LOCUS       NM_138876               2275 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus adenosine monophosphate deaminase 1 (Ampd1),
            mRNA.
ACCESSION   NM_138876
VERSION     NM_138876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Osanami,A., Sato,T., Toda,Y., Shimizu,M., Kuno,A., Kouzu,H.,
            Yano,T., Ohwada,W., Ogawa,T., Miura,T. and Tanno,M.
  TITLE     Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca2+
            overload in type 2 diabetes rat hearts
  JOURNAL   J Diabetes Investig 14 (4), 560-569 (2023)
   PUBMED   36815317
  REMARK    GeneRIF: Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca[2+]
            overload in type 2 diabetes rat hearts.
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Mattii,L., Bianchi,F., Falleni,A., Frascarelli,S., Masini,M.,
            Ali,G., Chiellini,G. and Sabbatini,A.R.M.
  TITLE     Ultrastructural Localization of Histidine-rich Glycoprotein in
            Skeletal Muscle Fibers: Colocalization With AMP Deaminase
  JOURNAL   J Histochem Cytochem 68 (2), 139-148 (2020)
   PUBMED   31880188
  REMARK    GeneRIF: Ultrastructural Localization of Histidine-rich
            Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP
            Deaminase.
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Collins,R.P., Palmer,B.R., Pilbrow,A.P., Frampton,C.M.,
            Troughton,R.W., Yandle,T.G., Skelton,L., Richards,A.M. and
            Cameron,V.A.
  TITLE     Evaluation of AMPD1 C34T genotype as a predictor of mortality in
            heart failure and post-myocardial infarction patients
  JOURNAL   Am Heart J 152 (2), 312-320 (2006)
   PUBMED   16875916
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Goodarzi,M.O., Taylor,K.D., Guo,X., Quinones,M.J., Cui,J., Li,X.,
            Hang,T., Yang,H., Holmes,E., Hsueh,W.A., Olefsky,J. and Rotter,J.I.
  TITLE     Variation in the gene for muscle-specific AMP deaminase is
            associated with insulin clearance, a highly heritable trait
  JOURNAL   Diabetes 54 (4), 1222-1227 (2005)
   PUBMED   15793265
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Yazaki,Y., Muhlestein,J.B., Carlquist,J.F., Bair,T.L., Horne,B.D.,
            Renlund,D.G. and Anderson,J.L.
  TITLE     A common variant of the AMPD1 gene predicts improved survival in
            patients with ischemic left ventricular dysfunction
  JOURNAL   J Card Fail 10 (4), 316-320 (2004)
   PUBMED   15309698
REFERENCE   6  (bases 1 to 2275)
  AUTHORS   Bausch-Jurken,M.T., Mahnke-Zizelman,D.K., Morisaki,T. and
            Sabina,R.L.
  TITLE     Molecular cloning of AMP deaminase isoform L. Sequence and
            bacterial expression of human AMPD2 cDNA
  JOURNAL   J Biol Chem 267 (31), 22407-22413 (1992)
   PUBMED   1429593
REFERENCE   7  (bases 1 to 2275)
  AUTHORS   Mineo,I., Clarke,P.R., Sabina,R.L. and Holmes,E.W.
  TITLE     A novel pathway for alternative splicing: identification of an RNA
            intermediate that generates an alternative 5' splice donor site not
            present in the primary transcript of AMPD1
  JOURNAL   Mol Cell Biol 10 (10), 5271-5278 (1990)
   PUBMED   2398891
REFERENCE   8  (bases 1 to 2275)
  AUTHORS   Morisaki,T., Sabina,R.L. and Holmes,E.W.
  TITLE     Adenylate deaminase. A multigene family in humans and rats
  JOURNAL   J Biol Chem 265 (20), 11482-11486 (1990)
   PUBMED   2365682
REFERENCE   9  (bases 1 to 2275)
  AUTHORS   Sabina,R.L., Morisaki,T., Clarke,P., Eddy,R., Shows,T.B.,
            Morton,C.C. and Holmes,E.W.
  TITLE     Characterization of the human and rat myoadenylate deaminase genes
  JOURNAL   J Biol Chem 265 (16), 9423-9433 (1990)
   PUBMED   2345176
REFERENCE   10 (bases 1 to 2275)
  AUTHORS   Sabina,R.L., Marquetant,R., Desai,N.M., Kaletha,K. and Holmes,E.W.
  TITLE     Cloning and sequence of rat myoadenylate deaminase cDNA. Evidence
            for tissue-specific and developmental regulation
  JOURNAL   J Biol Chem 262 (26), 12397-12400 (1987)
   PUBMED   3624265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2275
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /note="adenosine monophosphate deaminase 1"
                     /db_xref="GeneID:25028"
                     /db_xref="RGD:2109"
     exon            1..33
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2255
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /EC_number="3.5.4.6"
                     /note="myoadenylate deaminase; Ampd; adenosine
                     monophosphate deaminase 1 (isoform M)"
                     /codon_start=1
                     /product="AMP deaminase 1"
                     /protein_id="NP_620231.1"
                     /db_xref="GeneID:25028"
                     /db_xref="RGD:2109"
                     /translation="MPLFKLTGQGKQIDDAMRSFAEKVFASEVKDEGGRHEISPFDVD
                     EICPISLREMQAHIFHMENLSMSMDGRRKRRFQGRKTVNLSIPQSETSSTKLSHIEEF
                     ISSSPTYESVPDFQRVQITGDYASGVTVEDFEVVCKGLYRALCIREKYMQKSFQRFPK
                     TPSKYLRNIDGEALVAIESFYPVFTPPPKKGEDPFRREDLPANLGYHLKMKGGVIYIY
                     PDEAAASRDEPKPYPYPNLDDFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQM
                     LNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYHIDADRVVYST
                     KEKNLTLKELFAQLNMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYL
                     KTDNYINGEYFATIIKEVGADLVDAKYQHAEPRLSIYGRSPDEWSKLSSWFVGNRIYC
                     PNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFLPVFEATINPQTHPDLSVFLKHITG
                     FDSVDDESKHSGHMFSSKSPKPEEWTMENNPSYTYYAYYMYANIMVLNCLRKERGMNT
                     FLFRPHCGEAGALTHLMTAFMIADNISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNS
                     LFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEV
                     ARNSVLQCGISHEEKAKFLGNNYLEEGPVGNDIRRTNVAQIRMAYRYETWCYELNLIA
                     EGLKSTE"
     exon            34..45
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            46..226
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            227..392
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            393..558
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            559..778
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            779..908
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1103
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1235
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1399
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1526
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1690
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1811
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1985
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2096
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2274
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccagtcac aatgcctctg ttcaaactta caggtcaagg aaaacaaatt gatgatgcaa
       61 tgcgtagctt tgctgaaaaa gtatttgcct cagaagtcaa agatgaggga ggtcggcacg
      121 agatctcccc cttcgacgtg gatgagatct gcccaatttc ccttcgtgag atgcaggccc
      181 acatattcca catggagaac ctgtccatgt ccatggatgg caggaggaaa aggcgcttcc
      241 aaggacggaa gactgttaat ttgtccattc cgcaaagtga aacgtcttct accaaactgt
      301 cccacattga agaatttatt tcttcatccc cgacctatga gagtgtgcct gacttccaga
      361 gggtgcagat cactggtgac tatgcctctg gggtaactgt tgaagacttt gaggtggttt
      421 gtaaaggtct ctatcgggct ttgtgtatac gagagaaata catgcagaag tcattccaga
      481 ggttccccaa gaccccctcc aagtacctga ggaacatcga cggcgaagct ttggtagcaa
      541 tcgaaagctt ctatccagta tttacccctc ctccgaagaa gggagaagac ccctttcgca
      601 gagaagacct tcccgcaaac ctgggctatc acctcaagat gaagggtggt gtgatttaca
      661 tctaccctga tgaagcagca gccagcagag atgagcccaa gccctaccct tacccaaatc
      721 tggatgactt cctggatgac atgaattttt tgcttgctct aattgcacaa gggcctgtga
      781 agacttacac tcaccgccgt ctgaagttcc tctcctccaa gttccaggtc catcagatgc
      841 tgaatgagat ggacgagcta aaggagctga agaacaaccc ccaccgggac ttttataact
      901 gcaggaaggt ggatactcac atccacgcag ctgcctgcat gaaccagaag cacctgctgc
      961 gctttattaa gaaatcttac catattgatg ctgacagagt ggtctacagc accaaagaga
     1021 agaacctgac cctgaaggaa ctttttgctc aattaaatat gcatccatat gacctgactg
     1081 ttgactctct ggatgttcat gctggacggc agacgttcca acgcttcgat aagttcaatg
     1141 acaaatacaa tccggtgggt gcgagtgagc ttcgggacct ctacctaaaa acagacaact
     1201 acattaacgg agagtatttt gccactatca tcaaggaggt gggtgcagac ctggtggacg
     1261 ccaagtatca gcatgcggag ccccgcttgt ccatctacgg tcgcagtcca gatgagtgga
     1321 gcaaactctc ctcttggttt gtcggcaacc gtatttattg ccccaacatg acatggatga
     1381 tccaagtccc caggatctat gatgtgttcc gatccaagaa tttcctgcca cactttggaa
     1441 agatgctgga gaatattttc cttccagtgt ttgaggccac catcaacccc cagactcatc
     1501 cagacctcag tgtcttcctc aagcatatca ctggctttga cagtgtggat gatgagtcca
     1561 aacacagtgg tcacatgttt tcctccaaga gtcccaaacc tgaggagtgg acaatggaaa
     1621 acaacccgtc ttacacatat tatgcctact acatgtatgc aaacatcatg gtgctcaact
     1681 gcctgagaaa ggaacgaggc atgaatacat ttttgtttcg cccccattgt ggtgaggctg
     1741 gggctctcac tcacctcatg acagccttta tgatagcgga caatatttcg cacggcctga
     1801 acttaaagaa gagtcctgtg ttacagtacc tatttttctt agcccagatc cccattgcaa
     1861 tgtcgccatt gagtaacaac agcctgttcc tcgaatatgc aaaaaaccct ttcttagatt
     1921 tcctccagaa aggcctcatg atctcgctgt cgaccgatga cccgatgcag ttccatttca
     1981 ccaaggagcc cctgatggaa gagtacgcca tcgcagccca ggtcttcaag ctgagcactt
     2041 gtgacatgtg tgaggtggca aggaacagtg tcctgcagtg tggaatttct catgaggaaa
     2101 aagcaaagtt tctgggcaac aattaccttg aggaaggtcc tgttggaaat gacatccgaa
     2161 ggacaaatgt ggctcagatt cgcatggcct atcgttatga aacttggtgt tatgaactca
     2221 atttgattgc tgagggcctt aaatcaacag aatgaataaa gtatgtgaac cgaaa
//
