LOCUS       NP_620231                747 aa            linear   ROD 02-JUN-2024
DEFINITION  AMP deaminase 1 [Rattus norvegicus].
ACCESSION   NP_620231
VERSION     NP_620231.1
DBSOURCE    REFSEQ: accession NM_138876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 747)
  AUTHORS   Osanami,A., Sato,T., Toda,Y., Shimizu,M., Kuno,A., Kouzu,H.,
            Yano,T., Ohwada,W., Ogawa,T., Miura,T. and Tanno,M.
  TITLE     Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca2+
            overload in type 2 diabetes rat hearts
  JOURNAL   J Diabetes Investig 14 (4), 560-569 (2023)
   PUBMED   36815317
  REMARK    GeneRIF: Adenosine monophosphate deaminase in the endoplasmic
            reticulum-mitochondria interface promotes mitochondrial Ca[2+]
            overload in type 2 diabetes rat hearts.
REFERENCE   2  (residues 1 to 747)
  AUTHORS   Mattii,L., Bianchi,F., Falleni,A., Frascarelli,S., Masini,M.,
            Ali,G., Chiellini,G. and Sabbatini,A.R.M.
  TITLE     Ultrastructural Localization of Histidine-rich Glycoprotein in
            Skeletal Muscle Fibers: Colocalization With AMP Deaminase
  JOURNAL   J Histochem Cytochem 68 (2), 139-148 (2020)
   PUBMED   31880188
  REMARK    GeneRIF: Ultrastructural Localization of Histidine-rich
            Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP
            Deaminase.
REFERENCE   3  (residues 1 to 747)
  AUTHORS   Collins,R.P., Palmer,B.R., Pilbrow,A.P., Frampton,C.M.,
            Troughton,R.W., Yandle,T.G., Skelton,L., Richards,A.M. and
            Cameron,V.A.
  TITLE     Evaluation of AMPD1 C34T genotype as a predictor of mortality in
            heart failure and post-myocardial infarction patients
  JOURNAL   Am Heart J 152 (2), 312-320 (2006)
   PUBMED   16875916
REFERENCE   4  (residues 1 to 747)
  AUTHORS   Goodarzi,M.O., Taylor,K.D., Guo,X., Quinones,M.J., Cui,J., Li,X.,
            Hang,T., Yang,H., Holmes,E., Hsueh,W.A., Olefsky,J. and Rotter,J.I.
  TITLE     Variation in the gene for muscle-specific AMP deaminase is
            associated with insulin clearance, a highly heritable trait
  JOURNAL   Diabetes 54 (4), 1222-1227 (2005)
   PUBMED   15793265
REFERENCE   5  (residues 1 to 747)
  AUTHORS   Yazaki,Y., Muhlestein,J.B., Carlquist,J.F., Bair,T.L., Horne,B.D.,
            Renlund,D.G. and Anderson,J.L.
  TITLE     A common variant of the AMPD1 gene predicts improved survival in
            patients with ischemic left ventricular dysfunction
  JOURNAL   J Card Fail 10 (4), 316-320 (2004)
   PUBMED   15309698
REFERENCE   6  (residues 1 to 747)
  AUTHORS   Bausch-Jurken,M.T., Mahnke-Zizelman,D.K., Morisaki,T. and
            Sabina,R.L.
  TITLE     Molecular cloning of AMP deaminase isoform L. Sequence and
            bacterial expression of human AMPD2 cDNA
  JOURNAL   J Biol Chem 267 (31), 22407-22413 (1992)
   PUBMED   1429593
REFERENCE   7  (residues 1 to 747)
  AUTHORS   Mineo,I., Clarke,P.R., Sabina,R.L. and Holmes,E.W.
  TITLE     A novel pathway for alternative splicing: identification of an RNA
            intermediate that generates an alternative 5' splice donor site not
            present in the primary transcript of AMPD1
  JOURNAL   Mol Cell Biol 10 (10), 5271-5278 (1990)
   PUBMED   2398891
REFERENCE   8  (residues 1 to 747)
  AUTHORS   Morisaki,T., Sabina,R.L. and Holmes,E.W.
  TITLE     Adenylate deaminase. A multigene family in humans and rats
  JOURNAL   J Biol Chem 265 (20), 11482-11486 (1990)
   PUBMED   2365682
REFERENCE   9  (residues 1 to 747)
  AUTHORS   Sabina,R.L., Morisaki,T., Clarke,P., Eddy,R., Shows,T.B.,
            Morton,C.C. and Holmes,E.W.
  TITLE     Characterization of the human and rat myoadenylate deaminase genes
  JOURNAL   J Biol Chem 265 (16), 9423-9433 (1990)
   PUBMED   2345176
REFERENCE   10 (residues 1 to 747)
  AUTHORS   Sabina,R.L., Marquetant,R., Desai,N.M., Kaletha,K. and Holmes,E.W.
  TITLE     Cloning and sequence of rat myoadenylate deaminase cDNA. Evidence
            for tissue-specific and developmental regulation
  JOURNAL   J Biol Chem 262 (26), 12397-12400 (1987)
   PUBMED   3624265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..747
                     /product="AMP deaminase 1"
                     /EC_number="3.5.4.6"
                     /note="myoadenylate deaminase; Ampd; adenosine
                     monophosphate deaminase 1 (isoform M)"
                     /calculated_mol_wt=86301
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P10759.1)"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P10759.1)"
     Region          113..745
                     /region_name="AMP_deaminase"
                     /note="AMP deaminase; pfam19326"
                     /db_xref="CDD:437158"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P10759.1)"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P10759.1)"
     CDS             1..747
                     /gene="Ampd1"
                     /gene_synonym="Ampd01; RATAMPD01"
                     /coded_by="NM_138876.1:12..2255"
                     /db_xref="GeneID:25028"
                     /db_xref="RGD:2109"
ORIGIN      
        1 mplfkltgqg kqiddamrsf aekvfasevk deggrheisp fdvdeicpis lremqahifh
       61 menlsmsmdg rrkrrfqgrk tvnlsipqse tsstklshie efisssptye svpdfqrvqi
      121 tgdyasgvtv edfevvckgl yralcireky mqksfqrfpk tpskylrnid gealvaiesf
      181 ypvftpppkk gedpfrredl panlgyhlkm kggviyiypd eaaasrdepk pypypnlddf
      241 lddmnfllal iaqgpvktyt hrrlkflssk fqvhqmlnem delkelknnp hrdfyncrkv
      301 dthihaaacm nqkhllrfik ksyhidadrv vystkeknlt lkelfaqlnm hpydltvdsl
      361 dvhagrqtfq rfdkfndkyn pvgaselrdl ylktdnying eyfatiikev gadlvdakyq
      421 haeprlsiyg rspdewskls swfvgnriyc pnmtwmiqvp riydvfrskn flphfgkmle
      481 niflpvfeat inpqthpdls vflkhitgfd svddeskhsg hmfsskspkp eewtmennps
      541 ytyyayymya nimvlnclrk ergmntflfr phcgeagalt hlmtafmiad nishglnlkk
      601 spvlqylffl aqipiamspl snnslfleya knpfldflqk glmislstdd pmqfhftkep
      661 lmeeyaiaaq vfklstcdmc evarnsvlqc gisheekakf lgnnyleegp vgndirrtnv
      721 aqirmayrye twcyelnlia eglkste
//
