LOCUS       NM_012900               1903 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ameloblastin (Ambn), mRNA.
ACCESSION   NM_012900 XM_001073587
VERSION     NM_012900.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Wang,L., Zhu,Y. and Wang,D.
  TITLE     High-Dose Fluoride Induces Apoptosis and Inhibits Ameloblastin
            Secretion in Primary Rat Ameloblast
  JOURNAL   Biol Trace Elem Res 174 (2), 402-409 (2016)
   PUBMED   27193486
  REMARK    GeneRIF: Fluoride could decrease ameloblast viability, induce
            ameloblast apoptosis via activating FasL/Fas signaling pathway, and
            reduce AMBN secretion.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Iizuka,S., Kudo,Y., Yoshida,M., Tsunematsu,T., Yoshiko,Y.,
            Uchida,T., Ogawa,I., Miyauchi,M. and Takata,T.
  TITLE     Ameloblastin regulates osteogenic differentiation by inhibiting Src
            kinase via cross talk between integrin beta1 and CD63
  JOURNAL   Mol Cell Biol 31 (4), 783-792 (2011)
   PUBMED   21149578
  REMARK    GeneRIF: ameloblastin is expressed in osteoblasts and functions as
            a promoting factor for osteogenic differentiation via a novel
            pathway through the interaction between CD63 and integrin beta1
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Tamburstuen,M.V., Reseland,J.E., Spahr,A., Brookes,S.J.,
            Kvalheim,G., Slaby,I., Snead,M.L. and Lyngstadaas,S.P.
  TITLE     Ameloblastin expression and putative autoregulation in mesenchymal
            cells suggest a role in early bone formation and repair
  JOURNAL   Bone 48 (2), 406-413 (2011)
   PUBMED   20854943
  REMARK    GeneRIF: Findings suggest a role for this protein in early bone
            formation and repair.
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Sonoda,A., Iwamoto,T., Nakamura,T., Fukumoto,E., Yoshizaki,K.,
            Yamada,A., Arakaki,M., Harada,H., Nonaka,K., Nakamura,S., Yamada,Y.
            and Fukumoto,S.
  TITLE     Critical role of heparin binding domains of ameloblastin for dental
            epithelium cell adhesion and ameloblastoma proliferation
  JOURNAL   J Biol Chem 284 (40), 27176-27184 (2009)
   PUBMED   19648121
  REMARK    GeneRIF: AMBN promotes cell binding through the heparin binding
            sites and plays an important role in preventing odontogenic tumor
            development by suppressing cell proliferation and maintaining
            differentiation phenotype through Msx2, p21, and p27.
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Zalzal,S.F., Smith,C.E. and Nanci,A.
  TITLE     Ameloblastin and amelogenin share a common secretory pathway and
            are co-secreted during enamel formation
  JOURNAL   Matrix Biol 27 (4), 352-359 (2008)
   PUBMED   18281204
  REMARK    GeneRIF: subpopulation of granules containing only AMBN could be
            responsible for augmenting its local concentration along secretory
            surfaces against which hydroxyapatite crystals actively elongate
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Spahr,A., Lyngstadaas,S.P., Slaby,I. and Pezeshki,G.
  TITLE     Ameloblastin expression during craniofacial bone formation in rats
  JOURNAL   Eur J Oral Sci 114 (6), 504-511 (2006)
   PUBMED   17184233
  REMARK    GeneRIF: express[ed] during craniofacial bone development in rats
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Zeichner-David,M., Chen,L.S., Hsu,Z., Reyna,J., Caton,J. and
            Bringas,P.
  TITLE     Amelogenin and ameloblastin show growth-factor like activity in
            periodontal ligament cells
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 244-53 (2006)
   PUBMED   16674693
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Lee,S.K., Kim,S.M., Lee,Y.J., Yamada,K.M., Yamada,Y. and Chi,J.G.
  TITLE     The structure of the rat ameloblastin gene and its expression in
            amelogenesis
  JOURNAL   Mol Cells 15 (2), 216-225 (2003)
   PUBMED   12803485
  REMARK    GeneRIF: exon 3a and 11 are potential alternative splicing sites,
            producing 4 types of ameloblastin mRNA, from which ameloblastin I
            and II could be translated
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Cerny,R., Slaby,I., Hammarstrom,L. and Wurtz,T.
  TITLE     A novel gene expressed in rat ameloblasts codes for proteins with
            cell binding domains
  JOURNAL   J Bone Miner Res 11 (7), 883-891 (1996)
   PUBMED   8797107
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Krebsbach,P.H., Lee,S.K., Matsuki,Y., Kozak,C.A., Yamada,K.M. and
            Yamada,Y.
  TITLE     Full-length sequence, localization, and chromosomal mapping of
            ameloblastin. A novel tooth-specific gene
  JOURNAL   J Biol Chem 271 (8), 4431-4435 (1996)
   PUBMED   8626794
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012900.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35097.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840105,
                                           SAMN12840106 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000014.1  19898326-19898422   c
            98-166              JAXUCZ010000014.1  19897517-19897585   c
            167-232             JAXUCZ010000014.1  19895039-19895104   c
            233-280             JAXUCZ010000014.1  19893666-19893713   c
            281-391             JAXUCZ010000014.1  19892848-19892958   c
            392-631             JAXUCZ010000014.1  19891056-19891295   c
            632-670             JAXUCZ010000014.1  19890050-19890088   c
            671-730             JAXUCZ010000014.1  19889742-19889801   c
            731-775             JAXUCZ010000014.1  19889598-19889642   c
            776-820             JAXUCZ010000014.1  19889163-19889207   c
            821-1903            JAXUCZ010000014.1  19885802-19886884   c
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1903
                     /gene="Ambn"
                     /note="ameloblastin"
                     /db_xref="GeneID:25376"
                     /db_xref="RGD:2101"
     exon            1..97
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1351
                     /gene="Ambn"
                     /note="amelin"
                     /codon_start=1
                     /product="ameloblastin precursor"
                     /protein_id="NP_037032.1"
                     /db_xref="GeneID:25376"
                     /db_xref="RGD:2101"
                     /translation="MSASKIPLFKMKGLLLFLSLVKMSLAVPAFPQQPGAQGMAPPGM
                     ASLSLETMRQLGSLQGLNALSQYSRLGFGKALNSLWLHGLLPPHNSFPWIGPREHETQ
                     QYEYSLPVHPPPLPSQPSLQPHQPGLKPFLQPTAATGVQVTPQKPGPHPPMHPGQLPL
                     QEGELIAPDEPQVAPSENPPTPEVPIMDFADPQFPTVFQIAHSLSRGPMAHNKVPTFY
                     PGMFYMSYGANQLNAPARIGFMSSEEMPGERGSPMAYGTLFPGYGGFRQTLRGLNQNS
                     PKGGDFTVEVDSPVSVTKGPEKGEGPEGSPLQEASPDKGENPALLSQMAPGAHAGLLA
                     FPNDHIPNMARGPAGQRLLGVTPAAADPLITPELAEVYETYGADVTTPLGDGEATMDI
                     TMSPDTQQPPMPGNKVHQPQVHNAWRFQEP"
     exon            98..166
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            167..232
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            233..280
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            281..391
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            392..631
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            632..670
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            671..730
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            731..775
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            776..820
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1903
                     /gene="Ambn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggaaca gtccagaaaa aaattaatct tcttttctta gaactgtttt gattggcatc
       61 atcaggcctg ggagcacagt gaatgtcagc atctaagatt ccacttttca aaatgaaggg
      121 cctgctcctg ttcctgtccc tagtgaaaat gagcctcgcc gtgccggcat ttcctcaaca
      181 acctggggct caaggcatgg cacctcctgg catggctagt ttgagccttg agacaatgag
      241 acagttggga agcttgcagg ggctcaacgc actttctcag tattctagac ttggctttgg
      301 aaaagcactt aatagtttat ggttgcatgg actcctccca ccgcataatt ctttcccatg
      361 gataggacca agggaacatg aaacccaaca gtatgaatat tctttgcctg tgcatccccc
      421 acctctccca tcacagccat ccttgcagcc tcaccagcca ggactgaaac ccttcctcca
      481 gcccactgct gcaaccggtg tccaggtcac accccagaag ccagggcctc atcctccaat
      541 gcaccctgga cagctgccct tgcaggaagg agagctgata gcaccagatg agccacaggt
      601 ggcgccatca gagaacccac caacacccga ggtaccaata atggattttg ccgatccaca
      661 attcccaaca gtgttccaga tcgcccattc gctgtctcgg ggaccaatgg cacacaacaa
      721 agtacccact ttttacccag gaatgtttta catgtcttat ggagcaaacc aattgaatgc
      781 tcctgccaga atcggcttca tgagttcaga agaaatgcct ggagaaagag gaagtcccat
      841 ggcctacgga actctgttcc caggatatgg aggcttcagg caaaccctta ggggactgaa
      901 tcagaattca cccaagggag gagactttac tgtggaagta gattctccag tgtctgtaac
      961 taaaggccct gagaaaggag agggtccaga aggctctcca ctgcaagagg ccagcccaga
     1021 caagggcgaa aacccggctc tcctttcaca gatggccccc ggggcccatg caggacttct
     1081 tgctttcccc aatgaccaca tccccaacat ggcaaggggt cctgcagggc aaagactcct
     1141 cggagtcacc cctgcagctg cagacccact gatcacccct gaattagcag aagtttatga
     1201 aacctatggt gctgatgtta ccacaccctt gggggatgga gaagcaacca tggatatcac
     1261 catgtcccca gacactcagc agccaccgat gcctggaaac aaagtgcacc agccccaggt
     1321 gcacaatgca tggcgtttcc aagagccctg acaaccttga catagcagct acttcatgta
     1381 tgcacaagct tttcagcttt gtccccatag cgtaccttat tgctaaaaca cttgctaccc
     1441 ttccacagcg aaggtattaa gagcactaag catgtattaa taaatacaag tgcctagaaa
     1501 tagtgtaggt cccttcttgc ttccattctt atcgaaataa aacatatcaa ctgtctccgt
     1561 gacttagaaa tactatcgat gatgtcagag caagtctgag tgtcagcact tggtgatcta
     1621 gcatgtagct gtcttaggca tcataaaatt cctcttacta catgacatta ttatgcccag
     1681 gaaatgtgac accgcttctt tctctacgca aaagcactta gtttcagaat tccaaagtat
     1741 ttcatttaaa ccgtattaaa tggtgattgg tggagaatcc tgactgctat tactgggtat
     1801 catatattgg atttaaaatt cttatttata gaatatttta tttaatctag gaaaagaaaa
     1861 ggcaattggc ctgttttaaa taaagaattt ttctcactga aaa
//
