LOCUS       NM_030998               2049 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus anti-Mullerian hormone receptor type 2 (Amhr2),
            mRNA.
ACCESSION   NM_030998
VERSION     NM_030998.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Imhoff,F.M., Yang,D., Mathew,S.F., Clarkson,A.N., Kawagishi,Y.,
            Tate,W.P., Koishi,K. and McLennan,I.S.
  TITLE     The type 2 anti-Mullerian hormone receptor has splice variants that
            are dominant-negative inhibitors
  JOURNAL   FEBS Lett 587 (12), 1749-1753 (2013)
   PUBMED   23624077
  REMARK    GeneRIF: physiological function(s) of type 2 anti-Mullerian hormone
            receptor
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Song,J.Y., Chen,K.Y., Kim,S.Y., Kim,M.R., Ryu,K.S., Cha,J.H.,
            Kang,C.S., MacLaughlin,D.T. and Kim,J.H.
  TITLE     The expression of Mullerian inhibiting substance/anti-Mullerian
            hormone type II receptor protein and mRNA in benign, borderline and
            malignant ovarian neoplasia
  JOURNAL   Int J Oncol 34 (6), 1583-1591 (2009)
   PUBMED   19424576
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Bakkum-Gamez,J.N., Aletti,G., Lewis,K.A., Keeney,G.L., Thomas,B.M.,
            Navarro-Teulon,I. and Cliby,W.A.
  TITLE     Mullerian inhibiting substance type II receptor (MISIIR): a novel,
            tissue-specific target expressed by gynecologic cancers
  JOURNAL   Gynecol Oncol 108 (1), 141-148 (2008)
   PUBMED   17988723
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Zhan,Y., Fujino,A., MacLaughlin,D.T., Manganaro,T.F., Szotek,P.P.,
            Arango,N.A., Teixeira,J. and Donahoe,P.K.
  TITLE     Mullerian inhibiting substance regulates its receptor/SMAD
            signaling and causes mesenchymal transition of the coelomic
            epithelial cells early in Mullerian duct regression
  JOURNAL   Development 133 (12), 2359-2369 (2006)
   PUBMED   16687449
  REMARK    GeneRIF: Data suggest that Mullerian inhibiting substance (MIS)
            initiates an epithelial-to-mesenchymal transition of MISRI
            receptor-expressing cells and specifies the components of the
            receptor/SMAD8 signaling pathway by regulating their expression.
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Mendis-Handagama,S.M., Di Clementi,N., Ariyaratne,H.B. and
            Mrkonjich,L.
  TITLE     Detection of anti-Mullerian hormone receptor II protein in the
            postnatal rat testis from birth to sexual maturity
  JOURNAL   Histol Histopathol 21 (2), 125-130 (2006)
   PUBMED   16329036
  REMARK    GeneRIF: examined the presence of AMH receptor type II (AMHR-II) in
            fetal Leydig cells (FLC) and cells in the adult Leydig cells
            lineage in the postnatal testis; presence of AMHR-II in postnatal
            FLC suggests a possible role by AMH on FLC
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Teixeira,J., Kehas,D.J., Antun,R. and Donahoe,P.K.
  TITLE     Transcriptional regulation of the rat Mullerian inhibiting
            substance type II receptor in rodent Leydig cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13831-13838 (1999)
   PUBMED   10570158
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Mishina,Y., Rey,R., Finegold,M.J., Matzuk,M.M., Josso,N., Cate,R.L.
            and Behringer,R.R.
  TITLE     Genetic analysis of the Mullerian-inhibiting substance signal
            transduction pathway in mammalian sexual differentiation
  JOURNAL   Genes Dev 10 (20), 2577-2587 (1996)
   PUBMED   8895659
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Teixeira,J., He,W.W., Shah,P.C., Morikawa,N., Lee,M.M.,
            Catlin,E.A., Hudson,P.L., Wing,J., Maclaughlin,D.T. and
            Donahoe,P.K.
  TITLE     Developmental expression of a candidate mullerian inhibiting
            substance type II receptor
  JOURNAL   Endocrinology 137 (1), 160-165 (1996)
   PUBMED   8536608
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Imbeaud,S., Faure,E., Lamarre,I., Mattei,M.G., di Clemente,N.,
            Tizard,R., Carre-Eusebe,D., Belville,C., Tragethon,L., Tonkin,C.,
            Nelson,J., McAuliffe,M., Bidart,J.M., Lababidi,A., Josso,N.,
            Cate,R.L. and Picard,J.Y.
  TITLE     Insensitivity to anti-mullerian hormone due to a mutation in the
            human anti-mullerian hormone receptor
  JOURNAL   Nat Genet 11 (4), 382-388 (1995)
   PUBMED   7493017
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Baarends,W.M., van Helmond,M.J., Post,M., van der Schoot,P.J.,
            Hoogerbrugge,J.W., de Winter,J.P., Uilenbroek,J.T., Karels,B.,
            Wilming,L.G., Meijers,J.H. et al.
  TITLE     A novel member of the transmembrane serine/threonine kinase
            receptor family is specifically expressed in the gonads and in
            mesenchymal cells adjacent to the mullerian duct
  JOURNAL   Development 120 (1), 189-197 (1994)
   PUBMED   8119126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 20, 2020 this sequence version replaced NM_030998.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X71916.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000007.1  135457922-135458046
            126-234             JAXUCZ010000007.1  135458313-135458421
            235-417             JAXUCZ010000007.1  135458700-135458882
            418-609             JAXUCZ010000007.1  135459081-135459272
            610-681             JAXUCZ010000007.1  135459529-135459600
            682-800             JAXUCZ010000007.1  135459794-135459912
            801-1031            JAXUCZ010000007.1  135460027-135460257
            1032-1146           JAXUCZ010000007.1  135464529-135464643
            1147-1319           JAXUCZ010000007.1  135464760-135464932
            1320-1467           JAXUCZ010000007.1  135465065-135465212
            1468-1604           JAXUCZ010000007.1  135465358-135465494
            1605-2049           JAXUCZ010000007.1  135466343-135466787
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2049
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /note="anti-Mullerian hormone receptor type 2"
                     /db_xref="GeneID:29530"
                     /db_xref="RGD:70964"
     exon            1..125
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            126..234
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1859
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /EC_number="2.7.11.30"
                     /note="anti-Mullerian hormone type 2 receptor;
                     anti-Muellerian hormone type-2 receptor; anti-Muellerian
                     hormone type II receptor; AMH type II receptor; MIS type
                     II receptor; anti-Mullerian hormone receptor type 11 SV1;
                     anti-Mullerian hormone receptor, type II"
                     /codon_start=1
                     /product="anti-Muellerian hormone type-2 receptor
                     precursor"
                     /protein_id="NP_112260.1"
                     /db_xref="GeneID:29530"
                     /db_xref="RGD:70964"
                     /translation="MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEVVD
                     AGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCLDSDEPGCESLHCDPVPRAHPSP
                     SSTLFTCSCGTDFCNANYSHLPPSGNRGAPGPQEPQATPGGPIWMAQLLLGVFLVLLL
                     SIIILALLQRKACRVQGGSDPEPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAG
                     RLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGPLPSGPLLV
                     LELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSS
                     QNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDK
                     TLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACE
                     LWALAVAERKRPNIPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAY
                     PQVASSFPESCPQGCPENCPAAPASAAFPCRPQQSSCLLSVQQGSGSKS"
     exon            235..417
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            418..609
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            610..681
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            682..800
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1031
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1146
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1319
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1467
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1604
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..2049
                     /gene="Amhr2"
                     /gene_synonym="C14; MISRII; MRII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgaagtct tctctgttca ggatgctaca aatgagttct caatccatgg gaaccatctt
       61 gggcagagct gagcgcccaa aatatctttc tgaaaaagac ggaaggtcca gcaccttctt
      121 ccaaggaagc gttgacgagg gtagctgtgc tggtgtgtgc tgtcctgctg acatccttta
      181 gtaggatgct ggggacactg gggctttgga cactgcttcc tgcagctgca caagtatccc
      241 caaacaggag gacctgtgtg ttctttgagg ctcctggagt tcggggaagc acaaaaacac
      301 tgggggaagt ggtagatgca ggaccaggcc ccccgaaggg tatccgctgc ctctacagcc
      361 attgctgctt tgggatctgg aatctgaccc atggccgggc acaagtggag atgcaaggat
      421 gcctagacag tgatgaaccc ggctgtgagt ccctccactg tgaccccgtc ccccgagcgc
      481 accccagccc cagctccaca ctcttcacat gctcctgcgg taccgacttc tgcaatgcca
      541 actacagcca tctgcctcct tcaggaaacc gaggggctcc cggcccccag gagcctcagg
      601 ctaccccagg tgggcccatc tggatggcgc agctgctgct gggagtgttc cttgtgctgc
      661 tgctgagtat catcatcttg gccctgttac aacgaaaagc ctgtagagtg caaggtgggt
      721 cagacccgga gccggagcca ggctcaggag gagactgcag tgaggaactg cccgagttgg
      781 ctgagctgcg cttctcccag gtaatccagg aaggaggtca tgcagtcgtc tgggctggga
      841 ggctccaggg tgagatggta gccatcaagg ccttcccccc aagggctgtg gcccagttcc
      901 gagctgagcg agctgtgtac cagctgctag gcctacagca taaccacatt gttcgcttta
      961 tcactgctgg ccagggaggc cctggcccct tgccctctgg gcctttgctg gtactggaac
     1021 tgtaccctaa gggctcctta tgccactact tgactcagta cacgagcgac tggggcagtt
     1081 ccttgaggat ggctctgtcc ctggccgagg gcctggcgtt tctccacggg gagcgttggc
     1141 aggatggcca gtacaaacca ggtatcgctc accgagacct gagcagccag aatgtgctca
     1201 ttcgggaaga taggtcatgt gccatcggag acctgggcct tgccttggta ctccctggcc
     1261 ttgctcagcc ccctgccttg gcccctactc aaccccgagg cccagctgcc attttggagg
     1321 ctggcaccca gaggtacatg gctccggagc tcttggacaa gactctagac ctgcaggact
     1381 ggggcacagc tctccagaga gcggatgttt actctctggc tctactactg tgggagatcc
     1441 tgagccgctg ttccgatttg aggcctgacc acagaccacc accttttcaa ttggcttatg
     1501 aggcagaact gggcagcaat cccagtgcct gtgagctctg ggccctggcg gtcgcggaga
     1561 ggaagcgccc caacatccct tcctcttgga gctgctctgc cacagaccct agggggctga
     1621 gggagctcct ggaagattgc tgggacgcag acccagaagc aaggctgaca gctgagtgtg
     1681 tgcagcagcg cctggcagcc ctggcttatc ctcaggtggc ttcctccttc ccagagagct
     1741 gtccacaggg ctgcccagag aactgccctg cagcgcctgc ctctgcggct ttcccctgca
     1801 ggcctcagca gagttcttgt ctcctcagtg ttcagcaagg ctctggctct aagtcctgag
     1861 cctgtaagtg ccactgttca ggtgtatgta aatgagcagc tcatatgaac tctgtacagg
     1921 ctgacatgcg tgtggccgac atgcgtgtgt caggtgtcag cctcatgcct gttgatgtca
     1981 ttctgtgtgg gtttctaacc catcgggtag ctatgctcag gaaagagaat aaagcaagat
     2041 tcccactca
//
