LOCUS       NM_031717               4141 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus angiomotin like 2 (Amotl2), mRNA.
ACCESSION   NM_031717 XM_001060762 XM_001068539 XM_343457
VERSION     NM_031717.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4141)
  AUTHORS   Deng,J., Yang,G., Zhong,N., Liang,L. and Chen,H.
  TITLE     Upregulation of Angiomotin-Like 2 Ameliorates Experimental
            Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling
  JOURNAL   J Cardiovasc Pharmacol 84 (3), 356-369 (2024)
   PUBMED   39027975
  REMARK    GeneRIF: Upregulation of Angiomotin-Like 2 Ameliorates Experimental
            Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4141)
  AUTHORS   Zhao,B., Li,L., Lu,Q., Wang,L.H., Liu,C.Y., Lei,Q. and Guan,K.L.
  TITLE     Angiomotin is a novel Hippo pathway component that inhibits YAP
            oncoprotein
  JOURNAL   Genes Dev 25 (1), 51-63 (2011)
   PUBMED   21205866
REFERENCE   3  (bases 1 to 4141)
  AUTHORS   Sugihara-Mizuno,Y., Adachi,M., Kobayashi,Y., Hamazaki,Y.,
            Nishimura,M., Imai,T., Furuse,M. and Tsukita,S.
  TITLE     Molecular characterization of angiomotin/JEAP family proteins:
            interaction with MUPP1/Patj and their endogenous properties
  JOURNAL   Genes Cells 12 (4), 473-486 (2007)
   PUBMED   17397395
REFERENCE   4  (bases 1 to 4141)
  AUTHORS   Patrie,K.M.
  TITLE     Identification and characterization of a novel tight
            junction-associated family of proteins that interacts with a WW
            domain of MAGI-1
  JOURNAL   Biochim Biophys Acta 1745 (1), 131-144 (2005)
   PUBMED   16019084
REFERENCE   5  (bases 1 to 4141)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Nov 20, 2008 this sequence version replaced
            XM_343457.3, XM_001060762.1, XM_001068539.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132274,
                              SAMD00132279 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4141
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4141
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /note="angiomotin like 2"
                     /db_xref="GeneID:65157"
                     /db_xref="RGD:70977"
     exon            1..88
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            89..881
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2472
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /note="Leman coiled-coil protein"
                     /codon_start=1
                     /product="angiomotin-like protein 2"
                     /protein_id="NP_113905.1"
                     /db_xref="GeneID:65157"
                     /db_xref="RGD:70977"
                     /translation="MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAG
                     AGGTGSPQASLEIGAPEDSQVLQQATRQEPQGQEHQGGETHLAENRLYRLCPQPSKGE
                     ELPTYEEAKAHSQYYAAQQAGSRLHGGDRDPRGASGGSRRQDEALRELRHGHVRSLSE
                     RLLQLSLERNGARVPSHMSSSHSFPQLARSQQGPQPRGPPAEGPEPRGPPPQYPHAVM
                     AQETAAVNDPRYRPRSSPHFQHAEVRILQAQVPPVFLQQQQYQYLQQPQEHSPPLHPA
                     ALGHGPPSSFSPPALEGPPGAQATSGSAHLAQMESVLRENARLQRDNERLQRELESTS
                     EKASCIEKLENEIQRLSEAHESLMRTSSKREALEKTMRNKMDSEMRRLQDFNRDLRER
                     LESANRHLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRA
                     ELLEQALGNAQSRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTR
                     LEQELKALRAQQRQTGTLTGGGGSHTGSTELSALRLSEQLREKEEQILALEADMTKWE
                     QKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLAGNHRHQEMESR
                     LKVLHAQILEKDAVIKVLQQRSRKDPGKATQGTLRPAKSVPSIFAAAVGTQGWQGFST
                     SERQTDAPARQTVDRGPAEEPPATPPLPAHTKHGSRDGSTQTDGPADSTSACLASEPD
                     SLLGCNGSQRTTSLDSIAATRVQDLSDMVEILI"
     exon            882..1176
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1321
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1414
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1710
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2021
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2236
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2413
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..4141
                     /gene="Amotl2"
                     /gene_synonym="Lccp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgccacc gacgagtgcg cacctccgtt gccgaccgta cctaagccga acccggtctg
       61 cgtgcgccgg cagccgcggg ccgcagcggt gctctgagac caggtgcctg ctggccattg
      121 tctaggcagg tgtgtgcaag ccagagaagc atgaggacac tggaagactc ctcagggaca
      181 gtcctgcacc gcctcatcca ggagcagctg cgctacggca acctgacaga gactcgcact
      241 ctgttggcca tccagcagca ggccctgcgg ggtggggctg gagctggggg cacagggagc
      301 ccccaggcct ccctggagat cggagcaccc gaggacagtc aggtgctaca gcaggccacc
      361 aggcaggagc cccagggcca ggagcatcag ggtggagaga cccacctggc agagaacagg
      421 ctgtaccgac tctgcccaca gcccagcaag ggagaagagc tgcccaccta tgaggaagcc
      481 aaagcccatt cgcagtacta tgcagcgcag caggcaggct cccggctgca tggtggggac
      541 cgggatccta gaggggcctc aggaggcagc cgacgtcagg atgaggctct tcgagagttg
      601 aggcacggcc atgtgcgctc cttgagtgaa cgacttctgc agctgtccct ggaaagaaat
      661 ggtgcccggg tccccagcca catgagctct tcccacagtt tccctcagct ggcccgcagc
      721 cagcaaggtc cccagccccg aggaccccca gctgagggcc cggagccccg tgggccacca
      781 cctcagtacc cacacgctgt aatggctcag gagactgcgg ctgtcaatga cccaagatac
      841 cgtccgagaa gcagcccaca cttccagcat gctgaagtca ggatcctgca ggcacaggta
      901 ccaccggttt tcctccagca gcaacagtac cagtacctgc agcaacccca ggagcactcc
      961 ccacccctcc atccagccgc tctaggccat ggtcccccaa gttccttcag tccacctgcc
     1021 ctggagggac cacccggtgc ccaggccact tcgggcagtg cccacctggc ccagatggag
     1081 agcgtgctga gggagaacgc caggctgcag agggacaatg agcggttgca gagagagctg
     1141 gagagcactt cagagaaggc cagctgcata gaaaagctgg aaaatgaaat ccagcggctc
     1201 tcagaggccc atgagagcct gatgaggacc tcgtccaagc gtgaggccct ggagaagacc
     1261 atgaggaaca agatggacag tgaaatgaga cggttacagg actttaaccg agaccttaga
     1321 gagagattgg agtccgcaaa ccgccacctg gcaagcaaga cccaggaagc ccaggcgggc
     1381 agtcaggaca tggtggctaa actgcttgct cagagctatg agcagcaaca ggagcaagag
     1441 aagctggagc gggagatggc gctgctgcgt ggtgccatcg aggaccagag gcgacgggct
     1501 gaactgctgg agcaggctct gggcaacgcg cagagccgcg ccgctcgagc ggaggaggag
     1561 ctacgcaaga agcaggccta cgtggagaag gtggagcggc tgcagcaggc gctgggacag
     1621 ttgcaggctg cttgtgaaaa gcgggagcag ctggagctgc gtctgcgcac gcgcctggag
     1681 caggaactca aagccttgcg cgcgcagcag aggcagacag gcaccctcac aggtggtggc
     1741 ggtagccaca ctgggtccac ggagctcagt gccctgcgac tgtcagaaca gcttcgggag
     1801 aaggaggaac agatactggc tctagaggcg gacatgacca agtgggaaca aaagtatttg
     1861 gaggaacggg ccatgaggca gtttgccatg gatgcggctg ccactgcggc tgcccagcga
     1921 gacaccactc tcatcagaca ctccccccag ccctcgccca gcagcagttt caacgaaggc
     1981 ctgctggcag gcaaccacag gcaccaggag atggagagca ggttgaaggt gctccatgcc
     2041 cagatcctag agaaagacgc agtgatcaag gtccttcaac agcgttccag gaaagaccct
     2101 ggcaaggcta cccagggcac cctacggccc gccaagtcgg tgccgtccat ctttgcagct
     2161 gcagtgggga ctcagggctg gcaagggttc tcaaccagcg agcgacaaac tgatgcacct
     2221 gcccgacaga cagtagaccg tggaccagca gaagagcccc cggccacacc tcctctccct
     2281 gcccacacca aacatggcag cagagacggg agcacccaaa ctgatggccc tgcagacagc
     2341 acctctgcct gcttggcctc agaacccgac agcctcctgg ggtgcaacgg tagccagagg
     2401 acaacctctc tggactctat agctgcaacc agagtccagg atctgtcaga catggtggaa
     2461 atactgatct gaaggaagga ggccttgggg accctgaagc ctggctcccc catggcattc
     2521 cagcaattgt cttcaaatgc tgcacctcac ttcctccaac cagcaatggt ttggtgcagg
     2581 agctcagaga ggagcactcc aggggagcca gaaaaggctg cacccccaga agactgcttt
     2641 tttttgacct atatttctcc cacgacaatg aggaaggaag aggtctgttg ctggagcagg
     2701 aaggggctga gccccctccg tcctgccagt ttgtatttgg gcatgaaggg aaaggagact
     2761 ggattctgat tcccaagaat ggctggacac cagccaaatg gtctgcaggg ataatcaggc
     2821 caaaccatgg tgttctgtgg ctaagcatgg ccccagccag ccctaactgc tctcagtccc
     2881 tcactgcctt cttcagatca ctaagacttg aatcttttgg ggaaccattg ggagtgtgag
     2941 cctttcggga gccaccagca tgtccccttg cttggagtag gttagaggcc atttgagagg
     3001 cccgcagaac agtgtgtttt gtatataatt ctctttcctt gggaacagaa gactaagcat
     3061 gctggttcag agtctccttc cagagctgtg ctgcctgccc ctgcttgcca cagttcttga
     3121 aacatttgac aggtctacca gatgtccctc tgcctccagt tcttggcggt gtttttttga
     3181 tactggttgc ctttcctctg ttttaaaccc ctgtgttcaa tgcccgtggg attcttgtca
     3241 ccagcctttg ttgtgaacgg ctccaccgct cctacccctg ggacatcctg tcagtttggt
     3301 tataaactga gccagatgcg atgagccaca acaagcggat atctgtcata cccagcccca
     3361 ggttctcttt gaagaaactg gagacgttgt tctcataaac gtgttcgttc ccaccagcag
     3421 ggactgggag agggagctat gctgttaaaa gtaatcggtg aacttaaaga aaagtcccca
     3481 ctaggtgccc ccatcacaga atggcaccca agaggctggc tcctcgagct ttggtgcccc
     3541 agccctgaag cagggccagc tactcggaat taggcagcct accagcagca gtgactttaa
     3601 cttctggtct taaagtaacc cccattcagc tgaaaaagcg attggtggat tgcagatctg
     3661 ttgtgttttc tcttgttgtt ttgttcgttt tttctctcat tgtttgaagt tctgtctgtt
     3721 gttccattcc catggttctc cgtgtttcct ttttaaacat ttgcatttgc tgggcaattg
     3781 cgtatttttt taattcccct tttcccctgt gtaaagctga gaaatacatc tggttcatgt
     3841 gcgttgttta caaagataaa agtttaaaaa aaaaacaaaa aaaaaggagg gaaaaacaaa
     3901 aaatatcgtg aaagaaaaaa aacaacttaa tatattttgg attaatattt ggtatttctt
     3961 ttaaaatatt ttttttgtgc tgtgaacgtt ttctgccaaa gaccatgacg tgtgtctgtg
     4021 tgtttaagtt atcatgaata tttaaggtgc aaacatggct gttttgtcac gccactctgt
     4081 accaggattg ccgaagcatt ccactgggta tgacagtatt ttaataaaaa aaaaagctta
     4141 t
//
