LOCUS       NM_001271074             808 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus amelogenin, X-linked (Amelx), transcript variant
            1, mRNA.
ACCESSION   NM_001271074
VERSION     NM_001271074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Buchko,G.W., Lin,G., Tarasevich,B.J. and Shaw,W.J.
  TITLE     A solution NMR investigation into the impaired self-assembly
            properties of two murine amelogenins containing the point mutations
            T21-->I or P41-->T
  JOURNAL   Arch Biochem Biophys 537 (2), 217-224 (2013)
   PUBMED   23896516
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Le Norcy,E., Kwak,S.Y., Wiedemann-Bidlack,F.B., Beniash,E.,
            Yamakoshi,Y., Simmer,J.P. and Margolis,H.C.
  TITLE     Leucine-rich amelogenin peptides regulate mineralization in vitro
  JOURNAL   J Dent Res 90 (9), 1091-1097 (2011)
   PUBMED   21653221
REFERENCE   3  (bases 1 to 808)
  AUTHORS   Buchko,G.W., Tarasevich,B.J., Roberts,J., Snead,M.L. and Shaw,W.J.
  TITLE     A solution NMR investigation into the murine amelogenin
            splice-variant LRAP (Leucine-Rich Amelogenin Protein)
  JOURNAL   Biochim Biophys Acta 1804 (9), 1768-1774 (2010)
   PUBMED   20304108
REFERENCE   4  (bases 1 to 808)
  AUTHORS   Deshpande,A.S., Fang,P.A., Simmer,J.P., Margolis,H.C. and
            Beniash,E.
  TITLE     Amelogenin-collagen interactions regulate calcium phosphate
            mineralization in vitro
  JOURNAL   J Biol Chem 285 (25), 19277-19287 (2010)
   PUBMED   20404336
  REMARK    GeneRIF: interactions between collagen and amelogenin might play an
            important role in the formation of the DEB providing structural
            continuity between dentin and enamel
REFERENCE   5  (bases 1 to 808)
  AUTHORS   Biz,M.T., Marques,M.R., Crema,V.O., Moriscot,A.S. and dos
            Santos,M.F.
  TITLE     GTPases RhoA and Rac1 are important for amelogenin and DSPP
            expression during differentiation of ameloblasts and odontoblasts
  JOURNAL   Cell Tissue Res 340 (3), 459-470 (2010)
   PUBMED   20387077
  REMARK    GeneRIF: The aim of this study was to verify the expression,
            distribution and role of Rho GTPases in ameloblasts and
            odontoblasts during tooth development in correlation with actin and
            tubulin arrangements and amelogenin and dentin sialophosphoprotein
            expression.
REFERENCE   6  (bases 1 to 808)
  AUTHORS   Bonass,W.A., Kirkham,J., Brookes,S.J., Shore,R.C. and Robinson,C.
  TITLE     Isolation and characterisation of an alternatively-spliced rat
            amelogenin cDNA: LRAP--a highly conserved, functional
            alternatively-spliced amelogenin?
  JOURNAL   Biochim Biophys Acta 1219 (3), 690-692 (1994)
   PUBMED   7948026
REFERENCE   7  (bases 1 to 808)
  AUTHORS   Aldred,M.J., Crawford,P.J., Roberts,E. and Thomas,N.S.
  TITLE     Identification of a nonsense mutation in the amelogenin gene
            (AMELX) in a family with X-linked amelogenesis imperfecta (AIH1)
  JOURNAL   Hum Genet 90 (4), 413-416 (1992)
   PUBMED   1483698
REFERENCE   8  (bases 1 to 808)
  AUTHORS   Salido,E.C., Yen,P.H., Koprivnikar,K., Yu,L.C. and Shapiro,L.J.
  TITLE     The human enamel protein gene amelogenin is expressed from both the
            X and the Y chromosomes
  JOURNAL   Am J Hum Genet 50 (2), 303-316 (1992)
   PUBMED   1734713
REFERENCE   9  (bases 1 to 808)
  AUTHORS   Lagerstrom,M., Dahl,N., Nakahori,Y., Nakagome,Y., Backman,B.,
            Landegren,U. and Pettersson,U.
  TITLE     A deletion in the amelogenin gene (AMG) causes X-linked
            amelogenesis imperfecta (AIH1)
  JOURNAL   Genomics 10 (4), 971-975 (1991)
   PUBMED   1916828
REFERENCE   10 (bases 1 to 808)
  AUTHORS   Fincham,A.G., Hu,Y.Y., Pavlova,Z., Slavkin,H.C. and Snead,M.L.
  TITLE     Human amelogenins: sequences of 'TRAP' molecules
  JOURNAL   Calcif Tissue Int 45 (4), 243-250 (1989)
   PUBMED   2509010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000021.1  28648803-28648856
            55-120              JAXUCZ010000021.1  28650192-28650257
            121-168             JAXUCZ010000021.1  28652146-28652193
            169-213             JAXUCZ010000021.1  28653551-28653595
            214-651             JAXUCZ010000021.1  28653866-28654303
            652-696             JAXUCZ010000021.1  28658075-28658119
            697-808             JAXUCZ010000021.1  28659988-28660099
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..808
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /note="amelogenin, X-linked"
                     /db_xref="GeneID:29160"
                     /db_xref="RGD:2107"
     exon            1..54
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            55..120
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..726
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich amelogenin peptide; amelogenin X
                     chromosome"
                     /codon_start=1
                     /product="amelogenin, X isoform isoform 1 precursor"
                     /protein_id="NP_001258003.1"
                     /db_xref="GeneID:29160"
                     /db_xref="RGD:2107"
                     /translation="MGTWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQS
                     MIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMM
                     PVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQAIPPQSHQPMQPQSPLHPMQPLAPQ
                     PPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVAFSPMKWYQGTARHPLNMETTTE
                     K"
     exon            121..168
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            169..213
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            214..651
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            652..696
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            697..808
                     /gene="Amelx"
                     /gene_synonym="Amel; LRAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggatcaag catccctgag cttcagacag aaagtcactg agcatacact caagaaccat
       61 caagaaatgg ggacctggat cttgtttgcc tgcctcctgg gagcagcttt tgctatgccc
      121 ctaccacctc atcctgggag ccctggttat atcaacttaa gctatgaggt gcttaccccc
      181 ttgaagtggt accagagcat gataaggcag ccgtatcctt cctatggtta cgaacccatg
      241 ggtggatggc tgcaccacca aatcatccct gtgctgtctc aacagcatcc cccgagtcac
      301 acccttcagc ctcatcacca cctcccagtg gtgccagctc aacagcccgt ggccccccag
      361 caaccaatga tgccagttcc tggccaccac tccatgactc caacccaaca ccatcagcca
      421 aacatccctc catccgccca gcagcccttc cagcagccct tccagcccca ggccattcca
      481 ccccagtctc atcagcccat gcagccccag tcacctctgc atcccatgca gcccctggca
      541 ccacagccac ctctgcctcc actgttctcc atgcagcccc tgtcccccat tcttcctgag
      601 ctgcctctgg aagcttggcc agcgacagac aagaccaagc gggaagaagt ggcattttct
      661 cctatgaagt ggtaccaggg cacggcaagg catccgctta acatggaaac cacaacagaa
      721 aaatgattca accactctcc tacccttgca gaacacaatg gcatgtagta gtattcaata
      781 ttgctttaat aaaaatctca ctggctta
//
