LOCUS       NM_012921               1760 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ALX homeobox 1 (Alx1), mRNA.
ACCESSION   NM_012921
VERSION     NM_012921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Yuan,H., Kajiyama,H., Ito,S., Yoshikawa,N., Hyodo,T., Asano,E.,
            Hasegawa,H., Maeda,M., Shibata,K., Hamaguchi,M., Kikkawa,F. and
            Senga,T.
  TITLE     ALX1 induces snail expression to promote epithelial-to-mesenchymal
            transition and invasion of ovarian cancer cells
  JOURNAL   Cancer Res 73 (5), 1581-1590 (2013)
   PUBMED   23288509
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Kuijper,S., Beverdam,A., Kroon,C., Brouwer,A., Candille,S.,
            Barsh,G. and Meijlink,F.
  TITLE     Genetics of shoulder girdle formation: roles of Tbx15 and
            aristaless-like genes
  JOURNAL   Development 132 (7), 1601-1610 (2005)
   PUBMED   15728667
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Iioka,T., Furukawa,K., Yamaguchi,A., Shindo,H., Yamashita,S. and
            Tsukazaki,T.
  TITLE     P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1),
            paired-like homeoprotein, through acetylation of the conserved
            lysine residue adjacent to the homeodomain
  JOURNAL   J Bone Miner Res 18 (8), 1419-1429 (2003)
   PUBMED   12929931
  REMARK    GeneRIF: p300/CBP stimulate Cart1-dependent transcription activity,
            and this transactivation is inhibited by E1A and Tax, oncoproteins
            that suppress the activity of p300/CBP
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Furukawa,K., Iioka,T., Morishita,M., Yamaguchi,A., Shindo,H.,
            Namba,H., Yamashita,S. and Tsukazaki,T.
  TITLE     Functional domains of paired-like homeoprotein Cart1 and the
            relationship between dimerization and transcription activity
  JOURNAL   Genes Cells 7 (11), 1135-1147 (2002)
   PUBMED   12390248
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Qu,S., Tucker,S.C., Zhao,Q., deCrombrugghe,B. and Wisdom,R.
  TITLE     Physical and genetic interactions between Alx4 and Cart1
  JOURNAL   Development 126 (2), 359-369 (1999)
   PUBMED   9847249
REFERENCE   6  (bases 1 to 1760)
  AUTHORS   Cai,R.L.
  TITLE     Human CART1, a paired-class homeodomain protein, activates
            transcription through palindromic binding sites
  JOURNAL   Biochem Biophys Res Commun 250 (2), 305-311 (1998)
   PUBMED   9753625
REFERENCE   7  (bases 1 to 1760)
  AUTHORS   Gordon,D.F., Wagner,J., Atkinson,B.L., Chiono,M., Berry,R.,
            Sikela,J. and Gutierrez-Hartmann,A.
  TITLE     Human Cart-1: structural organization, chromosomal localization,
            and functional analysis of a cartilage-specific homeodomain cDNA
  JOURNAL   DNA Cell Biol 15 (7), 531-541 (1996)
   PUBMED   8756334
REFERENCE   8  (bases 1 to 1760)
  AUTHORS   Zhao,Q., Behringer,R.R. and de Crombrugghe,B.
  TITLE     Prenatal folic acid treatment suppresses acrania and
            meroanencephaly in mice mutant for the Cart1 homeobox gene
  JOURNAL   Nat Genet 13 (3), 275-283 (1996)
   PUBMED   8673125
REFERENCE   9  (bases 1 to 1760)
  AUTHORS   Zhao,G.Q., Zhou,X., Eberspaecher,H., Solursh,M. and de
            Crombrugghe,B.
  TITLE     Cartilage homeoprotein 1, a homeoprotein selectively expressed in
            chondrocytes
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8633-8637 (1993)
   PUBMED   7690966
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L14018.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14018.1, BC158591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..1760
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /note="ALX homeobox 1"
                     /db_xref="GeneID:25401"
                     /db_xref="RGD:2273"
     exon            1..686
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..1441
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /note="cartilage homeo protein 1; CART-1; cartilage
                     homeoprotein 1"
                     /codon_start=1
                     /product="ALX homeobox protein 1"
                     /protein_id="NP_037053.1"
                     /db_xref="GeneID:25401"
                     /db_xref="RGD:2273"
                     /translation="MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKA
                     TAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDGCNNL
                     RMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVY
                     VREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSY
                     PQIQNNLWAGNTSGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFGHVP
                     LNNFFTDSLLTGTTNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM"
     exon            687..991
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1120
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1758
                     /gene="Alx1"
                     /gene_synonym="Cart1; CART1X"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctctgcg ttctcaccag gctcctcggc aatgccagtc cactgtggag gcgactaggt
       61 ttctgggtgt ccttgtctct cctggcattt gtctgaagtg gaccgtctgt ctgaactagg
      121 ccggacgctc cctgccctgg gtaaggagga aagatggggg tggggtgggg gaggaggggg
      181 ccctggggtg agttagtccc tgcctatttt catattcatt aggactggag gttgccggag
      241 gagcccagct gagtttcaag atataaaagc aacttcgggt gccccttctg cagccgggac
      301 gtattaagag tctgggagct gggcagctcc tggcgtcgcg gggctcgctt cccctttccc
      361 tcctctttga ccctcctcct cccgcccact gctccctcct ccttatgcgc tctccagcct
      421 cggttcgccc gggagagctc cgggacagcc ttccaggatt atggagtttc tgagcgagaa
      481 gtttgccctt aagagcccgc cgagtaaaaa cagtgacttt tacatgggca caggaggcgc
      541 gttggagcac gttatggaga cgctggacaa tgagtccttt tatggcaaag cgacggctgg
      601 caaatgcgtg caggccttcg ggccgctgcc gcgagctgag catcacgtgc gcctggacag
      661 gacctcgccc tgtcaggaca gcagcgtgaa ctatgggatc accaaagtag aaggacagcc
      721 ccttcacacc gagctcaatc gagcaatgga cggctgcaac aatctcagga tgtctcctgt
      781 gaaggggatg ccagagaaga gcgaactgga tgaacttggg gacaaatgcg acagcaatgt
      841 atccagcagc aaaaagagga gacaccgaac tacgttcacc agtttgcagc tagaggaact
      901 agagaaggtc ttccaaaaaa cgcattaccc ggatgtatat gtcagagaac agcttgcact
      961 gagaacggag ctcactgagg ccagggtcca ggtttggttt caaaatcgaa gggccaagtg
     1021 gagaaaaaga gaacgttacg gccaaataca gcaagctaaa agccacttcg ctgccaccta
     1081 cgacatatca gttttaccaa ggactgacag ctatccacag attcagaaca atttgtgggc
     1141 aggaaataca agcggtggtt ctgtggttac ctcatgcatg ctaccccgtg acgcgtcctc
     1201 ctgcatgaca ccttattctc actcgcctcg gacagattcc agttacacgg ggttttcgaa
     1261 ccaccagaat cagttcggcc acgtgcccct caacaatttt ttcactgact ctcttctcac
     1321 tggaactacc aacggacacg catttgaaac aaagccagag tttgaaagga ggtcttccag
     1381 tatcgccgtc ctgaggatga aggccaagga gcacacagcc aatatttcat gggccatgta
     1441 acatacagta ctcttttatt ttccttttca tagcaaagta aaacattctt atttctcatt
     1501 tttaaaggat gccacaataa gctgctgtgt gtggaagggc taaaggtcaa gatagacggt
     1561 gagaccagct tacgtgaata gttgttatta tttaacattt aaatctaaga atggattccc
     1621 tgaaaggact gaataggttt accatacacc agcctccaca aactctgttt tagtagtaag
     1681 tgtttttttt tcccctattg tacaagtcaa tgaaatatga tcatgcaact tcttaaagga
     1741 ataaatgtat taaacaaaaa
//
