LOCUS       NM_012816               1542 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus alpha-methylacyl-CoA racemase (Amacr), mRNA.
ACCESSION   NM_012816
VERSION     NM_012816.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Szponar,A., Beothe,T. and Kovacs,G.
  TITLE     How useful is alpha-methylacyl-CoA racemase (AMACR)
            immunohistochemistry in the differential diagnosis of kidney
            cancers?
  JOURNAL   Histopathology 56 (2), 263-265 (2010)
   PUBMED   20102405
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Honma,I., Torigoe,T., Hirohashi,Y., Kitamura,H., Sato,E.,
            Masumori,N., Tamura,Y., Tsukamoto,T. and Sato,N.
  TITLE     Aberrant expression and potency as a cancer immunotherapy target of
            alpha-methylacyl-coenzyme A racemase in prostate cancer
  JOURNAL   J Transl Med 7, 103 (2009)
   PUBMED   20003233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Gunia,S., May,M., Scholmann,K., Storkel,S., Hoschke,B., Koch,S.,
            Dietel,M. and Kristiansen,G.
  TITLE     Expression of alpha-methylacyl-CoA racemase correlates with
            histopathologic grading in noninvasive bladder cancer
  JOURNAL   Virchows Arch 453 (2), 165-170 (2008)
   PUBMED   18648853
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Stewart,J., Fleshner,N., Cole,H., Toi,A. and Sweet,J.
  TITLE     Prognostic significance of alpha-methylacyl-coA racemase among men
            with high grade prostatic intraepithelial neoplasia in prostate
            biopsies
  JOURNAL   J Urol 179 (5), 1751-5 (2008)
   PUBMED   18343427
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Schmitz,W., Helander,H.M., Hiltunen,J.K. and Conzelmann,E.
  TITLE     Molecular cloning of cDNA species for rat and mouse liver
            alpha-methylacyl-CoA racemases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 883-889 (1997)
   PUBMED   9307041
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Reichel,C., Brugger,R., Bang,H., Geisslinger,G. and Brune,K.
  TITLE     Molecular cloning and expression of a 2-arylpropionyl-coenzyme A
            epimerase: a key enzyme in the inversion metabolism of ibuprofen
  JOURNAL   Mol Pharmacol 51 (4), 576-582 (1997)
   PUBMED   9106621
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Reichel,C., Bang,H., Brune,K., Geisslinger,G. and Menzel,S.
  TITLE     2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue
            localization
  JOURNAL   Biochem Pharmacol 50 (11), 1803-1806 (1995)
   PUBMED   8615858
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Schmitz,W., Albers,C., Fingerhut,R. and Conzelmann,E.
  TITLE     Purification and characterization of an alpha-methylacyl-CoA
            racemase from human liver
  JOURNAL   Eur J Biochem 231 (3), 815-822 (1995)
   PUBMED   7649182
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Schmitz,W., Fingerhut,R. and Conzelmann,E.
  TITLE     Purification and properties of an alpha-methylacyl-CoA racemase
            from rat liver
  JOURNAL   Eur J Biochem 222 (2), 313-323 (1994)
   PUBMED   8020470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM061736.1 and BC127505.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012816.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127505.1, CO572763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                FM061736.1         1-11
            12-1542             BC127505.1         1-1531
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1542
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /note="alpha-methylacyl-CoA racemase"
                     /db_xref="GeneID:25284"
                     /db_xref="RGD:3048"
     exon            1..254
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1156
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /EC_number="5.1.99.4"
                     /note="2-methylacyl-CoA racemase; 2-arylpropionyl-CoA
                     epimerase"
                     /codon_start=1
                     /product="alpha-methylacyl-CoA racemase"
                     /protein_id="NP_036948.2"
                     /db_xref="GeneID:25284"
                     /db_xref="RGD:3048"
                     /translation="MALRGVRVLELAGLAPGPFCGMILADFGAEVVLVDRLGSVNHPS
                     HLARGKRSLALDLKRSPGAAVLRRMCARADVLLEPFRCGVMEKLQLGPETLQQDNPKL
                     IYARLSGFGQSGIFSKVAGHDINYVALSGVLSKIGRSGENPYPPLNLLADFGGGGLMC
                     TLGILLALFERTRSGLGQVIDANMVEGTAYLSTFLWKTQAMGLWAQPRGQNLLDGGAP
                     FYTTYKTADGEFMAVGAIEPQFYTLLLKGLGLESEELPSQMSIEDWPEVKKKFADVFA
                     RKTKAEWCQIFDGTDACVTPVLTLEEALHHQHNRERGSFITDEEQHASPRPAPQLSRT
                     PAVPSAKRDPSVGEHTVEVLKDYGFSQEEIHQLHSDRIIESNKLKANL"
     exon            255..398
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..559
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..746
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1511
                     /gene="Amacr"
                     /gene_synonym="Da1-8; Marc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggccatg gcgctgcgtg gcgtcagggt tctggagctg gcaggcctgg ccccagggcc
       61 gttctgcggg atgatcctgg cggacttcgg cgccgaggtg gtgctcgtgg acagactggg
      121 ctccgtgaac caccccagtc acctggcccg aggcaagcgc tcgctggcgc tggacctgaa
      181 gcggtctccg ggagccgcgg tgttgcggcg catgtgcgca cgcgcggacg tgttgctgga
      241 gcccttccgt tgcggtgtca tggagaaact ccagcttggg ccagagactc tacagcagga
      301 caatccaaag ctcatctatg ccaggctgag tggatttggc cagtcgggaa ttttctccaa
      361 agtagctggc catgacatca actatgtggc tttgtcaggt gtcctgtcaa agattggcag
      421 gagcggtgag aacccatacc ctcccctgaa cctcctggcc gactttggtg gcggtggcct
      481 catgtgcaca ttgggcattt tgctggctct cttcgaacgc acgcggtctg gcctagggca
      541 ggtcattgat gcgaacatgg tggaaggaac ggcatactta agtactttcc tgtggaaaac
      601 tcaagccatg ggtctgtggg cacagcctcg agggcaaaac ctgttagatg gcggggcacc
      661 tttctacaca acctacaaga ccgcagatgg ggagttcatg gctgtaggtg caatagaacc
      721 ccagttctac acactgctgc ttaaaggact tggacttgag tctgaggaac tccccagcca
      781 gatgagcata gaagattggc cagaagtgaa gaagaaattt gcagatgtgt ttgcaaggaa
      841 gactaaggca gagtggtgcc agatctttga cgggacagat gcatgtgtga ccccagtgct
      901 gactcttgag gaggccctcc accaccagca caacagagaa cggggctcct tcatcactga
      961 cgaggagcag catgcaagcc cccgtcctgc accccagctt tccagaaccc ctgctgttcc
     1021 ttctgccaaa agggaccctt ctgtgggaga gcacactgta gaggtgctta aagactatgg
     1081 attcagtcag gaagagatcc atcagctgca ctcggataga atcattgaaa gtaataagct
     1141 aaaagccaac ctctgactca ggttcacagc tcaagtgaat ctgaaggctg tatctgtact
     1201 ggagaaggat gcccaccact gtccgtatgg aaatgtgaat gaacagtaat gaagtaatcc
     1261 aaatattcca atcaagacac aacgaaagac tgattacaga gaaatgactg tgctctcaca
     1321 ctgctcatcc gagcctctga ttgaggagta tttttgtgtg tgtactgata ttaacttgtg
     1381 gcagttttct gcctttcagc tcacttggtg aagtgcattc actgattaaa acccttttgt
     1441 aaatgcaact ctgataatat attaaatgaa ctaatataac tttaataaat aaagcttttt
     1501 ttttccttga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
