LOCUS       NM_013059               2411 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus alkaline phosphatase, biomineralization
            associated (Alpl), mRNA.
ACCESSION   NM_013059 NM_134342
VERSION     NM_013059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Favarin,B.Z., Bolean,M., Ramos,A.P., Magrini,A., Rosato,N.,
            Millan,J.L., Bottini,M., Costa-Filho,A.J. and Ciancaglini,P.
  TITLE     Lipid composition modulates ATP hydrolysis and calcium phosphate
            mineral propagation by TNAP-harboring proteoliposomes
  JOURNAL   Arch Biochem Biophys 691, 108482 (2020)
   PUBMED   32710882
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Gao,L., Wang,L.Y., Liu,Z.Q., Jiang,D., Wu,S.Y., Guo,Y.Q., Tao,H.M.,
            Sun,M., You,L.N., Qin,S., Cheng,X.C., Xie,J.S., Chang,G.L. and
            Zhang,D.Y.
  TITLE     TNAP inhibition attenuates cardiac fibrosis induced by myocardial
            infarction through deactivating TGF-beta1/Smads and activating P53
            signaling pathways
  JOURNAL   Cell Death Dis 11 (1), 44 (2020)
   PUBMED   31969558
  REMARK    GeneRIF: TNAP inhibition attenuates cardiac fibrosis induced by
            myocardial infarction through deactivating TGF-beta1/Smads and
            activating P53 signaling pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Zhang,F., Sun,X., Yu,H., Yang,X., Song,M., Han,Y., Li,Y. and Zhu,Y.
  TITLE     Effects of aluminum trichloride on the cartilage stimulatory growth
            factors in rats
  JOURNAL   Biometals 30 (1), 143-150 (2017)
   PUBMED   27885436
  REMARK    GeneRIF: he rats body weight were decreased, the cartilage
            histological structure were disrupted, the cartilage and serum
            contents of Al and the serum level of C-telopeptide of type II
            collagen were all increased, the serum level of type II collagen
            (Col II) and alkaline phosphatase (ALP), and the mRNA expressions
            of TGF-beta1, BMP-2, ALP and Col II were all decreased in the
            AlCl3-treated groups compared with those in control g...
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Kazemi,S., Mousavi Kani,S.N., Ghasemi-Kasman,M., Aghapour,F.,
            Khorasani,H. and Moghadamnia,A.A.
  TITLE     Nonylphenol induces liver toxicity and oxidative stress in rat
  JOURNAL   Biochem Biophys Res Commun 479 (1), 17-21 (2016)
   PUBMED   27590577
  REMARK    GeneRIF: Data show that nonylphenol (NP) increased serum alkaline
            phosphatase, lead to liver damage and can increase the expression
            of heme oxygenase-1 (HO1) and growth arrest and
            DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify
            the toxic effects on liver through induction of oxidative stress.
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Zernik,J., Kream,B. and Twarog,K.
  TITLE     Tissue-specific and dexamethasone-inducible expression of alkaline
            phosphatase from alternative promoters of the rat
            bone/liver/kidney/placenta gene
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1149-1156 (1991)
   PUBMED   2039500
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Hahnel,A.C., Rappolee,D.A., Millan,J.L., Manes,T., Ziomek,C.A.,
            Theodosiou,N.G., Werb,Z., Pedersen,R.A. and Schultz,G.A.
  TITLE     Two alkaline phosphatase genes are expressed during early
            development in the mouse embryo
  JOURNAL   Development 110 (2), 555-564 (1990)
   PUBMED   2133555
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Toh,Y., Yamamoto,M., Endo,H., Misumi,Y. and Ikehara,Y.
  TITLE     Isolation and characterization of a rat liver alkaline phosphatase
            gene. A single gene with two promoters
  JOURNAL   Eur J Biochem 182 (2), 231-237 (1989)
   PUBMED   2544423
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Misumi,Y., Tashiro,K., Hattori,M., Sakaki,Y. and Ikehara,Y.
  TITLE     Primary structure of rat liver alkaline phosphatase deduced from
            its cDNA
  JOURNAL   Biochem J 249 (3), 661-668 (1988)
   PUBMED   2895632
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Ogata,S., Hayashi,Y., Yasutake,K. and Ikehara,Y.
  TITLE     Chemical identification of lipid components in the membranous form
            of rat liver alkaline phosphatase
  JOURNAL   J Biochem 102 (6), 1609-1615 (1987)
   PUBMED   2834351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013059.3.
            
            On Nov 26, 2020 this sequence version replaced NM_013059.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03572.1, BC088399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000005.1  155289722-155289785 c
            65-213              JAXUCZ010000005.1  155254077-155254225 c
            214-333             JAXUCZ010000005.1  155249090-155249209 c
            334-449             JAXUCZ010000005.1  155248503-155248618 c
            450-624             JAXUCZ010000005.1  155247376-155247550 c
            625-800             JAXUCZ010000005.1  155246133-155246308 c
            801-944             JAXUCZ010000005.1  155242922-155243065 c
            945-1014            JAXUCZ010000005.1  155241164-155241233 c
            1015-1149           JAXUCZ010000005.1  155239888-155240022 c
            1150-1341           JAXUCZ010000005.1  155236858-155237049 c
            1342-1461           JAXUCZ010000005.1  155236196-155236315 c
            1462-2411           JAXUCZ010000005.1  155234770-155235719 c
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2411
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /note="alkaline phosphatase, biomineralization associated"
                     /db_xref="GeneID:25586"
                     /db_xref="RGD:2100"
     exon            1..64
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            65..213
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1727
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /EC_number="3.1.3.1"
                     /EC_number="3.9.1.1"
                     /note="alkaline phosphatase 2, liver; alkaline
                     phosphatase, tissue-nonspecific isozyme; TNSALP; AP-TNAP;
                     alkaline phosphatase liver/bone/kidney isozyme;
                     Tissue-nonspecific ALP alkaline phosphatase;
                     tissue-nonspecific alkaline phosphatase; phosphoamidase;
                     phosphocreatine phosphatase; alkaline phosphatase,
                     liver/bone/kidney"
                     /codon_start=1
                     /product="alkaline phosphatase, tissue-nonspecific isozyme
                     precursor"
                     /protein_id="NP_037191.2"
                     /db_xref="GeneID:25586"
                     /db_xref="RGD:2100"
                     /translation="MILPFLVLAIGTCLTNSFVPEKEKDPSYWRQQAQETLKNALKLQ
                     KLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYN
                     TNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKS
                     VGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVI
                     MGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELL
                     ALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNPKGFFLLVEGG
                     RIDHGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRG
                     NSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLR
                     HETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWASSASSPSP
                     GALLLPLALFPLRTLF"
     exon            214..333
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            334..449
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            450..624
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            625..800
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            801..944
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1014
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1149
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1341
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1461
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2411
                     /gene="Alpl"
                     /gene_synonym="Akp2; PHOA; TNAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacggcgctc cttagggcca ccgctcggcg cgccgggaca gaccctcccc actcctgcct
       61 gcaggatcgg aacgtcaatt aacggctgac actgcccccc acctcttccc acccatctgg
      121 gctccagcga ggaacggatc tcggggtaca ccatgatctt gccattttta gtactggcca
      181 tcggcacctg ccttaccaac tcatttgtgc cagagaaaga gaaagacccc agttactggc
      241 gacagcaagc ccaagagacc ttgaaaaatg ccctgaaact ccaaaaactc aacaccaacg
      301 tggccaagaa catcatcatg ttcctgggag atggtatggg cgtctccaca gtgacagctg
      361 cccgcatcct taagggccag ctacaccaca acacgggcga ggagacacgg ctggagatgg
      421 acaagttccc ctttgtggct ctctccaaga cgtacaacac caacgctcag gtccccgaca
      481 gcgcgggcac tgccactgcc tacttgtgtg gcgtgaaggc caacgagggc accgtgggag
      541 tgagcgcggc cactgagcgc acgcgatgca acaccactca ggggaacgag gtcacgtcca
      601 tcctgcgctg ggccaaggat gctgggaagt ccgtgggcat cgtgaccacc actcgggtga
      661 accacgccac tcccagtgca gcctatgcgc actcggccga tcgggactgg tactcggaca
      721 atgagatgcc gccagaggct ctgagccagg gctgcaagga catcgcctat cagctaatgc
      781 acaacatcaa ggacatcgat gtgatcatgg gtggcggccg gaagtacatg taccccaaga
      841 acagaactga tgtggaatat gaactggatg agaaggccag gggcaccaga ctggatggcc
      901 tggacctcat cagcatttgg aagagcttca aacctagaca caagcactcc cactatgtct
      961 ggaaccgcac tgaactgctg gcccttgacc cctccagggt ggactacctc ttaggtctct
     1021 ttgagcccgg ggacatgcag tatgagttga atcggaacaa cctgactgac ccttccctct
     1081 cggagatggt ggaggtggcc ctccggatcc tgacaaagaa tcccaaaggc ttcttcttgc
     1141 tagtggaagg aggcaggatt gaccacgggc accatgaagg caaggccaag caggcgctgc
     1201 atgaggccgt ggagatggat gaggccatcg gaaaggcggg caccatgact tcccagaaag
     1261 acacgttgac tgtggttact gctgatcact cccacgtttt cacgtttggt ggctacaccc
     1321 ccaggggcaa ctccattttt ggtctggctc ccatggtgag tgacacggac aagaagccct
     1381 tcacagccat cctgtatggc aacgggcctg gttacaaggt ggtggacggt gaacgggaga
     1441 acgtctccat ggtggattat gctcacaaca actaccaggc ccagtccgct gtccccctgc
     1501 ggcacgagac ccacggtggg gaagatgtgg cggtctttgc caagggccct atggctcacc
     1561 tgcttcacgg cgtccatgag cagaactaca tcccccacgt catggcgtat gcctcctgca
     1621 ttggagccaa ccttgaccac tgtgcctggg ccagctctgc gagcagcccc tccccagggg
     1681 ccctgctgct tccactggct ctgttccccc tacgcaccct gttctgaggg cccaggtccc
     1741 acaagagccc acaatggaca gccggctccc ctccctttgt ggcctgccac ctggccgccc
     1801 acactcaacg gggaggccca ggcaacctcg agcaggaaca gaagtttgct acctgcctca
     1861 cttccgcccg gaaccctccg tgggtcggat tcctggctct gccgttgttt ctctattcac
     1921 tgccttttgg ccagcagggt gggtttctct cttgggccgg caggacacag actgcgcaga
     1981 ttcccaaagc accttatttt tctaccaaat atactctcca gaccctgcaa ccatcatgga
     2041 acattccaga tctgaccttc tctcccctac cccttctctc tggaacactg ggtcccatag
     2101 tcacagccag tccctcaacc caaccctccc tggagggaag accaggtctg ctcagggtga
     2161 gactcccagg aagccacctc cggggttggc tgtctaccca gggtggccag gctgggaaga
     2221 acaacccagc cggacaggac gcacacactc cccacccagc tccagagact cgccaaccct
     2281 tcactgaagc gactcccctg tttggaatag caaaaaaaaa aaagaaagaa aaaaaagaaa
     2341 aaaattttaa tttctctttt tggtgttggt taaaagggaa cacaagacat ttaaataaaa
     2401 tgttccaaat a
//
