LOCUS       NM_031011               3169 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus adenosylmethionine decarboxylase 1 (Amd1), mRNA.
ACCESSION   NM_031011
VERSION     NM_031011.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3169)
  AUTHORS   Chen,K., Liu,H., Liu,Z., Luo,S., Patz,E.F. Jr., Moorman,P.G.,
            Su,L., Shen,S., Christiani,D.C. and Wei,Q.
  TITLE     Genetic variants in RUNX3, AMD1 and MSRA in the methionine
            metabolic pathway and survival in nonsmall cell lung cancer
            patients
  JOURNAL   Int J Cancer 145 (3), 621-631 (2019)
   PUBMED   30650190
REFERENCE   2  (bases 1 to 3169)
  AUTHORS   Ali,H.E.A., Lung,P.Y., Sholl,A.B., Gad,S.A., Bustamante,J.J.,
            Ali,H.I., Rhim,J.S., Deep,G., Zhang,J. and Abd Elmageed,Z.Y.
  TITLE     Dysregulated gene expression predicts tumor aggressiveness in
            African-American prostate cancer patients
  JOURNAL   Sci Rep 8 (1), 16335 (2018)
   PUBMED   30397274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3169)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   4  (bases 1 to 3169)
  AUTHORS   Tabassum,R., Jaiswal,A., Chauhan,G., Dwivedi,O.P., Ghosh,S.,
            Marwaha,R.K., Tandon,N. and Bharadwaj,D.
  TITLE     Genetic variant of AMD1 is associated with obesity in urban Indian
            children
  JOURNAL   PLoS One 7 (4), e33162 (2012)
   PUBMED   22496743
REFERENCE   5  (bases 1 to 3169)
  AUTHORS   Raney,A., Law,G.L., Mize,G.J. and Morris,D.R.
  TITLE     Regulated translation termination at the upstream open reading
            frame in s-adenosylmethionine decarboxylase mRNA
  JOURNAL   J Biol Chem 277 (8), 5988-5994 (2002)
   PUBMED   11741992
REFERENCE   6  (bases 1 to 3169)
  AUTHORS   Raney,A., Baron,A.C., Mize,G.J., Law,G.L. and Morris,D.R.
  TITLE     In vitro translation of the upstream open reading frame in the
            mammalian mRNA encoding S-adenosylmethionine decarboxylase
  JOURNAL   J Biol Chem 275 (32), 24444-24450 (2000)
   PUBMED   10829027
REFERENCE   7  (bases 1 to 3169)
  AUTHORS   Wang,J.Y., Viar,M.J., McCormack,S.A. and Johnson,L.R.
  TITLE     Effect of putrescine on S-adenosylmethionine decarboxylase in a
            small intestinal crypt cell line
  JOURNAL   Am J Physiol 263 (4 Pt 1), G494-G501 (1992)
   PUBMED   1415709
REFERENCE   8  (bases 1 to 3169)
  AUTHORS   Pulkka,A., Ihalainen,R., Aatsinki,J. and Pajunen,A.
  TITLE     Structure and organization of the gene encoding rat
            S-adenosylmethionine decarboxylase
  JOURNAL   FEBS Lett 291 (2), 289-295 (1991)
   PUBMED   1936275
REFERENCE   9  (bases 1 to 3169)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
REFERENCE   10 (bases 1 to 3169)
  AUTHORS   Wilson,J., Corti,A., Hawkins,M., Williams-Ashman,H.G. and Pegg,A.E.
  TITLE     The decarboxylation of S-adenosylmethionine by detergent-treated
            extracts of rat liver
  JOURNAL   Biochem J 180 (3), 515-522 (1979)
   PUBMED   486130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 10, 2021 this sequence version replaced NM_031011.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061532.1, M34464.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN09345331 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 10829027
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               JAXUCZ010000020.1  45265547-45265982   c
            437-523             JAXUCZ010000020.1  45257995-45258081   c
            524-650             JAXUCZ010000020.1  45256773-45256899   c
            651-753             JAXUCZ010000020.1  45255701-45255803   c
            754-796             JAXUCZ010000020.1  45254511-45254553   c
            797-1034            JAXUCZ010000020.1  45253164-45253401   c
            1035-1190           JAXUCZ010000020.1  45252908-45253063   c
            1191-3169           JAXUCZ010000020.1  45250289-45252267   c
FEATURES             Location/Qualifiers
     source          1..3169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..3169
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /note="adenosylmethionine decarboxylase 1"
                     /db_xref="GeneID:81640"
                     /db_xref="RGD:2104"
     exon            1..436
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12..32
                     /regulatory_class="uORF"
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:10829027]"
                     /note="this uORF is predicted to encode a 6 aa peptide
                     (PMID:10829027)"
     CDS             327..1328
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /EC_number="4.1.1.50"
                     /note="S-Adenosylmethionine decarboxylase 1B;
                     S-adenosylmethionine decarboxylase 1; S-adenosylmethionine
                     decarboxylase 1A; SAMDC; adoMetDC"
                     /codon_start=1
                     /product="S-adenosylmethionine decarboxylase proenzyme"
                     /protein_id="NP_112273.3"
                     /db_xref="GeneID:81640"
                     /db_xref="RGD:2104"
                     /translation="MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLL
                     KDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYS
                     GFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLY
                     TLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVI
                     DATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFK
                     PGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQS"
     exon            437..523
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            524..650
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            651..753
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            754..796
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1034
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1190
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..3169
                     /gene="Amd1"
                     /gene_synonym="Amd1a; Amd1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttacacag tatggccggc gacattagct agcgctcgct caactctctc taacgggaaa
       61 gcagcggact acaagagact gaactgtatc tgcctctatt tccaacggac tcacgttcaa
      121 ctttcgctca cgaaaatagc cgggaaaatt ttattagtcc tttttttaaa aaaagttaat
      181 ataaaattat agcaaaaaaa aaaaaaagga acctgaactt tagtaacaca gctggaacaa
      241 tccgcagcgg cggcaggagc ggcgggagaa gagatttaat ttagttgatt ttctgtggtt
      301 gttggttgtt cgctagtctc acggtgatgg aagctgcaca ttttttcgaa gggaccgaga
      361 aactgctgga ggtctggttc tccagacagc agtccgacgc aagccaggga tctggggacc
      421 ttcgtaccat cccaagatcc gagtgggatg tccttctgaa ggatgtgcag tgctcaatca
      481 taagtgtgac aaagactgac aagcaggaag cttatgtact cagtgagagt agcatgtttg
      541 tctccaagag acgtttcatt ttgaagacat gtggtaccac cctcttactg aaagcactgg
      601 ttcccctgtt gaagcttgct agggactaca gtgggtttga ctcgattcaa agcttctttt
      661 attctcgtaa gaatttcatg aagccttctc accaagggta cccacaccgg aatttccagg
      721 aagaaatcga gtttcttaat gcaattttcc caaacggagc agcatattgt atgggacgta
      781 tgaattctga ctgttggtac ctgtacactt tggatctccc agagagccga gtaatcaatc
      841 agccagatca aaccctggaa attctgatga gtgagcttga cccagcagtt atggaccagt
      901 tctacatgaa agatggtgtt actgcaaagg atgtcactcg tgagagtgga attcgtgacc
      961 tgataccagg ttctgtcatt gatgccacac tgttcaatcc ttgtggctac tcaatgaatg
     1021 gaatgaaatc ggatggaaca tattggacta ttcacatcac tccagaacca gaattttctt
     1081 atgttagctt tgaaacaaac ctaagtcaga cctcctatga cgacctgatc aggaaagttg
     1141 tggaagtctt caagccagga aaatttgtga ccaccttgtt tgttaatcag agttctaagt
     1201 gtcgcacagt gctttcttcg ccccagaaga ttgacggttt caaacgtctt gattgccaga
     1261 gcgctatgtt caacgattac aattttgttt ttaccagttt tgctaagaaa cagcaacaac
     1321 agagttgatt aggaaaaatg aaaaagaaaa aacgcaaaaa gagaagacac acaggaggtg
     1381 gtggctgctt tctagatgtt gatcctgggg gccatgctga ccgtgaccac caccttgtag
     1441 ctgcagaaag ccctaggtgt aatgatagtg taatcatttt gaagtgtatg cattattata
     1501 tcaaggagtt agatatcttg catgaatgct ctcttctgtg tttaggtgtt ctatgccact
     1561 cttgctgtgg aactgaagtg catgtagaaa agaactctga ctgtatgaat ctttacgaca
     1621 cttgtgaaaa cgattcgact tggtttatgc acagcgtaat atttctgcag gcatcgtcca
     1681 aaatccccca cagacaaggc tttcgtcccc attagatgcg gcctcagctg accattggcg
     1741 actgttctat ttgctgccag agtttttaca tccagttacc tccactttct agagcatatt
     1801 ctctactaat gttcaaaacc gatttctact tcatacaggt gtcttatgca atggcaatta
     1861 aagttttctt ccacaagttg agtctttgta aggaaatgat tccagttgct tgttttgtgt
     1921 tctactgttt tagtaattgc tcctgcattt atagtcctat ggttttttca ctacccctga
     1981 tgaagcaata cacggtcaca ctgtgggctt acattgtaat cttcatccca gatgggagct
     2041 cagagacggt cccttgctca tttttcccta agatgtagaa tgtggccttg ctattggcat
     2101 gcccttctgt ggaagataaa tgatggaagt gaaagtatcc cgggggtgag caaggagaac
     2161 caacccatgg cagtgatggg ctgtgcagtg cactccgagc tctcacagtg gagtgcccac
     2221 catgccttca ctaactcact gagcagtgat agggatgccc accaagtcag agcagaaatc
     2281 taaccctaag gattctcacc tcggtaagtg ccgccattgc caccacttta ctaaaggaag
     2341 tttccgctca gaggagagtc tgtacttccc gcctgtccta atgtcagctg ttctctctgg
     2401 tctttcacca tggcgttcag atgctcaaat gaacggctga tcggccgcag ggaggactct
     2461 ccgggttact gggcctggag aatggagaaa cagcacggta ttctgacagt taatggcacc
     2521 agagatgcgg gctttcaaga gctggcctgt tagtggcatt tttaagcaga aaagagcaaa
     2581 ctagacgaag ttccctattt attgccctcc cactgtttcc ttggcagttt ctggactggc
     2641 gcaatgatgc cttgttcctt ccgtatttat aacgaacgaa acactttttt agcgtttcta
     2701 agcatggagt ctacttggtt tgaaatcaag tggttggaac actgtctgga tttttacttt
     2761 acgcagtgtt gattgaacgc ttcgttgggg aagccttcag tccgcttcat cggtctgttc
     2821 tgtaatgagc acagcacacc tagtttgaat tgctgtttgg agggccagtg cttatttgag
     2881 ctgggtcttg taacccagta gattttggct tgaggtctga ctcccccatc ttacgaaatt
     2941 aagaattcta atgttggaaa ttgcataggg tttgcgtgga aaaaagccca ggaaaaaaaa
     3001 aaaaaaaaaa cagaaggcgg actagtgatc tagtgtgatt acaggcgggg aagttttggt
     3061 gccataattt ctttgttggt gttggacttt taatcagctg aaatgtattt ctgtaccaca
     3121 atgtaagctt caataaaagt ttgcttaatt gtctagtaac atccagaaa
//
