LOCUS       NM_182816               3097 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 2 (Amigo2),
            mRNA.
ACCESSION   NM_182816
VERSION     NM_182816.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Li,Z., Khan,M.M., Kuja-Panula,J., Wang,H., Chen,Y., Guo,D.,
            Chen,Z.J., Lahesmaa,R., Rauvala,H. and Tian,L.
  TITLE     AMIGO2 modulates T cell functions and its deficiency in mice
            ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   Brain Behav Immun 62, 110-123 (2017)
   PUBMED   28119027
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Kanda,Y., Osaki,M., Onuma,K., Sonoda,A., Kobayashi,M., Hamada,J.,
            Nicolson,G.L., Ochiya,T. and Okada,F.
  TITLE     Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to
            Liver Endothelial Cells Resulting in Liver Metastases
  JOURNAL   Sci Rep 7, 43567 (2017)
   PUBMED   28272394
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Park,H., Lee,S., Shrestha,P., Kim,J., Park,J.A., Ko,Y., Ban,Y.H.,
            Park,D.Y., Ha,S.J., Koh,G.Y., Hong,V.S., Mochizuki,N., Kim,Y.M.,
            Lee,W. and Kwon,Y.G.
  TITLE     AMIGO2, a novel membrane anchor of PDK1, controls cell survival and
            angiogenesis via Akt activation
  JOURNAL   J Cell Biol 211 (3), 619-637 (2015)
   PUBMED   26553931
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Rabenau,K.E., O'Toole,J.M., Bassi,R., Kotanides,H., Witte,L.,
            Ludwig,D.L. and Pereira,D.S.
  TITLE     DEGA/AMIGO-2, a leucine-rich repeat family member, differentially
            expressed in human gastric adenocarcinoma: effects on ploidy,
            chromosomal stability, cell adhesion/migration and tumorigenicity
  JOURNAL   Oncogene 23 (29), 5056-5067 (2004)
   PUBMED   15107827
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_182816.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB078879.1, AY237730.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3097              JAXUCZ010000007.1  130270639-130273735 c
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3097
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
     exon            1..3097
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /inference="alignment:Splign:2.1.0"
     CDS             702..2264
                     /gene="Amigo2"
                     /gene_synonym="Ali1"
                     /note="amphoterin-induced protein 2; alivin 1; AMIGO-2;
                     amphoterin induced gene 2; transmembrane protein AMIGO2;
                     transmembrane protein AMIGO2-like"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_877968.3"
                     /db_xref="GeneID:300186"
                     /db_xref="RGD:727911"
                     /translation="MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSSSGLCPTAC
                     ICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLIVRHN
                     NITSISTGSFSTTPNLKCLDLSSNRLKSVKSAMFQELKVLEVLLLYNNHISYLDPAAF
                     GGLSHLQKLYLSGNFLTKFPMDLYVGRFKLADLTFLDVSYNQIASIPMHHINLVPGKQ
                     LRGIFLHGNPFVCDCSLYSLLTFWYRRHFNSVTDFKHDYTCRLWLDSRHSHQLLLLQD
                     SFLNCSHSVINGSFHALGFIHEAQVGERAIVHCDGKTGNGNTDFIWVGPDNRLLEPDK
                     DTGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHHA
                     HEAFNTAFTTLAACVVSIVLVLLYLYLTPCPCKCRDKRQKNALNQSNAHSSILSPGPT
                     RDASAEDRKAGKRVVFLEPLKDPAVGQNGKVKLVPSETVIAEGILKSSRAKSDSDSVN
                     SVFSDTPFVAST"
ORIGIN      
        1 gcgccaccgg cgggccggct ttccccgccg cccaccccgc tcccggcgcg gccgagctcc
       61 ggcggtacct gcagccgagc cagagagccg gggagccctc gccgccgcct cgaaactcgc
      121 caaagttgag aggctgccgc ccaccgggag ctggagggaa ggtgcgagcg cgcggggcgc
      181 gaaccggcag acggacgcgc ggaccttctg agcgcaccgc cgtcggcggc ctctcccgag
      241 ccgctgcggc ttccccgcgc tgtgagtggt cggctagacc gacggctggc taagtatttc
      301 cgttcaattg tttatgggat gcgattgtgt attttttgtg tcggcggagg gagttaaggc
      361 agaatgcacc ctttaaaaac aaaaacaaca acaacaaaaa aaatcctgag tttctgatag
      421 tgagactgtt gcattgagag gaggtacctg gaaatcgtac tgagttggag taatctagga
      481 aaaatgcatt taacaggttc tttttttttt aaagaccccc caattggaga tggaacccat
      541 ctcaaaagtt gattggaacg aaagcaatta cggaataact ctaaggggtt aactagtggc
      601 agttaacttg tacttctctc ccgtttttaa atgttgttac cagattggtg ggaggctgtg
      661 ctggtgagaa gcgactggca agaggctcag aggcgaccat aatgtcgtta aggttccaca
      721 cactgcccac cctgcctaga gctgtcaaac cgggttgcag agagctgctg tgtctgttgg
      781 tgatcgcagt gatggtgagc cccagctcct caggactgtg ccctacggct tgcatctgtg
      841 ccactgacat tgtaagctgc accaacaaaa acctgtctaa ggtgcctggg aaccttttcc
      901 gactgattaa aagactggat ctgagctata acagaatcgg actcctggat gccgactgga
      961 ttccggtgtc gttcgtcaag ctgagcaccc tgattgttcg ccacaacaac atcaccagca
     1021 tttccacggg cagcttctcc accactccaa atttaaagtg tctcgactta tcgtccaata
     1081 ggctgaagtc ggtgaaaagt gccatgttcc aggagctaaa ggttctggaa gtgctcctgc
     1141 tttacaacaa ccacatttcc tatctggacc cggcagcgtt cggagggctc tcccacttgc
     1201 agaaactcta cctgagtggg aacttcctca cgaagttccc tatggatttg tatgtcggga
     1261 ggttcaagct ggctgatctg acatttttag atgtttcgta caatcaaatt gcttccatac
     1321 caatgcacca cataaattta gtgccgggaa agcagctgag gggcatcttc cttcacggga
     1381 accctttcgt ctgtgactgt tccctgtact ccttgctgac cttctggtac cgtaggcact
     1441 ttaactctgt gacggatttc aagcatgact acacctgtcg cctgtggttg gactccaggc
     1501 actcccacca gctgttgctg ctccaggata gctttctgaa ctgttctcac agcgtcatca
     1561 acggctcctt ccacgcactt ggctttatcc acgaggctca ggttggggaa agggcgattg
     1621 tccactgtga cggcaaaacc ggtaacggga acaccgattt catctgggtg ggtcccgaca
     1681 acaggctgtt ggagccggat aaagacacgg ggaactttcg agtgttttac aacggaagcc
     1741 tggttataga gaaccctggt tttgaggacg ccggggttta ctcctgtatc gccatgaaca
     1801 ggcagcgcct gttgaatgag acggtggaca tcatgataaa cgtgagcaat ttcaccataa
     1861 acagatccca ccacgcccac gaggcattta acacggcttt caccaccctg gctgcctgcg
     1921 tggtcagtat cgtcctagtg ctactgtacc tgtacctgac accgtgtccc tgcaaatgta
     1981 gagacaagag acagaaaaac gcactgaacc aaagcaacgc ccattcgtcc attctcagtc
     2041 ccggccccac ccgggatgcc tctgctgagg atcggaaggc aggtaaaaga gtggtgtttt
     2101 tggagcccct gaaggatcca gcggtgggac agaatggaaa agtcaagctt gtccccagtg
     2161 agaccgttat agccgagggc atcttaaagt cctccagggc aaaatctgac tcagactcgg
     2221 tcaattccgt gttctcagac acacccttcg tggcatccac ttaaccgtgt gcctgtgttc
     2281 gtctggtgtc gtgatttgac ctctccctac ccaactgcag tccacgaaat tagtagcagg
     2341 agagaaactg ttttgtcttt ttgagagaaa accaaatggt gtctttatga tggttgctag
     2401 gaagtgaggc agagcaccct ggttgcttcc tcgtgctggg taaagatcca gttgattttg
     2461 agagtcttaa gttcccagta acagccatca gcatctttga ggatttcagg ctggcctgaa
     2521 ggcggtagga ccagccatta tctcctggtt atctcggagg gaaaaaaaat aaagctatgt
     2581 gttagcattc tttaaaaata gaacctttta acttactaga gccaaagttg agctgagctt
     2641 ttcttatttt taagaaaaac acgagtggct tctttcccct ctaaaagatg tagaaggaag
     2701 aatcggttat ttatagatca taaagttagc atagaggttt ttcagccgaa accatcattt
     2761 cggaccagga tagacacact agtaacatcc acagaatcat gccacgtccc atggagtgca
     2821 caggggccta gcttttagct gtcttctccg tcatctctgt gctgtatcct ggtacaaaag
     2881 atgcccccca aaaagttaaa ggtgtcttta tgtgttgcca agagtatgtg tcactgccaa
     2941 actgtctgag tcactcccta caccctcacc gcagcagact caggtttgtc cacctgcgtg
     3001 tgtatatgta aaaccttaag ttctatgaat ggccgtatag accccaatgt actgtattcc
     3061 agacatttaa atcagcgtaa atacacgtgc tctgtga
//
