LOCUS       NM_001101681            3387 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adenosine monophosphate deaminase 2 (Ampd2),
            mRNA.
ACCESSION   NM_001101681 XM_001069998 XM_342313
VERSION     NM_001101681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Helmering,J., Juan,T., Li,C.M., Chhoa,M., Baron,W., Gyuris,T.,
            Richards,W.G., Turk,J.R., Lawrence,J., Cosgrove,P.A., Busby,J.,
            Kim,K.W., Kaufman,S.A., Cummings,C., Carlson,G., Veniant,M.M. and
            Lloyd,D.J.
  TITLE     A mutation in Ampd2 is associated with nephrotic syndrome and
            hypercholesterolemia in mice
  JOURNAL   Lipids Health Dis 13, 167 (2014)
   PUBMED   25361754
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Akizu,N., Cantagrel,V., Schroth,J., Cai,N., Vaux,K., McCloskey,D.,
            Naviaux,R.K., Van Vleet,J., Fenstermaker,A.G., Silhavy,J.L.,
            Scheliga,J.S., Toyama,K., Morisaki,H., Sonmez,F.M., Celep,F.,
            Oraby,A., Zaki,M.S., Al-Baradie,R., Faqeih,E.A., Saleh,M.A.,
            Spencer,E., Rosti,R.O., Scott,E., Nickerson,E., Gabriel,S.,
            Morisaki,T., Holmes,E.W. and Gleeson,J.G.
  TITLE     AMPD2 regulates GTP synthesis and is mutated in a potentially
            treatable neurodegenerative brainstem disorder
  JOURNAL   Cell 154 (3), 505-517 (2013)
   PUBMED   23911318
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Toyama,K., Morisaki,H., Cheng,J., Kawachi,H., Shimizu,F., Ikawa,M.,
            Okabe,M. and Morisaki,T.
  TITLE     Proteinuria in AMPD2-deficient mice
  JOURNAL   Genes Cells 17 (1), 28-38 (2012)
   PUBMED   22212473
  REMARK    Erratum:[Genes Cells. 2014 Jun;19(6):540]
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Juan,T., Veniant,M.M., Helmering,J., Babij,P., Baker,D.M.,
            Damore,M.A., Bass,M.B., Gyuris,T., Chhoa,M., Li,C.M., Ebeling,C.,
            Amato,J., Carlson,G.A. and Lloyd,D.J.
  TITLE     Identification of three loci affecting HDL-cholesterol levels in a
            screen for chemically induced recessive mutations in mice
  JOURNAL   J Lipid Res 50 (3), 534-545 (2009)
   PUBMED   18974039
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Mahnke-Zizelman,D.K., Tullson,P.C. and Sabina,R.L.
  TITLE     Novel aspects of tetramer assembly and N-terminal domain structure
            and function are revealed by recombinant expression of human AMP
            deaminase isoforms
  JOURNAL   J Biol Chem 273 (52), 35118-35125 (1998)
   PUBMED   9857047
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Mahnke-Zizelman,D.K., D'cunha,J., Wojnar,J.M., Brogley,M.A. and
            Sabina,R.L.
  TITLE     Regulation of rat AMP deaminase 3 (isoform C) by development and
            skeletal muscle fibre type
  JOURNAL   Biochem J 326 (Pt 2) (Pt 2), 521-529 (1997)
   PUBMED   9291127
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Bausch-Jurken,M.T., Mahnke-Zizelman,D.K., Morisaki,T. and
            Sabina,R.L.
  TITLE     Molecular cloning of AMP deaminase isoform L. Sequence and
            bacterial expression of human AMPD2 cDNA
  JOURNAL   J Biol Chem 267 (31), 22407-22413 (1992)
   PUBMED   1429593
REFERENCE   8  (bases 1 to 3387)
  AUTHORS   Morisaki,T., Sabina,R.L. and Holmes,E.W.
  TITLE     Adenylate deaminase. A multigene family in humans and rats
  JOURNAL   J Biol Chem 265 (20), 11482-11486 (1990)
   PUBMED   2365682
REFERENCE   9  (bases 1 to 3387)
  AUTHORS   Ashby,B. and Holmsen,H.
  TITLE     Platelet AMP deaminase. Purification and kinetic studies
  JOURNAL   J Biol Chem 256 (20), 10519-10523 (1981)
   PUBMED   7287721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166402.1.
            
            On Apr 29, 2008 this sequence version replaced NM_001101681.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166402.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3387
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /note="adenosine monophosphate deaminase 2"
                     /db_xref="GeneID:362015"
                     /db_xref="RGD:2110"
     exon            1..136
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2523
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /EC_number="3.5.4.6"
                     /note="adenosine monophosphate deaminase 2 (isoform L)"
                     /codon_start=1
                     /product="AMP deaminase 2"
                     /protein_id="NP_001095151.1"
                     /db_xref="GeneID:362015"
                     /db_xref="RGD:2110"
                     /translation="MASYPGPGKSKAKYPFKKRASLQASAAAPEARSGLGASPLQSAR
                     SLPGTAPCLKHFPLDLRTSMDGKCKEIAEELFSRSLAESELRSAPYEFPEESPIEQLE
                     ERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLYKEQGEGQGDRGLWERDVV
                     LEREFQRVIISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPTTRRYLQQ
                     LAEKPLETRTYEQSPDTPVSADAPVHPPALEQHPYEHCEPSTMPGDLGLGLRMVRGVV
                     HVYTRRDPDEHCPEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQM
                     HVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIV
                     HVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLRE
                     IFIKTDNKISGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVNHR
                     VHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHPELHLFLEH
                     VDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLRRQRG
                     FHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLS
                     NNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDM
                     CELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQELA
                     LITQAVQSEMLETIPEEVGIVMSPGP"
     exon            137..267
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            268..398
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            399..467
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            468..579
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            580..766
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            767..908
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            909..998
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1128
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1323
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1455
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1619
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1746
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1910
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2031
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2205
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2316
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3363
                     /gene="Ampd2"
                     /gene_synonym="Ampd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggcccca gctggtgagg ttcctccgct gtcgccttgg ccccagccat ggcatcctat
       61 cctggcccag gcaagtccaa ggccaaatat ccctttaaga agcgggccag cctgcaagct
      121 tccgctgccg ctccagaagc tcgaagtggt ctgggggcct ctccactgca gtctgcccga
      181 tccctgccag gcaccgcccc ctgccttaag catttcccgc tcgaccttcg cacgtctatg
      241 gatggcaaat gcaaggagat cgctgaggag ttgttcagcc gctcactggc tgagagtgag
      301 ctccgtagcg ccccttatga gttcccggag gaaagcccca tcgagcagct agaggagcgg
      361 aggcagcggc tggagcgcca gatcagccag gatgtcaagc tggagccaga tattctgctt
      421 cgggccaagc aagatttcct gaagacagac agtgattcgg acttacagct gtacaaggag
      481 caaggagagg gacaggggga caggggtctt tgggaacgtg atgtggtact ggaacgggaa
      541 tttcagcggg tcatcatttc tggggaggag aagtgtgggg tgccattcac agacctctta
      601 gatgcagcca aaagtgtggt tcgagcactg ttcatccggg agaagtacat ggccctatcg
      661 ctgcagagct tctgtcccac cacccgccgt tacctgcagc agctggcgga aaaacccctg
      721 gagactcgaa cctatgaaca gagtcctgat acccctgtgt ctgccgatgc cccagtgcac
      781 ccccctgcgc tggaacagca cccatatgag cactgtgagc caagcaccat gcctggggac
      841 ctgggcttgg gtctgcgcat ggtacgtggt gtggtacatg tctacacccg cagggaccct
      901 gatgagcact gtccagaggt ggagcttcca taccctgacc tacaggaatt tgtagctgat
      961 gtcaatgtgc tgatggccct gattatcaat ggtcccataa agtcattctg ctaccgccgg
     1021 cttcagtacc tgagctccaa gttccagatg cacgttttgc tcaatgagat gaaggagctg
     1081 gctgctcaga agaaagtgcc acaccgggac ttctacaata tccgtaaggt ggacacacac
     1141 atccatgcct cgtcctgcat gaaccagaag catctgctgc gcttcatcaa gcgggcgatg
     1201 aagcggcatc tggaggagat cgtgcatgtg gagcagggcc gagagcagac gctgcgagaa
     1261 gtcttcgaga gcatgaacct cactgcctac gacttaagtg tggacacgct ggatgtgcac
     1321 gcggacagga atacctttca tcgatttgac aaattcaatg ccaaatacaa ccctattggg
     1381 gagtctgtcc tccgagagat cttcataaaa actgacaaca agatttctgg gaagtacttt
     1441 gctcacatca tcaaggaggt gatgtcagac ctggaggaga gcaaatacca gaatgcagag
     1501 ctccggctgt ccatctacgg gcgttcgaga gacgagtggg acaagctggc ccgctgggca
     1561 gtgaaccaca gagtgcactc gcccaatgtc cgctggctgg tgcaggtgcc ccgcctcttt
     1621 gatgtatacc gcaccaaggg ccagctggcc aacttccaag agatgctgga gaacatcttc
     1681 ctgccactgt ttgaagctac tgtgcaccct gccagccacc cagagctgca cctcttcctg
     1741 gagcatgtgg atggttttga cagtgtggat gatgagtcta agccagagaa ccatgtcttc
     1801 aacctggaaa gtcccctccc agaagcttgg gtggaggagg ataaccctcc ctatgcctac
     1861 tacctgtatt acaccttcgc taacatggcc atgctgaacc atctgcgcag gcagagaggt
     1921 ttccacacgt ttgtgctgag gccccactgt ggggaggctg ggcccatcca ccacctggta
     1981 tcagccttca tgctggccga gaacatctcc cacgggctgc ttctgcgaaa ggcccctgtc
     2041 ctgcagtacc tgtattacct ggctcagatt ggcattgcca tgtccccact cagcaacaac
     2101 agcctgttcc tcagctacca ccggaaccct ctacctgagt acttgtcccg tggcctcatg
     2161 gtctcgctgt ccacggatga ccccttgcag ttccacttca ccaaggagcc cctgatggag
     2221 gagtacagca tcgccaccca ggtgtggaag ctcagctcct gtgatatgtg tgagctggcc
     2281 cgaaacagtg tgctcatgag cggcttctct cacaaggtga agagccactg gctgggaccc
     2341 aactatacca aggagggccc tgagggtaac gacatccgcc gcaccaatgt gccggacatc
     2401 cgagtaggct accgctacga gaccctgtgc caggagctgg cgctgatcac acaggccgtc
     2461 caaagtgaga tgctggagac catcccagag gaagtgggca ttgtcatgag ccctgggccg
     2521 tagggaacct ggcctgagca gtgcgtgccc catctcagcg acttgattgt gtctgtgatc
     2581 agacccctcc cacctggtgt ggtctctgca tgtctccgtg ctatgtctct gtcctgcatg
     2641 tctttgacca tgtcttgcct ctgggccacc tcaatgaaag ccaagtccaa gaatctgctt
     2701 cgttattgtc tcagctcagg tgatacctga tggctgagat tttaaaagtt ggccctgcta
     2761 gtgacccgtc ccagaatcgt cagaagtctg gctgtcctac ggtgtcttca gtgtccacag
     2821 gggcttggga tggttgtgtg gggctggccc cttgagccct ggaagcccag gctttggtta
     2881 gagttcaggt tgagtttctc tcctgtgtgt gtggcctggg gcaggagatc attatatctc
     2941 tgctgtggca ctggctgctc agcctctgaa gccccagctg gtctgtgctg ggcagagcag
     3001 gacttgggct cgctcatggc cctggaggct tggcctgagg ggctggacca ccactcatca
     3061 gcctccggtt cctccccagt ccacgtgttc ctttgttacc aactcccttg tacccccatg
     3121 tgaggggcag ctgccctgaa ccgtctacag ttggaggctg ctggagttgg aaggtgctgg
     3181 gactgtcact agccctggag atggcacctt ctttggggtt tccaggtctt tgaccagacc
     3241 cagttcccag ctcgcctcct gtgttatgtt ctagacaagg tctttgctat gaagaacagt
     3301 gtttcatatg acccattttt cctagtgcat gagaaataaa aagattattt aattaatgcg
     3361 gcaaaaaaaa aaaaaaaaaa aaaaaaa
//
