LOCUS       NM_001134341            5291 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus autophagy and beclin 1 regulator 1 (Ambra1),
            mRNA.
ACCESSION   NM_001134341 XM_001069366
VERSION     NM_001134341.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5291)
  AUTHORS   Zhao L, Cheng L and Wu Y.
  TITLE     Ambra1 Alleviates Hypoxia/Reoxygenation Injury in H9C2 Cells by
            Regulating Autophagy and Reactive Oxygen Species
  JOURNAL   Biomed Res Int 2020, 3062689 (2020)
   PUBMED   33083461
  REMARK    GeneRIF: Ambra1 Alleviates Hypoxia/Reoxygenation Injury in H9C2
            Cells by Regulating Autophagy and Reactive Oxygen Species.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5291)
  AUTHORS   Miki Y, Tanji K, Mori F, Tatara Y, Utsumi J, Sasaki H, Kakita A,
            Takahashi H, Fimia GM and Wakabayashi K.
  TITLE     AMBRA1, a novel alpha-synuclein-binding protein, is implicated in
            the pathogenesis of multiple system atrophy
  JOURNAL   Brain Pathol 28 (1), 28-42 (2018)
   PUBMED   27875637
REFERENCE   3  (bases 1 to 5291)
  AUTHORS   Chauhan S, Mandell MA and Deretic V.
  TITLE     IRGM governs the core autophagy machinery to conduct antimicrobial
            defense
  JOURNAL   Mol Cell 58 (3), 507-521 (2015)
   PUBMED   25891078
REFERENCE   4  (bases 1 to 5291)
  AUTHORS   Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A,
            Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M and
            Cecconi F.
  TITLE     AMBRA1 is able to induce mitophagy via LC3 binding, regardless of
            PARKIN and p62/SQSTM1
  JOURNAL   Cell Death Differ 22 (3), 419-432 (2015)
   PUBMED   25215947
  REMARK    Erratum:[Cell Death Differ. 2015 Mar;22(3):517. PMID: 25661525]
REFERENCE   5  (bases 1 to 5291)
  AUTHORS   Shi C, Wu J, Fu M, Zhang B, Wang J, Yang X and Chi Y.
  TITLE     Ambra1 modulates starvation-induced autophagy through AMPK
            signaling pathway in cardiomyocytes
  JOURNAL   Biochem Biophys Res Commun 452 (3), 308-314 (2014)
   PUBMED   25117440
  REMARK    GeneRIF: Ambra1 is a crucial regulator of autophagy and apoptosis
            through AMPK signaling pathway in cardiomyocytes that maintains the
            balance between autophagy and apoptosis.
REFERENCE   6  (bases 1 to 5291)
  AUTHORS   Cui J, Shi S, Sun X, Cai G, Cui S, Hong Q, Chen X and Bai XY.
  TITLE     Mitochondrial autophagy involving renal injury and aging is
            modulated by caloric intake in aged rat kidneys
  JOURNAL   PLoS One 8 (7), e69720 (2013)
   PUBMED   23894530
REFERENCE   7  (bases 1 to 5291)
  AUTHORS   Kubli DA and Gustafsson AB.
  TITLE     Mitochondria and mitophagy: the yin and yang of cell death control
  JOURNAL   Circ Res 111 (9), 1208-1221 (2012)
   PUBMED   23065344
  REMARK    Review article
REFERENCE   8  (bases 1 to 5291)
  AUTHORS   Ma C, Wang N, Detre C, Wang G, O'Keeffe M and Terhorst C.
  TITLE     Receptor signaling lymphocyte-activation molecule family 1 (Slamf1)
            regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by
            recruiting a Beclin-1/Vps34/ultraviolet radiation
            resistance-associated gene (UVRAG) complex
  JOURNAL   J Biol Chem 287 (22), 18359-18365 (2012)
   PUBMED   22493499
REFERENCE   9  (bases 1 to 5291)
  AUTHORS   Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K,
            De Strooper B and Vandenberghe W.
  TITLE     Parkin interacts with Ambra1 to induce mitophagy
  JOURNAL   J Neurosci 31 (28), 10249-10261 (2011)
   PUBMED   21753002
REFERENCE   10 (bases 1 to 5291)
  AUTHORS   Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S,
            Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P,
            Piacentini M, Chowdhury K and Cecconi F.
  TITLE     Ambra1 regulates autophagy and development of the nervous system
  JOURNAL   Nature 447 (7148), 1121-1125 (2007)
   PUBMED   17589504
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000118.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001134341.4.
            
            On Feb 11, 2021 this sequence version replaced NM_001134341.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JACYVU010000118.1  1568001-1568246
            247-500             JACYVU010000118.1  1603657-1603910
            501-559             JACYVU010000118.1  1604285-1604343
            560-743             JACYVU010000118.1  1604862-1605045
            744-916             JACYVU010000118.1  1606159-1606331
            917-983             JACYVU010000118.1  1608050-1608116
            984-2440            JACYVU010000118.1  1609395-1610851
            2441-2527           JACYVU010000118.1  1640507-1640593
            2528-2707           JACYVU010000118.1  1645175-1645354
            2708-2788           JACYVU010000118.1  1659143-1659223
            2789-2889           JACYVU010000118.1  1659939-1660039
            2890-3000           JACYVU010000118.1  1719817-1719927
            3001-3189           JACYVU010000118.1  1729272-1729460
            3190-3344           JACYVU010000118.1  1730336-1730490
            3345-3484           JACYVU010000118.1  1739747-1739886
            3485-3577           JACYVU010000118.1  1748734-1748826
            3578-3771           JACYVU010000118.1  1749819-1750012
            3772-5291           JACYVU010000118.1  1755767-1757286
FEATURES             Location/Qualifiers
     source          1..5291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..5291
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /note="autophagy and beclin 1 regulator 1"
                     /db_xref="GeneID:59319"
                     /db_xref="RGD:621330"
     exon            1..246
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..500
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..4268
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /note="ischemia related factor NYW-1; autophagy/beclin 1
                     regulator 1"
                     /codon_start=1
                     /product="activating molecule in BECN1-regulated autophagy
                     protein 1"
                     /protein_id="NP_001127813.3"
                     /db_xref="GeneID:59319"
                     /db_xref="RGD:621330"
                     /translation="MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEG
                     KRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVT
                     FHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEI
                     HFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGT
                     ELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQ
                     PSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPAS
                     ARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPT
                     RRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLS
                     VLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGNIRHELQCDLRRFF
                     LEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHL
                     NRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTE
                     GQMPNSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPE
                     ESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRD
                     SIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMS
                     APSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNI
                     ANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQR
                     GFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPST
                     EHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTN
                     KGDLVICRPEALNSGIEYYWDQLNETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNA
                     IGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGTASSGPGEGEGSEYGGSGE
                     DALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAART
                     SSPQPSTSRGLLSEPGQLAERGLSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLA
                     SNEGPTMHCNVTNNSHLPEGDSSNVGEAAGPSGEPRNR"
     exon            501..559
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..743
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..916
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..983
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..2440
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2527
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2707
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2788
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2889
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3000
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3189
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3344
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3484
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3577
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3771
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..5291
                     /gene="Ambra1"
                     /gene_synonym="Nyw1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctttgat gtctgggcgt tcgtgtgttc gatgatcttt tgcagcgtct tctaggttga
       61 tgtctccaga gcggcggcgg cggtgccagg tcctggactg agttatccgg gagaccccgg
      121 gctctggccg ctttcttccg ctggtcggtc gagcgggccc ctcgcttcct tcagcctctc
      181 cccgccttcc gtccgtggct ccgtgcgctc gttggccttc cggccaagct ctcactcgcc
      241 tcgcagattt ccatgaggac agctgacaag gacctgaatg gcctcatttt agctacttct
      301 gtctgtggag ctatttcttg ctccttcagt tctgatccct ggtgcgacag tggctcctga
      361 gcaccatgaa agttgtccca gagaagaatg ctgtacgaat cctctggggc cgagagcggg
      421 gcactcgtgc catgggtgcc cagcggcttc tgcaggagct ggtggaggat aagactcgat
      481 ggatgaaatg ggagggcaag agagtagaac ttcctgatag tccacgctcg accttcttac
      541 tggccttcag cccagacagg actctcttgg cgtccacaca tgtgaaccat aacatctata
      601 ttacagaggt taagactggc aagtgtgttc actctctgat tggacaccgc cgtactccat
      661 ggtgtgtcac ttttcatccc actatctcag gccttattgc ttctggctgc ctagatgggg
      721 aagttaggat ttgggactta catggtggca gtgaaagctg gttcacagat agcaacaatg
      781 ccatagcttc tttggctttc caccctacgg ctcagctcct gctgatcgcc actgcaaatg
      841 agatccattt ctgggattgg agtcgtcggg aaccctttgc tgtggtgaaa acagctagtg
      901 agatggagcg tgttcgtctg gtgagatttg atccacttgg acactactta cttacagcta
      961 ttgttaaccc ctctaatcag cagggtgatg atgaaccaga aatccctata gatggaacag
     1021 aattatctca ttaccgtcag cgtgccctcc tgcaatcaca gccagttcgc cggacacccc
     1081 tcctccacaa tttcctgcat atgctgtcct cccgctcctc tggcatccag gtgggagagc
     1141 aaagcacagt acaagattct gctaccccct cacccccacc gcctccccct cagccctcca
     1201 cggagcgtcc caggacttcc gcttacatca gactccgaca gcgggtcagt taccccacca
     1261 cagttgagtg ctgccagcac cctgggatcc tgtgcctttg cagccgttgt gctggcactc
     1321 gagttccttc cctcttgcca caccaggaca gtgtcccccc tgcttctgcc agagctacta
     1381 ccccttcctt ttcttttgta cagaccgagc ccttccatcc cccggagcag gcttcatcaa
     1441 cgcagcagga ccaaggcctc ctgaaccggc cgtctgcctt cagtacagtc cagagcagca
     1501 ctgcgggcaa cacgctccgc aacctcagtc tgggtcctac ccgtcgctct ttggggggcc
     1561 cactgtccag ccacccatct aggtatcaca gagaactagc ccctgggctg acaggttctg
     1621 agtggacccg gacagtactc actctgaact cacgttctga ggtagaatct atgcccccac
     1681 cgaggaccag tgcctcctca gtgagtttgc tttctgtact gagacagcag gaaggtggct
     1741 ctcaggcatc tgtgtatact tcagccacag aagggagggg ttttccatca tcagggttgg
     1801 caactgagtc agatggaggg aatggttcca gccaaaacaa ctcaggcaac attcgccatg
     1861 agcttcagtg tgacctgaga cgcttttttt tggagtatga caggctgcag gagctggatc
     1921 agagcctgag tggggaaact ccccagaccc aacaggccca ggaaatgctc aacaataata
     1981 ttgaatctga gagaccaggt ccttcccatc agcctacccc acacagcagt gagaacaact
     2041 ccaacctttc tcggggccac cttaatcgat gccgtgcttg ccataatctt ctaaccttca
     2101 acaatgatac ccttcgttgg gaaagaacca cacctaacta ctcatccggt gaggctagct
     2161 cttcctggca tgtctccact acttttgagg gcatgccacc gagtggcaac caactaccac
     2221 ctcttgagcg gactgagggc caaatgccta actccagcag gctggagttg agcagttctg
     2281 ctagttcaca agaggagagg actgtggggg tggcctttaa ccaggagacc ggccattggg
     2341 aacgaattta tacccagtcc agcagatctg gaactgtatc acaggaggcc ttacatcaag
     2401 atatgcctga ggaaagctct gaggaagact ccctgaggag gaggctgctg gagtcttccc
     2461 tcatttcatt atcccgttat gatggagcag gatccagaga gcacccaatt tacccagacc
     2521 cagcgagatt atctcctgct gcatactacg cccagaggat gatccagtat ctctcaagga
     2581 gagacagtat tcgccagcgc tccatgcgct accaacagaa tcggcttcgt tcttccacct
     2641 cctcttcttc ctcagacaac cagggtccat cagtagaggg aaccgacttg gaatttgagg
     2701 actttgagga caatggtgac agatctaggc accgagctcc ccgaaatgcc cgaatgtctg
     2761 caccatcact tggacgcttt gtcccaaggc gttttttgct gcctgagtac ttgccttatg
     2821 ctgggatttt tcatgagcgt ggacagcctg gcttggctac tcattcttct gttaacaggg
     2881 tcctggcagg ggcagtaatt ggagatggac agtctgctgt ggccagtaac attgccaata
     2941 ctacctacag gctccagtgg tgggacttca ccaagtttga ccttccagaa atcagtaatg
     3001 cctccgtgaa tgtcctggta cagaactgca agatctacaa tgatgccagc tgtgacattt
     3061 ctgcagatgg ccagctcctg gcagctttca tcccgagtag ccagaggggc tttcctgatg
     3121 aaggcatcct ggcagtgtat tccctggccc cccataactt gggggaaatg ctctacacca
     3181 agcgatttgg tcccaatgcc atttctgtaa gcctgtcccc aatgggccga tacgttatgg
     3241 tgggcttggc ctcacgaagg atcctgctgc acccctctac agagcacatg gtagcccagg
     3301 tcttcaggct gcagcaggcc catggtggtg agacttccat gaggagagtt ttcaacgtcc
     3361 tttaccccat gcctgcggac cagcggagac acgtcagcat caactctgcc cgctggctac
     3421 ctgagccagg gctcggtttg gcctatggca ccaacaaagg agacctggtg atctgccgac
     3481 cagaggcctt aaactctggc attgagtact actgggacca gctaaatgaa acggtcttca
     3541 ctgtccactc aagtagcagg agcagcgagc ggcctggaac cagcagagcc acatggcgga
     3601 cagacagaga catgggcttg atgaatgcaa ttgggctgca acctcggaac cctaccacct
     3661 ctgtgacatc tcagggcacc cagactctgg ccctccagtt gcagaatgct gaaacacaga
     3721 ctgagaggga ggaagaggaa ccagggacag catcctcagg tcctggtgaa ggcgagggct
     3781 cggaatatgg tggcagtggg gaagatgccc tcagccggat ccagaggcta atggccgagg
     3841 gtggcatgac agctgtggta cagcgagaac agagtaccac catggcctcc atgggtggct
     3901 tcggcaacaa catcatcgtt agccaccgca ttcaccgcag ctcccagaca ggcacagagt
     3961 caggggctgc tcgtacctcc tcaccccagc cctccacctc tcgaggacta ctctcagaac
     4021 ctgggcaact ggcagagcga ggactaagcc cccggacagc ctcctgggac cagcctagta
     4081 cctctggaag ggaactaccc cagccagccc tgtcctcttc ctcccctgtc cccattccag
     4141 tcccccttgc cagcaatgag ggaccaacca tgcactgcaa tgtgaccaat aacagtcacc
     4201 ttcctgaggg tgatagtagc aatgtggggg aagctgcagg ccctagtggg gagccacgga
     4261 accgatagag acaaaaccag gtactggtac ctccctcaag ctgctgagca ggagcaggac
     4321 ctcacggctg gctgggaact ggacacagaa gagctgatgc ttgcatccag gaacaggagc
     4381 aatgagaggg tggggcagtg ggtaaggggc agtccaactg gcaaggctgg cctgggatac
     4441 tagagccttc catgatctag agcccagaag agcctcactg ctgaacctgg tgtgaatgaa
     4501 gaagcaagtg ggtatctctg ctatgagccc catttctcct aggatcactg acctagggga
     4561 ctcaaccctg ggcatgagcc ccagaagagc gaagtcttcc agagctagac cacaccatcc
     4621 tggacagaat ggtgggacag ttcttctccg cccactactg gagggaagag ccaccaggag
     4681 cagaggagca gcgccccccc cccccccaat tgcttccatc tttaaaactt ccagagttcc
     4741 agcctctcac atcctcttag cccacagaga cggaaaggtc aagcccagct tccatgccag
     4801 tgacttgtta cactcacgag tgcgacacct gtggagtgaa ggagatagcc tacttgactg
     4861 acacaggatg gagtcgatac acggtggtgg acaggtcctc aggagtgggg ggggtgtagg
     4921 ctggcccgcc cccagcatgt ccaccaagct ccccccttcc acaagaccct ccgtgcagca
     4981 cctatgggtg tcagtattac ctaagcatag gccaaagcca gcccaaggtt ggagggagga
     5041 gattccaggt cagaatgtga ggtcttggtc tgtgacttga ggtgttgcat gtggaatcct
     5101 gaactgtacg tgtagttttt agtggagaaa tcaaggctct gatcattttg tttttagtat
     5161 gaaaatgtga tttcctttct gtttgtcact catcatagaa acattgtggt gggaggagag
     5221 gggacagtct actgctaatg agggagacac caaagatcta catcattaaa atgatgacat
     5281 gcccctcatc a
//
