LOCUS       NM_012901               1145 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus alpha-1-microglobulin/bikunin precursor (Ambp),
            mRNA.
ACCESSION   NM_012901
VERSION     NM_012901.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1145)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1145)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 1145)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1145)
  AUTHORS   Puczko-Michalczuk,A., Zoch-Zwierz,W., Wasilewska,A., Porowska,T.
            and Korzeniecka-Kozerska,A.
  TITLE     [Evaluation of inflammatory and renal injury markers in youngest
            children with pyelonephritis]
  JOURNAL   Pol Merkur Lekarski 25 (150), 451-454 (2008)
   PUBMED   19205372
REFERENCE   5  (bases 1 to 1145)
  AUTHORS   Madalena,L., Facio,M.L., Angerosa,M., Pandolfo,M., Bresciani,P.,
            Alejandre,M., Pizzolato,M. and Toblli,J.E.
  TITLE     Urinary excretion of low molecular weight proteins in patients with
            pure monoclonal light chain proteinuria
  JOURNAL   J Nephrol 20 (6), 683-688 (2007)
   PUBMED   18046670
REFERENCE   6  (bases 1 to 1145)
  AUTHORS   Falkenberg,C., Enghild,J.J., Thogersen,I.B., Salvesen,G. and
            Akerstrom,B.
  TITLE     Isolation and characterization of fibronectin-alpha 1-microglobulin
            complex in rat plasma
  JOURNAL   Biochem J 301 (Pt 3) (Pt 3), 745-751 (1994)
   PUBMED   7519849
REFERENCE   7  (bases 1 to 1145)
  AUTHORS   Itoh,H., Ide,H., Ishikawa,N. and Nawa,Y.
  TITLE     Mast cell protease inhibitor, trypstatin, is a fragment of
            inter-alpha-trypsin inhibitor light chain
  JOURNAL   J Biol Chem 269 (5), 3818-3822 (1994)
   PUBMED   7508921
REFERENCE   8  (bases 1 to 1145)
  AUTHORS   Lindqvist,A., Bratt,T., Altieri,M., Kastern,W. and Akerstrom,B.
  TITLE     Rat alpha 1-microglobulin: co-expression in liver with the light
            chain of inter-alpha-trypsin inhibitor
  JOURNAL   Biochim Biophys Acta 1130 (1), 63-67 (1992)
   PUBMED   1371936
REFERENCE   9  (bases 1 to 1145)
  AUTHORS   Kido,H., Yokogoshi,Y. and Katunuma,N.
  TITLE     Kunitz-type protease inhibitor found in rat mast cells.
            Purification, properties, and amino acid sequence
  JOURNAL   J Biol Chem 263 (34), 18104-18107 (1988)
   PUBMED   3263966
REFERENCE   10 (bases 1 to 1145)
  AUTHORS   Kastern,W., Bjorck,L. and Akerstrom,B.
  TITLE     Developmental and tissue-specific expression of alpha
            1-microglobulin mRNA in the rat
  JOURNAL   J Biol Chem 261 (32), 15070-15074 (1986)
   PUBMED   2429963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012901.3.
            
            On Nov 26, 2020 this sequence version replaced NM_012901.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088166.1, SRR26643286.16819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000005.1  81593732-81593857   c
            127-269             JAXUCZ010000005.1  81592480-81592622   c
            270-346             JAXUCZ010000005.1  81591152-81591228   c
            347-463             JAXUCZ010000005.1  81589978-81590094   c
            464-565             JAXUCZ010000005.1  81589046-81589147   c
            566-612             JAXUCZ010000005.1  81588349-81588395   c
            613-694             JAXUCZ010000005.1  81586137-81586218   c
            695-862             JAXUCZ010000005.1  81584962-81585129   c
            863-1036            JAXUCZ010000005.1  81584459-81584632   c
            1037-1145           JAXUCZ010000005.1  81583637-81583745   c
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..1145
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /note="alpha-1-microglobulin/bikunin precursor"
                     /db_xref="GeneID:25377"
                     /db_xref="RGD:2102"
     exon            1..126
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1062
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /note="protein AMBP; Alpha-1 microglobulin/bikunin; alpha
                     1 microglobulin/bikunin; ulinastatin; urinary trypsin
                     inhibitor"
                     /codon_start=1
                     /product="protein AMBP precursor"
                     /protein_id="NP_037033.1"
                     /db_xref="GeneID:25377"
                     /db_xref="RGD:2102"
                     /translation="MQGLGALFLLLTACLTLKADNVPTLPDIQVQENFNEARIYGKWF
                     NLAVGSTCPWLRRIKNKMSVSTLVLQEGATEAEISVTSTQWRKGVCEEISGVYQKTDI
                     DGKFLYHKSKWNATLESYVVHTNYDEYAIFLTKKFSHRHGPTITAKLYGREPQLRDSL
                     LQEFREVALSVGIPENSIVFMADRGECVPGDREVESTSFARARRAVLPQENEGSGSEP
                     LITGTLKKEDSCQLNYSEGPCLGMQQKYYYNGASMACETFQYGGCLGNGNNFASEKEC
                     LQTCRTIAACNLPIVQGPCRAFAELWAFDAAQGKCIQFIYGGCKGNGNKFYSEKECKE
                     YCGVPGDGYEELTRS"
     exon            127..269
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            270..346
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            347..463
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            464..565
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            566..612
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            613..694
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            695..862
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1036
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1145
                     /gene="Ambp"
                     /gene_synonym="UTI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgcagag ccatgcaggg tctcggggcc ctgttcttgt tgctgactgc ctgcctcact
       61 ttgaaggctg acaatgtgcc aacactgcca gatatccagg ttcaggagaa cttcaatgag
      121 gcccggatct atggaaaatg gttcaacctg gcggtgggct ccacctgccc gtggctgagg
      181 cggattaaga acaagatgag cgtgagcacg ctggtgctgc aggagggggc gacagaagcc
      241 gagatcagcg tgaccagtac tcaatggcgg aaaggtgtct gcgaggagat ctccggggtg
      301 tatcagaaga cagacattga cggaaagttc ctttaccaca aatccaaatg gaatgcaacc
      361 ttggaatctt atgtggtcca caccaactat gacgaatatg ccattttcct taccaagaag
      421 ttcagccacc gccacggacc caccatcact gccaagctct atggccggga accacagctg
      481 agggacagcc ttctgcagga gttcagggag gtggccctga gtgtgggcat ccctgagaac
      541 tccattgttt ttatggccga cagaggagaa tgtgtccctg gggatcggga ggtagagtcc
      601 acttcatttg caagagcccg gcgggcagtg ctgccccaag agaatgaagg gtcagggagt
      661 gagccactca taactgggac cctcaagaaa gaagactcct gccagctcaa ctactcagaa
      721 ggtccctgcc tggggatgca gcagaagtat tactacaatg gcgcctccat ggcctgcgag
      781 accttccaat atggcggctg cctaggcaat ggtaacaact tcgcctccga gaaggaatgc
      841 ctgcagacgt gccggaccat agcggcctgc aatctcccca tagtccaagg cccctgccga
      901 gcctttgcag aactctgggc atttgatgca gcgcaaggga agtgcatcca attcatctat
      961 gggggctgca aaggcaacgg caacaagttc tactctgaga aggagtgcaa ggagtactgt
     1021 ggagtccctg gtgatgggta cgaggagcta acacgcagtt gaaggagccg gtctgcaagc
     1081 cagagggtag ccacggtccg tcactgtgca gtccagctta gatgatctgg acccaataaa
     1141 acaag
//
