LOCUS       NM_012902               1730 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus anti-Mullerian hormone (Amh), mRNA.
ACCESSION   NM_012902
VERSION     NM_012902.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Zhang,Y., Yu,X., Liu,L. and Zheng,J.
  TITLE     Mechanisms of DHEA-induced AMH increase in the ovarian tissues of
            PCOS rat
  JOURNAL   Reprod Biol 23 (4), 100797 (2023)
   PUBMED   37633225
  REMARK    GeneRIF: Mechanisms of DHEA-induced AMH increase in the ovarian
            tissues of PCOS rat.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Sominsky,L., Younesi,S., De Luca,S.N., Loone,S.M., Quinn,K.M. and
            Spencer,S.J.
  TITLE     Ovarian follicles are resistant to monocyte
            perturbations-implications for ovarian health with immune
            disruptiondagger
  JOURNAL   Biol Reprod 105 (1), 100-112 (2021)
   PUBMED   33709094
  REMARK    GeneRIF: Ovarian follicles are resistant to monocyte
            perturbations-implications for ovarian health with immune
            disruptiondagger.
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Risvanli,A., Ocal,H., Timurkaan,N., Ipek,P., Cevik,A. and Seker,I.
  TITLE     Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats
  JOURNAL   Exp Clin Transplant 18 (5), 618-625 (2020)
   PUBMED   31724927
  REMARK    GeneRIF: Effects of Ovarian Transplant on Anti-Mullerian Hormone,
            Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   da Rosa,L.A., Escott,G.M., Simonetti,R.B., da Silva,J.C.D.,
            Werlang,I.C.R., Goldani,M.Z., de Fraga,L.S. and Loss,E.D.S.
  TITLE     Role of non-classical effects of testosterone and epitestosterone
            on AMH balance and testicular development parameters
  JOURNAL   Mol Cell Endocrinol 511, 110850 (2020)
   PUBMED   32387527
  REMARK    GeneRIF: Role of non-classical effects of testosterone and
            epitestosterone on AMH balance and testicular development
            parameters.
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Lee,J.H., Lee,M., Ahn,C., Kang,H.Y., Tran,D.N. and Jeung,E.B.
  TITLE     Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene
            Diepoxide-Induced Ovarian Failure Model
  JOURNAL   Int J Environ Res Public Health 14 (2), 161 (2017)
   PUBMED   28208728
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Segev,D.L., Hoshiya,Y., Stephen,A.E., Hoshiya,M., Tran,T.T.,
            MacLaughlin,D.T., Donahoe,P.K. and Maheswaran,S.
  TITLE     Mullerian inhibiting substance regulates NFkappaB signaling and
            growth of mammary epithelial cells in vivo
  JOURNAL   J Biol Chem 276 (29), 26799-26806 (2001)
   PUBMED   11356848
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Tian,X.Y., Sha,Y.S., Zhang,S.M., Chen,Y.B., Miao,S.Y., Wang,L.F.
            and Koide,S.S.
  TITLE     Extracellular domain of YWK-II, a human sperm transmembrane
            protein, interacts with rat Mullerian-inhibiting substance
  JOURNAL   Reproduction 121 (6), 873-880 (2001)
   PUBMED   11373173
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   McGee,E.A., Smith,R., Spears,N., Nachtigal,M.W., Ingraham,H. and
            Hsueh,A.J.
  TITLE     Mullerian inhibitory substance induces growth of rat preantral
            ovarian follicles
  JOURNAL   Biol Reprod 64 (1), 293-298 (2001)
   PUBMED   11133686
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Carre-Eusebe,D., Imbeaud,S., Harbison,M., New,M.I., Josso,N. and
            Picard,J.Y.
  TITLE     Variants of the anti-Mullerian hormone gene in a compound
            heterozygote with the persistent Mullerian duct syndrome and his
            family
  JOURNAL   Hum Genet 90 (4), 389-394 (1992)
   PUBMED   1483695
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Haqq,C., Lee,M.M., Tizard,R., Wysk,M., DeMarinis,J., Donahoe,P.K.
            and Cate,R.L.
  TITLE     Isolation of the rat gene for Mullerian inhibiting substance
  JOURNAL   Genomics 12 (4), 665-669 (1992)
   PUBMED   1572639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 11, 2022 this sequence version replaced NM_012902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.25650.1,
                                           SRR26643293.38219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               JAXUCZ010000007.1  9559460-9559867     c
            409-551             JAXUCZ010000007.1  9558984-9559126     c
            552-660             JAXUCZ010000007.1  9558708-9558816     c
            661-820             JAXUCZ010000007.1  9558461-9558620     c
            821-1730            JAXUCZ010000007.1  9557451-9558360     c
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1730
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /note="anti-Mullerian hormone"
                     /db_xref="GeneID:25378"
                     /db_xref="RGD:2108"
     exon            1..408
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1670
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /note="muellerian-inhibiting factor; anti-Muellerian
                     hormone; muellerian-inhibiting substance; Anti - Mullerian
                     hormone (Mulerian inhibiting substance)"
                     /codon_start=1
                     /product="muellerian-inhibiting factor precursor"
                     /protein_id="NP_037034.1"
                     /db_xref="GeneID:25378"
                     /db_xref="RGD:2108"
                     /translation="MQGPHLSLLLLLLATMGAVLQADTVEELTNTRGLIFLEDGVWPP
                     SSPPEPLCLVAVRGEGDTSKASLTVVGGLHSYEHAFLEAVQESRWGPQDLATFGVCST
                     DSQTTLPALQRLGAWLGETGEQQLLVLHLAEVIWEPQLLLKFQEPPPGGASRWEQALL
                     VLYPGPGPQVTVTGAGLQGTQSLCPTRDTRYLVLTVHFPAGAWSGSGLALTLQPSKEG
                     ATLTIAQLQAFLFGSDSRCFTRMTPTLVLLPPTGPTPQPAHGQLDTVPFPQPGLSLEP
                     EDLPHSADPFLETLTRLVRALRGPLTRASNTRLALDPGALASFPQGLVNLSDPVALGR
                     LLDGEEPLLLLLSPAAATVGEPMRLHSPTSAPWAAGLARRVAVELQAAASELRDLPGL
                     PPTAPPLLSRLLALCPNDSRSAGDPLRALLLLKALQGLRAEWRGREGRGRAGRSKGTG
                     TDGLCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQA
                     RGAALGRLPCCVPTAYTGKLLISLSEEHISAHHVPNMVATECGCR"
     exon            409..551
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            552..660
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            661..820
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1730
                     /gene="Amh"
                     /gene_synonym="MIS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccaccat gcaggggcca cacctctctc tgctgctgct gctgctagcg actatggggg
       61 ctgtgttaca ggctgacaca gttgaagaac tgaccaatac caggggcctc atcttccttg
      121 aagatggggt ctggcctccc agcagtcccc ctgagccttt gtgcctggtg gcggtgagag
      181 gggaagggga cacaagcaag gcttccctga cggtggtggg gggcctgcac agctatgagc
      241 atgccttcct ggaggctgtc caagagtctc gctggggacc tcaagaccta gccaccttcg
      301 gagtctgcag tactgactcc cagactaccc tgcctgccct tcagcgcctc ggggcctggc
      361 tcggagagac tggggaacag cagttgctag tcctacatct ggctgaagtg atatgggagc
      421 ctcagctctt gctgaagttc caagagcctc cacctggggg agccagccgc tgggagcaag
      481 ccctgttagt gctataccct ggacctgggc cccaggtcac agtcacagga gctggactgc
      541 agggcacaca gagcctctgc cctactcggg acacccgcta tttggtgctg actgtgcact
      601 ttccagcggg ggcctggagc ggctcggggc tcgccctaac ccttcaacca agcaaagaag
      661 gtgccaccct gaccatcgct cagctgcagg cctttctgtt tggctctgat tcccgctgtt
      721 tcacgcggat gactcccacc ctagtgctgc tgccacccac cgggccgaca ccgcagccag
      781 cacatggcca gctggacacc gtgcctttcc cgcagcctgg gctgtccctg gagcctgagg
      841 acctgccaca cagtgctgac cccttcctag agaccctcac tcgcttggtt cgtgctctgc
      901 ggggacctct gacccgggcc tcgaacactc gtctggccct ggaccctggt gcgctggcca
      961 gcttcccaca gggcctggtc aacctttcag accccgtggc gctgggacgt ctgctcgatg
     1021 gggaggaacc cctattactg ctgctgtcac ccgctgcggc cactgtgggg gaacctatgc
     1081 ggctgcacag ccccacatct gctccctggg cagcaggcct ggcacgcagg gtagcggtag
     1141 agctgcaggc agcggcctcg gagctgcggg acctcccagg cctgccaccc acagcccccc
     1201 cattgctgtc gcgcctactg gcgctgtgcc ccaacgactc ccgcagcgcc ggggacccgc
     1261 tgcgagcgct gctgctgctg aaggcactgc agggcctgcg tgcagagtgg cgagggcggg
     1321 aagggcgcgg gagggcgggg cgcagcaagg ggacagggac agatgggctg tgcgcgctgc
     1381 gcgagctgag cgtggacctt cgagcagagc gctcagtgct catcccggag acctaccaag
     1441 ccaacaactg ccaaggcgcc tgtgcatggc cacagtcgga ccgtaaccca cggtacggga
     1501 accacgtggt gctgctgcta aaaatgcagg cacgcggggc cgccctgggt cgcctgccct
     1561 gctgtgtgcc cactgcctac accggcaagc tgctcatcag cctgtcggag gagcacatca
     1621 gcgcgcacca cgtgcccaac atggtggcta ccgaatgcgg ctgccggtga tgtccgccct
     1681 accccatccc ccgtgtcccc agtcagcgcc ccaataaaga ttagcaagca
//
