LOCUS       NM_001399520           10309 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus APC membrane recruitment protein 2 (Amer2), mRNA.
ACCESSION   NM_001399520 XM_039093898
VERSION     NM_001399520.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10309)
  AUTHORS   Pfister,A.S., Hadjihannas,M.V., Rohrig,W., Schambony,A. and
            Behrens,J.
  TITLE     Amer2 protein interacts with EB1 protein and adenomatous polyposis
            coli (APC) and controls microtubule stability and cell migration
  JOURNAL   J Biol Chem 287 (42), 35333-35340 (2012)
   PUBMED   22898821
  REMARK    GeneRIF: the Amer2-EB1-APC complex regulates cell migration by
            altering microtubule stability.
REFERENCE   2  (bases 1 to 10309)
  AUTHORS   Pfister,A.S., Tanneberger,K., Schambony,A. and Behrens,J.
  TITLE     Amer2 protein is a novel negative regulator of Wnt/beta-catenin
            signaling involved in neuroectodermal patterning
  JOURNAL   J Biol Chem 287 (3), 1734-1741 (2012)
   PUBMED   22128170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 10, 2022 this sequence version replaced XM_039093898.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643293.59919.1,
                                        SRR26643429.48762.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10309             JAXUCZ010000015.1  38701509-38711817
FEATURES             Location/Qualifiers
     source          1..10309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..10309
                     /gene="Amer2"
                     /gene_synonym="Fam123a; RGD1559605"
                     /note="APC membrane recruitment protein 2"
                     /db_xref="GeneID:498529"
                     /db_xref="RGD:1559605"
     exon            1..10309
                     /gene="Amer2"
                     /gene_synonym="Fam123a; RGD1559605"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2363
                     /gene="Amer2"
                     /gene_synonym="Fam123a; RGD1559605"
                     /note="family with sequence similarity 123A"
                     /codon_start=1
                     /product="APC membrane recruitment protein 2"
                     /protein_id="NP_001386449.1"
                     /db_xref="GeneID:498529"
                     /db_xref="RGD:1559605"
                     /translation="METGRSRGGGAAVSERGGARAGVCRRQEQAGALAADMDSHCECA
                     AETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPAGMVRSRTHDG
                     LAEVLVLEGSKKEEPPGGSDHSGARPIPGPPKASGPGLGSLASSSVAKSHSFFSLLKK
                     NGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKAARAAGPGSLV
                     LPGSLTASLECVKEEPPRTARRPDSPGQDAPRHAAGEPAGGEQAPASAERAPERTCLE
                     ASSPTGPGDQSSRGEDAEGHRRAEKPGAALESGAGEVQAAEDASRTGDVPIKTVPLVD
                     SEGGSGRASAVPDPSSVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADPEEEA
                     GPSCDKHAPGPGKPVLSKKNPSVVAYQGGGEEMASPDEVDDTYLPEFWDMLSQTEDQG
                     QGTQEGAAKAATASDTKLAPETSNDARCGEAAKDVSLVKRRRLHRIPIESQQKEEPKH
                     PEKEHQEGVPNSDEGYWDSTTPGPEEVSVSNSSSSKKVVIPRDSNSGDVLCDLYVEPE
                     ASPAALPATEDPPCLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLSNLPSSHPV
                     VHQQPARSEVPRTKIPVSKVLVRRVSNRGLAGTTIRAAACHDSAKKL"
ORIGIN      
        1 ggtaatgtct gaaactagga tcccgggaaa agctgggcta gcggaagaac ctgaagtgat
       61 gagaatcaac gcactgggaa cctaagccca caattacaaa tttcattttt tctttcgcct
      121 ggaggctgtg atgaaagctc ttgctacaca aaaatctatg tggcacccag ggtattatat
      181 aagcccttga caggagggga gatagtccgg tctgtgcgct tcagccgccg cagtcgcagt
      241 agccacggcg cagcagcgag agccgctcag gttgatttag aacgcgggtg acagtggcct
      301 ggcgcgagcc tacggctgac gacagcggct gatcccactc ggtttccatg gagacgggca
      361 ggagccgagg cggcggcgcg gctgtcagcg agcgcggcgg cgcgcgcgcg ggggtctgca
      421 ggaggcagga gcaggccggg gccctcgctg cagacatgga ctcgcattgt gagtgcgccg
      481 cggagacgcc cgccgcagag ccgccgtcgg ggaagatcaa taaggctgcg ttcaagttat
      541 tcaagaagag gaaatcgggg ggcaccatgc ccagcatttt tggggtcaaa aacaaagggg
      601 atgggaagag ctcggggccg gcggggatgg tgagaagcag gacccacgac ggactagccg
      661 aggtgctggt gctggagggc agcaagaagg aggagccgcc tggcgggagc gatcacagcg
      721 gggcccgacc gatccccgga ccccccaaag cctccgggcc tggcctgggc tccctggcca
      781 gcagctcggt ggccaagtcc cacagcttct tctccctgct gaaaaagaac gggcgatcgg
      841 agaccggcaa gggagaccat gccgaggcga gcaaggctgg cggcaaacaa aagagggggc
      901 tgaaagggat cttcagcagc atgcgctggc accggaggga caagcgcggc aaggaggagg
      961 aggagaaggc ggcgcgcgcg gcgggcccgg gcagcctggt cctgcccggc tcgctcaccg
     1021 ccagcctgga gtgcgtcaag gaggagccgc cccgaaccgc gcgtcgcccg gacagcccgg
     1081 gccaggacgc cccgcgacac gcagcaggtg agcccgcagg gggagagcag gcgcccgcgt
     1141 ccgccgagcg cgccccggag cggacctgcc tcgaggcctc gagccccacc ggccctggcg
     1201 atcaaagctc ccggggagag gacgccgagg ggcatcggcg cgcggagaag cccggggcag
     1261 ccctcgagtc gggagccggt gaggtccagg cggccgagga tgcgtccagg acaggtgacg
     1321 ttccgataaa gaccgtcccc cttgtcgact ccgaaggtgg cagcggccgg gcgtctgctg
     1381 tccctgaccc ttcctctgtt gatccaccct cagacccgtc ggcagatcgt atttgtttga
     1441 tgttttctga cgtgacttca ctgaaaagct ttgactctct tacaggctgt ggagatatta
     1501 ttgcagaccc agaagaagag gcaggcccca gctgtgacaa gcatgccccc gggccaggca
     1561 agccagttct ctctaaaaag aaccccagcg tggtggccta ccaaggagga ggggaggaga
     1621 tggccagccc agatgaggtg gacgacacct atctcccgga attctgggac atgttgtccc
     1681 agactgagga ccaagggcaa ggaacccagg agggcgccgc gaaggcagcc actgcttcgg
     1741 acaccaagtt ggcccctgag acttccaatg atgcccggtg tggggaagca gccaaggacg
     1801 tgtccttggt caagcgcagg aggctccaca ggattcccat tgagtcccag cagaaggagg
     1861 agcccaaaca cccggagaag gagcatcaag aaggtgtccc taacagcgat gagggctact
     1921 gggactccac cactcctggc ccagaagaag tgagcgtcag caacagcagc agcagcaaga
     1981 aggtggtcat ccccagggat agcaacagtg gtgatgttct ctgtgatctc tacgttgaac
     2041 ctgaagcaag cccagccgcc cttcctgcca cagaggaccc accctgcttg tcccggttaa
     2101 agccggtgtc tccaggcacc atcacctgtc ctttgagaac acccggcagc ttgctgaagg
     2161 actctaaaat ccctattagc atcaagcatc tctccaacct tccgtccagc catccggtgg
     2221 tgcaccagca accagccagg agtgaggtgc ccagaacaaa aatccctgtt tccaaagtgc
     2281 tggtccgcag ggtcagcaac cggggcttgg ctggaaccac catcagggca gcagcatgcc
     2341 atgacagtgc caaaaagttg tgaggtcccc aaggccaagg aggatggatg ggccatatgt
     2401 taaggaatac aactttcccc tggaaaccac tgaaggaaat tcgctttctc caaagcaaat
     2461 catttaggac ccacccttct ccatatggcc tagaagtctt tgttggagac agggggcagg
     2521 acaccctgga agggggatgt tacacctgga gttcagataa gtttctgaga attcttttct
     2581 agcactttcc tttttctttt aaccttttca aaagatctgg gctttttgtc tccttctcct
     2641 ccccctcttc ttccacttcc tgctcctcct cctcctccta tttccttatt tcatggatca
     2701 ctcagaagtc acctttcctt gcctttgcag aaaataagat ttaaccaaat ctaacaacaa
     2761 caacaacaac aaaagtcaca ccaggatatc aggctgttct agagtcaaaa gggccttgag
     2821 gaatcagtaa acagcagaat tcttgccttt ctttccagga aagaaaaaaa aaaaaaagac
     2881 cttcacttta tcactgtgtg gaaatcacct caaagctaaa gatgcatgta gctgtgtgac
     2941 tagacaaggg ggctgctgac tggcaggaag tgccccagct gccagttatg caaatagcga
     3001 gagctctgtg tctaggaaga aaacagagag gtttagtatg gctgactcag atcatttgtc
     3061 tgaggagaaa taaaaggctc acgagtagtt tatgtggttt ttttgtttgt gtattttttt
     3121 ttaatccact cctccctctt ggtgcaaagt tcaggatcag ggaaagatct cagtaaatgc
     3181 tgattacact gtattttgtc gtttgtaaac atcaaccttc ttatgtataa ctaatgcata
     3241 ttttacggtt tatctcgcac ctaacattct tcaacccctt cattgtatag gatttaaagt
     3301 ctggtcttac agctgaattt aatgacaaga caagccattg aggttcttta tgtactatag
     3361 cctgaggcag tgctgctttt gatttattag ggtcctttgc acacacacac ccacacccac
     3421 acacccacac acacagacac acacatacac agacacacag acacacacag acacacacac
     3481 acacaccaca cacacatata tatgtgtgtg tgatatatgt gtgtgtgtat gtatgtataa
     3541 ttgatgccct tgaacagtag ttttcctggc cttggttaag agtctgcatg tcaacacaaa
     3601 ccagaaattt tacctggttt ataaaatgtt ggatccaacc atttccccaa agatatgtcc
     3661 aaaatgttca atatagaaag tacaagttta aaactattct tttgacattt gctatataaa
     3721 cctctgcctg agacaggtgt gttggccata agacactgca aacctaagta cgtaaacatg
     3781 ctactaaatt actctttgag aaggggtttg attggataca tgctttctag tgtttcagct
     3841 gacactctga agccttggca gcctgaacca cacagcgaac aggttcctag gatgctctta
     3901 ggatctgctg attaaactga tatccttctg tggatgcact tcagggcatt taactccaag
     3961 ggccagagct tctaccagag gtactgtggc tcgccaggag atggcacaga tcccagtgac
     4021 ccggcatgtg tgtgaatgat agaagcatag tgtgattcgg gttctagaga gatgactaag
     4081 aaatggtctg ctattttgtg ttttaagatt ttagttatat tttgtaaaag aaaaaaaaga
     4141 agctaaatat atgaaaactt attttaatag tatgagggaa gcgaagataa gtggccatca
     4201 aggaaaactt gacaaggcat agaagagcct attcctactt ctgatttgta gtgattcggg
     4261 gagcttagaa gagagggggg cagaagtctg ctgcatacct tagtcagact gttggctttc
     4321 atcgtattgt ctcaggtccg tgctgttatc tcaaagcaat gctttatttt ttaatttccc
     4381 tgtgtctaca gatgagaccc cccctgcccc atgtactcac caccctaagc tctagactcc
     4441 tgatcagaaa ccatacaagc atctcaacca tgctcaggaa tccatccgca caaaaactaa
     4501 cagacaaaaa acatctcaaa atagctgaga tctgacaata ctttgacatt tatttctgcc
     4561 cttgaggaaa gactttaaat ttgattaata ttgatagaaa tatttagacc caaattgcat
     4621 ttgtttctcc tagaactgga gagaatataa attttactcc tagcaggaaa acaaaggggc
     4681 ttttttttgt cttatgcttt tccctgtaaa gattctattt acctttgcac agctccatgg
     4741 cggggtgctg tttgctctcc ttcagtgtag gaaaggtaat gtatgaagaa cgggaccaga
     4801 cactgtcaga gtaatgatag cagctgctta ctaaagcacc aggagctact cttccaagcg
     4861 ctcccagctt gggggtttat ctatgcattc acccttcctc catcctctct ttgtaagtga
     4921 aggaaaattt agcaagattt gccttcactt ccgctggcag ttgatcactt gcaaaagacc
     4981 taaaatgttt gatttatact tctcaccaca ctcttttccc ctctgacttt tttttttctc
     5041 ctttacccag tacgtttaag aacagcagcc atgccagccg agtagaggac ttggcaaaga
     5101 attaaatgtc cctagccatt atcaggcggg atggtggtca gccttccccg aacacagaaa
     5161 ggggatcaga gttgctctca cgtgccaagg attactttac cttatctgtg tttctagact
     5221 tacactcaac tgtttatgaa tgtgttattg gatactggat agccttctga ggattggatg
     5281 ggctccttca cttttttttt gagaaagatc agacatgagc aaatgatgca ttcttggttt
     5341 gtacagtcct aaggtccact gagttggcac tctttgggca aagaactgcc taaaatgaga
     5401 gcacagaaag tcaaatcaat tgttgggcag aaatttgtca gtttaatggc tctgcataag
     5461 acaacctgtc tttaaaatct aacacacaca cacacacaca cacacacaca cacacacaca
     5521 cacacacaca acgtaaagcc aatttagtcc tgctttacct ctactggcaa tgaagaccct
     5581 tactcttctc tgtcggggac tggaagacat ttctgtttac catagcatct caaatcatca
     5641 caagagaaaa taaatactta tcacttcatg taataacaat agaataaagt aacaatagaa
     5701 taaagatcaa cagggcttcc ttgagatgta ttttgcacaa aagttagtct gctgagagac
     5761 atgcaaatta tgttcagtgt ttaacctgtg cagatgagtc tagcccagct agaagggctc
     5821 cctcactcaa ctcagtcatt ctgattcctt gagatcaata tgcagagagc cctttgctga
     5881 tccaattgtc aaggtcaaaa ggccctatca ggcgttaaga tttctctgac caaactttct
     5941 ggagttttcc ttgtttccgt ctctctattt ggggaagcta ttcactgagc attccttgaa
     6001 ggttgacttg tgtggcttta tctctcccat tttgttcatc ctcgttgctt gctgccctag
     6061 gacagtgaga gtacgaccct cctcacgtgg ttggccttct ggaccgtgtt agcaggtttt
     6121 gctccttcct tgctttctat cattatgtct gccttgcttt gggaatgtga ggacttgact
     6181 cactgtgctt ggcctctact gagacatctt aaacagtctc ccatgttttg cttccctcat
     6241 gagtgcttaa aaattaaccc aagaatttct agctgccctt caccagcagg accagttaga
     6301 aggctctgca taagaaacct caaataccac gctaaccttg gtccctccct tcccagccgc
     6361 taagaaagga cccagttatt tgtgtaaact cagccttaga aatttcccat ttattacaca
     6421 aaaattttta tggaccagaa tgggacgagc aaggtctcag cagggtgtct cttagatgct
     6481 gctgtgtggc agaagaaaga tgctcaggaa cacctcaggg cgctagtgtg accgcagagt
     6541 ggtcattgac tgtgtcatct ggccctgctc tcgagacttt tagtggctgt cagttctaga
     6601 gtgagtatct ggggccttct actcaggtga tgttcaaagg acatagtgtg ttgccacaat
     6661 aaccacttag aagggaagta attgctccac ccgcagacag aggaagcctt caaaaggtgg
     6721 tttttggaat tgaactagga ggaggagttc ttttttgaac taaaacaggg aagattagag
     6781 tgtcacaaag cctccagctg acgggcatca gcttttatga tattgatttg aatccaatgc
     6841 agcccgtatc tccaggacat gtactgtatc caatacttaa taaaaaaata agggcaattg
     6901 ggggcttaca tgttgccgtg ttgttattgg attttctcaa taatcattaa aagccatctc
     6961 accttcgtat gttttgcatt tgtatgtatt gcttaaagtt tgtatgatgg agcagaatgg
     7021 aggtcaatca agccgcataa atgcttctaa aattcctgtg tggctatgct tccgggagct
     7081 cgactgagag tcactccacc ctgcgaagcg gaataatctc cctggtagga ctttaattca
     7141 gactttgtgt ttctccttca gtgcagactc cctctctgta tctccttctt tccctagtct
     7201 ctggggcggg ggtatgaact gtctaacgcc ctgtggtagc ggaagagcta agagctgctg
     7261 aagacattga cctcccttcg cttctaacag acaaagccaa ctcacatcca aaccggtgac
     7321 cttacctttt gtgtcacaca cagagacacc tgcagctccc tggtcctcgg tggtccatag
     7381 gcaaacagtt ggtttccttc tctttggagc accctctcct tctagggatt acatggaaag
     7441 tacagacaga agtctctttt gttgccatgg caacactcct tccccgatag gattttggcc
     7501 attccaggca cgcttctctt aaggtgtttt cctaccttaa gcctagactt gccttgttct
     7561 gagtattctg ggtttatctt cattgtagta ggaaattcag catgaagtgt gtcctctttg
     7621 attttcacgt gtacaacaca gtacatgtga ctccacatac actgcttata gcttatgctt
     7681 agagtccatg catcctggag taatggacac tttattgctc acggatcagc aactcctcat
     7741 gtcccctttc cagcccctga caactagcat tctgctctct gattctagga gttggactgg
     7801 tttacatacc tcaaaacaat ggggtctggt aggttttgtg cttttgtgac ttgctcattt
     7861 cactgagcac aacatctcca gggccaacat ccaccctgtc atatatttaa gagttctccc
     7921 tttctagaag ctggatccaa tgggcagcag gtatactcat tgtttgtcta gtcacctttc
     7981 aacagataca gtactgtgtc ttggctactg tgaataattc cccagtgtag acgaggatgg
     8041 gaaatatctt ttcaagactc aaccctcaag cttttagata atatccagaa gtgaacttgc
     8101 tgggccatac agtaatttca tttttaaacc tgtgctgacc atttatactg tttcccacag
     8161 ccattctaca ctcctaactt ccgttcacaa gggcccagtt tccccaccat caccttttgt
     8221 ctgttgtcca cttaaatggg gagcagatga gtcatccttt gccccggtcc aactctgaat
     8281 tccagatgca agtaccttcc attgtaaggc attcatcctg cttcctcagt ggccctggaa
     8341 tcttgatcta catcttccaa tttattaatt cactcaactg atatttattg agcacatact
     8401 atgattttta tggttacttc taccaccttc cagaggccgt ttcctggagc gttagacacg
     8461 atgctcctta cctggtttta ccatgtcatc tggtttgttt tggctacatt ttccagagaa
     8521 agaaactggt ctttgagaag gttgaaggtc ttggggcctg aaccttgctt tgagtaacag
     8581 gggcagcctt gaacctgact ccacagcgta ggctttaatt ggaggccctt ttccagccca
     8641 tactcccctt ttggattgct tgttttagtt aagaacccca ttgaaattct caactatgag
     8701 aatctgactc catttctatg acggtggatg tcatttaaat gataatctca attaaaactg
     8761 aacttggttt ttaaatagcc accaatagcc ttcatttaaa aaaaataata aagcctacat
     8821 tacaactcta aagggttgat ccaggggcaa gcaagctttt tcctatctag gccagttaag
     8881 atctggggtc atagcctcca gttatttaga ttggacttat ggactataca ctcttatctc
     8941 tgttttgcca ataatatagc cagaaaagcc atttcagtgg ggaatccatt aggcttcgac
     9001 ctcgtttcct ttctctctga tcccagtgag atgcctttct cagtatttag ggaaaatgag
     9061 tttgaaatta catcaatatc acaactaaca agattatttt acctacacat gttacctacc
     9121 gctagtcaac ctttcctcac ctcagtgtaa cgagaaacag tggggggatc aacacctgtg
     9181 cttactctgt tgaatcatga gctgggagga gttaggaggg gtatttaata attaacactc
     9241 tcctctaaaa tacagaacac acatttctaa tgcagcctca gctcctggtt ctttgagatg
     9301 cactcaacag tcttggacat cttcaaatct gaatcattta ataaactaaa gtagaaatgt
     9361 tagaatgtat gtgacccaag agcacagggc gtggcgggta aacacagcat ctagcacggg
     9421 gggcatgaag gggacacagc attatcacgt gtggacaatt ctggcacctg tggcattgcc
     9481 ctggtagctg gctagtttta atgaatgttc ttagcagcct aataaataac cactggagat
     9541 tttttcttgc ttccagaata aatttagcag aactgattcg attgatagca gtagagtaag
     9601 gaagaatatc agtgaaaagt gtctctgacc gtaaagccct gtgggtttca tttgtcatca
     9661 gcaacccacc agcccccggt gaacttcaga ttgcctgtct tgcagcatct cagtgtaata
     9721 tatataaaaa aagagcaggt tgttcagcag caatgacttg ggtttcctta aacccaagca
     9781 gaaactccac ttctctacta gtcttccagc caggagagcc tctgagaaca gggcttggct
     9841 gcctcacttt tgtgcacaag aggaaactcc tcagtaactg gtaggtttat agatattatt
     9901 tttataatag aatgttaagc ccctgaaaaa tatcaaaaaa ctagtgtcct aaaatgagct
     9961 ctatgctttc caaacctact tggaagaagg gttctaaaca ccagtagggt cctttttcct
    10021 tcgctactcc aatgctctaa tgggatagat gaatcaatgt ttatattttt aaacctgtaa
    10081 atatttttat tttgaagatt ttgtatattt gttgatacaa ttccattttg tgcatatgta
    10141 ctactgtgca tgttgctggt tttgatagtc actgttttag caaatgtaaa caggttggac
    10201 taatgggcgc ttttctgtct ctccatctta caatgaaaat acaatgttgc catttgaact
    10261 attgtgttta aatttggtca ataaattccg ttgctccttt gcaattaaa
//
