LOCUS       NM_001412551            5013 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus adhesion molecule with Ig like domain 1 (Amigo1),
            mRNA.
ACCESSION   NM_001412551 XM_008761391
VERSION     NM_001412551.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5013)
  AUTHORS   Peltola,M.A., Kuja-Panula,J., Liuhanen,J., Voikar,V., Piepponen,P.,
            Hiekkalinna,T., Taira,T., Lauri,S.E., Suvisaari,J., Kulesskaya,N.,
            Paunio,T. and Rauvala,H.
  TITLE     AMIGO-Kv2.1 Potassium Channel Complex Is Associated With
            Schizophrenia-Related Phenotypes
  JOURNAL   Schizophr Bull 42 (1), 191-201 (2016)
   PUBMED   26240432
REFERENCE   2  (bases 1 to 5013)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   3  (bases 1 to 5013)
  AUTHORS   Chen,Y., Hor,H.H. and Tang,B.L.
  TITLE     AMIGO is expressed in multiple brain cell types and may regulate
            dendritic growth and neuronal survival
  JOURNAL   J Cell Physiol 227 (5), 2217-2229 (2012)
   PUBMED   21938721
  REMARK    GeneRIF: Data show that AMIGO is a glycosylated protein widely
            expressed in the central nervous system (CNS), and can be found in
            neurons, astrocytes as well as oligodendrocytes.
REFERENCE   4  (bases 1 to 5013)
  AUTHORS   Peltola,M.A., Kuja-Panula,J., Lauri,S.E., Taira,T. and Rauvala,H.
  TITLE     AMIGO is an auxiliary subunit of the Kv2.1 potassium channel
  JOURNAL   EMBO Rep 12 (12), 1293-1299 (2011)
   PUBMED   22056818
  REMARK    GeneRIF: AMIGO is a function-modulating auxiliary subunit for
            Kv2.1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5013)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced XM_008761391.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.9763.1,
                                           SRR26643297.9091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               JAXUCZ010000002.1  198511308-198511625
            319-5013            JAXUCZ010000002.1  198512048-198516742
FEATURES             Location/Qualifiers
     source          1..5013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5013
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="adhesion molecule with Ig like domain 1"
                     /db_xref="GeneID:295365"
                     /db_xref="RGD:1303079"
     exon            1..318
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /inference="alignment:Splign:2.1.0"
     exon            319..5013
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1896
                     /gene="Amigo1"
                     /gene_synonym="Amigo"
                     /note="amphoterin-induced protein 1; AMIGO-1; alivin-2;
                     amphoretin-induced gene and ORF; transmembrane protein
                     AMIGO"
                     /codon_start=1
                     /product="amphoterin-induced protein 1 precursor"
                     /protein_id="NP_001399480.1"
                     /db_xref="GeneID:295365"
                     /db_xref="RGD:1303079"
                     /translation="MQPQRDLRGLWLLLLSLFLLLFEVARAGRPVVSCPANCLCASNI
                     LSCSKQQLPNVPQSLPGYTALLDLSHNNLSRLKAEWTPTRLTNLHSLLLSHNHLNFIS
                     SEAFVPVPNLRYLDLSSNHLHTLDEFLFSGLQALEVLLLYNNHIVVVDRNAFEDMAQL
                     QKLYLSQNMISRFPLELIKDANRLPKLTLLDLSSNKLKKLPLTDLQKLPAWVKNGLYL
                     HNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCVHSKKLHNVFSLDFFNCSEYKES
                     AWEAHLGDTLTITCDTKQQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVE
                     DGGVYTCYAMGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLY
                     LTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPG
                     QGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV"
ORIGIN      
        1 gctcgctgcc cccacgctgc tccctcggct gggatcgcgg cgtctcccgc tcgccgcact
       61 gctccacgcc tggcccgtgg ctccggaggc ggcagtcgtg ccaggtgggc tcgggtggac
      121 aggcgcggcg gtcggggcga ggcggcggca cgggtggaca gcgcggaacc cagcaagttc
      181 ctcgcaggcg atgtcgccgg gcgcgggccc ctgcgtacgc cgggcgccgt gacaggccag
      241 ccggggaggc gcggacgggg gaggccgcga cggagctccc ggactggcca tgggctgagc
      301 cgcatcctca cggagcagcc tgtagtgaaa gtgacccttc catactccac cagaacatgc
      361 cggggtgact ctctcccaga tcccgtggcc ttcctcgctc tccccagtga cactatgcaa
      421 ccccagcgtg acctgcgagg cctctggctc ctgctgctct ccttgttcct gcttctcttt
      481 gaggtagcta gggcaggccg acctgtggtc agttgtcccg ccaattgcct gtgcgccagc
      541 aacatcctca gctgctccaa gcagcagcta cccaatgtgc cccaatcttt gccgggctac
      601 acagcgctac tggacctcag ccacaacaac ttgagccggc tgaaggctga gtggaccccc
      661 acccgtctga ccaacctgca ctccctgctg ctgagccaca accacctgaa cttcatctcc
      721 tctgaggcct tcgtcccggt acccaacctt cggtacctgg acctctcctc caaccatctt
      781 cacacgctgg atgagttcct gttcagcggc ctgcaggcac tggaagtgct gctgctctac
      841 aataaccaca ttgtggtggt ggaccggaat gccttcgagg acatggccca gctgcagaaa
      901 ctctacctaa gccagaatat gatctctcgc tttcctctgg aactgatcaa ggatgcaaac
      961 agattaccca aactaacgct cttggatctg tcctccaaca agctgaagaa gttgcccctg
     1021 actgacctgc agaaattgcc agcctgggtc aagaatgggc tgtacctgca taacaacccc
     1081 ctggagtgtg actgcaagct ctaccagctc ttttcacact ggcagtaccg gcagctgagt
     1141 tctgtgatgg acttccagga ggatctgtat tgcgtgcact ccaagaagct gcataacgtc
     1201 ttcagtctgg atttcttcaa ttgcagcgag tacaaggaaa gtgcctggga ggctcacctg
     1261 ggagacacct tgaccatcac gtgcgatacc aaacagcaag ggatgaccaa agtgtgggtg
     1321 accccaagca atgagcaggt gctaaaccag ggggccaatg gcacggtgac cgtgtccgag
     1381 gatggcaacc ttcattttaa agaggtgcag gttgaggatg ggggtgtgta tacctgctat
     1441 gccatggggg agactttcaa cgaaacactg tctgtggagt tgaaagtgta taacttcacc
     1501 ttgcacggac accatgacac cctcaacaca gcctatacta ccctggtggg ctgcatcctc
     1561 agtgtggttc tggtcctcat atacttgtac ctcacacctt gccgctgctg gtgccggggt
     1621 gtggagaagc cttccagcca tcaaggagat agcctcagct cttctatgct cagtaccaca
     1681 cccaaccatg accctatggc tggtggggac aaagatgatg gttttgaccg gcgggtggcc
     1741 ttcctggaac ctgctggacc agggcagggt caaaatggca aactcaagcc aggcaacact
     1801 ctgccggtgc ccgaggcaac aggcaagggc caacggagga tgtcagatcc agagtcggtc
     1861 agctcggtct tttctgatac acccattgtg gtgtgagcag tataggctga tggggaggtt
     1921 ctgccccagg agaggtagtg tacccctgag ggatatgagg gggtggaaga gagggctggc
     1981 tgcccaaggg agtgggttcc tcctgaccac cagggaatcg gtcatgggca caggaggagg
     2041 caagacccca gtgagggtgt ggatgctgtg agtttcacac atggatatat tcatcctcag
     2101 gcagatacca caccctaccc aaagccttgg ctattctcag tgtggtagag gaggagggat
     2161 acgtctgagt tggacaggaa cgaggaaaag ggtgtgggga ggagcagatt ccctaaactt
     2221 tttttgaggt catccctagc tccttaagag aaaaccattt gaaaaacaac tttttttttc
     2281 tgtctctgcc cacccacacc tgcgaagttg tgtgttgggg gggcctccac aggagccatg
     2341 ctgggaagct gcagtgtctt ctctggtcag ggagtcgaat tcatagctag tgaactggaa
     2401 acctttggaa aatgagtcag gaaaaggctg agacctggat caataccact ctgtaatgct
     2461 gctgtgagac ttctcactag agctgtcttc tttccctggg agtcctgagt aggtgaatct
     2521 ttgcaggagc ctggcctctt gcctgttagt tatggcagca atataggaca ttgtgtctgt
     2581 gccttgtcct ggggcaggtg gcacagttgg gtacagaatg aattaatagg tccctgtcct
     2641 agcataaaac ttgtagatgg ggcataaatt ccaggtaggc taattccctg gctgggagaa
     2701 agccttgatt agtatttgtc tcccaatgtc tatctgttgg gacaagagta ggggacactg
     2761 aagaaggagc attatggtgc ctgccaccac tgtggcacaa gggccatact tgctgagaga
     2821 accgggaaga ccggcctgtg atgtagcagt cagccagacc tacctgatcc ttcatgtatg
     2881 ccatctcttc tgtcaacctt ctgatggact caggtggggt tctgagcctt cctcagacgc
     2941 tgctctgcaa aggagggggc agtgagacga ggtctggaga tagacgggac ctaatgttta
     3001 ttttctctct gctgacaggg ctgcctcact cctgcaaagc caaagtgtgg gatttctgtc
     3061 atctgaaggg ttagaaccta gtggtctttt gtcccacaat ggcgatacag agtgtggctt
     3121 agagttctgc cctctcccac caggcactca ggccgtcttg taactgaggc ggaaggggca
     3181 ctaaactttg aaaaggaagg aagttctgcc ataccgttcc tgtcagttgg agatcagtgc
     3241 agtcctggct gtcagagcag agggacttaa aaacaaaccc agccttagct tccatccagg
     3301 cttgcaagat gctttcggta cagagatgac tctgccttgc tgcatcccgt gagcaaactg
     3361 caggccccag aggcagttgt tctgagcttt ggaagagggg tgagcagggc agaggtgaaa
     3421 gcgttcccta gcgttggtct tttccggtgt cttttctttc tcgtttcctg tggttggaag
     3481 tcgtccaggt cctctagttt cctgacctgc ttttgaggtt ctaaggggtg ttgtttacct
     3541 gtgggtgagg gctgcttagt gctgggaggg cctgtcaggc tgcttataag gactggggaa
     3601 gagaaactga agtaaacatt gtcccctgtc tgctcctggg atctcaaggc tgctgtccat
     3661 cttttattag taacctagtt ttatcaagag agaggtgcag cgatcccctt taagtagttg
     3721 catgctcctg ggtacgcatg ctcctaggta tgcatgcaca ccagcacctt gacctccacc
     3781 aggacagtga gtctgtggcc ccctctgatg ccatcattct agaacagctt ccacccacgc
     3841 acacaacttc tcacacacag ttttcttgca ctgcaggaga gacagtgacc atgccaggct
     3901 cctcaaatgc acaatctctt gtactttaat ttctgaacac cctgaatttt tacccatatc
     3961 tccatggagc tgaatcactt ttctgcagat gctggagtta ggggggacca cacactggag
     4021 cttttgggag gttagtaagg tactagctgg ttcatcggac tcctcaggaa ctctccttaa
     4081 aaactatata tctataagac aggaggctag aaccagagca acgaaggact ccgaaggatg
     4141 ctggtggagg ctaagcagct ctgaattgtt cttcctgtgt cctaatagac aagggttgga
     4201 gaggaattgg ttgtattcca aagacttctg ggcactttgt caccagaggt ccaagagcca
     4261 gacctccatc agcagactca caaggaaatg agaaaatctc ttagtggcag catcctctcc
     4321 tgataccatc aagggttgtg agactcttta aaatgaaagt caaatgaaat ttgccttctg
     4381 gggcattcta gctgagcttc tgagggccag gagggtcatt ttctttttaa gtcctactct
     4441 gaagcctagc tctccctact ataacagcta acttgggccc tagttcaaga cacctgcagg
     4501 acatgtctgg acgctctacc aggacattta actgatttct ctcctcgtgg tttcagttct
     4561 tatgacccaa ctttgtcctt gtaggggggt gtacatgtat gtctgtattc caaaaacata
     4621 tgatcccatt agaccttggg aaaaaaacga ccaggtgtag atataagaaa ggctggcctt
     4681 caccccatct atactcataa actatctccc aggaaggaga agcaggttcc tctggagaca
     4741 ggatgtgaca ggactctaca gtctgtgtaa ttatctgtga tctttttctt tgctgtatct
     4801 atggggcccc tggaggaggc caggaagggt agacctgtct ggggagaaca aagccgattt
     4861 ccgggtgtgt atgtgtcttt gccttgtaat tctctctttc tgtgtctagg actcttcctc
     4921 ccactgtgta caccaggctg gcaaacctcg gagcccacgg gctctggaac tagacaatga
     4981 ccattaaacc tggcttgagt ctctgctctg gca
//
