LOCUS       NM_001106553            1747 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ALX homeobox 4 (Alx4), mRNA.
ACCESSION   NM_001106553 XM_001078593 XM_231005
VERSION     NM_001106553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Zhao,J., Chen,H.Q., Yang,H.F., Li,Y., Chen,D.J., Huang,Y.J.,
            He,L.X., Zheng,C.F., Wang,L.Q., Wang,J., Zhang,N., Cao,J.,
            Liu,J.Y., Shu,W.Q. and Liu,W.B.
  TITLE     Epigenetic silencing of ALX4 regulates microcystin-LR induced
            hepatocellular carcinoma through the P53 pathway
  JOURNAL   Sci Total Environ 683, 317-330 (2019)
   PUBMED   31132711
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Shi,Y., Sun,X. and He,X.
  TITLE     Overexpression of Aristaless-Like Homeobox-4 Inhibits
            Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells
  JOURNAL   Oncol Res 25 (1), 11-18 (2017)
   PUBMED   28081728
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Ghasemvand,F., Nezafat,N., Hesami Tackallou,S., Momenzadeh,D. and
            Rahmanzadeh,S.
  TITLE     Differential expression of aristaless-like homeobox 4: a potential
            marker for gastric adenocarcinoma
  JOURNAL   Gastroenterol Hepatol Bed Bench 9 (4), 286-294 (2016)
   PUBMED   27895854
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Salehi,R., Atapour,N., Vatandoust,N., Farahani,N., Ahangari,F. and
            Salehi,A.R.
  TITLE     Methylation pattern of ALX4 gene promoter as a potential biomarker
            for blood-based early detection of colorectal cancer
  JOURNAL   Adv Biomed Res 4, 252 (2015)
   PUBMED   26918234
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Liu,W.B., Han,F., Du,X.H., Jiang,X., Li,Y.H., Liu,Y., Chen,H.Q.,
            Ao,L., Cui,Z.H., Cao,J. and Liu,J.Y.
  TITLE     Epigenetic silencing of Aristaless-like homeobox-4, a potential
            tumor suppressor gene associated with lung cancer
  JOURNAL   Int J Cancer 134 (6), 1311-1322 (2014)
   PUBMED   24037716
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Qu,S., Tucker,S.C., Zhao,Q., deCrombrugghe,B. and Wisdom,R.
  TITLE     Physical and genetic interactions between Alx4 and Cart1
  JOURNAL   Development 126 (2), 359-369 (1999)
   PUBMED   9847249
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Hudson,R., Taniguchi-Sidle,A., Boras,K., Wiggan,O. and Hamel,P.A.
  TITLE     Alx-4, a transcriptional activator whose expression is restricted
            to sites of epithelial-mesenchymal interactions
  JOURNAL   Dev Dyn 213 (2), 159-169 (1998)
   PUBMED   9786416
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Qu,S., Niswender,K.D., Ji,Q., van der Meer,R., Keeney,D.,
            Magnuson,M.A. and Wisdom,R.
  TITLE     Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
  JOURNAL   Development 124 (20), 3999-4008 (1997)
   PUBMED   9374397
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Dunn,N.R., Winnier,G.E., Hargett,L.K., Schrick,J.J., Fogo,A.B. and
            Hogan,B.L.
  TITLE     Haploinsufficient phenotypes in Bmp4 heterozygous null mice and
            modification by mutations in Gli3 and Alx4
  JOURNAL   Dev Biol 188 (2), 235-247 (1997)
   PUBMED   9268572
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Dunwoodie,S.L., Henrique,D., Harrison,S.M. and Beddington,R.S.
  TITLE     Mouse Dll3: a novel divergent Delta gene which may complement the
            function of other Delta homologues during early pattern formation
            in the mouse embryo
  JOURNAL   Development 124 (16), 3065-3076 (1997)
   PUBMED   9272948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001106553.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.10828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               JAXUCZ010000003.1  100067052-100067654
            604-914             JAXUCZ010000003.1  100093973-100094283
            915-1043            JAXUCZ010000003.1  100100964-100101092
            1044-1747           JAXUCZ010000003.1  100102921-100103624
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..1747
                     /gene="Alx4"
                     /note="ALX homeobox 4"
                     /db_xref="GeneID:296511"
                     /db_xref="RGD:1310201"
     exon            1..603
                     /gene="Alx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1373
                     /gene="Alx4"
                     /note="aristaless-like homeobox 4; aristaless 4"
                     /codon_start=1
                     /product="homeobox protein aristaless-like 4"
                     /protein_id="NP_001100023.1"
                     /db_xref="GeneID:296511"
                     /db_xref="RGD:1310201"
                     /translation="MNAETCVSYCESPATAMDAYYSPVSQSREGSSPFRGFPGGDKFG
                     TTFLSAAAKGQGFGDAKGRARYGAGQQDLAAPLESNAGARGSFNKFQPQPPTPQPPPA
                     PPAPPAHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELPPDSEP
                     VGMDNSYLSVKETGAKGPQDRAGAEIPSPLEKTDSESSKGKKRRNRTTFTSYQLEELE
                     KVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTA
                     YELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSV
                     SDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNGYEMNGEPDRKTSSIAALRMKAKEHS
                     AAISWAT"
     exon            604..914
                     /gene="Alx4"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1043
                     /gene="Alx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1747
                     /gene="Alx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagagag agagagagag agagagagag agagagagag agagagagaa caggcaggcc
       61 gggcgcagag cactgccacc gcctccttgg ctccccaact cccagccaag gcgcgcggtg
      121 gcgtcctcgc gccctcgccg gcgcccccgc cccgtcaccc gcgcaggcca ggcatgaacg
      181 ctgagacttg cgtctcttac tgcgagtcgc cggccactgc catggacgcc tactacagcc
      241 cggtgtcgca gagccgggaa ggttcgtcgc cttttagggg attcccagga ggcgacaagt
      301 tcggtacaac ttttctgtcg gccgcggcca aaggacaggg attcggggac gccaagggcc
      361 gggcccgcta cggcgcgggg cagcaggacc tggcggcacc gctggaaagc aacgctgggg
      421 cgcggggatc ctttaacaag ttccagccgc agccgcccac cccgcagccg ccgcccgctc
      481 cgcccgcgcc gcctgcgcat ctctacttgc agaggggcgc ctgcaaaacg cccccggacg
      541 gcagcctcaa gctccaggag ggcagcggcg gccacaacgc ggccttgcag gtcccctgct
      601 acgccaaaga gagcaacctg ggtgagccag agctgccccc tgactctgag cccgtgggca
      661 tggacaacag ctacctcagt gtgaaggaga caggggccaa ggggccccaa gaccgggctg
      721 gcgctgaaat accaagcccc ctggaaaaaa ccgactctga gagtagcaaa ggcaagaagc
      781 ggcggaacag aaccaccttc acgagctacc agctggagga gctggagaaa gtcttccaga
      841 agacacacta ccctgatgtg tatgcccggg agcagctggc tatgaggacc gacctcaccg
      901 aggcccgcgt gcaggtttgg ttccagaacc ggagggccaa gtggcgaaag agggagcgct
      961 ttgggcagat gcagcaggtc cgaacccact tctccacggc ctatgagttg cccctcctca
     1021 cccgagccga gaactatgcc cagattcaga acccgtcctg gattggcaac aatggggctg
     1081 cctcgccagt gccagcctgt gtggtcccct gtgacccagt gcctgcctgc atgtcccctc
     1141 acgctcaccc tcctggctct ggagccagca gcgtctccga cttcttgagt gtctctggag
     1201 ctggcagtca cgtgggccag acacacatgg gcagcctgtt tggagcagct ggcatcagtc
     1261 cgggcctcaa cggctacgag atgaatggcg agccagaccg caagacctcg agtattgctg
     1321 ccctgcgcat gaaggccaag gagcacagtg cagccatctc ttgggccaca tgacagagcc
     1381 cctcctgcca ctcctgatgt catccccttc cctggggccc tggccatgcc cctgttttcc
     1441 aggccccagc ttcccacttg actttcctct taggaacctg gcctggccca ggggcctggc
     1501 cctcagcact ttcagccacc ccaagtctga gaccccaggg actgctggga gggagggggc
     1561 gagggtaggc tcttgcccct ccctggctct gaggtcatga cccctgctcc ctgccaaagg
     1621 cagtggagaa agccaggtgg ccctgtgtgt agctttgcat cacgtaagct gaggccctgt
     1681 ctctcttcct gttcttttgc cccttccatt tgacttgagt caaagttagg ctcccttcca
     1741 gacctag
//
