LOCUS       NM_001109320            3663 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Rattus norvegicus APC membrane recruitment protein 1 (Amer1), mRNA.
ACCESSION   NM_001109320 XM_001066848 XM_576986
VERSION     NM_001109320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Lieu CH, Golemis EA, Serebriiskii IG, Newberg J, Hemmerich A,
            Connelly C, Messersmith WA, Eng C, Eckhardt SG, Frampton G, Cooke M
            and Meyer JE.
  TITLE     Comprehensive Genomic Landscapes in Early and Later Onset
            Colorectal Cancer
  JOURNAL   Clin Cancer Res 25 (19), 5852-5858 (2019)
   PUBMED   31243121
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Lee DW, Han SW, Kang JK, Bae JM, Kim HP, Won JK, Jeong SY, Park KJ,
            Kang GH and Kim TY.
  TITLE     Association Between Fusobacterium nucleatum, Pathway Mutation, and
            Patient Prognosis in Colorectal Cancer
  JOURNAL   Ann Surg Oncol 25 (11), 3389-3395 (2018)
   PUBMED   30062471
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Slattery ML, Herrick JS, Mullany LE, Samowitz WS, Sevens JR, Sakoda
            L and Wolff RK.
  TITLE     The co-regulatory networks of tumor suppressor genes, oncogenes,
            and miRNAs in colorectal cancer
  JOURNAL   Genes Chromosomes Cancer 56 (11), 769-787 (2017)
   PUBMED   28675510
REFERENCE   4  (bases 1 to 3663)
  AUTHORS   Sanz-Pamplona R, Lopez-Doriga A, Pare-Brunet L, Lazaro K, Bellido
            F, Alonso MH, Ausso S, Guino E, Beltran S, Castro-Giner F, Gut M,
            Sanjuan X, Closa A, Cordero D, Moron-Duran FD, Soriano A, Salazar
            R, Valle L and Moreno V.
  TITLE     Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in
            Colorectal Cancer
  JOURNAL   Clin Cancer Res 21 (20), 4709-4718 (2015)
   PUBMED   26071483
REFERENCE   5  (bases 1 to 3663)
  AUTHORS   Tanneberger K, Pfister AS, Kriz V, Bryja V, Schambony A and Behrens
            J.
  TITLE     Structural and functional characterization of the Wnt inhibitor APC
            membrane recruitment 1 (Amer1)
  JOURNAL   J Biol Chem 286 (22), 19204-19214 (2011)
   PUBMED   21498506
REFERENCE   6  (bases 1 to 3663)
  AUTHORS   Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB,
            Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ,
            Kronenberg HM, Baron R, Haber DA and Bardeesy N.
  TITLE     The WTX tumor suppressor regulates mesenchymal progenitor cell fate
            specification
  JOURNAL   Dev Cell 20 (5), 583-596 (2011)
   PUBMED   21571217
  REMARK    Erratum:[Dev Cell. 2012 May 15;22(5):1109-17]
REFERENCE   7  (bases 1 to 3663)
  AUTHORS   Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas
            MV, Kriz V, Schulte G, Bryja V and Behrens J.
  TITLE     Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6
            phosphorylation
  JOURNAL   EMBO J 30 (8), 1433-1443 (2011)
   PUBMED   21304492
REFERENCE   8  (bases 1 to 3663)
  AUTHORS   Grohmann A, Tanneberger K, Alzner A, Schneikert J and Behrens J.
  TITLE     AMER1 regulates the distribution of the tumor suppressor APC
            between microtubules and the plasma membrane
  JOURNAL   J Cell Sci 120 (Pt 21), 3738-3747 (2007)
   PUBMED   17925383
REFERENCE   9  (bases 1 to 3663)
  AUTHORS   Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C,
            Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S and Moon RT.
  TITLE     Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin
            signaling
  JOURNAL   Science 316 (5827), 1043-1046 (2007)
   PUBMED   17510365
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473966.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066848.1, XM_576986.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00155314
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..3663
                     /gene="Amer1"
                     /gene_synonym="Fam123b; RGD1560322"
                     /note="APC membrane recruitment protein 1"
                     /db_xref="GeneID:501584"
                     /db_xref="RGD:1560322"
     exon            1..232
                     /gene="Amer1"
                     /gene_synonym="Fam123b; RGD1560322"
                     /inference="alignment:Splign:2.1.0"
     exon            233..3663
                     /gene="Amer1"
                     /gene_synonym="Fam123b; RGD1560322"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..3659
                     /gene="Amer1"
                     /gene_synonym="Fam123b; RGD1560322"
                     /note="family with sequence similarity 123B; protein
                     FAM123B; family with sequence similarity 123, member B;
                     APC membrane recruitment 1"
                     /codon_start=1
                     /product="APC membrane recruitment protein 1"
                     /protein_id="NP_001102790.1"
                     /db_xref="GeneID:501584"
                     /db_xref="RGD:1560322"
                     /translation="MEIQQDETVQIKRTSTSSDAQDQGAEKGAKNKTAETTEGSTSEP
                     PLSGPGRLKKTALKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLNKSKTHDGLSES
                     SHGPEDVVVEETELSTPLSKSPSQFPSSQSAHGALEIGSRHKTSVTEAVEKAGVEKVP
                     SVHKPKKGLKGFLNSIRRHRKSKVSGADQSGLGAKELEGTRTMSQEHVSSISLPSSEE
                     IFRDAIKENTKPQDAPGPKMSPAREHFSLTTEKTACKNPEKLTMTCASEFMQPKPILE
                     ASSLEEPHTSETEGKVVTGDANPPNGPVGDQLSLLFGDVTSLKSFDSLTGCGDIIAEQ
                     DMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDNEEEEEEDEEVELE
                     DEEEEVKDGEEDDDLEYLWASAQIYPRFNMNLGYHTAISPSHQGYMLLDPVQSYPNLG
                     LGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVHRDCLPRDSYSGDALYE
                     FYEPDDSLEHSPPGDDCLYDLRGRNSEMLDPFLNLEPFSSRPPGAMETEEERLVTIQK
                     QLLYWELRREQREAQEACAREAHAREAYSRDTHTRESYGKNTRARETQALEVHSQEGR
                     VQETKVRQEKPALEYQMRPLGPSVMGLVPGTPGGSQTSHRGTTSAFPATSSSEPDWRD
                     FRPLEKRFEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRKAYPSYSPPEEPE
                     EEEDENEGNATVSFSQALVEFTSNGNLFTSMSYSSDSDSSFTQNLPELPPMVTFDIAD
                     VERDGEGKCEENPEFNNDEDLTASLEAFELGYYHKHAFNSYHSRFYQGLPWGVSSLPR
                     YLGLPGVHPRPPPAAMALNRRSRSLDNAETLELELSSSHLAQGYVESDELQDHQEDSD
                     EEGEEEEGEWGRDSPLSLYTEPPGVYDWPPWAHCPVPVGPGLAWLSPNQLDEPFNQSS
                     YVQATCCVPPVAMSVPGRAPGDSVSQPARPSHLPLPMGPCYNLQSQASQSGRARPRDV
                     LLPVDEPSCSSISGANSLSQAKPVGITHGIPQLPRVRPEPLQLQPNHYRASNLDLSKE
                     RGEQGASLSTSYSSTAMNGNLAK"
ORIGIN      
        1 atgcctgcca atcagatcac ggacgtccca ccctataact gtggagtccg gggagaaggg
       61 ggtatggggg agctgctcag agcctggaga agggtagtcg gggcaggaga ctgttgtagt
      121 cctggtgggg gctgctgcag gagcagtggt ggcggcgttc tcagcagagg ttccagctca
      181 gatccgagca gcgcagcaga caataaccgc gctgggagca ggacctggca ggaccccact
      241 gtgatgcttc ctgactgatc atgttataag tgtgcctgga atccaaaggc agcgtttcca
      301 attggagagt tctcttcatc atcatggaga ttcaacagga tgaaacagtt caaatcaaga
      361 ggacatcaac ttccagtgat gcccaagatc agggagctga gaagggagcc aagaataaga
      421 cagctgagac aacagaagga tcaacatcag agccaccctt atcaggccca ggtaggctga
      481 agaaaactgc cttgaaactc tttggtggca agaagggaat ctgtactctg cctagtttct
      541 ttgggggtgg acgaagcaaa ggttctggga aaggcagctc caagaagggt ctaaacaaga
      601 gcaagaccca cgatggtctg agtgaatcat ctcacggccc tgaagatgtt gtcgttgaag
      661 aaacagagct ctctacacct ttgtccaagt caccttctca atttcctagc tcccagagtg
      721 cccatggagc tttggagata ggctctagac ataagacatc tgtgactgaa gctgtagaga
      781 aagctggagt tgagaaggta ccctctgtgc acaagccgaa gaaaggccta aaaggctttt
      841 taaacagtat ccgccgtcac cgaaagagca aggtttctgg ggctgaccaa agtgggctag
      901 gggccaagga acttgagggg acaagaacca tgtctcaaga gcatgtgagt tcaatctctc
      961 tgcccagctc tgaggagata ttccgagatg ctataaagga aaataccaaa ccccaggatg
     1021 cccctggacc aaaaatgtct ccagcaagag aacatttttc actaactact gagaagacag
     1081 cttgtaaaaa tccagaaaaa cttacaatga cctgtgcctc agagttcatg cagcccaagc
     1141 ctattcttga agctagtagt ctagaagagc cccacacttc agaaacagaa ggaaaagtgg
     1201 taacaggaga cgcaaaccca cccaatggcc cggttgggga tcagctaagc ctcttgtttg
     1261 gggatgttac atccctgaaa agctttgact cgctgacagg ttgtggtgac attatagcag
     1321 aacaggacat ggacagtatg acagatagca tggcctctgg tggccagagg gccaaccgag
     1381 atgggaccaa gcgaagttcc tgcttggtga cctaccaagg aggtggggag gaaatggcct
     1441 tgccagatga cgatgacaat gaagaggaag aagaagagga tgaggaggta gaattagagg
     1501 atgaggaaga ggaggtcaag gatggggagg aagatgatga cttagagtat ctgtgggcaa
     1561 gtgcccagat atacccaaga tttaatatga acctgggcta tcatactgct atatctccca
     1621 gccaccaggg ctacatgctt cttgacccag ttcagtctta tcctaaccta ggcctgggag
     1681 aacttttgac acctcagagt gaccagcaag agtctgctcc caatagtgat gaaggttatt
     1741 atgactctac cacaccagga tttgaggatg attcgggtga ggccctgggg cttgtccata
     1801 gggattgtct acccagagac agctatagtg gtgatgctct ttatgaattc tatgagccag
     1861 atgacagtct tgagcactcc ccacctgggg atgactgcct ttatgacctc cgtggacgca
     1921 actcagagat gttggatcct ttcttgaact tggagccctt ttcttctcga ccacctgggg
     1981 caatggaaac agaagaagaa cggctggtaa ccatccagaa gcagttgctg tactgggaac
     2041 ttcgccggga gcagcgtgag gctcaagagg catgtgccag agaggctcat gccagagaag
     2101 cttattctcg agacacccac actcgggaat cttacggcaa aaatacccga gcccgagaaa
     2161 cccaagccct agaggttcat tctcaagagg gtcgagtcca agagaccaaa gtacggcaag
     2221 agaagcctgc cttggaatat cagatgaggc cattaggccc ctcggtgatg ggtctggtgc
     2281 cagggacacc aggaggttct cagacttcac accggggaac cacttcagct ttcccagcta
     2341 cttccagtag tgaaccagac tggcgggatt tccgtcctct ggagaagcgt tttgagggga
     2401 cttgctccaa aaaagatcaa agtacttgtt taatgcagct ctttcagagt gatgccatgt
     2461 ttgaaccaga catgcaagaa gcaaatttcg gaggctctcc caggaaggcc taccctagtt
     2521 actcaccccc tgaagagcca gaggaagagg aagatgagaa cgaagggaat gccactgtga
     2581 gtttttcaca agctctagta gagtttacca gcaatggaaa cctttttacc agcatgtcct
     2641 acagctctga ttctgactca tccttcactc aaaatctccc tgagttgccc cccatggtca
     2701 cctttgacat tgctgatgtg gaacgggatg gagaaggcaa gtgtgaagag aatcctgagt
     2761 tcaacaatga tgaagatctt acggcctcct tggaagcttt tgagctgggt tattaccaca
     2821 aacatgcctt caacagctat cacagccggt tctaccaagg cctgccctgg ggtgttagca
     2881 gcctccctcg atacttagga ctcccgggtg tacatcctcg acctccaccc gctgcaatgg
     2941 cactcaatag gagaagccgt tcccttgaca atgcagagac cctggagctg gagctctcca
     3001 gttctcacct agcccagggt tatgtggagt ctgatgagct acaggaccac caggaagatt
     3061 cagatgaaga aggtgaagaa gaggaaggag aatggggccg ggacagcccc ttgtcactct
     3121 acactgaacc tccaggggtc tatgactggc caccctgggc tcactgtcct gttccagtgg
     3181 gaccaggtct tgcttggcta agccctaatc agttggatga gcctttcaat cagtcttcat
     3241 atgtgcaagc aacctgttgt gtacctcctg tggcaatgtc agtgccagga agagcacctg
     3301 gagactctgt gtctcagcca gctcgacctt cacacctacc cctgcccatg ggtccttgct
     3361 ataaccttca atcacaggcc tcccagagtg ggagggccag gcctcgggat gtactgctgc
     3421 ctgtagatga gcccagttgc tcctccattt ctggagccaa ctctctgtct caagccaagc
     3481 ctgtaggcat cacccatggt atccctcagc tgcccagggt acggcctgaa ccccttcagc
     3541 ttcaacccaa tcactaccga gcttccaacc ttgacctttc aaaggagagg ggtgaacaag
     3601 gtgcctctct ctctaccagc tactcctcca ctgccatgaa tggaaaccta gccaagtagt
     3661 cat
//
