LOCUS       NM_001108061            1759 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus amnion associated transmembrane protein (Amn),
            mRNA.
ACCESSION   NM_001108061 XM_001071620 XM_234547
VERSION     NM_001108061.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Vazquez-Carretero MD, Palomo M, Garcia-Miranda P, Sanchez-Aguayo I,
            Peral MJ, Calonge ML and Ilundain AA.
  TITLE     Dab2, megalin, cubilin and amnionless receptor complex might
            mediate intestinal endocytosis in the suckling rat
  JOURNAL   J Cell Biochem 115 (3), 510-522 (2014)
   PUBMED   24122887
  REMARK    GeneRIF: We conclude that the megalin/cubilin/amnionless/Dab2
            complex/es participate in intestinal processes, mainly during the
            lactation period and that Dab2 may act as an adaptor in intestinal
            processes mediated by ApoER2 and VLDLR.
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Pedersen GA, Chakraborty S, Steinhauser AL, Traub LM and Madsen M.
  TITLE     AMN directs endocytosis of the intrinsic factor-vitamin B(12)
            receptor cubam by engaging ARH or Dab2
  JOURNAL   Traffic 11 (5), 706-720 (2010)
   PUBMED   20088845
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Ahuja R, Yammani R, Bauer JA, Kalra S, Seetharam S and Seetharam B.
  TITLE     Interactions of cubilin with megalin and the product of the
            amnionless gene (AMN): effect on its stability
  JOURNAL   Biochem J 410 (2), 301-308 (2008)
   PUBMED   17990981
  REMARK    GeneRIF: Three distinct regions of cubilin bind to megalin and its
            interactions with both megalin and amnionless are essential for its
            intracellular stability.
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Broides A, Yerushalmi B, Levy R, Hadad N, Kaplun N, Tanner SM,
            Chapelle Ade L and Levy J.
  TITLE     Imerslund-Grasbeck syndrome associated with recurrent aphthous
            stomatitis and defective neutrophil function
  JOURNAL   J Pediatr Hematol Oncol 28 (11), 715-719 (2006)
   PUBMED   17114957
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   He Q, Madsen M, Kilkenney A, Gregory B, Christensen EI, Vorum H,
            Hojrup P, Schaffer AA, Kirkness EF, Tanner SM, de la Chapelle A,
            Giger U, Moestrup SK and Fyfe JC.
  TITLE     Amnionless function is required for cubilin brush-border expression
            and intrinsic factor-cobalamin (vitamin B12) absorption in vivo
  JOURNAL   Blood 106 (4), 1447-1453 (2005)
   PUBMED   15845892
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Coudroy G, Gburek J, Kozyraki R, Madsen M, Trugnan G, Moestrup SK,
            Verroust PJ and Maurice M.
  TITLE     Contribution of cubilin and amnionless to processing and membrane
            targeting of cubilin-amnionless complex
  JOURNAL   J Am Soc Nephrol 16 (8), 2330-2337 (2005)
   PUBMED   15976000
  REMARK    GeneRIF: AMN interacts with the EGF domains of cubilin for membrane
            attachment and export from the endoplasmic reticulum, while
            extracellular cubilin does apical sorting of the complex in a
            carbohydrate-dependent manner
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Strope S, Rivi R, Metzger T, Manova K and Lacy E.
  TITLE     Mouse amnionless, which is required for primitive streak assembly,
            mediates cell-surface localization and endocytic function of
            cubilin on visceral endoderm and kidney proximal tubules
  JOURNAL   Development 131 (19), 4787-4795 (2004)
   PUBMED   15342463
  REMARK    Erratum:[Development. 2004 Oct;131(4):5211]
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Fyfe JC, Madsen M, Hojrup P, Christensen EI, Tanner SM, de la
            Chapelle A, He Q and Moestrup SK.
  TITLE     The functional cobalamin (vitamin B12)-intrinsic factor receptor is
            a novel complex of cubilin and amnionless
  JOURNAL   Blood 103 (5), 1573-1579 (2004)
   PUBMED   14576052
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Tanner SM, Aminoff M, Wright FA, Liyanarachchi S, Kuronen M,
            Saarinen A, Massika O, Mandel H, Broch H and de la Chapelle A.
  TITLE     Amnionless, essential for mouse gastrulation, is mutated in
            recessive hereditary megaloblastic anemia
  JOURNAL   Nat Genet 33 (3), 426-429 (2003)
   PUBMED   12590260
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474034.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071620.1, XM_234547.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1759
                     /gene="Amn"
                     /note="amnion associated transmembrane protein"
                     /db_xref="GeneID:314459"
                     /db_xref="RGD:1308634"
     exon            1..112
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1449
                     /gene="Amn"
                     /note="protein amnionless; amnionless homolog"
                     /codon_start=1
                     /product="protein amnionless precursor"
                     /protein_id="NP_001101531.1"
                     /db_xref="GeneID:314459"
                     /db_xref="RGD:1308634"
                     /translation="MGALGRVLLWLQLCALTRAAYKLWVPNTSFDTASNWNQNRTPCA
                     GDAVQFPADKMVSVLVRDSHAISDMLLPLNGEFVLASGAAFSAAGGDSDPACNPGAPL
                     LFRNPDRFSWLDPHLWSSGTQESGIFFVDAERVPCTYDDVLFPRNGSFRVALGPGPNP
                     VHVRSVSAVGQTFTRDEDLAAFLASREGRLRFHGSGALRVGSQACTDATGCVCGNAET
                     LPWICASLLQPLGGRCPEATCQDPVRPQGQCCDLCGAIVSLTHDPTFDLERYRARLLD
                     LFLKQPQYQGLQVAVSKVLRDAHTEIQVVLLETRPATGAAGQLGHALLQDAVAQGSVL
                     GIVSATLRQSGKPTAANSALDQNGSGAGLAGGVAAVVLLALVGTVLLLLHRSGRLRWR
                     RHGDAEPTSAGLPLGFRNPIFDVMVFKQQQASVEFADSTQKVDILDIDTNFGCFVNPL
                     FAGEAEAEA"
     exon            113..231
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            232..276
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            277..364
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            365..582
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            583..720
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            721..829
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            830..912
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1060
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1238
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1332
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1759
                     /gene="Amn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcccgg tcacgtgggg acctcggagc gaagtccgcg ccggtgagag cctgggcggc
       61 ggcggagaga tgggtgccct gggccgggtg ctgctgtggc tgcagctctg tgcactgact
      121 cgggccgcct acaaactttg ggtccccaac acttccttcg ataccgcctc caactggaac
      181 cagaaccgga ccccgtgcgc gggagatgcg gtccagttcc cggcggacaa gatggtgtcg
      241 gtcctggtgc gagacagtca cgccatctcg gatatgctcc tgccgctgaa cggggagttc
      301 gtcctggcct cgggagctgc attcagcgct gcaggaggcg actccgaccc ggcttgtaac
      361 cctggcgccc cgttgctctt ccgcaatccc gaccgcttct cctggcttga ccctcaccta
      421 tggagctccg gaacccagga gtctggcatc ttcttcgtgg acgccgagcg cgtgccctgc
      481 acctacgacg acgtcctctt cccgcgcaac gggtctttcc gcgtggcgct tggcccaggc
      541 cccaacccgg tgcacgtccg cagcgtctcg gccgtgggtc agacgttcac gcgcgacgag
      601 gacctggccg ctttcctggc gtcccgcgag ggccgcctgc gcttccacgg gtcgggcgcg
      661 ctgagagtgg gctcccaggc ctgcaccgac gcgacgggct gcgtctgcgg caacgccgag
      721 acgctgccgt ggatctgcgc gtctctgctg cagcccctgg gcggccgctg ccccgaggcc
      781 acctgccagg accccgtaag gcctcaagga cagtgctgcg acctctgcgg agctatcgtg
      841 tcgttgaccc acgaccccac atttgacctg gagcggtacc gagcgcggct gctggacctc
      901 ttcctgaagc agccccagta ccagggcctg caggtggcgg tgtccaaggt gctgcgcgac
      961 gcccacaccg agatccaggt ggtgctgctg gagacccggc cggcgaccgg cgcagcgggg
     1021 cagctgggcc acgcgctcct tcaggacgcg gtggcacaag gcagcgtgct cggcatcgtg
     1081 tcggcgaccc tgcggcagtc gggcaagccc acggcggcaa actcggcgct ggatcagaac
     1141 gggtccggag ccgggctggc gggcggcgtg gcggccgtgg tgctgctggc tctggtgggg
     1201 actgtgctgt tgctgctaca ccgcagcggg aggctcaggt ggagaaggca cggagatgct
     1261 gagcccacat cggctgggct gccgctgggt ttccgaaatc cgattttcga cgtgatggtc
     1321 ttcaagcagc agcaggcctc ggtagagttt gctgactcaa ctcagaaggt ggacatcttg
     1381 gacattgata ccaacttcgg ctgcttcgtt aacccactct ttgctgggga ggcagaggca
     1441 gaggcctgac ctgctgggag ggtactaggt ctccaacctg tggactcttc acccctctga
     1501 gaccatgact tccttctggt ggcaaggaca agcctacttt gcccaataaa gggttgtttg
     1561 ttcatttgtt tttttaattt gctagcaaga tgtcatttgt aagcgtgctt tacttgactg
     1621 acgggggtct gaactcaggt cctcagatcc acgtagcaag tgcttttacc attcagccac
     1681 cctgtggttt gtggtgtttc attttgaggt gggagtctca ccatgtactc taggaagaca
     1741 ttaaacttct gggctcaaa
//
