactt tatgaacatg
     2581 ctcacttcat tagcgtttct gagccagagg ctggctctct tccatggggc tctgggagct
     2641 ggcactgtgt acacctgtcc ttggttgtcc gagtctcctg tgattaccaa tgtttatatg
     2701 gttggggctg ggactttgca aggctgaatg ccaagtgaca caaggcctgt ctggtgtctg
     2761 ccacagtcct cccagcagac cctgtagagc agttctcact ttggtatctg gctggctggc
     2821 tgcctgaacc cccaccaaag ccccttttat aaaggggcta cctagagaaa atacaaagct
     2881 cccctgctga cgatttgtgc acttttaaaa acaagttttt ttccctgtga gcacccctcc
     2941 ttcctgtcta ggtaggaagc ccaacgcacc ctctgaggtc atcacttctg ttattttcct
     3001 catctaggaa tgagtcatct caaaccatgt tctgtgaacc catctcatgg tccactccta
     3061 ggctggggaa gatacagggt gaggttctgg ggctgttctc acttttttgt ttttttaaat
     3121 gaaggccttt gaaaagcata ggacctctgc tccttttggc tctaatgtcc tatgattgta
     3181 gctgtcacca ccttccccca ggagtcagac cagggactga ctcctcaggg gagtgaaatg
     3241 tttcaggaca tacaggacta gagccaagtt cctgatccag tcacacccgg tccccgactc
     3301 ccctgcttcc acctactatt ttaggcttca catattttaa ttttttttta aagaatcact
     3361 gtaacagtgc attttatttt aaagcagatt tcttcagaag ctatcatggt cccagggacc
     3421 aggtagagtt aagtttaatg tggactctag ctttatcaga ctactcatct ttgttactag
     3481 tgcctagaac atagtaggtg ctcaataaat acatatggag taattgaatt actttctctt
     3541 ttggcatctg tatgtacaga atactgaaca atgttcaaag atcttcctaa ctgttcacaa
     3601 ggcaggaagt cctgtaccat acttagatga acctaattgc acctggaaga tgctcatgta
     3661 actaattacc ccgtcctgtg actctgccag ccttccagtg ttcacacagc gtatggaagg
     3721 aaccatgtca tgccttacta ggcaaataaa cataccaccc tacatagctg attatgaaac
     3781 cgaatgaaac ctgtcgttat gagggattat ttttgaaaag cctccatttg tatacatttg
     3841 cccaaacata gcaagtattg tacagttttt cattgtatca aatacttttt taaagactac
     3901 aaataaagtc tgttaggac
//
